期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 32, 期 6, 页码 851-855出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-009-1606-2
关键词
Echinosophora koreensis; Flavonoids; 3-Hydroxy-kenusanone B; Alcohol dehydrogenase (ADH); Aldehyde dehydrogenase (ALDH)
资金
- Ministry of Education and Human Resources Development, South Korea [BK21]
- Korea Institute of Science and Technology institutional program [2Z03020, 2Z03100]
- Ministry of Education, Science & Technology (MoST), Republic of Korea [2Z03100, 2Z03020] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 mu g/mL and 50 mu g/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent 'hangovers' after alcohol intake.
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