期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 37, 期 3, 页码 315-323出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0188-1
关键词
Lycoris aurea; Amaryllidaceae alkaloids; Phenolic compound; Neuroprotective
资金
- Ministry of Science and Technology of the People's Republic of China [2010DFA32430]
- Natural Science Foundation of China [81072547, 31270394, 30873361]
Three new alkaloids, 2 alpha-hydroxy-6-O-n-butyloduline, O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine (1-3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-2'-methylbenzene-3',6'-diol (14), along with ten known alkaloids (4-13), were isolated from the bulbs of Lycoris aurea collected from Huaihua County of Hunan Province, China. Their structures were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. All the isolated compounds were tested for their neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell death. Compounds 1-7 and 10 exhibited significant neuroprotective effects against CoCl2-induced SH-SY5Y cell injury, while compounds 1-5, 7, 10 and 12 showed obvious neuroprotective effects against H2O2-induced SH-SY5Y cell death.
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