期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 35, 期 6, 页码 1083-1089出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-0616-7
关键词
Rhamnetin; 3T3-L1 cells; Adipogenesis; Clonal expansion; Obesity
资金
- Chungbuk National University
Adipocyte differentiation plays a pivotal role in the progression of obesity which is a major risk factor for several diseases such as diabetes, hypertension and coronary heart disease. In this study, the inhibitory effect of rhamnetin, a flavonoid compound, on adipogenesis in 3T3-L1 cells was investigated. Rhamnetin decreased the accumulation of lipid droplets, and inhibited the elevation of triglyceride content in the adipocytes (IC50 = 17.3 mu M). The expressions of PPAR gamma, C/EBP alpha, and perilipin, adipocyte differentiation markers, were significantly reduced by rhamnetin. Triglyceride biosynthesis and clonal expansion of adipocytes were completely inhibited during the early stage by rhamnetin. Additionally, rhamnetin significantly decreased the expression of C/EBP beta, an early stage marker. Our results indicate that suppression of clonal expansion during the early stage of adipogenesis by rhamnetin may be associated with inhibition of the C/EBP beta, C/EBP alpha, and PPAR gamma pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据