Article
Rehabilitation
Andrea Manca, Lucia Ventura, Gianluca Martinez, Antonella Cano, Gabriele Matta, Elena Aiello, Franca Deriu
Summary: This study compared oxygen consumption and energy expenditure in people with multiple sclerosis (PwMS) and healthy controls during activities of daily living (ADL). The results showed that PwMS had significantly higher oxygen consumption and energy expenditure in tasks involving walking compared to the controls. Additionally, PwMS took longer to complete ADL tasks and used significantly more energy in most activities.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Jelka Jansa, Sofie Ferdinand, Meta Milo, Inger G. Loyning, Tarja Huilla, Lene Kallmayer, Stephan Ilsbroukx, Nuria Fillo, Joke Raats, Jytte Jakobson, Daphne Kos
Summary: This study systematically investigated the performance of activities of daily living (ADL) in people with multiple sclerosis (MS). The results showed that ADL performance decreased with increasing EDSS score, indicating a need for assistance in motor skills and process skills. The study emphasized the importance of screening and providing relevant rehabilitation interventions for all MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Rehabilitation
Tobia Zanotto, Irina Galperin, Anat Mirelman, Shahar Yehezkiyahu, John Estes, Lingjun Chen, Keren Regev, Arnon Karni, Tanja Schmitz-Hubsch, Friedemann Paul, Sharon G. Lynch, Abiodun E. Akinwuntan, Hannes Devos, Jeffrey M. Hausdorff, Jacob J. Sosnoff
Summary: Frailty is significantly associated with a history of falls in people with multiple sclerosis (MS), independent of age, sex, and disease severity.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Neurosciences
Anne Macnamara, Celia Chen, Victor R. Schinazi, Dimitrios Saredakis, Tobias Loetscher
Summary: Investigating difficulties during daily activities is crucial for developing vision-related intervention strategies. This review synthesizes the types of AMD simulation methods used and emphasizes the importance of choosing simulation methods based on the nature of the study. Consistency in simulation methodology is critical for generating realistic behavioral responses.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Julia Wojzischke, Juergen M. Bauer, Andreas Hein, Rebecca Diekmann
Summary: This study investigated the prevalence of obesity among geriatric rehabilitation patients and its impact on functional recovery, finding that obesity was common in this age group but was not significantly associated with improvements in activities of daily living during the rehabilitation process.
Article
Engineering, Biomedical
Jianwei Lai, Aiguo Song, Jiajin Wang, Ye Lu, Ting Wu, Huijun Li, Baoguo Xu, XiangShan Wei
Summary: This paper presents the development of a novel honeycomb pneumatic actuator (HPA) constructed using flexible thermoplastic polyurethane (TPU) coating through hot pressing or ultrasonic welding techniques. Compared to the previously utilized double-layer fabric-based pneumatic actuators (DLFPAs), the HPAs yields a remarkable 862% increase in end output force. The integration of HPAs onto a soft pneumatic glove enables the facilitation of various activities of daily living and significantly enhances the patients' daily functioning.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Review
Multidisciplinary Sciences
Catalina Pizarro-Pennarolli, Carlos Sanchez-Rojas, Rodrigo Torres-Castro, Roberto Vera-Uribe, Diana C. Sanchez-Ramirez, Luis Vasconcello-Castillo, Lilian Solis-Navarro, Gonzalo Rivera-Lillo
Summary: A systematic review revealed that post-COVID-19 patients experience worsening of ADL performance, leading to loss of independence. The previous ADL functional status is crucial for predicting disease severity and mortality. The most common assessment tools used across different subject levels were the Barthel Index and ADL score.
Article
Clinical Neurology
Marco Pisa, Jennifer A. Ruiz, Gabriele C. DeLuca, Marta de Andres Crespo, Heather M. DelMastro, Kayla M. Olson, Elizabeth W. Triche, Albert C. Lo
Summary: Dysfunction in upper limb function is common in persons with multiple sclerosis, even in those with mild disability. Box and Block Test (BBT), finger-nose test (FNT), and Nine-Hole Peg Test (NHPT) have been identified as the most accurate measures to detect upper limb dysfunction.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Rheumatology
Aoi Nagano, Masaki Takeuchi, Nobuyuki Horita, Takeshi Teshigawara, Tatsukata Kawagoe, Yuki Mizuki, Akira Meguro, Hiroto Nakano, Yohei Kirino, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Michiko Kurosawa, Takeshi Fukumoto, Mitsuhiro Takeno, Takeshi Kaneko, Nobuhisa Mizuki
Summary: This study found that ocular lesions, neurological manifestations, and arthritis affect the activities of daily living (ADL) in patients with Behcet's disease. Patients with ocular lesions or neurological manifestations are more likely to require physical assistance.
Article
Rehabilitation
Takuaki Tani, Shinobu Imai, Kiyohide Fushimi
Summary: Longer daily supervised rehabilitation improves activities of daily living after laparoscopic surgery for colorectal cancer.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Hannah E. Wurzinger, Tamar Abzhandadze, Lena Rafsten, Katharina S. Sunnerhagen
Summary: The study revealed that dependency in personal ADL within the first 2 days after stroke could predict dependency at 3 and 12 months post-stroke, highlighting the importance of early assessment in understanding rehabilitation needs for stroke patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ole Petter Norvang, Anne Eitrem Dahl, Pernille Thingstad, Torunn Askim
Summary: The purpose of this study was to assess whether resilience assessed early after stroke can be associated with independence in basic activities of daily living 3 months later. The results showed that resilience was not associated with basic activities of daily living.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Tan Van Nguyen, Huyen Thanh Dang, Mason Jenner Burns, Hiep H. H. Dao, Tu Ngoc Nguyen
Summary: The study aimed to investigate the prevalence of impairment of activities of daily living in older patients with heart failure, and found that ADL impairment was common and significantly increased the risk of readmission in this population.
Article
Rehabilitation
Maryam Seddighi-Khavidak, Nahid Tahan, Alireza Akbarzadeh-Baghban
Summary: Using lavender oil as an olfactory stimulus during vestibular rehabilitation exercises can improve balance and reduce fear of falling in people with multiple sclerosis.
DISABILITY AND REHABILITATION
(2022)
Article
Computer Science, Information Systems
Qingyun Meng, Guanxin Liu, Qiaoling Meng, Xin Xu, Liang Qin, Hongliu Yu
Summary: This paper presents the mechanical design and test of a portable hand-elbow combination linkage upper limb rehabilitation robot, which can replicate the complete grasping action. The bionic mechanism for the joints based on human upper limb and hand characteristics is designed, and SolidWorks motion module is used for simulation and analysis. Measurement and grasping experiments confirm the robot's smooth movement and ability to assist with daily tasks. The design satisfies rehabilitation training requirements for the hand and upper limb.
Article
Neurosciences
Lorenzo Diana, Giulia Scotti, Edoardo N. Aiello, Patrick Pilastro, Aleksandra K. Eberhard-Moscicka, Rene M. Mueri, Nadia Bolognini
Summary: This research investigated the effects of tDCS on visuo-spatial attentional asymmetries and found that the efficacy of offline conventional tDCS and HD-tDCS in modulating attention in an ecological setting is not clear.
Review
Clinical Neurology
Diana Aguiar de Sousa, Michele Romoli, Mayte Sanchez Van Kammen, Mirjam R. Heldner, Andrea Zini, Jonathan M. Coutinho, Marcel Arnold, Jose M. Ferro
Summary: Cerebral venous thrombosis (CVT) is a common thrombotic manifestation associated with vaccine-induced thrombotic thrombocytopenia (HIT). This study aimed to review the incidence, clinical features, and prognosis of CVT in patients with HIT. The results showed that CVT is rare in patients with HIT, but HIT-related CVT has a higher risk of intracerebral hemorrhage and mortality.
Article
Clinical Neurology
A. Hakim, C. Kurmann, K. Pospieszny, T. R. Meinel, M. A. Shahin, M. R. Heldner, R. Umarova, S. Jung, M. Arnold, M. El-Koussy
Summary: This study evaluated the diagnostic accuracy of high-resolution 3D T2 sampling perfection with application-optimized contrasts (T2-SPACE) in patients with cerebral venous sinus thrombosis. The results showed that T2-SPACE had better overall performance compared to contrast-enhanced 3D T1-MPRAGE.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph Kamtchum-Tatuene, Luca Saba, Mirjam R. Heldner, Michiel H. F. Poorthuis, Gert J. de Borst, Tatjana Rundek, Stavros K. Kakkos, Seemant Chaturvedi, Raffi Topakian, Joseph F. Polak, Glen C. Jickling
Summary: This study demonstrates that circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression. A cutoff of 2.0 pg/mL for IL-6 levels could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Pierre Seners, Caroline Arquizan, Louis Fontaine, Wagih Ben Hassen, Mirjam R. Heldner, Davide Strambo, Simon Nagel, Emmanuel Carrera, Laura Mechtouff, Margy McCullough-Hicks, Mahmoud H. Mohammaden, Jean-Philippe Cottier, Hilde Henon, Andreea Aignatoaie, Nadia Laksiri, Jeremie Papassin, Ludovic Lucas, Pierre Garnier, Aude Triquenot, Gioia Mione, Steven Hajdu, Vincent Costalat, Arne Potreck, Olivier Detante, Fabrice Bonneville, Yves Berthezene, Serge Bracard, Igor Sibon, Nicolas Bricout, Claire Boutet, Pasquale Mordasini, Patrik Michel, Catherine Oppenheim, Jean-Marc Olivot, Raul G. Nogueira, Gregory W. Albers, Jean-Claude Baron, Guillaume Turc
Summary: This study found that bridging therapy (intravenous thrombolysis followed by mechanical thrombectomy) was associated with lower rates of good outcome compared to intravenous thrombolysis alone in minor stroke patients with large vessel occlusion. However, mismatch volume was a strong modifier of the effect of bridging therapy, with worse outcome observed in patients with mismatch volume <= 40 mL. Randomized trials should consider adding perfusion imaging for patient selection.
Article
Clinical Neurology
C. C. Kurmann, J. Kaesmacher, S. Pilgram-Pastor, E. I. Piechowiak, A. Scutelnic, M. R. Heldner, T. Dobrocky, J. Gralla, P. Mordasini
Summary: This study compared collateral assessment using multiphase flat panel CTA and flat panel CTP with collateral assessment using DSA as the gold-standard. The results showed a correlation between the two methods and suggested that collateral scoring derived from flat panel detector CT was clinically reliable.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Brigitte C. Kaufmann, Dario Cazzoli, Manuela Pastore-Wapp, Tim Vanbellingen, Tobias Pflugshaupt, Daniel Bauer, Rene M. Muri, Tobias Nef, Paolo Bartolomeo, Thomas Nyffeler
Summary: This study found that lesions at a specific white matter intersection can cause a breakdown of the multiple-demand network, leading to impaired cognitive performance. These findings have the potential to influence future rehabilitative approaches.
Article
Clinical Neurology
Valerian L. Altersberger, Norman Rusche, Nicolas Martinez-Majander, Christian Hametner, Jan F. Scheitz, Hilde Henon, Maria Luisa Dell'Acqua, Davide Strambo, Jeffrey Stolp, Mirjam R. Heldner, Ilaria Grisendi, Dejana R. Jovanovic, Yannick Bejot, Alessandro Pezzini, Ronen R. Leker, Georg Kagi, Susanne Wegener, Carlo W. Cereda, Erik Lindgren, George Ntaios, Ines Piot, Alexandros A. Polymeris, Philippe A. Lyrer, Silja Raty, Gerli Sibolt, Marjaana Tiainen, Miriam Heyse, Hebun Erdur, Olfa Kaaouana, Visnja Padjen, Marialuisa Zedde, Marcel Arnold, Paul J. Nederkoorn, Patrik Michel, Guido Bigliardi, Andrea Zini, Charlotte Cordonnier, Christian H. Nolte, Peter A. Ringleb, Sami Curtze, Stefan T. Engelter, Henrik Gensicke
Summary: Based on data from a large registry, this study found that the safety of intravenous thrombolysis in very elderly patients with acute ischemic stroke is similar to that in younger patients. However, the probability of death and poor functional outcome was higher in the very elderly group.
Article
Clinical Neurology
Candice Sabben, Frederique Charbonneau, Francois Delvoye, Davide R. Strambo, Mirjam Heldner, Elodie Ong, Adrien Ter Schiphorst, Hilde Henon, Wagih Ben Hassen, Thomas Agasse-Lafont, Loic Legris, Igor Sibon, Valerie Wolff, Denis Sablot, Mahmoud Elhorany, Cecile Preterre, Nour Nehme, Sebastien Soize, David Weisenburger-Lile, Aude Triquenot-Bagan, Gioia Mione, Andreea Aignatoaie, Jeremie Papassin, Roxana Poll, Yannick Bejot, Emmanuel Carrera, Pierre Garnier, Patrik Michel, Guillaume Saliou, Pasquale Mordasini, Yves Berthezene, Vincent Costalat, Nicolas W. Bricout, Gregory Albers, Mikael Mazighi, Guillaume Turc, Pierre Seners
Summary: This observational study found that endovascular therapy (EVT) added on best medical management (BMM) did not improve functional outcome in patients with proximal posterior cerebral artery occlusion, but was associated with higher risks of intracranial hemorrhage and early neurological deterioration.
Article
Clinical Neurology
Erik Lindgren, Katarzyna Krzywicka, Maria A. de Winter, Mayte Sanchez Van Kammen, Mirjam R. Heldner, Sini Hiltunen, Diana Aguiar de Sousa, Maryam Mansour, Patricia Canhao, Esme Ekizoglu, Miguel Rodrigues, Elisa Martins Silva, Carlos Garcia-Esperon, Valentina Arnao, Paolo Aridon, Naaem Moin Simaan, Suzanne M. Silvis, Susanna M. Zuurbier, Adrian Scutelnic, Mine Sezgin, Andrey Marisovich Alasheev, Andrey Smolkin, Daniel Guisado-Alonso, Nilufer Yesilot, Miguel Barboza, Masoud Ghiasian, Ronen R. Leker, Antonio Arauz, Marcel Arnold, Jukka Putaala, Turgut Tatlisumak, Jonathan M. Coutinho, Katarina Jood
Summary: A prognostic score was developed to predict dependency and death after cerebral venous thrombosis (CVT). The SI(2)NCAL(2)C score showed adequate performance in estimating individual risk of mortality and dependency after CVT.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Martina B. Goeldlin, Elena S. Wenz, Chantal Kottler, Urs Fischer, Claudio L. A. Bassetti, Selma Aybek, Mirjam R. Heldner
Summary: We established a peer-led networking group to address clinical, research, and gender-related challenges among young female clinical neuroscientists. Participants felt empowered and benefited from the meetings and new network. We identified challenges in combining clinical and research activities, some of which were perceived to be gender-related. Peer-to-peer networking is a low-budget intervention that encourages engagement in research activities, promotes interdisciplinary teamwork, and provides a protected environment to discuss and overcome gender-related challenges.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Lisa Herzog, Lucas Kook, Janne Hamann, Christoph Globas, Mirjam R. Heldner, David Seiffge, Kateryna Antonenko, Tomas Dobrocky, Leonidas Panos, Johannes Kaesmacher, Urs Fischer, Jan Gralla, Marcel Arnold, Roland Wiest, Andreas R. Luft, Beate Sick, Susanne Wegener
Summary: This study collected clinical and magnetic resonance imaging data of 222 patients with large vessel occlusion stroke and used interpretable deep learning models to predict functional recovery. The model based on clinical variables and diffusion weighted imaging achieved the highest prediction performance, while adding perfusion weighted imaging did not improve the outcome prediction. The deep learning models significantly outperformed experienced neurologists when imaging data were provided.
Article
Cardiac & Cardiovascular Systems
Ekaterina Bakradze, Liqi Shu, Nils Henninger, Shyam Prabhakaran, James E. Siegler, Gian Marco De Marchis, James A. Giles, Tolga Dittrich, Mirjam R. Heldner, Kateryna Antonenko, Wayneho Kam, David S. Liebeskind, Alexis N. Simpkins, Thanh N. Nguyen, Shadi Yaghi, Ava L. Liberman
Summary: A quarter of patients with CVT were diagnosed more than 10 days after symptom onset, with delayed diagnosis associated with isolated headache but not adverse clinical outcomes. Identifying factors associated with delayed diagnosis of CVT can inform future strategies for early detection.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Prabitha Urwyler, Rajnish Kumar Gupta, Michael Falkner, Joel Niklaus, Rene Martin Muri, Tobias Nef
Summary: This study investigates the benefits of dynamic adaptive casual puzzle games on cognitive function and well-being in healthy adults and older people. The results show that participants showed improvements in their visual attention and visuospatial measures after the puzzle game intervention. Digital games are a feasible way to train cognition, with the algorithm-based dynamic adaption allowing accommodations for persons with different cognitive levels of skill.
Article
Medicine, General & Internal
Magdalena Camenzind, Aleksandra K. Eberhard-Moscicka, Dario Cazzoli, Rene M. Mueri
Summary: This paper presents the observation of a patient who had a right hemispheric stroke and subsequently produced remarkable paintings. The patient's post-stroke productivity and the distribution of text and drawings were analyzed. The patient showed enhanced verbal and figural creativity compared to the control group. Interestingly, the paintings were predominantly located on the right side, while the text was aligned to the left side. This dissociation between writing and painting behavior was also reflected in the patient's neuropsychological performance.
