Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

(2014) S.R. Crowell et al.   TOXICOLOGY LETTERS

The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy

(2013) M. Refik Gökmen et al.   ANNALS OF INTERNAL MEDICINE

Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene

(2013) R. L. Chang et al.   CARCINOGENESIS

Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway

(2013) Béatrice Dendelé et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

(2013) Heinz H. Schmeiser et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel p53 Mutant Found in Iatrogenic Urothelial Cancers Is Dysfunctional and Can Be Rescued by a Second-site Global Suppressor Mutation

(2013) Adam F. Odell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene

(2013) Amal I. Malik et al.   MUTAGENESIS

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid

(2013) Marie Stiborová et al.   XENOBIOTICA

Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53

(2012) Ido Goldstein et al.   CARCINOGENESIS

Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts

(2012) Jill E. Kucab et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Subchronic Oral Exposure to Benzo(a)pyrene Leads to Distinct Transcriptomic Changes in the Lungs That Are Related to Carcinogenesis

(2012) Sarah Labib et al.   TOXICOLOGICAL SCIENCES

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

(2012) Lisbeth K. Siddens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene

(2011) Hamza Hamouchene et al.   BMC GENOMICS

Rapid derivation of genetically related mutants from embryonic cells harboring a recombinase-specificTrp53platform

(2011) Quan-Xiang Wei et al.   CELL CYCLE

Hepatic mRNA, microRNA, and miR-34a-Target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation

(2011) Amal I. Malik et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and dna adducts in mutaTMmouse

(2011) Christine L. Lemieux et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

(2011) O. Laptenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and cell signaling in alcoholic liver disease

(2010) Juliane I. Beier et al.   BIOLOGICAL CHEMISTRY

Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-Nitrobenzanthrone and Carcinogenic 3-Nitrobenzanthrone

(2010) Marie Stiborová et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model

(2010) Jill E. Kucab et al.   FEBS Journal

Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors

(2010) Tao Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Haplo-insufficiency: a driving force in cancer

(2010) Alice H Berger et al.   JOURNAL OF PATHOLOGY

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

(2009) S. Sur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53

(2008) Maria L. Simões et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY