Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

Expression of Aldo-Keto Reductase Family 1 Member B10 in the Early Stages of Human Hepatocarcinogenesis

(2014) Hironori Tsuzura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance

(2013) J Rysä et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

PXR cross-talks with internal and external signals in physiological and pathophysiological responses

(2013) Susumu Kodama et al.   DRUG METABOLISM REVIEWS

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

(2013) Krisstonia Spruiell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Profiling Unravels Cancer-Related Hepatic Molecular Signatures in Steatohepatitis but Not in Steatosis

(2012) Julia Starmann et al.   PLoS One

Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor

(2011) E Hoffart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nuclear Receptors as New Perspective for the Management of Liver Diseases

(2011) Michael Trauner et al.   GASTROENTEROLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

(2011) Romi Ghose et al.   LIFE SCIENCES

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Murine aldo-keto reductase family 1 subfamily B: identification of AKR1B8 as an ortholog of human AKR1B10

(2010) Amit Joshi et al.   BIOLOGICAL CHEMISTRY

ChIPing the cistrome of PXR in mouse liver

(2010) Julia Yue Cui et al.   NUCLEIC ACIDS RESEARCH

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls

(2009) Chun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease

(2009) Silvia Sookoian et al.   Pharmacogenetics and Genomics

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4

(2008) Shingo Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Inhibition of Site 1 Protease Activity Inhibits Sterol Regulatory Element-Binding Protein Processing and Reduces Lipogenic Enzyme Gene Expression and Lipid Synthesis in Cultured Cells and Experimental Animals

(2008) J. L. Hawkins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics

Nonalcoholic Fatty Liver Disease: Pathogenesis and Potential for Nuclear Receptors as Therapeutic Targets

(2007) Jacob George et al.   MOLECULAR PHARMACEUTICS