Article
Immunology
Eve Victoria Singleton, Chloe Jayne Gates, Shannon Christa David, Timothy Raymond Hirst, Justin Bryan Davies, Mohammed Alsharifi
Summary: In this study, the immunogenicity of gamma-irradiated influenza vaccine under different temperature conditions was compared, and it was found that regardless of temperature, the structural integrity and vaccine efficacy were well maintained. Interestingly, using higher temperature and lower radiation dose seemed to induce stronger immune responses. This suggests that simplifying irradiation protocols to manufacture effective irradiated vaccines may be possible.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chimuka Handabile, Toshiki Sekiya, Naoki Nomura, Marumi Ohno, Tomomi Kawakita, Masashi Shingai, Hiroshi Kida
Summary: Despite the use of vaccines, seasonal influenza remains a risk to public health. A study compared the immunological potency of a inactivated whole virus particle vaccine (WPV) and a split vaccine (SV) and found that WPV induced higher levels of antibodies against heterologous influenza viruses, providing better protection. Specifically, WPV induced neuraminidase-inhibition (NI) antibodies that recognized NA of divergent strains, contributing to its effectiveness in protecting against infection from heterologous influenza viruses.
Article
Immunology
Yaping Chen, Yanhui Xiao, Ying Ye, Feng Jiang, Hanqing He, Linyun Luo, Haiping Chen, Lubin Shi, Qiuyue Mu, Wei Chen, Xue Guo, Min Zhang, Jun Li, Qinghu Guan, Zhiping Chen, Xiaoming Yang
Summary: This study demonstrates that in infants, coadministration of an inactivated enterovirus 71 vaccine (EV71 vaccine) with trivalent split-virion inactivated influenza vaccine (IIV3) is safe and does not interfere with immunogenicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Olga Syrkina, Ajinkya Inamdar, Sophie Wague, Celine Monfredo, Markku Nissila, Anne-Laure Chabanon, Laurence Serradell
Summary: This study conducted enhanced safety surveillance for the quadrivalent inactivated split-virion influenza vaccine (IIV4) in Finland during the 2020/21 season. The results showed no clinically significant changes in what is known or expected for IIV4, supporting the safety profile of this vaccine and maintaining public confidence in influenza vaccination.
Article
Biochemistry & Molecular Biology
Shaohuan Wu, Ted M. Ross, Michael A. Carlock, Elodie Ghedin, Hyungwon Choi, Christine Vogel
Summary: The study identifies determinants of influenza vaccine efficacy, with prior vaccination history, baseline titer level, and age being major factors. Other factors such as BMI, comorbidities, vaccine dose, and race have negligible effects. Models can accurately predict categorical responses in most cases, and generate a new seroconversion score corrected for these factors, facilitating future biomarker identification.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Article
Immunology
Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Kazuhiko Kimachi, Ryotarou Mitsumata, Tomio Ikeda, Hiroki Kitayama, Hironori Hatanaka, Tomoyoshi Sobue, Fumihito Muro, Saori Suzuki, Cong Thanh Nguyen, Hirohito Ishigaki, Misako Nakayama, Yuya Mori, Yasushi Itoh, Marios Koutsakos, Brendon Y. Chua, Lorena E. Brown, David C. Jackson, Katherine Kedzierska, Kazumasa Ogasawara, Yoichiro Kino, Hiroshi Kida
Summary: The study showed that whole virus particle vaccines (WPVs) are more effective in priming immune responses and inducing innate immune responses compared to split vaccines (SVs), making them a potential alternative for seasonal influenza vaccines, especially for children.
Article
Immunology
Yonghong Liu, Shirin Strohmeier, Irene Gonzalez-Dominguez, Jessica Tan, Viviana Simon, Florian Krammer, Adolfo Garcia-Sastre, Peter Palese, Weina Sun
Summary: By generating and sequentially vaccinating mice with inactivated influenza B viruses displaying mosaic HAs, researchers have successfully induced long-lasting and cross-protective antibody responses. These findings represent a significant step towards the development of a universal influenza B virus vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Constantina Boikos, Lauren Fischer, Dan O'Brien, Joe Vasey, Gregg C. Sylvester, James A. Mansi
Summary: This study estimated the relative vaccine effectiveness (rVE) of cell-propagated inactivated quadrivalent influenza vaccine (ccIIV4) versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018-2019 US season. The results showed a statistically significantly greater reduction in influenza-related medical encounters in individuals vaccinated with ccIIV4 compared to eIIV4, supporting ccIIV4 as a potentially more effective public health measure against influenza.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Anne-Laure Chabanon, Sophie Wague, Annick Moureau, Markku Nissila, Laurence Serradell
Summary: The passive safety surveillance of a quadrivalent inactivated split-virion influenza vaccine in Finland for the 2019/20 season did not reveal any clinically significant changes in expected adverse drug reactions. The most frequently reported suspected adverse reactions within 7 days post-vaccination were site pain, site reaction, and fever, with no serious adverse reactions reported. Reported adverse reaction rates were consistent with previous assessments, indicating an overall safe profile for the vaccine.
Article
Pharmacology & Pharmacy
Chia-Ying Wu, Shao-En Kao, Yung-Chieh Tseng, Yu-Po Lin, Jen-Tzu Hou, Li-Yang Wu, Sharon Chiu, Che Alex Ma, Pei-Wen Hsiao, Jane Hsiao, Juine-Ruey Chen
Summary: Influenza epidemics and pandemics caused by newly emerging virus strains call for the development of a universal vaccine. A monoglycosylated vaccine has been shown to provide broader protection in mice than conventional vaccines, but the challenge lies in developing a robust manufacturing process for mass production and verifying its immunogenicity in inducing cross-protective immunity.
ANTIVIRAL RESEARCH
(2023)
Article
Immunology
Richard I. Walker, A. Louis Bourgeois
Summary: Oral immunization is an effective strategy against mucosal enteric pathogens. Inactivated whole bacterial cells can also induce protective immunity. Developing a safe and simple delivery format with controlled immunogenic amounts of complex antigens is essential. Enhancing the efficacy of whole cell vaccines can be achieved through genetic engineering and the use of mucosal adjuvants. The development of ETVAX, a vaccine candidate against enterotoxigenic Escherichia coli (ETEC), has shown promising results.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Huapeng Feng, Ruolin Sun, Guanru Song, Shunfan Zhu, Zhenyu Nie, Liming Lin, Ruonan Yi, Shixiang Wu, Genzhu Wang, Yulong He, Siquan Wang, Pei Wang, Li Wu, Jianhong Shu
Summary: This study found that 7DW8-5 can enhance the protective efficacy of split influenza vaccine by promoting antibody production and reducing virus shedding.
Article
Biochemistry & Molecular Biology
Eduardo Alfredo Adami, Stefanni Liliane Chavez Rico, Milena Apetito Akamatsu, Cosue Miyaki, Isaias Raw, Dourival de Oliveira, Priscila Comone, Ricardo das Neves Oliveira, Maria Leonor Sarno de Oliveira, Patricia Antonia Estima Abreu, Carolina Yumi Takano, Mauricio Meros, Alessandra Soares-Schanoski, Paulo Lee Ho
Summary: This study presents the production of active antigen under current Good Manufacturing Practices for the pandemic influenza vaccine candidate against A(H7N9). The formulated H7N9 vaccine is poorly immunogenic and requires adjuvanted to achieve an optimal immune response. These data are important for initial production planning and preparedness in the case of a H7N9 pandemic.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Marumi Ohno, Masataka Sagata, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Masafumi Endo, Kazuhiko Kimachi, Saori Suzuki, Cong Thanh Nguyen, Misako Nakayama, Hirohito Ishigaki, Kazumasa Ogasawara, Yasushi Itoh, Yoichiro Kino, Hiroshi Kida
Summary: Among inactivated influenza vaccines, whole virus particle vaccine (WPV) shows better ability in inducing humoral and cellular immunity compared to split virus vaccine (SV). However, there are concerns about the potential adverse reactions, such as fever, caused by WPV due to its strong immunogenicity. This study investigated the febrile response induced by subcutaneous injection with quadrivalent inactivated influenza vaccines in cynomolgus macaques and found that WPV caused an increase in body temperature at the first vaccination but not at the second shot, while SV did not affect body temperature at both points.
Article
Gastroenterology & Hepatology
Anne Finne Pihl, Shan Feng, Anna Offersgaard, Garazi Pena Alzua, Elias Honerod Augestad, Christian Kjaerulff Mathiesen, Tanja Bertelsen Jensen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jan Pravsgaard Christensen, Jens Bukh, Judith Margarete Gottwein
Summary: This study developed inactivated whole HCV vaccine candidates using licensed adjuvants and demonstrated their ability to induce broadly neutralizing antibodies. HCV variants with modified envelope proteins exhibited similar immunogenicity compared to the virus with the original envelope proteins.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bahman Homayun, Chengmeng Sun, Ankit Kumar, Carlo Montemagno, Hyo-Jick Choi
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2018)
Article
Infectious Diseases
Euna Oh, Junghee Bae, Ankit Kumar, Hyo-Jick Choi, Byeonghwa Jeon
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Multidisciplinary Sciences
Ah-Ra Kim, Dong-Hun Lee, Su-Hwa Lee, Ilaria Rubino, Hyo-Jick Choi, Fu-Shi Quan
Article
Chemistry, Medicinal
Bahman Homayun, Ankit Kumar, Priscila T. H. Nascimento, Hyo-Jick Choi
ARCHIVES OF PHARMACAL RESEARCH
(2018)
Review
Pharmacology & Pharmacy
Bahman Homayun, Xueting Lin, Hyo-Jick Choi
Article
Pharmacology & Pharmacy
Min-Chul Kim, Ki-Hye Kim, Jeong Woo Lee, Yu-Na Lee, Hyo-Jick Choi, Yu-Jin Jung, Yu-Jin Kim, Richard W. Compans, Mark R. Prausnitz, Sang-Moo Kang
Article
Pharmacology & Pharmacy
Hae-Ji Kang, Su-Hwa Lee, Min-Ju Kim, Ki-Back Chu, Dong-Hun Lee, Manika Chopra, Hyo-Jick Choi, Hyunwoo Park, Hui Jin, Fu-Shi Quan
Article
Chemistry, Multidisciplinary
Surjith Kumaran, Euna Oh, Sumin Han, Hyo-Jick Choi
Summary: The development of a universal, antiviral, and antibacterial material that can be coated on conventional mask fabrics to exhibit antimicrobial activities has been reported. The antimicrobial fabrics rapidly inactivated multiple types of viruses and bacteria, providing an immediate method to contain infectious diseases.
Article
Infectious Diseases
Mohammad Moniruzzaman, Hunhwan Kim, Haewon Shin, Hyunsoo Kim, Nayoung Kim, Sungyeon Chin, Adhimoolam Karthikeyan, Hyojick Choi, Gonsup Kim, Taesun Min
Summary: The results of the study demonstrate that dietary supplementation of curcumin nanospheres can significantly improve the growth performance and feed utilization of weaned piglets, reduce total cholesterol levels, and decrease fecal coliform bacteria and ammonia gas emissions.
Article
Chemistry, Multidisciplinary
Euna Oh, Seung Joon Choi, Sumin Han, Kyu Hyoung Lee, Hyo-Jick Choi
Summary: This study aims to improve the efficiency of alcohol-based disinfectants by adding a physical pathogen inactivation mechanism through salt recrystallization, preventing the emergence of alcohol tolerance. The experiment showed that additional salt crystallization facilitated stronger biocidal effects compared to alcohol-only formulations, regardless of the types of solid surfaces and pathogens.
Review
Pharmacology & Pharmacy
Sumin Han, Panjae Lee, Hyo-Jick Choi
Summary: Non-invasive vaccines have gained attention due to the limitations of conventional invasive vaccines. Various approaches for formulating and administrating non-invasive vaccines have emerged, but each faces challenges associated with vaccine bioavailability, toxicity, and other issues. Researchers have developed novel supplementary materials and delivery systems to overcome these limitations and this review article aims to provide up-to-date information and guide future research and development efforts in vaccine formulation for non-invasive vaccines.
Article
Food Science & Technology
Manika Chopra, Surjith Kumar Kumaran, Euna Oh, Seok Chan Park, Seong-O Choi, Dominic Sauvageau, Hyo-Jick Choi
Summary: This study developed a microfabricated probiotic formulation that can protect the activity of probiotics in digestive conditions and environmental storage. The technology enhances the efficacy of probiotics and reduces the required amount and costs.
ACS FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sumin Han, Euna Oh, Erin Keltie, Jong Sung Kim, Hyo-Jick Choi
Summary: Developing highly effective and low-cost methods to protect against direct transmission of respiratory diseases is a major challenge during pandemic outbreaks. Current filtration in respirators and masks raises safety concerns. Reusability of masks has gained attention during the COVID-19 pandemic. Our group has developed antimicrobial coating technologies for respiratory devices and focuses on salt-coated polypropylene fibers.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Immunology
Ki-Hye Kim, Young-Man Kwon, Young-Tae Lee, Min-Chul Kim, Hye Suk Hwang, Eun-Ju Ko, Youri Lee, Hyo-Jick Choi, Sang-Moo Kang
Article
Pharmacology & Pharmacy
Min-Chul Kim, Yu-Na Lee, Yu-Jin Kim, Hyo-Jick Choi, Ki-Hye Kim, Youn-Jeong Lee, Sang-Moo Kang
ANTIVIRAL RESEARCH
(2017)