Article
Integrative & Complementary Medicine
Riezki Amalia, Diah Lia Aulifa, Dichy Nuryadin Zain, Anisa Pebiansyah, Jutti Levita
Summary: This study investigated the cytotoxicity and nephroprotective activity of the ethanol extract of Angelica keiskei Koidzumi on the N-acetyl-p-benzoquinone imine (NAPQI) induced human embryonic kidney (HEK293) cell line. Results showed that the extract was not toxic at lower concentrations and exhibited nephroprotective activity against NAPQI-induced damage.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Diah Lia Aulifa, I. Ketut Adnyana, Sukrasno Sukrasno, Jutti Levita
Summary: The yellow sap of Angelica keiskei Koidzumi, traditionally used in Indonesia as a blood sugar reducer, contains xanthoangelol (XA) which shows potential as an inhibitor of alpha-glucosidase and dipeptidyl peptidase-IV (DPP-IV) through in silico and in vitro studies.
Article
Chemistry, Multidisciplinary
Youzhe Chen, Chengbo Xu, Weiping Wang, Xiaoliang Wang, Qinglan Guo, Jiangong Shi
Summary: Three phthalide-derived analogues, oxaspiroangelioic acids A-C, were isolated from aqueous extract of Angelica sinensis root heads. Oxaspiroangelioic acids A and B were separated into enantiomers by chiral HPLC. They share similar inhibiting activity and may be biosynthesized through novel pathways.
CHINESE CHEMICAL LETTERS
(2021)
Article
Medical Laboratory Technology
Yisi Liu, Fangqin Wu, Ying Wu, Malcolm Elliott, Wei Zhou, Ying Deng, Dianxu Ren, Haibo Zhao
Summary: Clinical observation and ex vivo studies have shown a strong association between inflammation and POAF. IL-6 plays a mechanistic role in sPOAF by inducing early fibrosis in the left atrium, leading to an increased susceptibility to POAF. Identifying IL-6 in pericardial drainage could serve as a potential noninvasive biomarker for predicting POAF.
TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yu Wang, Xianghe Liu, Guanghui Hu, Chenfei Hu, Yang Gao, Miaomiao Huo, Hongxia Zhu, Mei Liu, Ningzhi Xu
Summary: The study revealed that MSA upregulated miR-146a to directly target EGFR, inhibiting its protein expression and pathway activity, subsequently reducing IL-6 secretion. The inhibitory effect of MSA on esophageal cancer was found to be IL-6 dependent, suggesting its potential as a drug for treating this type of cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Donna L. Gruol, Claudia Melkonian, Salvador Huitron-Resendiz, Amanda J. Roberts
Summary: Neuroimmune factors, such as IL-6, play crucial roles in regulating CNS function under physiological and pathological conditions. Elevated IL-6 expression in the CNS is associated with disorders like excessive alcohol use, affecting cerebellar function by altering gene expression. Interactions between IL-6 and alcohol can modify IL-6 signal transduction partners, potentially contributing to cerebellar actions of alcohol.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ismail Che Noh, Imran Ahmad, Siti Suraiya, Nur Fadhlina Musa, Asma Abdullah Nurul, Abu Bakar Ruzilawati
Summary: The study found significant associations between IL-10 rs1800871, IL-10 rs1800896 gene polymorphism and susceptibility to chronic hepatitis C virus infection among Malay male drug abusers, while no significant differences were observed in gene polymorphism for other cytokines.
Article
Biochemistry & Molecular Biology
Hussaam Ul Haq Mansoor, Abrar Ahmed, Fatima Rasool
Summary: Inflammation is a natural reaction of the body to harmful factors, and inhibiting cytokine signaling networks, particularly IL-6, can be an effective treatment option. F. carica possesses anti-inflammatory properties and can inhibit carrageenan-induced paw edema in rats.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Hyejung Jo, Dahae Lee, Cheolhyeon Go, Yoojin Jang, Naghyung Chu, Suhyun Bae, Dongmin Kang, Jong Pil Im, Yejin Kim, Jae Seung Kang
Summary: This study examined the influence of vitamin C on the development and progression of inflammatory bowel disease (IBD). The results suggest that vitamin C insufficiency can lead to severe colitis and can also play a preventive role by regulating the production of cytokines and the induction of inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill
Summary: The study found that genetically predicted IL-6 signaling is positively associated with CVD risk, and the increase in CVD risk is linearly related to baseline hsCRP levels. There is no heterogeneity in the association of genetically predicted IL-6 signaling with CVD risk when stratifying the population by sex, age, body mass index, estimated glomerular filtration rate, or systolic blood pressure, but there is evidence of greater associations in individuals with low-density lipoprotein cholesterol >= 160 mg/dL.
Article
Pharmacology & Pharmacy
Helene Salvator, Stanislas Grassin-Delyle, Marion Brollo, Louis-Jean Couderc, Charlotte Abrial, Tatiana Victoni, Emmanuel Naline, Philippe Devillier
Summary: The study found that adiponectin released by lung tissue is negatively correlated with body mass index, AdipoR1 and AdipoR2 receptors are expressed in lung macrophages, and recombinant adiponectin and AdipoRon can significantly inhibit the release of inflammatory factors.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Haya Ayyal Salman, Amira Suriaty Yaakop, Saleem Aladaileh, Morad Mustafa, Mohammed Gharaibeh, Ummirul Mukminin Kahar
Summary: Inflammation is a necessary immune system reaction to eliminate pathogens. Many herbal extracts and phytoconstituents have anti-inflammatory effects. This study focused on the molecular docking of E. alte phytoconstituents with human anti-inflammatory cytokine receptors. The results showed that beta-Sitosterol and Androstan-3-one had better binding energies and inhibition constants, suggesting their potential as effective anti-inflammatory compounds and reducers of oxidative stress.
Article
Cardiac & Cardiovascular Systems
Latife Atasoy Karakas, Duygu Tugrul, Nihal Sahin Uysal, Sertac Esin, Niyazi Kursat Tokel, Yunus Kasim Terzi
Summary: The results of this study suggest that there is no relationship between IL-1 alpha, IL-1 beta, IL-6, and TNF alpha promoter gene polymorphisms and the occurrence of TGA.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Neurosciences
Donna L. Gruol, Delilah Calderon, Katharine French, Claudia Melkonian, Salvador Huitron-Resendiz, Chelsea Cates-Gatto, Amanda J. Roberts
Summary: The neuroimmune system of the brain, primarily composed of astrocytes and microglia, regulates homeostatic mechanisms crucial for normal brain function. Alcohol consumption and neuroimmune factors, such as proinflammatory cytokines IL-6 and TNF-alpha, disrupt this regulation by acting on common targets in the brain. Recent studies suggest that IL-6 plays a role in alcohol drinking and its effects on brain activity, but more research is needed.
Article
Chemistry, Medicinal
Hua-Sheng Zhang, Yong-Ming Yan, Dai-Wei Wang, Qing Lv, Yong-Xian Cheng, Shu-Mei Wang
Summary: Two new glycosides were isolated from the ethanol extract of Periplaneta americana, along with 3 compounds reported from a natural source for the first time. One of the compounds showed potential to develop novel agents against inflammation-related diseases.
NATURAL PRODUCT COMMUNICATIONS
(2021)
