Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Toxicology
Ana Paula Martins Castanha, Laiza Moura Almeida-Terassi, Estela Guardado-Yordi, Maria Joao Matos, Edson Luis Maistro
Summary: This study explored the safety and genotoxicity of a newly synthesized coumarin derivative, and found that the compound exhibited no cytotoxicity and protected cells from DNA damage at tested concentrations.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Environmental Sciences
Ali Acar
Summary: In this study, the toxic effects of monosodium glutamate (MSG) on plants and the protective role of cape gooseberry extract were investigated using Allium cepa L. as test material. The results showed that MSG caused various adverse physiological and genetic changes, while cape gooseberry extract helped alleviate these effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Jefferson Hollanda Veras, Camila Regina Do Vale, Elisa Flavia Luiz Cardoso Bailao, Murilo Machado Dos Anjos, Clever Gomes Cardoso, Matheus Gabriel de Oliveira, Jose Realino de Paula, Guilherme Roberto de Oliveira, Carolina Ribeiro E. Silva, Lee Chen-Chen
Summary: A coumarin-chalcone hybrid, 4-MET, was synthesized and evaluated for its genotoxic, cytotoxic, and protective effects. The results demonstrated that 4-MET showed chemopreventive potential and significantly reduced the harmful effects of certain mutagens, exhibiting a chemoprotective effect against DNA damage.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Margherita Lavorgna, Severina Pacifico, Roberta Nugnes, Chiara Russo, Elena Orlo, Simona Piccolella, Marina Isidori
Summary: This study investigated the biological properties and chemical composition of two samples of Criollo var. cocoa raw beans from Indonesia and Peru. Results showed that the Indonesian bean hydroalcoholic extracts had better antioxidant activity and exhibited antimutagenic and antigenotoxic effects, with inhibitory effects on breast and hepatic cancer cells. Different environmental conditions in the geographical areas affected the composition of fatty acids and (epi)catechins in the beans.
Review
Environmental Sciences
Juana Sanchez-Alarcon, Mirta Milic, Lilia Patricia Bustamante-Montes, Keila Isaac-Olive, Rafael Valencia-Quintana, Ninfa Ramirez-Duran
Summary: The genotoxic potential of mercury and its derivatives remains controversial, with organic mercury compounds being more toxic than inorganic and elemental ones but all still posing a potential risk. There is not sufficient evidence for mercury to be classified as a human carcinogen. Studies have shown that inorganic mercury compounds such as mercury chloride and mercury nitrate, and organic compounds like methylmercury and thimerosal, are widely studied in populations with accidental, occupational, or iatrogenic exposure.
Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
S. Shruthi, K. Bhasker Shenoy
Summary: This study evaluated the genoprotective effects of gallic acid (GA) against cyclophosphamide (CP) induced genotoxicity in Swiss albino mice. The results showed that GA significantly reduced DNA damage and micronucleus frequency caused by CP, as well as protected the hepatic tissue against reactive oxygen species (ROS) mediated damage. GA also ameliorated histological changes induced by CP in hepatic tissue, indicating its potential as a versatile antioxidant for protection against CP induced genotoxicity and hepatic damage in Swiss albino mice.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Akemi Vieira Hosokawa, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Thays Millena Alves Pedroso, Rinneu Elias Borges, Susi Missel Pacheco, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Habitat loss and fragmentation pose significant threats to biodiversity. The use of bioindicators can provide insight into the health of the environment. A study conducted in agricultural areas found higher genotoxic damage in bats compared to a control area.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Alice Lopes, Marcelino Benvindo-Souza, Wanessa Fernandes Carvalho, Hugo Freire Nunes, Phamella Neres de Lima, Matheus Santos Costa, Edson Jose Benetti, Vinicius Guerra, Simone Maria Teixeira Saboia-Morais, Carolina Emilia Santos, Karina Simoes, Rogerio Pereira Bastos, Daniela de Melo e Silva
Summary: The study evaluated the genotoxic, mutagenic, and histopathological hepatic responses of Dendropsophus minutus tadpoles to acute exposure to the herbicide glyphosate and the surfactant polyoxyethylene amine. Results showed that both glyphosate and polyoxyethylene amine have potential genotoxic, mutagenic, and hepatotoxic effects in the tadpoles, with polyoxyethylene amine showing a higher impact. Findings emphasize the need for continued monitoring of amphibian populations in agricultural areas to mitigate the long-term impacts of pollutants on anuran tadpoles.
ENVIRONMENTAL POLLUTION
(2021)
Article
Food Science & Technology
Julia Buchmueller, Anne-Margarethe Enge, Antonia Peters, Johanna Ebmeyer, Jan-Heiner Kuepper, Bernd Schaefer, Albert Braeuning, Stefanie Hessel-Pras
Summary: This study investigated the genotoxic profile of varying degrees of esterification of unsaturated pyrrolizidine alkaloids (PAs). The results revealed that diester-type PAs had more pronounced effects than monoester-type PAs, including cytotoxicity, DNA damage, and cell cycle perturbation. Additionally, in vitro experiments showed that lasiocarpine had aneugenic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Antonio Cascajosa-Lira, Maria Puerto, Ana I. Prieto, Silvia Pichardo, Leticia Diez-Quijada Jimenez, Alberto Banos, Enrique Guillamon, Rosario Moyano, Veronica Molina-Hernandez, Angeles Jos, Ana M. Camean
Summary: This study confirmed the lack of in vivo genotoxicity of PTS at the doses tested, indicating that it is a promising natural alternative in animal feed without adverse effects on genetic material.
Article
Food Science & Technology
Concepcion Medrano-Padial, Maria Puerto, Ana Isabel Prieto, Nahum Ayala, Pauline Beaumont, Caroline Rouger, Stephanie Krisa, Silvia Pichardo
Summary: This study investigated the in vivo genotoxic effects of rats orally exposed to different doses of ST-99 and found no genotoxicity in the cells isolated from stomach, liver, and blood. Analytical studies confirmed the presence of stilbenes and their metabolites in plasma and tissues, supporting the safety profile of ST-99 for potential application as a preservative in the wine industry.
Article
Oncology
Raquely M. Lenzi, Luciano H. Campestrini, Simone C. Semprebon, Jonas A. R. Paschoal, Monique A. G. Silva, Selma F. Zawadzki-Baggio, Mario S. Mantovani, Carmen L. O. Petkowicz, Juliana B. B. Maurer
Summary: Consumption of GL-rich foods like Brassica vegetables and maca is linked to reduced cancer risk. Maca has significantly higher GL content and shows growth-inhibitory effects against cancer cell lines, supporting its categorization as a superfood.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rafael Claudino dos Santos, Raquel Oliveira Nascimento de Freitas, Mary Ann Foglio, Joao Ernesto de Carvalho, Ana Lucia Tasca Goes Ruiz, Lucas Roberto Pessatto, Rodrigo Juliano Oliveira, Adrivanio Baranoski, Bruna Isabela Biazi, Mario Sergio Mantovani, Candida Aparecida Leite Kassuya, Pedro Cruz de Oliveira Junior, Anelise Samara Nazari Formagio
Summary: This study synthesized and evaluated a series of galloyl-substituted compounds for their antiproliferative activity. The results showed that some of these compounds exhibited moderate to high inhibition activity against various human cancer cells, and galloyl hydrazide also demonstrated cytotoxicity in hepatocarcinoma cells.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Toxicology
Andressa Megumi Niwa, Simone Cristine Semprebon, Glaucia Fernanda Rocha D'Epiro, Lilian Areal Marques, Thalita Alves Zanetti, Mario Sergio Mantovani
Summary: The study demonstrates that salinomycin has antitumor potential against human hepatocellular carcinoma cells through inducing cell cycle arrest, upregulating certain genes related to apoptosis, and modulating hepatic cytochrome P450 expression. These findings suggest that salinomycin may interfere with chemotherapy treatment by affecting metabolizing enzymes and should be considered in conjunction with other treatments.
TOXICOLOGY MECHANISMS AND METHODS
(2022)
Article
Environmental Sciences
Luan Vitor Alves de Lima, Matheus Felipe da Silva, Virginia Marcia Concato, Debora Berbel Lirio Rondina, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Sandra Regina Lepri, Ane Stefano Simionato, Galdino Andrade Filho, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: Fluopsin C, an antibiotic compound derived from microorganisms, has exhibited antitumor, antibacterial, and antifungal activities. This study investigated the mechanisms of fluopsin C's antiproliferative effects, including cytotoxicity, genotoxicity, cell cycle arrest, apoptosis induction, mitochondrial membrane potential change, and modulation of mRNA expression of genes involved in stress response and cell death. The results demonstrated that fluopsin C interferes with tumor spheroid growth and regulates essential molecular processes associated with stress and cell death.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Biotechnology & Applied Microbiology
Matheus Felipe da Silva, Luan Vitor Alves de Lima, Thalita Alves Zanetti, Ingrid Felicidade, Phelipe Oliveira Favaron, Sandra Regina Lepri, Debora Berbel Lirio Rondina, Mario Sergio Mantovani
Summary: This study aimed to evaluate the mechanisms of action of diosgenin in human hepatocellular carcinoma cells. The results showed that diosgenin induced cell cycle arrest and apoptosis through DNA damage, leading to reduced cell viability and inhibited growth of spheroids.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Endocrinology & Metabolism
Marilia Rizzon Zaparolli Ramos, Ingrid Felicidade, Ligia de Oliveira Carlos, Nathalia Ramori Farinha Wagner, Mario Sergio Mantovani, Luan Vitor Alves de Lima, Lucia Regina Ribeiro, Thiago Inacio Barros Lopes, Fernanda Carla Henrique-Bana, Joao Vitor Zimmerman, Fernando Cesar Macedo Junior, Magda Rosa Ramos da Cruz, Antonio Carlos Ligocki Campos
Summary: This study investigated the effects of probiotic supplementation on the plasma metabolite profile after Roux-Y gastric bypass (RYGB). The results showed that probiotics were associated with significant differences in plasma metabolites, contributing to improved metabolic health.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Mycology
Cassia Milena de Souza, Alane Tatiana Pereira Moralez, Murilo Moreira dos Santos, Mario Sergio Mantovani, Luciana Furlaneto-Maia, Marcia Cristina Furlaneto
Summary: The structure and genetic factors of switched morphotypes colonies in Candida tropicalis were investigated. The switched colonies had distinct arrangements of ECM, higher amounts of total carbohydrates and proteins in ECM, and higher percentage of hyphae. The expression levels of EFG1, WOR1, and BCR1 were significantly higher in the switched colonies.
Article
Pharmacology & Pharmacy
Lilian Areal Marques, Simone Cristine Semprebon, Bruna Isabela Biazi, Ingrid Felicidade, Thalita Alves Zanetti, Adrivanio Baranoski, Virginia Marcia Concato, Wander Rogerio Pavanelli, Mario Sergio Mantovani
Summary: This study demonstrates the synergistic cytotoxic and antiproliferative effects of Salinomycin and 1,25D on MCF-7 breast carcinoma cells. The combination of these two drugs activates multiple cell death pathways and inhibits cell proliferation, suggesting a potential novel therapy strategy for breast cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Toxicology
Camila Lehnhardt Pires, Thalita Alves Zanetti, Mario Sergio Mantovani, Isabel O'Neill de Mascarenhas Gaivao, Fabio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Summary: This study investigated the effects of Pracaxi oil on HepG2/C3A cells and found that the oil did not have significant cytotoxic, cell cycle, or apoptosis effects. Additionally, the oil up-regulated genes related to metabolism, cell proliferation, and oxidative stress.
TOXICOLOGY IN VITRO
(2022)
Article
Toxicology
Ana Paula Oliveira De Quadros, Bruna Oshiiwa, Marcel Petreanu, Rivaldo Niero, Paulo Cesar Pires Rosa, Alexandra Christine Helena Frankland Sawaya, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Rubus rosifolius, a common medicinal plant in southern Brazil, has been found to have genotoxic and apoptotic effects in in vitro studies, indicating potential risks in human use.
TOXICOLOGY IN VITRO
(2023)
Article
Toxicology
Debora Berbel Lirio Rondina, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Thalita Alves Zanetti, Ingrid Felicidade, Lilian Areal Marques, Giuliana Castello Coatti, Mario Sergio Mantovani
Summary: This study evaluated the cytotoxicity of ZER combined with chemotherapeutic agents and its effect on the expression of mRNA genes related to cell cycle, cell death, xenobiotic metabolism, DNA damage, and endoplasmic reticulum stress. The results showed that ZER had cytotoxic and antiproliferative effects, and could modulate the expression of genes involved in various cellular processes. However, its efficacy might be influenced when combined with other chemotherapeutic agents.
TOXICOLOGY IN VITRO
(2022)
Article
Environmental Sciences
Ana Paula Oliveira de Quadros, Isabel Braganca Baraldi, Marcel Petreanu, Rivaldo Niero, Mario Sergio Mantovani, Isabel O'Neill De Mascarenhas Gaivao, Edson Luis Maistro
Summary: Extracts from the leaves and stems of Rubus rosifolius may have adverse effects on humans, causing genotoxic and mutagenic effects on DNA in cells.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Environmental Sciences
Liana Martins de Oliveira, Luan Vitor Alves de Lima, Matheus Felipe da Silva, Ingrid Felicidade, Sandra Regina Lepri, Mario Sergio Mantovani
Summary: Curcumin, extracted from Curcuma longa L, has been studied for its antiproliferative activity using different cell culture systems. This study investigated the effects of curcumin on cytotoxicity, genotoxicity, and spheroid growth, and found that curcumin exhibited potential for drug development with antiproliferative activity in cancer.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Pharmacology & Pharmacy
Nayane de Oliveira Silva, Luan Vitor Alves de Lima, Liana Martins de Oliveira, Matheus Felipe da Silva, Amanda Passuello de Aguiar, Simone Cristine Semprebon, Phelipe Oliveira Favaron, Sandra Regina Lepri, Ingrid Felicidade, Mario Sergio Mantovani
Summary: This study evaluated the antiproliferative effects of ZER on HT-29 cells, and found that ZER could inhibit cell migration, induce apoptosis and cell cycle arrest, and affect key signaling pathways.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Gerontology
Liliya Martynova
Summary: Since the 1960s, the goal of active longevity has been repeatedly mentioned in Russian policy documents. Two interpretations of the term exist, with one considering it synonymous with active aging and the other viewing it as a policy goal alongside other aspects of healthy aging, employment, and social participation. Current observations on active longevity policy implementations show progress in health-care development and social participation, but pose challenges in terms of employment and life expectancy data.
JOURNAL OF AGING & SOCIAL POLICY
(2023)
