Article
Environmental Sciences
Mohammad Hassanpour, Seyed Ali Hosseini Tafreshi, Masoud Salavati-Niasari, Masood Hamadanian
Summary: The study revealed that nanoparticles have a significant impact on the growth parameters of Dunaliella salina, with the effects being dependent on the nanoparticle concentration. Lower concentrations of nanoparticles (15 and 30 mg/L) promoted cell numbers, specific growth, biomass, and pigments, while a higher concentration (60 mg/L) led to elevated levels of malondialdehyde (MDA), indicating a destructive effect on algal cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Fisheries
Xiujuan Zhou, Jing Gong, Yue Zhuang, Fei Zhu
Summary: The study found that coumarin can enhance the immunity of Cherax quadricarinatus, reduce the number of WSSV infections, and delay the infection process. Coumarin also has a positive effect on important immune parameters such as THC, ACP activity, SOD activity, lysozyme activity, and PO activity.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Microbiology
Cheng Chen, Chang-Shuai Liang, Tao Wang, Jing-Lei Shen, Fei Ling, Hai-Feng Jiang, Peng-Fei Li, Gao-Xue Wang
Summary: This study identified rhein as a potent inhibitor of WSSV infection in red swamp crayfish. Rhein inhibited viral transcription, reduced viral load, and improved the survival rate of infected crayfish. It activated JAK/STAT and NF-kappa B pathways, decreased the expression of crustin-1 and BAF, and increased the expression of C-type lectin and proPO to arrest WSSV replication. Additionally, rhein attenuated oxidative and inflammatory stresses and enhanced innate immunity. This research provides great potential for the development of prophylaxis and therapy agents for controlling WSSV infection in crustacean aquaculture.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Hui-Wen Lin, Jiuan-Miaw Liao, Ke-Min Chen, Jen-Wei Tsai, Chia-Sung Chang, Chia-Yu Chou, Hsing-Hui Su, Pei-Hsun Liu, Ya-Chun Chu, Yi-Hsin Wang, Meilin Wang, Shiang-Suo Huang
Summary: This study found that D. salina extract can alleviate myocardial ischemia/reperfusion (I/R) injury and exert anti-inflammatory and anti-apoptotic effects through inhibiting TLR4-mediated signaling pathway, while reducing autophagy activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Xiyi Qian, Fei Zhu
Summary: The study demonstrated that GML can reduce mortality in crayfish infected with white spot syndrome virus, enhance the expression of immune-related genes, increase immune parameters, and induce hemocyte apoptosis, suggesting that GML can be used to maintain the health of crayfish.
Article
Fisheries
Long Zhang, Yanhe Li, Minglin Wu, Haofeng Ouyang, Ruixue Shi
Summary: The study explored the expression pattern of prophenoloxidase (proPO) upon white spot syndrome virus (WSSV) infection in red swamp crayfish, and obtained and analyzed the proPO genomic DNA sequence for the first time. It was found that proPO mRNA levels were significantly upregulated in various tissues after infection, and predicted features in the intron region of proPO were identified. Additionally, three single nucleotide polymorphisms (SNPs) in intron regions were associated with anti-WSSV traits, and recombinant proPO showed potential in reducing WSSV copy numbers and mortality in crayfish.
Article
Fisheries
Gaoliang Yuan, Lei Zhu, Xinyu Jiang, Jie Zhang, Chao Pei, Xianliang Zhao, Li Li, Xianghui Kong
Summary: The study identified Aeromonas veronii as a virulent bacterial pathogen infecting Procambarus clarkii, and also detected white spot syndrome virus (WSSV) co-infection. The co-infection led to 100% mortality in the tested crayfish, higher than single infections with either A. veronii or WSSV. The findings provide insights into co-infection strategies for disease diagnosis and control in P. clarkii populations.
Article
Fisheries
Jia Liu, Cheng Chen, Hui Du, Dexin Wang, Haixiang Ma, Gaoxue Wang, Tao Liu, Erlong Wang
Summary: This study evaluated the antiviral effects of twelve herbal extracts in a WSSV-infected crayfish model and found that Sophora flavescens extract showed the highest inhibition rate. Further investigation on the main bioactive component, matrine, showed that it significantly inhibited WSSV replication and improved the survival rate of infected crayfish. The study also revealed the mechanisms of matrine's antiviral effects.
Article
Fisheries
Jing Gong, Xiaoyi Pan, Xiujuan Zhou, Fei Zhu
Summary: This study found that GML enhances the resistance of red claw crayfish to WSSV infection by affecting the expression of immune-related genes and modulating immune parameters. GML has a positive impact on the immune system of crayfish, increasing their survival rate and antiviral ability.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Zhong-Chen Sun, Cheng Chen, Fei-Fan Xu, Bing-Ke Li, Jing-Lei Shen, Tao Wang, Hai-Feng Jiang, Gao-Xue Wang
Summary: The study found that naringenin (NAR) has potential as a preventive or therapeutic agent against WSSV, inhibiting viral replication and improving survival rates in crayfish. NAR can reduce viral loads and inhibit WSSV replication by regulating key genes and immune-related factors.
JOURNAL OF FISH DISEASES
(2021)
Article
Fisheries
Xiaohua Wang, Chenxi Lu, Faxiang Wan, M. M. Onchari, Xiulian Yin, Baoxia Tian, Jinfeng Zhang, Qingyun Bai, Chuping Luo
Summary: White spot disease caused by white spot syndrome virus (WSSV) is a serious crustacean disease in China. Addition of locillomycin could improve the survival rate of WSSV-infected crayfish. Spo0A and SpoIIID were found to negatively regulate the production of locillomycin in Bacillus velezensis Bs916, and disruption of them increased the production of locillomycin significantly. Feeding with B. velezensis Bs916 or Delta Spo0A + SpoIIID reduced the mortality of WSSV-challenged crayfish and improved their immune activities.
Article
Fisheries
Yitong Zhang, Jinxuan Wen, Yao Xu, Hao Wang, Liqun Lu, Rui Song, Jixing Zou
Summary: The study showed that different concentrations of EGCG can suppress WSSV infection in P. clarkii, with histopathological examination revealing no characteristic pathological changes in P. clarkii tissues due to EGCG administration. Pharmacokinetics studies demonstrated rapid absorption of EGCG in P. clarkii, with peak concentrations of 73.78 μg/g in the liver and 24.87 μg/g in the muscle. The results indicate the high potential applications of EGCG against WSSV in P. clarkii.
JOURNAL OF FISH DISEASES
(2022)
Article
Fisheries
Rui-lin Gao, Ling-ke Liu, Li-mei Guo, Ke-jian Wang, Hai-peng Liu
Summary: This study identified the involvement of protein phosphatase 2A (PP2A) subunits in combating white spot syndrome virus (WSSV) infection in crustaceans, potentially by regulating the expression of antimicrobial substances to inhibit WSSV infection. These findings shed new light on the mechanism of WSSV infection and antiviral response in crustaceans.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Virology
Chang-Shuai Liang, Cheng Chen, Zhi-Yang Lin, Jing-Lei Shen, Tao Wang, Hai-Feng Jiang, Gao-Xue Wang
Summary: Acyclovir exhibits potent inhibition on WSSV replication, suppressing viral proliferation through various mechanisms and reducing key WSSV gene expression during early infection, leading to improved survival rates in crayfish challenged with WSSV.
Article
Agriculture, Dairy & Animal Science
Yovita Permata Budi, Li-Chi Lin, Chang-Hsien Chung, Li-Li Chen, Yi-Fan Jiang
Summary: White spot syndrome virus is a lethal disease in shrimp culture systems. This study provides new structural information on the virus and contributes to the development of treatment or prevention strategies.
Article
Chemistry, Applied
Jia-Ying Zhao, Qi Liao, Jian-Wei Zhang, Guo-Qiang Lin, Zhengtao Wang, Dingding Gao, Qing-Hua Li, Ping Tian
Summary: In this study, a metal-free cascade dihalogenation-cyclization reaction was reported for the convenient preparation of dibrominated cis-tetrahydrobenzofuran-5(4H)-ones and cis-dihydrobenzopyran-6(5H)-ones. These products bear 1,4-dibromobut-1-enyl subunit in trans-trans and trans-cis form. The anticancer activity against MDA-MB-468 cells was also observed for the corresponding products.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Medicinal
Dingding Gao, Shuai Tang, Yixin Cen, Liang Yuan, Xiaojing Lan, Qing-Hua Li, Guo-Qiang Lin, Min Huang, Ping Tian
Summary: PHGDH is an important enzyme in serine biosynthesis pathway, and its overexpression in malignant tumor cells makes it a potential target for cancer treatment. In this study, a series of novel PHGDH inhibitors were discovered using compound screening and structural optimization. The lead compound D8 showed strong enzymatic inhibitory activity, high binding affinity, and sensitivity to PHGDH gene amplification or overexpression. Further experiments revealed the binding site of D8 on PHGDH and its potential antitumor efficacy in a xenograft mouse model.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Geosciences, Multidisciplinary
QingHua Li, Cong Chen
Summary: This study established a multi-dimension long-term carbon emission analysis model to explore the characteristic of Beijing's embodied carbon emissions. The analysis revealed the contribution of socioeconomic factors in local and imported carbon emissions and identified the key contributors to carbon emissions. The study is expected to provide decision support for policymakers in formulating carbon mitigation policies and allocating carbon mitigation responsibilities from multiple perspectives.
FRONTIERS IN EARTH SCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
Jun Wang, Qian Zhang, Pengwen Hou, Qinghua Li
Summary: This study establishes a theoretical model between a brand manufacturer and an e-commerce platform. The manufacturer aims to open a new online channel through the platform to attract more consumers, in addition to the traditional channel. However, the online channel faces the threat of counterfeits, and the platform can choose to adopt blockchain technology to address this issue. The main findings indicate that blockchain not only has an anti-counterfeiting effect but also has an incentive effect, where the platform can use blockchain to incentivize the manufacturer to open the online channel. Furthermore, both the supply chain and consumers can benefit from blockchain, and the impact of different channel characteristics on blockchain's value is analyzed.
COMPUTERS & INDUSTRIAL ENGINEERING
(2023)
Article
Automation & Control Systems
Le Liu, Qinghua Li, Zhipeng Lin, Yiming Fang
Summary: This article proposes a fixed-time prescribed performance optimization control method based on disturbance observers for the speed and tension system of the reversible cold strip rolling mill with output constraints, parameter perturbations, and load disturbance. The disturbance observers are constructed to estimate the system's unmatched uncertainties, and the observer errors can converge in fixed time. The designed controllers, combined with a time-varying logarithmic barrier Lyapunov function (TLBLF), command filtered backstepping approach, fixed-time control, and prescribed performance control, ensure the convergence of system states in fixed time and the constraints within predefined ranges.
INTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING
(2023)
Article
Materials Science, Multidisciplinary
Farah Siddique, Fuguo Li, Mirza Zahid Hussain, Qian Zhao, Qinghua Li
Summary: High-speed impact at strain rates >10(3) s(-1) has common characteristics in energy absorption and adiabatic temperature rise. An ultra-high strength low alloy steel subjected to high-speed impact was studied, with a focus on energy absorption driven by thermo-kinetics phenomenon and its correlation with target plate thickness. Deformation characteristics were explained using an analytical model that relates absorbed energy and plate thickness. EBSD and FE analysis revealed the formation of adiabatic shear bands due to adiabatic temperature rise in specific zones, while the radial direction experienced increased stress resulting in a higher proportion of recrystallized grain structure. Micro hardness testing confirmed the differences in hardness between the distinct zones.
METALS AND MATERIALS INTERNATIONAL
(2023)
Article
Environmental Sciences
Xinxin Zhang, Xianzhong Ke, Yao Du, Yanqiu Tao, Jiangkai Xue, Qinghua Li, Xianjun Xie, Yamin Deng
Summary: The biodegradation of organic matter and the dissolution of iron oxides play important roles in the release of geogenic phosphorus to groundwater. However, the combined effects of natural organic matter and iron oxides on phosphorus mobilization are not well understood. This study investigates sediment samples from boreholes in the Central Yangtze River Basin and finds that sediments with high phosphorus levels contain more bioavailable phosphorus, particularly iron oxide bound phosphorus and organic phosphorus, compared to sediments with low phosphorus levels. The study also reveals the formation of stable phosphorus-iron-organic matter complexes that inhibit the dissolution of iron oxides and the degradation of organic matter, thereby limiting phosphorus mobilization.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Ecology
Yanjun Shen, Qinghua Li, Ruli Cheng, Yang Luo, Yufeng Zhang, Qing Zuo
Summary: In this study, the complete mitogenomes of Sinopotamon chishuiense and the nearly complete mitogenomes of S. wushanense were sequenced and analyzed. Novel patterns of gene rearrangement were detected, and the phylogenetic relationship was revealed. The results have significant implications for understanding the evolutionary history and taxonomic relationship of Sinopotamon.
ECOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Qing-Hua Li, Gui-Shan Zhang, Feng Wang, Yixin Cen, Xi-Liang Liu, Jian-Wei Zhang, Yu-Hui Wang, Albert W. M. Lee, Dingding Gao, Guo-Qiang Lin, Ping Tian
Summary: Researchers report an asymmetric rearrangement of cyclopropylcarbinyl cations using artificial organic catalysts, resulting in chiral homoallylic sulfide products with high yields and enantioselectivities (up to 99% enantiomeric excess). The reaction involves the dehydration of prochiral cyclopropylcarbinols catalyzed by a chiral SPINOL-derived N-triflyl phosphoramide catalyst, followed by trapping of the resulting cyclopropylcarbinyl cations by thione-containing nucleophiles. The synthetic utility of the process is demonstrated through subgram-scale experiments and downstream transformations.
Article
Computer Science, Information Systems
Weijing Liu, Xinfu Pan, Jiangnan Liu, Qinghua Li
Summary: By using TCAD simulation, the electro-thermal properties of TreeFET are investigated and optimized by considering the interbridge width, nanosheet space, and nanosheet width. It is found that a smaller interbridge width mitigates short-channel effects and increases electron concentration, but also increases thermal resistance. A larger nanosheet space increases on-state current and compensates for gate drive loss, but results in longer conduction paths, limiting further improvements. Additionally, a suitable nanosheet width is required to lessen the decline of gate controllability induced by interbridge channels. Therefore, suitable geometry parameters should be selected to achieve a compromise between thermal and electrical performance.
Article
Remote Sensing
Bo Liu, Shulei Wang, Qinghua Li, Xinyang Zhao, Yunqing Pan, Changhong Wang
Summary: UAV swarm applications are crucial for the future, but creating a dynamic and scalable assignment algorithm is a challenge. To address this, we propose the Ex-MADDPG algorithm, which improves robustness and scalability. Through simulations and real-world experiments, our results demonstrate the effectiveness and scalability of the Ex-MADDPG algorithm in handling various groups and tasks. This algorithm holds great promise for mission planning and decision-making in UAV swarm applications.
Article
Metallurgy & Metallurgical Engineering
Zimin Li, Zilong Zhu, Jianqiu Wang, Meng Wang, Ting Hou, Qinghua Li, Pei Yu
Summary: This study aims to optimize the concentration and pH value of two corrosion inhibitors, nitrite-based and mixture of nitrite and molybdate, for carbon steel protection in closed cooling water systems. The study reveals that the mixture of nitrite and molybdate exhibits higher inhibition efficiency due to its double layer structure.
ANTI-CORROSION METHODS AND MATERIALS
(2023)
Article
Environmental Sciences
Qiang Wang, Jin Wang, Xingjiang Cao, Qinghua Li, Shi Xie, Junyang Sang, Yifei Zhang, Cheng Xue, Qiang Fu
Summary: This study surveyed whole-body positron emission tomography/computed tomography (PET-CT) examinations in Jiangsu Province and established diagnostic reference levels (DRLs). Nine hospitals in three regions of Jiangsu Province were included in the study. Various metrics were used to establish the DRLs, including activity duration product (ADP), activity per body weight (A(W)), dose-length product (DLP), and total effective dose (E-T). The DRLs for whole-body PET-CT examinations in Jiangsu Province were determined to be 922 mGy • cm (DLP), 4453 MBq.min (ADP), 5.22 MBq.kg(-1)(A(W)), and 19.8 mSv (E-T). The E-T for whole-body PET-CT examinations in Jiangsu Province was found to be higher than in other countries.
RADIATION PROTECTION DOSIMETRY
(2023)
Article
Ecology
Ruli Cheng, Yang Luo, Yufeng Zhang, Qinghua Li, Yingwen Li, Yanjun Shen
Summary: This study used the efficient and noninvasive environmental DNA metabarcoding (eDNA) approach to survey the aquatic ecology of 12 river sections in the Wujiang River. The results revealed a decline in fish diversity and a change in fish community structure in the mainstream of the river, caused by anthropogenic factors such as hydropower and overfishing. The eDNA method was found to complement traditional methods and provide accurate information on fish composition.
ECOLOGY AND EVOLUTION
(2023)
Article
Biotechnology & Applied Microbiology
Zheng Zhuang, Xueqing Zhong, Qinghua Li, Tian Liu, Qing Yang, Guo-Qiang Lin, Qing-Li He, Qunfei Zhao, Wen Liu
Summary: In this study, we report on the successful preparation of 3R-torosachrysone (4), a tetrahydroanthracene precursor of physcion, in Aspergillus oryzae NSAR1 by heterologous expression of related genes mined from the phlegmacins-producing ascomycete Talaromyces sp. F08Z-0631. The conditions for converting 4 into physcion were studied and optimized, leading to the development of a concise approach for extracting high-purity physcion from the alkali-treated fermentation broth of the 4-producing A. oryzae strain.
BIORESOURCES AND BIOPROCESSING
(2023)