Article
Rehabilitation
Milica Lazovic, Dejan Nikolic, Francois C. Boyer, Kristian Borg, Maria G. Ceravolo, Mauro Zampolini, Carlotte Kiekens
Summary: This study evaluates the role of PRM physicians and PRM practice in patients with muscular dystrophies, with a systematic literature review and consensus procedure resulting in 33 recommendations.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Rehabilitation
Laure Le Goff, Katherine G. Meilleur, Gina Norato, Pascal Rippert, Minal Jain, Margaret Fink, A. Reghan Foley, Melissa Waite, Sandra Donkervoort, Carsten G. Boennemann, Carole Vuillerot
Summary: The study found that the MFM showed strong responsiveness in individuals with LAMA2-RD and COL6-RD, and it is important for assessing muscle function in patients.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Review
Cell Biology
Nicola Mosca, Sara Petrillo, Sara Bortolani, Mauro Monforte, Enzo Ricci, Fiorella Piemonte, Giorgio Tasca
Summary: Oxidative stress is a prominent factor in the pathophysiology of various muscle disorders, but specific mechanisms and targeted antioxidant therapies still require further research and clinical trials.
Review
Biochemistry & Molecular Biology
Alan Rawls, Bridget K. Diviak, Cameron I. Smith, Grant W. Severson, Sofia A. Acosta, Jeanne Wilson-Rawls
Summary: Muscular dystrophies are genetic muscle-wasting disorders characterized by chronic inflammation and fibrotic scarring in muscle tissue. Duchenne muscular dystrophy, the most common form, is typically treated with anti-inflammatory glucocorticoids; however, their long-term use is limited by adverse side effects. Developing new pharmacotherapeutic approaches to reduce muscle damage and promote repair is crucial.
Article
Oncology
Yu Zhang, Takahiko Nishiyama, Eric N. Olson, Rhonda Bassel-Duby
Summary: Muscular dystrophies are a group of neuromuscular disorders with genetic causes that lead to muscle loss and degeneration. The CRISPR/Cas system offers a new path for treatment, potentially correcting genetic mutations permanently and benefiting skeletal muscle due to its post-mitotic and multinucleated features. However, challenges remain for translating CRISPR/Cas genome editing into a viable therapy for muscular dystrophies.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Rehabilitation
Sydney E. Valentino, Michael J. Hutchinson, Victoria L. Goosey-Tolfrey, Maureen J. MacDonald
Summary: This study analyzed and summarized the effect of regulating exercise intensity with subjective measures on cardiorespiratory fitness in adults with spinal cord injury. The results showed that there was an improvement in cardiorespiratory fitness in adults with SCI when exercise intensity was regulated using subjective measures.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Clinical Neurology
Ze-Jian Chen, Ming-Hui Gu, Chang He, Cai-Hua Xiong, Jiang Xu, Xiao-Lin Huang
Summary: This study aimed to investigate the effects of robot-assisted arm training on stroke patients with unilateral spatial neglect. The results showed that this training program was feasible and safe, leading to significant improvements in neglect symptoms, motor function recovery, and social participation, but not in activities of daily living. The findings provide preliminary support for using robot-assisted arm training to remediate unilateral spatial neglect after stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arlek Gonzalez-Jamett, Walter Vasquez, Gabriela Cifuentes-Riveros, Rafaela Martinez-Pando, Juan C. Saez, Ana M. Cardenas
Summary: Muscular dystrophies are a heterogeneous group of neuromuscular disorders characterized by muscle pain, weakness, and atrophy. These diseases are caused by gene mutations that affect the structure and function of skeletal muscles, leading to inflammation, oxidative stress, and muscle degeneration. Dysregulation of connexin hemichannels plays a crucial role in these processes.
Article
Rehabilitation
Steven Kirshblum, Amanda Botticello, John Benedetto, Fatma Eren, Jayne Donovan, Ralph Marino
Summary: The study aimed to determine the differences in neurologic recovery between AIS grade A and B in patients with initial cervical spinal cord injuries. The findings showed that although both groups had similar upper extremity motor score recovery, the rate of conversion to motor incomplete status, lower extremity motor score, and sensory recovery were significantly different for patients with AIS grade B.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Medicine, General & Internal
Camille Bouchard, Jacques P. Tremblay
Summary: This review article presents 39 genes associated with limb-girdle muscular dystrophies (LGMDs), which can be inherited dominantly or recessively. The classification of LGMDs has evolved over time and now requires a mutation causing proximal muscle weakness found in multiple unrelated families. The article also discusses available and developing therapies for LGMDs, aiming to address the root cause of the disease instead of treating individual symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Susanne Palmcrantz, Anneli Wall, Katarina Skough Vreede, Pavel Lindberg, Anna Danielsson, Katharina S. Sunnerhagen, Charlotte K. Hager, Jorgen Borg
Summary: This study examined the impact of training with an electromechanically assisted gait training (EAGT) system, specifically the Hybrid Assistive Limb(R) (HAL), integrated with conventional rehabilitation on long-term improvements in individuals post-stroke. The findings suggest that intensive conventional gait training induced significant improvements while the integration of treadmill-based EAGT did not provide additional value in this study sample.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Immunology
Andrea Farini, Chiara Villa, Luana Tripodi, Mariella Legato, Yvan Torrente
Summary: Muscular dystrophies and inflammatory myopathies are muscular disorders characterized by progressive muscle weakness and mass loss, with shared features of inflammation and immune response. Immune mechanisms involved include complement cascade activation and auto-antibodies directed against muscular proteins.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Viviana Lo Buono, Michele Torrisi, Simona Leonardi, Alessandra Pidala, Francesco Corallo
Summary: This case report describes the positive effect of multisensory environment rehabilitation on patients with spastic quadriplegia and intellectual disability. By providing stimuli in a multisensory room, designed activities can improve self-harm, motor stereotypies, sustained attention, and therapeutic compliance.
Article
Rehabilitation
Yi-chun Li, Keh-chung Lin, Chia-ling Chen, Grace Yao, Ya-ju Chang, Ya-yun Lee, Chien-ting Liu, Wen-Shiang Chen
Summary: This study aimed to compare the effects of mirror therapy and bilateral arm training in stroke rehabilitation. It found that mirror therapy was more effective in improving upper limb motor function, and the effect can be maintained at three months follow-up.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Review
Biochemistry & Molecular Biology
Martina Sandona, Giorgia Cavioli, Alessandra Renzini, Alessia Cedola, Giuseppe Gigli, Dario Coletti, Timothy A. McKinsey, Viviana Moresi, Valentina Saccone
Summary: Histone deacetylases (HDACs) regulate the deacetylation of proteins, affecting cellular processes. Abnormal HDAC expression or activity is associated with various pathologies, making them potential therapeutic targets. For example, HDAC inhibitors have shown positive effects in preclinical and clinical studies for Duchenne Muscular Dystrophy (DMD). Understanding the cellular functions of HDACs in dystrophic muscles provides new insights for the development of effective therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Olivier Remy-Neris, Anais Le Jeannic, Angelina Dion, Beatrice Medee, Emmanuel Nowak, Elodie Poiroux, Isabelle Durand-Zaleski
Summary: In patients with moderate-to-severe impairment in the subacute phase of stroke, the purchase and use of complex devices to provide additional upper limb training may not be necessary: simply educating patients to regularly move and stretch their limbs appears sufficient.
Article
Rehabilitation
Milica Lazovic, Dejan Nikolic, Francois C. Boyer, Kristian Borg, Maria G. Ceravolo, Mauro Zampolini, Carlotte Kiekens
Summary: This study evaluates the role of PRM physicians and PRM practice in patients with muscular dystrophies, with a systematic literature review and consensus procedure resulting in 33 recommendations.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Letter
Rehabilitation
Ozoua Ble, Djamel Bensmail, Dominic Perennou, Bernard Parratte, Pierre-Alain Joseph, Francois-Constant Boyer, Hugues Michelon, Thibaud Lansaman, Jonathan Levy
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Rehabilitation
Milica Lazovic, Dejan Nikolic, Francois C. Boyer, Kristian Borg, Maria G. Ceravolo, Mauro Zampolini, Carlotte Kiekens
Summary: This paper defines the role of the PRM physician and professional practice in managing ALS patients, with 32 recommendations resulting from a systematic review and consensus procedure. The main responsibility is to conduct functional assessments and deliver the best PRM care program.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Genetics & Heredity
Benoit Sanson, Caroline Stalens, Celine Guien, Luisa Villa, Catherine Eng, Sitraka Rabarimeriarijaona, Rafaelle Bernard, Pascal Cintas, Guilhem Sole, Vincent Tiffreau, Andoni Echaniz-Laguna, Armelle Magot, Raul Juntas Morales, Francois Constant Boyer, Aleksandra Nadaj-Pakleza, Agnes Jacquin-Piques, Christophe Beroud, Sabrina Sacconi, French Fshd Registry Collaboration Group
Summary: The study evaluated the data quality of the French National Registry of FSHD. The results showed that patient and physician answers were largely concordant when addressing quantitative and objective items. However, there was a poor correlation between data provided in the two forms for FSHD-specific signs. The revised data collection forms rely more on patient-reported data to improve efficiency and quality of data collection.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Chemistry, Analytical
Sameh Mahjoub, Larbi Chrifi-Alaoui, Bruno Marhic, Laurent Delahoche
Summary: With the rapid development of smart grids and measuring infrastructure, short term power consumption forecasting has become increasingly important. This study proposes three different machine learning algorithms, namely LSTM, GRU, and Drop-GRU, for time series power forecasting. Experimental results using real data from French cities show that the LSTM model outperforms the other methods, with fewer prediction errors and higher precision. These predictions based on the LSTM method have a significant impact on power quality planning and equipment maintenance.
Review
Rehabilitation
Etienne Allart, Dominique Mazevet, Stephane Idee, Francois Constant Boyer, Isabelle Bonan
Summary: This study assessed the efficacy of non-pharmacological adjunct therapies in spastic adults and found that joint posture procedures and active adjunct therapies may further improve treatment outcomes. However, further research is needed to determine the optimal strategies for adjunct therapies due to the diversity of treatment methods and heterogeneity of studies.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Letter
Rehabilitation
Tymothee Poitou, Francois Constant Boyer, Charlene Benoit, Jean-Baptiste Ferte, Charlotte Pineau, Redha Taiar, Amandine Rapin
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Rehabilitation
Jean-Baptiste Ferte, Francois Constant Boyer, Redha Taiar, Charlotte Pineau, Coralie Barbe, Amandine Rapin
Summary: A systematic review found that resistance training has a significant effect on functional improvement in patients with chronic obstructive pulmonary disease (COPD), particularly in terms of walking ability and muscle strength.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Rehabilitation
Mauro Zampolini, Melissa Selb, Paolo Boldrini, Catarina A. Branco, Volodymyr Golyk, Xiaolei Hu, Carlotte Kiekens, Stefano Negrini, Anda Nulle, Aydan Oral, Markos Sgantzos, Aleksei Shmonin, Iuly Treger, Gerold Stucki
Summary: To facilitate the interaction between health professionals and patients, a framework for the rehabilitation process is needed. This framework includes a rehabilitation management plan, Individual Rehabilitation Project (IRP), and rehabilitation cycle(s). The IRP focuses on optimizing a patient's functioning across the continuum of care and is provided by a multi-professional team led by a physical and rehabilitation medicine physician.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Biology
Amandine Rapin, Peter-Joe Noujaim, Redha Taiar, Sandy Carazo-Mendez, Gaetan Deslee, Damien Jolly, Francois Constant Boyer
Summary: Analyzing how healthcare institutions adapted to the first wave of the COVID-19 pandemic will make it possible to better prepare for future crises. Analyzing the characteristics of patients admitted to rehabilitation units during the first wave makes it possible to better understand rehabilitation needs during a pandemic crisis. The study described the characteristics of all patients admitted to a single university hospital for SARS-CoV-2 infection during the first wave in Northeast France. The deployment of rehabilitation services and the need for rehabilitation wards during a pandemic are important considerations for the long-term functioning of infected patients.
Article
Clinical Neurology
B. Delbarrea, A. Rapin, F. C. Boyer, A. Thierry, J. M. Perotin, S. Dury, A. Dumazet, J. Hagenburg, D. Perdu, G. Deslee, C. Launois
Summary: Combining respiratory symptom screening and respiratory function testing is crucial in identifying the appropriate time for ventilatory support initiation in DM1. Dyspnea has been little investigated in this patient group. However, the use of dyspnea assessment tools, such as the mMRC scale, may be useful in evaluating dyspnea in daily living in these patients.
NEUROMUSCULAR DISORDERS
(2023)
Article
Energy & Fuels
Sameh Mahjoub, Sami Labdai, Larbi Chrifi-Alaoui, Bruno Marhic, Laurent Delahoche
Summary: This work proposes a smart home occupancy prediction technique based on environmental variables utilizing machine learning and forecasting strategies. The Long Short-Term Memory (LSTM) neural network, along with Genetic Algorithm (GA) and Particle Swarm Optimization (PSO), has been used to optimize weight updates for better prediction results. The experiments demonstrate that the GA and PSO approaches outperform the LSTM networks in forecasting parameters with high accuracy.
Article
Rehabilitation
Amandine Rapin, Francois Constant Boyer, Bruno Mourvillier, Guillaume Giordano Orsini, Claire Launois, Redha Taiar, Gaetan Deslee, Antoine Goury, Sandy Carazo-Mendez
Summary: This study aims to investigate the impact of improved intensive care for COVID-19 patients on the prevalence of post-intensive care syndrome (PICS). It found that improved intensive care unit management was not associated with a decrease in the prevalence of PICS. Female sex and diabetes were significantly associated with PICS.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Correction
Rehabilitation
T. Lejeune, S. Khatkova, L. Turner-Stokes, P. Picaut, P. Maisonobe, J. Balcaitiene, F. C. Boyer
JOURNAL OF REHABILITATION MEDICINE
(2021)