Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Akemi Vieira Hosokawa, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Thays Millena Alves Pedroso, Rinneu Elias Borges, Susi Missel Pacheco, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Habitat loss and fragmentation pose significant threats to biodiversity. The use of bioindicators can provide insight into the health of the environment. A study conducted in agricultural areas found higher genotoxic damage in bats compared to a control area.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Alice Lopes, Marcelino Benvindo-Souza, Wanessa Fernandes Carvalho, Hugo Freire Nunes, Phamella Neres de Lima, Matheus Santos Costa, Edson Jose Benetti, Vinicius Guerra, Simone Maria Teixeira Saboia-Morais, Carolina Emilia Santos, Karina Simoes, Rogerio Pereira Bastos, Daniela de Melo e Silva
Summary: The study evaluated the genotoxic, mutagenic, and histopathological hepatic responses of Dendropsophus minutus tadpoles to acute exposure to the herbicide glyphosate and the surfactant polyoxyethylene amine. Results showed that both glyphosate and polyoxyethylene amine have potential genotoxic, mutagenic, and hepatotoxic effects in the tadpoles, with polyoxyethylene amine showing a higher impact. Findings emphasize the need for continued monitoring of amphibian populations in agricultural areas to mitigate the long-term impacts of pollutants on anuran tadpoles.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Lais Fernanda Oya-Silva, Taynah Vicari, Geonildo Rodrigo Disner, Juliana Roratto Lirola, Tatiane Klingelfus, Helyandra de Lourdes Schicora Goncalves, Thalita Pires Borges Leite, Sabrina Loise de Morais Calado, Carmen Lucia Voigt, Helena Cristina Silva de Assis, Marta Margarete Cestari
Summary: The study revealed that both NPTiO2 alone and their co-exposure with Pb can cause genotoxicity in blood and kidney tissues, impact hepatic antioxidant enzyme activities, leading to an antioxidant imbalance, and increase lipid peroxidation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Niels Hadrup, Jorid B. Sorli, Anoop K. Sharma
Summary: Molybdenum, lithium, and tungsten are constituents of many products and exposure to these elements potentially occurs at work. Dose descriptors for inhalation toxicity were identified and the potential for genotoxicity and carcinogenicity was assessed.
Article
Environmental Sciences
Luiza Flavia Veiga Francisco, Debora da Silva Baldivia, Bruno do Amaral Crispim, Syla Maria Farias Ferraz Klafke, Pamella Fukuda de Castilho, Lucilene Finoto Viana, Edson Lucas dos Santos, Kelly Mari Pires de Oliveira, Alexeia Barufatti
Summary: The study found that high concentrations of aluminum and manganese exhibit cytotoxic and genotoxic effects on cell lines, but do not show a clear mutagenic response.
Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Biodiversity Conservation
Claudio Barberini Camargo Filho, Alexandre Rosa dos Santos, Jeferson Luiz Ferrari, Bruno de Lima Preto, Sustanis Horn Kunz, Adriano Posse Senhorelo, Diego Lang Burak, Joao Luiz Rossi Junior
Summary: This study assessed the environmental quality of a lagoon in southeastern Brazil that receives industrial effluents from a large iron ore company. The study found poor environmental quality in the lagoon, with high levels of chromium and nickel and genotoxic damage in fish. The presence of trace elements, even at low concentrations or low bioavailability, can cause genotoxic damage.
Article
Environmental Sciences
Muryllo Santos Castro, Larissa Cristine Carvalho Penha, Thamires Alexsandra Torres, Marianna Basso Jorge, Luis Fernando Carvalho-Costa, Gilberto Fillmann, Ricardo Luvizotto-Santos
Summary: The study found that even at the lowest dose tested (0.35 μg g(-1)), chlorothalonil showed genotoxic and mutagenic effects, which increased in a dose-dependent manner with higher doses. This evidence suggests that the compound should be banned due to potential hazards to aquatic ecosystems and human health, outweighing any benefits to food production.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jamira Dias Rocha, Marilia Elias Gallon, Abel Vieira de Melo Bisneto, Vanessa Cristiane Santana Amaral, Luciane Madureira de Almeida, Leonardo Luiz Borges, Lee Chen-Chen, Leonardo Gobbo-Neto, Elisa Flavia Luiz Cardoso Bailao
Summary: This study evaluated the cytogenotoxic and anticytogenotoxic potential of V. polyanthes leaf extract, showing its potential application in protecting against toxic manifestations induced by doxorubicin (DXR).
Article
Environmental Sciences
Amr Adel Abdel-Khalek, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: Fish exposed to silver nanoparticles showed significant decreases in DNA damage and nuclear anomalies after treatment with orange and banana peels water, indicating an effective repairing mechanism. The highest level of DNA damage was observed in liver tissues after 24 hours of exposure, with a reduction in damage after 48 and 96 hours.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Article
Environmental Sciences
Ali Acar
Summary: Diquat dibromide, a commonly used herbicide in agriculture, was found to have dose-dependent toxic effects on plants, affecting physiological, genetic, and biochemical parameters. Increasing doses of diquat dibromide resulted in oxidative stress, decreased chlorophyll pigment levels, and various adverse effects on plant health.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Article
Nutrition & Dietetics
Tamiris Trevisan de Barros, Vinicius de Paula Venancio, Livia Cristina Hernandes, Lusania Maria Greggi Antunes, Elaine Hillesheim, Roberta Garcia Salomao, Mariana Giaretta Mathias, Carolina Almeida Coelho-Landell, Roseli Borges Donega Toffano, Maria Olimpia Ribeiro do Vale Almada, Jose Simon Camelo-Junior, Sofia Moco, Ornella Cominetti, Fabio da Veiga Ued, Jim Kaput, Jacqueline Pontes Monteiro
Summary: This study aimed to explore differences in proteomic profiles for individuals with different DNA damage and EPA/DHA levels, finding that low levels of n-3 long-chain PUFA may have a less protective role against DNA damage through the expression of pro-inflammatory proteins such as CDK8-CCNC, PIK3CA-PIK3R1, KYNU, and PRKCB.
Article
Engineering, Biomedical
Fernanda Gomes Leite, Juliana Fonzar Marana, Luiza Fernandes Tavares de Sa, Thais Francine Ribeiro Alves de Almeida, Helison Rafael Pereira do Carmo, Marco Vinicius Chaud, Denise Grotto, Lindemberg da Mota Silveira-Filho
Summary: The study found that the combination of polyaniline (PANi) with collagen and silk-fibroin (COL-SF) patches can safely promote improvement in left ventricular remodeling in a myocardial infarct rat model. These patches showed better performance in reducing infarct size and increasing left ventricular thickness compared to the control group, and did not cause worsening of echocardiographic measurements. However, the use of PANi may lead to signs of hepatotoxicity and pro-oxidant effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Food Science & Technology
Alexandre Ferro Aissa, Volodymyr P. Tryndyak, Aline de Conti, Ana Rita Thomazela Machado, Katiuska Tuttis, Carla da Silva Machado, Livia Cristina Hernandes, Patrick Wellington da Silva Santos, Juliana Mara Serpeloni, Igor P. Pogribny, Lusania Maria Greggi Antunes
Summary: A diet deficient in donors of methyl group, such as methionine, affects DNA methylation, hepatic lipid metabolism, and other epigenetic mechanisms. This study investigated the effects of methionine-supplemented or methionine-deficient diets on chromatin-modifying genes, global DNA methylation, genes related to lipid metabolism, and microRNAs in mouse liver. Both diets altered gene expression, global DNA methylation, and microRNA expression, with the methionine-deficient diet having a more substantial effect.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Physical
Natalia A. D'Angelo, Mayra C. C. Camara, Mariana A. Noronha, Denise Grotto, Marlus Chorilli, Felipe R. Lourenco, Carlota De O. Rangel-Yagui, Andre M. Lopes
Summary: This study investigates the co-encapsulation of chemotherapeutic drugs using nanostructures to improve treatment efficacy and reduce the risk of drug resistance. The researchers found that poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-PCL)-based polymersomes (Ps) can enhance the bioavailability and cellular uptake of drugs, as well as increase their solubility. The study also examines the influence of various conditions on the nanostructures and provides optimal parameters for their production.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Environmental Sciences
Andressa Y. Fujiike, Celina Y. A. L. Lee, Fabiana S. T. Rodrigues, Larissa C. B. Oliveira, Aneli M. Barbosa-Dekker, Robert F. H. Dekker, Ilce M. S. Colus, Juliana M. Serpeloni
Summary: This study investigated the anticancer effects of botryosphaeran and its carboxymethylated derivative on breast cancer cells and found that botryosphaeran can inhibit tumor cell growth and metastasis through inducing apoptosis, as well as suppress the formation of tumor spheroids.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Chemistry, Analytical
Silvana Ruella Oliveira, Katiuska Tuttis, Ana Rita Thomazela Machado, Cecilia Cristina de Souza Rocha, Lusania Maria Greggi Antunes, Fernando Barbosa
Summary: This study developed a new method to quantify the uptake of gold nanoparticles in individual cancer cells and revealed differences in the uptake ability among cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Diego Luis Ribeiro, Katiuska Tuttis, Larissa Cristina Bastos de Oliveira, Juliana Mara Serpeloni, Izabela Natalia Faria Gomes, Andre van Helvoort Lengert, Claudia Quintino da Rocha, Rui Manuel Reis, Ilce Mara de Syllos Colus, Lusania Maria Greggi Antunes
Summary: Brachydin A (BrA) extracted from Fridericia platyphylla exhibits significant cytotoxic effects on metastatic prostate cancer (mPCa) cells in both 2D and 3D cultures, through mechanisms involving mitochondrial dysfunction, apoptosis, and necrosis markers. This suggests that BrA could be a potential candidate drug for preclinical studies against mPCa.
Article
Biochemistry & Molecular Biology
Larissa Cristina Bastos de Oliveira, Diego Luis Ribeiro, Jessyane Rodrigues do Nascimento, Claudia Quintino da Rocha, Ilce Mara de Syllos Colus, Juliana Mara Serpeloni
Summary: Brachydin C has demonstrated anticancer effects in prostate cancer cells. The use of multicellular tumor spheroids (MCTS) can better mimic the microenvironment of tissues. MCTS showed higher resistance to Brachydin C-induced cell death and Brachydin C can modulate the expression of multiple genes and proteins.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Food Science & Technology
Emmanuel Ayobami Oyeniyi, Carlos Arterio Sorgi, Luiz Gustavo Gardinassi, Lara Ferreira Azevedo, Joseph Adewuyi Adeyemi, Olumuyiwa Temitope Omotoso, Lucia Helena Faccioli, Lusania Maria Greggi Antunes, Fernando Barbosa Jr
Summary: The study investigated the toxicity of D. tripetala fruit extract on mice using lipidomic analyses, comet and Acetylcholinesterase (AChE) assays. The fruit extract did not induce DNA damage, but significantly affected body weight and brain AChE activity in the mice. Additionally, the extract modulated the profile of brain phospholipids, potentially through activation of inflammation and methylation pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Jose Villacis-Chiriboga, Griet Jacobs, John Van Camp, Kathy Elst, Jenny Ruales, Veronica Marcillo-Parra, Volker Bohm, Andrea Bunea, Martina Cirlini, Neal Craft, Bruno De Meulenaer, M. Graca Dias, Giacomo Lazzarino, Antonio J. Melendez-Martinez, Pieter Versloot, Adriana Z. Mercadante, Begona Olmedilla-Alonso, Johana Ortiz-Ulloa, Carla M. Stinco, Stefan Voorspoels
Summary: An interlaboratory comparison was conducted to analyze carotenoids in freeze-dried mango. The results showed that freeze-dried mango pulp can be used as a reference material for specific analyses.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Food Science & Technology
Raphaela A. Mantovani, Ana Augusta O. Xavier, Guilherme M. Tavares, Adriana Z. Mercadante
Summary: This study evaluated the influence of the ratio of free to acylated lutein on hydrolysis and bioaccessibility in emulsion-based systems. The results showed that the stability of the emulsion did not significantly affect carotenoid bioaccessibility. The bioaccessibility of carotenoids increased with an increase in the percentage of free carotenoids in the emulsions.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Ana Rita Thomazela Machado, Katiuska Tuttis, Patrick Wellington da Silva Santos, Alexandre Ferro Aissa, Lusania Maria Greggi Antunes
Summary: The combination of diallyl disulfide (DADS) and sorafenib (SORA) has toxic effects on hepatocellular carcinoma cells and inhibits tumor proliferation, invasion, and metastasis. This combination therapy shows promise in developing new clinical protocols.
Article
Biochemistry & Molecular Biology
Carolina P. Bernardes, Neife A. G. Santos, Tassia R. Costa, Danilo L. Menaldo, Flavia M. Sisti, Martin K. Amstalden, Diego L. Ribeiro, Lusania M. G. Antunes, Suely V. Sampaio, Antonio C. Santos
Summary: In this study, the snake-venom-based tripeptide BTX-I was chemically modified to enhance its neurotrophic and neuroprotective effects. The ethyl-esterified peptide BTX-II showed significant improvement in promoting neuritogenesis and upregulating proteins and genes associated with cognitive improvements.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Environmental Sciences
Andressa Yuri Fujiike, Larissa Cristina Bastos de Oliveira, Diego Luis Ribeiro, Erica Romao Pereira, Nadia Calvo Martins Okuyama, Anna Gabriele Prado dos Santos, Ilce Mara de Syllos Colus, Juliana Mara Serpeloni
Summary: This study compared the effects of the chemotherapy drug Docetaxel (DTX) on 2D monolayer and 3D multicellular tumor spheroids (MCTS) of metastatic prostate cancer cells. The results showed that the response to DTX differed significantly between the two culture models, with the MCTS model demonstrating lower sensitivity to DTX compared to the 2D model. This suggests that incorporating MCTS models alongside 2D cultures is important when searching for new therapeutic targets.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Materials Science, Multidisciplinary
Victoria Soares Soeiro, Louise Lacalendola Tundisi, Venancio Alves Amaral, Fenando Batain, Priscila Gava Mazzola, Elias Basile Tambourgi, Jose Martins de Oliveira, Marco Vinicius Chaud, Denise Grotto, Norberto Aranha, Angela Faustino Jozala
Summary: The study evaluated the structural properties of BC-FB blend, showing that the obtained membranes have a hydrogen-bonded porous structure with closed and interconnected pores. This blend has potential applications in areas such as optoelectronic devices.
MATERIA-RIO DE JANEIRO
(2021)
