期刊
ARCHIVES OF VIROLOGY
卷 157, 期 11, 页码 2047-2057出版社
SPRINGER WIEN
DOI: 10.1007/s00705-012-1377-9
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资金
- BBSRC [BBS/E/D/20320000] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20320000] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20320000] Funding Source: Medline
Infectious bursal disease (IBD) is a viral immunosuppressive disease of chickens attacking mainly an important lymphoid organ in birds [the bursa of Fabricius (BF)]. The emergence of new variant strains of the causative agent [infectious bursal disease virus (IBDV)] has made it more urgent to develop new vaccination strategies against IBD. One of these strategies is the use of recombinant vaccines (DNA and viral-vectored vaccines). Several studies have investigated the host immune response towards IBDV. This review will present a detailed background on the disease and its causative agent, accompanied by a summary of the most recent findings regarding the host immune response to IBDV infection and the use of recombinant vaccines against IBD.
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