Abnormal hippocampal neurogenesis in Parkinson’s disease: relevance to a new therapeutic target for depression with Parkinson’s disease

LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1AReceptor Upregulation in Mice

(2018) Juhee Lim et al.   JOURNAL OF NEUROSCIENCE

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

(2018) Shigeto Sato et al.   Scientific Reports

NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats

(2017) Naoki Tajiri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficacy of antidepressive medication for depression in Parkinson disease

(2017) Chuanjun Zhuo et al.   MEDICINE

ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes

(2017) Sonu Singh et al.   NEUROCHEMISTRY INTERNATIONAL

Reduced CA2–CA3 Hippocampal Subfield Volume Is Related to Depression and Normalized by l-DOPA in Newly Diagnosed Parkinson’s Disease

(2017) Orsolya Györfi et al.   Frontiers in Neurology

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress

(2016) Lenita Lindgren et al.   CEREBRAL CORTEX

LRRK2 interferes with aggresome formation for autophagic clearance

(2016) Yeojin Bang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Serum immune markers and disease progression in an incident Parkinson's disease cohort (ICICLE-PD)

(2016) Caroline H. Williams-Gray et al.   MOVEMENT DISORDERS

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

(2016) Zacharias Kohl et al.   NEUROBIOLOGY OF DISEASE

Adult Neurogenesis and Psychiatric Disorders

(2016) Eunchai Kang et al.   Cold Spring Harbor Perspectives in Biology

Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus

(2016) Y Xi et al.   Cell Death & Disease

miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression

(2016) Junghee Jin et al.   Cell Reports

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

Chronic intestinal inflammation alters hippocampal neurogenesis

(2015) Svetlana Zonis et al.   Journal of Neuroinflammation

Effects of treadmill exercise on hippocampal neurogenesis in an MPTP /probenecid-induced Parkinson’s disease mouse model

(2015) Yun-Hee Sung   Journal of Physical Therapy Science

A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients

(2015) M Fava et al.   MOLECULAR PSYCHIATRY

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Defective Autophagy in Parkinson’s Disease: Lessons from Genetics

(2014) H. Zhang et al.   MOLECULAR NEUROBIOLOGY

β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats

(2014) Haiying Dong et al.   MOLECULES

The effect of dopamine on adult hippocampal neurogenesis

(2014) Naoki Takamura et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone

(2014) M Yazdankhah et al.   Cell Death & Disease

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Interleukin-17 inhibits Adult Hippocampal Neurogenesis

(2014) Qiang Liu et al.   Scientific Reports

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

(2014) Jorge Valero et al.   Frontiers in Neuroscience

Antidepressants for neuro-regeneration: from depression to Alzheimer’s disease

(2013) Hyun-Jung Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

The role of autophagy in Parkinson's disease: rotenone-based modeling

(2013) Nian Xiong et al.   Behavioral and Brain Functions

Depression and Parkinson’s Disease: Current Knowledge

(2013) Laura Marsh   Current Neurology and Neuroscience Reports

Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

(2013) Sasuk Kim et al.   EXPERIMENTAL NEUROLOGY

p21Ciprestrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation

(2013) Svetlana Zonis et al.   HIPPOCAMPUS

Non-motor parkinsonian pathology in aging A53T α-Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function

(2013) Kaitlin F. Farrell et al.   JOURNAL OF NEUROCHEMISTRY

In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise

(2013) N F Ho et al.   MOLECULAR PSYCHIATRY

FIP200 is required for maintenance and differentiation of postnatal neural stem cells

(2013) Chenran Wang et al.   NATURE NEUROSCIENCE

Hippocampal Granule Neuron Number and Dentate Gyrus Volume in Antidepressant-Treated and Untreated Major Depression

(2013) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Comparative Efficacy and Acceptability of Antidepressants in Parkinson's Disease: A Network Meta-Analysis

(2013) Jinling Liu et al.   PLoS One

A Meta-Analysis of Randomised Placebo-Controlled Treatment Trials for Depression and Anxiety in Parkinson’s Disease

(2013) Lakkhina Troeung et al.   PLoS One

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

(2012) Maura Boldrini et al.   BIOLOGICAL PSYCHIATRY

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

Partial reduction in neural cell adhesion molecule (NCAM) in heterozygous mice induces depression-related behaviour without cognitive impairment

(2012) Monika Jürgenson et al.   BRAIN RESEARCH

Adult neurogenesis in Parkinson’s disease

(2012) Franz Marxreiter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Social isolation impairs adult neurogenesis in the limbic system and alters behaviors in female prairie voles

(2012) Claudia Lieberwirth et al.   HORMONES AND BEHAVIOR

Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of Tuberous Sclerosis Complex

(2012) Marco Cambiaghi et al.   NEUROPHARMACOLOGY

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In vivo imaging of adult neurogenesis

(2011) Sebastien Couillard-Despres et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Necessity of Hippocampal Neurogenesis for the Therapeutic Action of Antidepressants in Adult Nonhuman Primates

(2011) Tarique D. Perera et al.   PLoS One

Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1

(2011) S. Uchida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Clinical profile of parkinsonism and Parkinson's disease in Lagos, Southwestern Nigeria

(2010) Njideka U Okubadejo et al.   BMC Neurology

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients

(2010) Paul J. Lucassen et al.   NEUROPHARMACOLOGY

APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation

(2010) Kaushik Ghosal et al.   PLoS One

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model

(2009) Beate Winner et al.   EXPERIMENTAL NEUROLOGY

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

(2009) Nicholas P. Whitney et al.   JOURNAL OF NEUROCHEMISTRY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Tumour necrosis factor-α impairs neuronal differentiation but not proliferation of hippocampal neural precursor cells: Role of Hes1

(2009) Aoife Keohane et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Antidepressants increase neural progenitor cells in the human hippocampus

(2009) Maura Boldrini et al.   NEUROPSYCHOPHARMACOLOGY

Immunosuppression Using the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus: Pilot Study Shows Significant Cognitive and Affective Improvement

(2009) U.E. Lang et al.   TRANSPLANTATION PROCEEDINGS

The contribution of failing adult hippocampal neurogenesis to psychiatric disorders

(2008) Gerd Kempermann et al.   CURRENT OPINION IN PSYCHIATRY

Non-motor symptoms in Parkinson’s disease

(2008) W. Poewe   EUROPEAN JOURNAL OF NEUROLOGY

Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys

(2008) Nicholas M. Kanaan et al.   GLIA

 -Synuclein Alters Notch-1 Expression and Neurogenesis in Mouse Embryonic Stem Cells and in the Hippocampus of Transgenic Mice

(2008) L. Crews et al.   JOURNAL OF NEUROSCIENCE

Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3β

(2007) R. Silva et al.   NEUROSCIENCE