期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 33, 期 12, 页码 1881-1889出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-1201-6
关键词
Autophagy; Small molecules; Chemical genomics
资金
- National Research Foundation of Korea (NRF)
- Korean Government (MEST) [2009-0092964, 2010-0017984]
- Translational Research Center for Protein Function Control (NRF) [2009-0083522]
- Brain Korea 21 project, Republic of Korea
- National Research Foundation of Korea [2009-0092964] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Autophagy is the mass degradation system that removes long-lived proteins and malfunctioning organelles within the cell. Dysfunctional autophagic processes can cause various diseases such as cancer and neurodegenerative disorders, but the underlying mechanisms responsible for such events remain undefined. Small molecules that control autophagy could be powerful tools to reveal autophagy mechanisms, and to develop treatments for autophagy-related diseases including Alzheimer's disease, Parkinson's disease and various cancer types. This review discusses the small molecules that have been identified to control autophagy and how they can be used to understand signaling pathways important for autophagy in the context of chemical genomics.
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