期刊
ARCHIVES OF VIROLOGY
卷 156, 期 7, 页码 1275-1279出版社
SPRINGER WIEN
DOI: 10.1007/s00705-011-0969-0
关键词
Dengue virus; Nonstructural protein 1; HepG2; NF-kappa B; Transcriptional activity
类别
资金
- FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- INCT Dengue (Institute for Science and Technology in Dengue)
Dengue virus nonstructural protein 1 (NS1) is a glycoprotein involved in viral RNA replication. NS1 associates with host cell proteins and can be found in lipid raft domains on the host cell surface, suggesting an involvement in signal transduction events. In this work, we observed that NS1 expression in HepG2 cells increases nuclear translocation of NF-kappa B p65 protein, which was paralleled by DNA-protein complex formation. Luciferase assays showed an increase in NF-kappa B transcriptional activities in NS1-expressing cells when compared to parental cells. NS1 may enhance NF-kappa B function in host cells and contribute to the pathogenesis of dengue.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据