Article
Pharmacology & Pharmacy
Patrycja Szumala, Adam Macierzanka
Summary: This review focuses on recent advancements in topical microemulsion systems related to the transport of active ingredients into the skin, including those with high molecular weight and high polarity. Permeation of therapeutic macromolecules can be increased by the correct design of the microemulsion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Instruments & Instrumentation
Soo Chin Yeoh, Choon Fu Goh
Summary: Salicylates have a long history in pain relief, with salicylic acid and methyl salicylate being widely used for keratolytic and anti-inflammatory actions. This review discusses strategies to enhance skin permeation of these compounds, highlighting the formulations targeting different skin indications and discussing pharmacokinetics and metabolisms of these salicylates. Future perspectives in topical delivery strategies are also discussed for translational considerations.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Medicine, Research & Experimental
Ziyad Binkhathlan, Raisuddin Ali, Abdullah H. Alomrani, Mohd Abul Kalam, Aws Alshamsan, Afsaneh Lavasanifar
Summary: This paper reviews the research progress of micellar ocular delivery systems, focusing on different micellar formulations and their advantages in ocular drug delivery. It also discusses the role of PMs in the management of ocular diseases and the current status of preclinical and clinical drug development in this field.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Nuria Garros, Paola Bustos-Salgados, Oscar Domenech, Maria Jose Rodriguez-Lagunas, Negar Beirampour, Roya Mohammadi-Meyabadi, Mireia Mallandrich, Ana C. C. Calpena, Helena Colom
Summary: Atopic dermatitis (AD) is a chronic autoimmune inflammatory skin disorder. This study aimed to develop and evaluate new topical liposomal formulations loaded with the reversible Janus-associated kinase (JAK)-inhibitor, Baricitinib (BNB), for the treatment of flare ups. Three liposomal formulations were prepared using different proportions of POPC, CHOL, and CER. Physicochemical characterization, release study, permeation and retention studies, histological analysis, and irritancy tests were performed. All liposomes showed good properties and stability. The POPC:CHOL:CER formulation had the highest flux and permeation, with retention in the skin equal to POPC:CHOL. The formulations exhibited no harmful effects and showed promising results for the aim of the study.
Article
Polymer Science
Maria Varghese, Kaitlynn A. Sockett, Sara El-Arid, Jenny Korunes-Miller, Jean-Michel Guigner, Mark W. Grinsta
Summary: We synthesized diblock poly-amido-saccharides (PASs) using living anionic ring-opening polymerization. The resulting amphiphilic polymers self-assembled into nanoparticles in water, forming spherical structures and exhibiting no cytotoxicity.
Article
Chemistry, Multidisciplinary
Mar Calzado-Delgado, M. Olga Guerrero-Perez, King Lun Yeung
Summary: The article describes two drug delivery systems for topical administration of vitamin C. The electrospun PVA nanofiber carrier releases vitamin C in bursts, while the PVA nanofiber-molecular capsule delivers vitamin C at a constant rate. Both systems protect vitamin C and provide increased heat stability.
Review
Polymer Science
Antiopi Vardaxi, Martha Kafetzi, Stergios Pispas
Summary: Proteins and peptides are important drugs for treating various diseases, but their delivery faces challenges. Polymeric nanostructures can serve as effective carriers to improve the bioavailability and biocompatibility of proteins.
Article
Chemistry, Medicinal
Breno N. Matos, Ana Luiza Lima, Camila O. Cardoso, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M. Gelfuso
Summary: This study prepared polymeric and lipidic nanoparticles (PNPs and NLCs) co-entrapping minoxidil and betamethasone for follicular drug delivery. The nanoparticles showed suitable size and thermal stability, significantly increasing the penetration of minoxidil and betamethasone into the hair follicles and delivering higher concentrations of betamethasone. The nanoparticles are suitable for topical therapy and effectively target the hair follicles.
Review
Polymer Science
Ketan Kuperkar, Dhruvi Patel, Leonard Ionut Atanase, Pratap Bahadur
Summary: This article mainly introduces the self-assembly of amphiphilic block copolymers in aqueous media forming various core-shell structures, and discusses different types of polymer micelles. The latest updates on polymerization-induced self-assembly and crystallization-driven self-assembly, as well as discussions on polyion complexes and polyion complex micelles, are also mentioned.
Article
Engineering, Chemical
Lalit Kumar, Himanshu Chaurasia, Gauree Kukreti, Ritesh Rana, Sumit Kumar, Mohit Chadha, Mohit Vij
Summary: The development of ethylcellulose-based polymeric microsponges loaded with vanillin for topical delivery has attracted global interest. The optimized formulation showed desirable particle size, high entrapment efficiency, and excellent antibacterial activity. The results demonstrated that the ethylcellulose microsponges can effectively treat wounds in Carbopol 940 gel form.
PARTICULATE SCIENCE AND TECHNOLOGY
(2023)
Article
Biology
Sheikh Abdur Rashid, Sajid Bashir, Faiza Naseem, Arshad Farid, Irfan A. Rather, Khalid Rehman Hakeem
Summary: Psoriasis, a chronic inflammatory illness, is linked to other life-threatening diseases. Methotrexate nanoemulsion gel formulation showed effectiveness in treating psoriasis and reducing symptoms, potentially providing a new treatment option.
Review
Pharmacology & Pharmacy
Jaskiran Kaur, Monica Gulati, Flavia Zacconi, Harish Dureja, Raimar Loebenberg, Md Salahuddin Ansari, Othman AlOmeir, Aftab Alam, Dinesh Kumar Chellappan, Gaurav Gupta, Niraj Kumar Jha, Terezinha de Jesus Andreoli Pinto, Andrew Morris, Yahya E. Choonara, Jon Adams, Kamal Dua, Sachin Kumar Singh
Summary: This paper discusses the application of polymeric micelles as smart drug delivery systems in the management of diabetes. The use of amphiphilic block copolymers provides a new approach to controlling blood glucose levels. However, research in this field is still limited and further clinical studies are needed.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Article
Biochemistry & Molecular Biology
Parinbhai Shah, Benjamin Goodyear, Nirali Dholaria, Vinam Puri, Bozena Michniak-Kohn
Summary: Psoriasis is a chronic autoimmune skin disease that poses challenges in drug delivery due to low bioavailability. This study explores the use of niosomes to improve drug bioavailability of corticosteroids for topical treatment of skin conditions, showing promise for potential use in treating diseases like psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Eiman Abdalla Madawi, Alaa Raad Al Jayoush, Mutasem Rawas-Qalaji, Hnin Ei Thu, Shahzeb Khan, Mohammad Sohail, Asif Mahmood, Zahid Hussain
Summary: The topical route is the most appropriate for drug delivery to skin tissues, but the stratum corneum acts as a significant barrier. Nanotechnology-aided interventions, especially polymeric nanoparticles (PNPs) made from natural polymers, have shown potential for the treatment of various topical skin diseases. The encapsulation or adsorption of drugs onto PNPs improves their properties and allows for controlled release, permeation, and retention in the skin layers. Further functionalization techniques have also shown success in optimizing PNPs' therapeutic efficacy.
Article
Engineering, Electrical & Electronic
Hyun-Woong Park, Sang-Jun Lee, Dong-Chul Cho, Sang-Hoon Lee, Jae-Kyun Kim, Jun-Hee Lee, Sang-Kyo Jung, Hong-Sik Nam, Patrick Hsu, Shin Low, Sung-Hwan Lim
MICROELECTRONICS RELIABILITY
(2018)
Article
Economics
Dongchul Cho, Wankeun Oh
Summary: This paper examines the predictive abilities of various inflation expectation indicators for inflation in Korea. The results suggest that break-even inflation (BEI) is at least as useful as other expectation indicators in forecasting inflation. Regression-based models using industrial production, oil price, and exchange rate do not help out-of-sample inflation forecasting, but the policy interest rate can significantly reduce forecasting errors and one percent point increase in the policy interest rate is estimated to suppress inflation for the subsequent 12 months by around one percent-point. These findings indicate that monetary policy is effective for controlling inflation and a simple model using the policy interest rate and an inflation expectation indicator may be preferred for inflation forecasting.
KOREAN ECONOMIC REVIEW
(2023)
Article
Economics
Dongchul Cho, Sukha Shin
JOURNAL OF POLICY ANALYSIS AND MANAGEMENT
(2012)
