Article
Immunology
Damien Levard, Izaskun Buendia, Anastasia Lanquetin, Martina Glavan, Denis Vivien, Marina Rubio
Summary: Over the past two decades, researchers have hoped for a new era in stroke treatment with a combination of reperfusion and neuroprotection, but despite positive results in preclinical stroke models, clinical trials have not shown efficacy. The existing preclinical data have depicted an incomplete picture of stroke pathophysiology, and there is a gap between clinical trials and preclinical results on stroke.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Endocrinology & Metabolism
Sule Canberk, Ana Rita Lima, Mafalda Pinto, Paula Soares, Valdemar Maximo
Summary: Cancer genomes often have alterations to the epigenome, including silencing of tumor suppressor genes. Epigenetic changes play a significant role in the differentiation and proliferation of thyroid follicular cells. However, research on the role of epigenomics in Hurthle cell neoplasms still faces limitations.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xin He, Xinyu Gao, Weidong Xie
Summary: This article reviews the interaction between skin metabolism and aging, covering glucose, protein, and lipid metabolism, and explores relevant strategies for regulating skin metabolism. It is found that skin aging affects the metabolism of glucose, protein, and lipids, and the metabolism of these substances also affects the process of skin aging. Regulating specific metabolic disorders in the skin is an important anti-aging strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Bruno Sousa, Jorge Lopes, Andre Leal, Maria Martins, Cristiano Soares, Manuel Azenha, Fernanda Fidalgo, Jorge Teixeira
Summary: This study investigated the detoxification mechanism of Diclofenac (DCF) in tomato plants, revealing that GSH-mediated DCF detoxification is the main mechanism preventing DCF bioaccumulation in fruits and minimizing concerns for human health. The research also found that DCF detoxification mainly occurs in roots, with enhanced GST activity being a key driving factor. The study highlights the importance of understanding GST activity in remediation of DCF-contaminated environments and improving plant growth under such conditions.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Polymer Science
Diana Rede, Cristina Delerue-Matos, Virginia Cruz Fernandes
Summary: Plastic, a crucial material in modern society, has caused significant ecological stress due to high production rates and inadequate waste management. Microplastics (MPs) have emerged as a major environmental problem globally, affecting both terrestrial and aquatic ecosystems. This review emphasizes the need for interdisciplinary collaboration to address the issue of MP pollution and highlights gaps in the existing literature for future research.
Article
Geosciences, Multidisciplinary
William D. Halliday
Summary: The article discusses the impact of climate change on the Arctic marine soundscapes, emphasizing the importance of filling geographic gaps and calling on researchers to continue studying the direct and indirect effects of climate change on underwater sound levels to establish a baseline for further research.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Xing-Kai Qian, Jing Zhang, Xiao-Dong Li, Pei-Fang Song, Li-Wei Zou
Summary: This article summarizes the structural characteristics, functions, and metabolism of the prolyl-specific peptidases or proteases family, as well as their importance in human physiology and drug metabolism.
CURRENT MEDICINAL CHEMISTRY
(2022)
Editorial Material
Cell Biology
Irene Miguel-Aliaga, Gordana Vunjak-Novakovic, Erin J. Stephenson, Frederic Gachon, Inoes Milagre, Evanna Mills, Joshua B. Rubin, Iva Kelava
Summary: Researchers in this collection explore the importance of sex differences in the development and progression of diseases, offering mechanistic clues on sexually dimorphic differences seen in interorgan communication, metabolic disease, neurological disorders, and more.
DEVELOPMENTAL CELL
(2022)
Article
Agriculture, Dairy & Animal Science
Mitsuki Kondo, Yoshinori Ikenaka, Shouta M. M. Nakayama, Yusuke K. Kawai, Mayumi Ishizuka
Summary: This study investigated the specific duplication and loss events of cytochrome P450 (CYP) genes in families 1-3 in Carnivora. It revealed the expansion of CYP2Cs and CYP3As in omnivorous species and their evolutionary adaptation. The phylogenetic analysis provided insights into the evolution of CYPs in Carnivora, which is crucial for the interpretation of pharmacokinetics or toxicokinetic data in wild carnivorans.
Article
Public, Environmental & Occupational Health
Belaydi Othmane, Zhenglin Yi, Chunyu Zhang, Jinbo Chen, Xiongbing Zu, Benyi Fan
Summary: This study aimed to examine the risk of second primary malignancy (SPM) in bladder cancer patients in relation to race and histology. The results showed that race and histology had an impact on the type and risk of SPMs, with Asian/Pacific Islanders having a more pronounced increase in SPMs.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Cell Biology
Hanaa Hariri, W. Mike Henne
Summary: This article discusses the important roles of SNX-RGS proteins in multiple interorganelle contact sites, as well as their emerging roles in cellular metabolism, human disease, and lipid trafficking.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Dermatology
Baochang Lai, Xinya Xie, Fan Li, Qi Cui, Erle Dang, Wenhuan Luo, Ning Wang, Yan Zheng, Gang Wang, Lei Xiao, Nanping Wang
Summary: The study demonstrates that CAR plays a pathogenic role in psoriasis and has the potential to be a target for its treatment. Xenobiotics and proinflammatory cytokines affect the expression of CAR and its target genes, further promoting the development of psoriatic skin lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Clinical Neurology
James A. Wiseman, Mike Dragunow, Thomas I-H Park
Summary: Identifying and interrogating cell type-specific populations within the human brain is crucial for understanding brain homeostasis and neurological disorders. The literature on nuclear markers in brain cells is limited, making it important to review and identify robust nuclear markers for more precise quantification and purification of cell populations.
Article
Multidisciplinary Sciences
Rik Oldenkamp, Constance Schultsz, Emiliano Mancini, Antonio Cappuccio
Summary: This article discusses a method to estimate antimicrobial resistance prevalence in countries lacking surveillance data by capturing the statistical relationship between socioeconomic characteristics and AMR prevalence. By establishing statistical models, accurate estimates of clinical AMR prevalence can be provided for low- and middle-income countries, informing 87% of all countries worldwide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Yerkezhan Amerzhanova, Luca Vangelista
Summary: This perspective provides an overview of CCR5 as a central molecular determinant and its potential therapeutic applications. The study focuses on CCR5 antagonism and its impact on receptor-ligand interactions. The analysis of CCL5 mutants reveals the potential for enhanced anti-HIV-1 activity. Furthermore, the exploration of strategies such as improving CCR5 interaction in regions distal to the chemokine N-terminus and developing allosteric antagonists opens up new possibilities for CCR5 blockade.
FRONTIERS IN IMMUNOLOGY
(2022)
