期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 38, 期 5, 页码 604-613出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0397-2
关键词
Lycoris longituba; Alkaloid; Neuroprotective activity; AChE inhibitory activity
资金
- Ministry of Science and Technology of the People's Republic of China [2010DFA32430]
- Natural Science Foundation of China [81072547, 31270394, 30873361]
Three novel alkaloids (1-3), together with nineteen known ones (4-22), were isolated from the bulbs of Lycoris longituba. Their structures were elucidated on the basis of extensive spectroscopic analyses, which belong to several Amaryllidaceae alkaloid skeletons. Among them, the harmane-type alkaloids (the new compound 1 and the known compounds 5, 6 and 7) were found for the first time from Lycoris genus. The isolates were tested for their neuroprotective activities against CoCl2, H2O2 and A beta(25-35)-induced SH-SY5Y cell injuries, and the majority of them exhibited neuroprotective activities of different degrees. The acetylcholinesterase (AChE) inhibitory activities of the isolated alkaloids were also evaluated, while compounds 12, 14-20 and 22 exhibited extremely significant AChE inhibitory activities.
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