☆ 4.6 Article

Neuroprotective Effects of Constituents of the Root Bark of Dictamnus dasycarpus in Mouse Hippocampal Cells

ARCHIVES OF PHARMACAL RESEARCH (2010)

期刊

ARCHIVES OF PHARMACAL RESEARCH

卷 33, 期 8, 页码 1269-1275

出版社

PHARMACEUTICAL SOC KOREA

DOI: 10.1007/s12272-010-0818-9

关键词

Glutamate-induced toxicity; Dictamnus dasycarpus; Obacunone; HT22; Heme oxygenase-1; p38 MAPK

类别

Chemistry, Medicinal Pharmacology & Pharmacy

资金

National Natural Science Foundation of China [30860343]

向作者/读者索取更多资源

Protocol

Reagent

摘要

Glutamate-induced oxidative injury causes neuronal degeneration related to many central nervous system diseases, such as Parkinson's disease, Alzheimer's disease, epilepsy and ischemia. The bioassay-guided fractionation of the EtOH extract of the root bark of Dictamnus dasycarpus Trucz. provided one neuroprotective limonoid, obacunone, together with a degraded limonoid, fraxinellone and two alkaloids, dictamine and haplopine. At concentrations of 100-150 mu M, obacunone showed the potent neuroprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells. In addition, we found that obacunone increased p38 MAPK phosphorylation and induced HO-1 expression via p38 MAPK pathway. These results suggest that obacunone isolated from the root bark of D. dasycarpus increases cellular resistance to glutamate-induced oxidative injury in mouse hippocampal HT22 cells, presumably through the p38 MAPK pathway-dependent HO-1 expression. These results suggest that obacunone could be the effective candidates for the treatment of ROS-related neurological diseases.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Pharmacology & Pharmacy

The traditional uses, phytochemistry, pharmacology and toxicology of Dictamnus dasycarpus: a review

Yu Qin, Hong-Feng Quan, Xi-Rong Zhou, Shu-Juan Chen, Wen-Xin Xia, Hang Li, Huan-Ling Huang, Xue-Yan Fu, Lin Dong

Summary: The review provides a comprehensive overview of the botany, traditional uses, phytochemistry, pharmacology, and toxicology of Dictamnus dasycarpus. Over 200 compounds have been identified from the plant, with confirmed pharmacological activities including anti-inflammatory, cardiovascular protective, liver injury improvement, and anti-cancer effects. Further studies are needed to focus on quality control, agricultural utilization, medicinal components of decoction, and toxicity for the advancement of clinical trials.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases

Anne Grunenwald, Lubka T. Roumenina, Marie Frimat

Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Medicinal

Neuroprotective effects of 2-heptyl-3-hydroxy-4-quinolone in HT22 mouse hippocampal neuronal cells

Baskar Selvaraj, Dae Woon Kim, Jin-Soo Park, Hak Cheol Kwon, Heesu Lee, Ki-Yeon Yoo, Jae Wook Lee

Summary: Compound 1 demonstrated neuroprotective effects by inhibiting cellular Ca2+ uptake and reducing ROS accumulation in response to glutamate-induced neurotoxicity. It also showed inhibition of the MAPK signaling pathway, leading to decreased levels of pro-apoptotic proteins and AIF translocation to the nucleus. Overall, compound 1 effectively protected neuronal cells from apoptotic cell death.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synergistic Protection by Isoquercitrin and Quercetin against Glutamate-Induced Oxidative Cell Death in HT22 Cells via Activating Nrf2 and HO-1 Signaling Pathway: Neuroprotective Principles and Mechanisms of Dendropanax morbifera Leaves

Hye-Jin Park, Ha-Neul Kim, Chul Young Kim, Min-Duk Seo, Seung-Hoon Baek

Summary: The study found that isoquercitrin and quercetin from DML's ethyl acetate-soluble extracts (DMLE) significantly inhibit glutamate-induced oxidative cell death by regulating intracellular reactive oxygen species levels and mitochondrial superoxide generation, calcium ion imbalance, mitochondrial dysfunction, and nuclear translocation of apoptosis-inducing factor.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Anti-Oxidative and Anti-Neuroinflammatory Effects of Sargassum horneri by Heme Oxygenase-1 Induction in BV2 and HT22 Cells

Wonmin Ko, Hwan Lee, Nayeon Kim, Hee Geun Jo, Eun-Rhan Woo, Kyounghoon Lee, Young Seok Han, Sang Rul Park, Ginnae Ahn, Sun Hee Cheong, Dong-Sung Lee

Summary: The study revealed that the extract from Sargassum horneri has antioxidant and anti-neuroinflammatory effects, potentially attenuating oxidative action and neuroinflammatory responses via HO-1 induction through different pathways.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Microbiology

Heme Oxygenase-1 Induction in Human BeWo Trophoblast Cells Decreases Toxoplasma gondii Proliferation in Association With the Upregulation of p38 MAPK Phosphorylation and IL-6 Production

Marcos Paulo Oliveira Almeida, Caroline Martins Mota, Tiago Wilson Patriarca Mineo, Eloisa Amalia Vieira Ferro, Bellisa Freitas Barbosa, Neide Maria Silva

Summary: This study demonstrates the crucial role of HO-1 in human trophoblast cells infected with Toxoplasma gondii, with its inducers inhibiting parasitism and promoting IL-6 production to control infection. The findings highlight the potential of HO-1 as a therapeutic target for Toxoplasma gondii infection during pregnancy.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways

Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen

Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1

Ming Gao, Zijuan Qi, Min Deng, Hongyang Huang, Zhijie Xu, Guijie Guo, Jiajun Jing, Xiaofeng Huang, Ming Xu, Jake A. Kloeber, Sijin Liu, Jinzhou Huang, Zhenkun Lou, Jinxiang Han

Summary: The deubiquitinase USP7 plays a key role in controlling redox homeostasis by promoting HO-1 deubiquitination and stabilization in hepatocytes. USP7 inhibitor might be a potential therapeutic agent for treating HO-1 overexpressed liver cancers.

ONCOGENE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Protective effects of selenium in tacrolimus-induced lung toxicity: potential role of heme oxygenase 1

Salwa Abdel-Tawab Ibrahim, Nashwa Fathy Eltahawy, Ahlam Mohamed Abdalla, Hanaa Mohamed Khalaf

Summary: This study found that selenium (Sel) can protect against tacrolimus (Tac)-induced lung toxicity and is associated with the expression of heme oxygenase 1 (HO-1). Oxidative stress and inflammatory markers in rat groups showed changes corresponding to HO-1 levels. Selenium has a protective role against Tac-induced lung toxicity.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2021)

添加到收藏夹

Article Nutrition & Dietetics

Vitis Vinifera Leaf Extract Protects Against Glutamate-Induced Oxidative Toxicity in HT22 Hippocampal Neuronal Cells and Increases Stress Resistance Properties in Caenorhabditis Elegans

Chatrawee Duangjan, Panthakarn Rangsinth, Shaoxiong Zhang, Xiaojie Gu, Michael Wink, Tewin Tencomnao

Summary: The study investigated the beneficial effects of V. vinifera leaf extract on neuroprotection and antioxidant properties, showing its potential in combating oxidative stress and aging. VVE extract demonstrated positive impact on antioxidant properties and neuroprotective effects.

FRONTIERS IN NUTRITION (2021)

添加到收藏夹

Article Biology

Neuroprotective Effects of Extracts from Tiger Milk Mushroom Lignosus rhinocerus Against Glutamate-Induced Toxicity in HT22 Hippocampal Neuronal Cells and Neurodegenerative Diseases in Caenorhabditis elegans

Parinee Kittimongkolsuk, Nattaporn Pattarachotanant, Siriporn Chuchawankul, Michael Wink, Tewin Tencomnao

Summary: The study established the neuroprotective effects of LR's ethanol extract (LRE) both in vitro and in vivo, suggesting potential for LRE as a candidate neuroprotectant.

BIOLOGY-BASEL (2021)

添加到收藏夹

Article Environmental Sciences

2, 2′, 4, 4′-tetrabromodiphenyl ether induces placental toxicity via activation of p38 MAPK signaling pathway in vivo and in vitro

Weijue Liu, Sihao Li, Qing Zhou, Zhushan Fu, Pinya Liu, Xiyue Cao, Shuhua Xi

Summary: BDE-47 impairs placental angiogenesis by inhibiting cell migration and invasion, and induces placental toxicity by inhibiting proliferation, increasing apoptosis and autophagy. In vitro, activation of the p38 MAPK signaling pathway is involved in the processes of placental injury caused by BDE-47.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

添加到收藏夹

Article Neurosciences

Bone marrow stromal cells-derived exosomes reduce neurological damage in traumatic brain injury through the miR-124-3p/p38 MAPK/GLT-1 axis

Zerui Zhuang, Mingfa Liu, Zhuozhi Dai, Jianming Luo, Bingna Zhang, Hanhui Yu, Jiajian Xue, Haixiong Xu

Summary: This research explores the therapeutic effects of miR-124-3p obtained from bone marrow stromal cell-derived exosomes (BMSCs-Exos) in attenuating glutamate-mediated excitotoxicity in traumatic brain injury (TBI). The findings show that BMSCs-ExosmiR-124-3p can upregulate GLT-1 in TBI rat models by inhibiting the p38 MAPK signaling pathway, reducing glutamate-mediated excitotoxicity and attenuating neurological damage post-TBI.

EXPERIMENTAL NEUROLOGY (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

Naoko Yamagishi, Yuta Yamamoto, Toshio Nishi, Takao Ito, Yoshimitsu Kanai

Summary: Lansoprazole exerts antioxidant effects by activating the Nrf2 pathway and provides hepatoprotection in a drug-induced hepatitis animal model. The cytoprotective effect of lansoprazole on liver epithelial cells against cisplatin-induced cytotoxicity is mediated through the p38 MAPK signaling pathway. This study suggests the potential application of lansoprazole in preventing and treating oxidative liver injury.

PLOS ONE (2023)

添加到收藏夹

Article Cell Biology

Banhasasim-Tang Ameliorates Spatial Memory by Suppressing Oxidative Stress through Regulation of ERK/p38 Signaling in Hippocampus of Mice

Malk Eun Pak, You-Chang Oh, Yeo Jin Park, Jae Kwang Kim, Min-Gyeong Shin, Jong Hyuk Yoon, Younghoon Go

Summary: Banhasasim-tang (BHS) has been traditionally used to treat functional dyspepsia in East Asia, and this study found that BHS administration can protect hippocampal neurons against oxidative stress, improve memory dysfunction, increase neuronal survival, and regulate multiple signaling pathways. This suggests that BHS may have therapeutic potential for reducing neuronal damage and improving memory in neurodegenerative diseases.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

添加到收藏夹

暂无数据

暂无数据

© Peeref 2019-2024. All rights reserved.