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ARCHIVES OF SURGERY
卷 143, 期 12, 页码 1218-1221出版社
AMER MEDICAL ASSOC
DOI: 10.1001/archsurg.143.12.1218
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Objectives: To delineate the clinical and pathological characteristics of solid pseudopapillary neoplasm ( SPN), compare them between adults and children, and determine the predictive features suggesting malignant potential. Design: Retrospective analysis of patients who underwent surgery for a pathologically confirmed SPN. Setting: Tertiary care referral center. Patients: Sixty-two consecutive patients who underwent surgery for a pathologically confirmed SPN between 1985 and 2006. Main Outcome Measures: Demographic information and clinical presentation, radiological details, surgical data, pathological characteristics, postoperative course, and long-term survival. Results: Among 62 patients, 47 patients were adults ( mean age, 36 years; range, 18-63 years) and 15 patients were children ( mean age, 12 years; range, 8-13 years). A palpable mass was the most common presenting symptom in children ( 9 of 15; 60%) and an incidentally detected pancreatic mass, in adults ( 18 of 47; 38.3%) ( P= .001). The mean tumor size in children was significantly larger than in adults ( 8.0 vs 6.0 cm; P < .03). In children, the tumor was located in the head of the pancreas ( 10 of 15; 66.7%) and in adults, in the body or tail ( 38 of 47; 80.9%) ( P = .001). Nine patients ( 14.5%) had malignant SPN. There was no significant clinical factor suggesting malignant potential. Two patients had a tumor recurrence. They were still alive after debulking surgery. There were no tumor-related deaths. Conclusion: Solid pseudopapillary neoplasm had different clinical features in adults and children. Because long-term survival can be achieved, even with the synchronous or metachronous metastatic lesions, SPN should be treated aggressively, with complete resection, even if this requires metastatectomy.
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