Article
Biochemistry & Molecular Biology
Sameh A. Ahmed, Yaser M. Alahmadi, Yasser A. Abdou
Summary: This study aimed to assess the levels of individual reactive oxygen species (ROS) and reactive nitrogen species (RNS) in COVID-19 patients and clarify their usefulness as potential disease severity biomarkers for the first time. The results showed significantly higher levels of individual ROS and RNS in the sera of COVID-19 patients compared to healthy subjects, with significant positive correlations with biochemical markers. Furthermore, significantly elevated levels of ROS and RNS were observed in intensive care unit (ICU) patients compared with non-ICU patients. Therefore, serum ROS and RNS concentrations can be used as biomarkers to track the prognosis of COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Article
Nanoscience & Nanotechnology
Runze Zhao, Xiaoyue Ning, Mengqi Wang, Huanhuan Wang, Guang Xing, Li Wang, Chengzhi Lu, Ao Yu, Yongjian Wang
Summary: The study developed a redox-responsive nanoprodrug that achieved targeted drug release to plaques and synergistic therapeutic effects of simvastatin and ticagrelor on atherosclerosis treatment, showing promising therapeutic efficacy and biosafety profile.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Hematology
Julian Kamhieh-Milz, Lei Chen, Claudia Goettsch, Anna Maria Pfefferkorn, Anja Hofmann, Coy Brunssen, Gregor M. Mueller, Thomas Walther, Muhammad Imtiaz Ashraf, Guido Moll, Henning Morawietz, Janusz Witowski, Rusan Catar
Summary: This study analyzed the mechanism by which NOX2 contributes to Ang II-induced ET-1 production in human microvascular endothelial cells. The results showed that high-fat diet increased the expression of Ang II and ET-1 in wild-type mice, but not in Nox2-deficient mice. In vitro experiments revealed that Ang II promoted NOX2 expression through induction of the Oct-1 protein and increased production of superoxide anions. Inhibition of Oct-1 and superoxide attenuated Ang II-induced ET-1 production.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Niklas Mueller, Timothy Warwick, Kurt Noack, Pedro Felipe Malacarne, Arthur J. L. Cooper, Norbert Weissmann, Katrin Schroeder, Ralf P. Brandes, Flavia Rezende
Summary: ROS play a crucial role in cardiovascular signal transduction, with different types and concentrations leading to distinct metabolic and transcriptomic responses in endothelial cells. High levels of H2O2 significantly impact both metabolism and gene expression, while other ROS mainly affect gene expression levels.
Article
Environmental Sciences
Xifeng Shan, Ling Liu, Gang Li, Kexin Xu, Bingyan Liu, Wei Jiang
Summary: In this study, the cytotoxic effects of PM2.5, BC, and Kaolin were investigated using human bronchial epithelial cells. BC and Kaolin mainly induced cell necrosis, while PM2.5 caused both apoptosis and necrosis. Excess ROS production was involved in organelle damage and cell death, with ROS playing a more significant role in BC-induced cytotoxicity compared to Kaolin. Removal of ROS partially mitigated PM2.5-induced apoptosis and necrosis, suggesting the existence of ROS-dependent and ROS-independent mechanisms in PM2.5 toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Biomedical
Qian-Xiao Huang, Jun-Long Liang, Chi-Hui Yang, Ke Li, Mei-Ting Niu, Jin-Xuan Fan, Xian-Zheng Zhang
Summary: In this study, a stimulation-responsive mucoadhesive probiotic Lac@HDP was constructed for specific adhesion and ROS depletion in colitis. The results showed that the Lac@HDP probiotics were more effective in alleviating colitis symptoms and increasing the abundance of intestinal flora compared to antioxidants and probiotics alone. This provides a promising clinical application for the future.
Article
Biochemistry & Molecular Biology
Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
Summary: The study revealed that CCL8 may promote atherosclerosis by inducing endothelial permeability increase. The NOX2/ROS signaling pathway may be the underlying mechanism for this effect. This research contributes to a deeper understanding of the connection between chemokines and atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alessio Biagioni, Sara Peri, Giampaolo Versienti, Claudia Fiorillo, Matteo Becatti, Lucia Magnelli, Laura Papucci
Summary: Blood vessels are crucial for cancer cells to survive and spread in the body, and the formation of abnormal vessel networks is closely related to patients' prognosis. It is urgent to find new pharmaceutical solutions to control and normalize the formation of these networks.
Article
Cardiac & Cardiovascular Systems
Yi Song, Hang Xing, Yixin He, Zhiqi Zhang, Guangbin Shi, Su Wu, Yuhong Liu, Elizabeth O. Harrington, Frank W. Sellke, Jun Feng
Summary: This study suggests that the use of the mitochondrial-targeted antioxidant Mito-Tempo can protect coronary endothelial function and small conductance calcium-activated potassium channel activity, and enhance endothelium-dependent vasorelaxation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Pharmacology & Pharmacy
Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong
Summary: Vitamin D not only affects calcium and phosphorus homeostasis but also regulates about 3% of human gene transcription. It has protective effects on cardiovascular disease and hypertension by modulating COX-1 and COX-2 expression to maintain normal vascular function.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
