Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Hadley Johnson, Marcella R. Aquino, Alan Snyder, Reid W. Collis, Katlein Franca, Alina Goldenberg, Jennifer Y. Sui, Dawn Z. Eichenfield, Brittany J. Kozy, Jennifer K. Chen, Chelsea Shope, Ari M. Goldminz, JiaDe Yu
Summary: Children with atopic dermatitis are more likely to have allergic contact dermatitis and should undergo evaluation and patch testing for allergic contact dermatitis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Nutchaya Amornruk, Noppachai Siranart, Prattana Sittiwattanawong, Patipark Kueanjinda, Suwimon Loplumlert, Jongkonnee Wongpiyabovorn
Summary: This study aimed to determine the prevalence of immediate patch test reactions to fragrance in patients with fragrance allergic contact dermatitis. The results revealed that cinnamic aldehyde and cinnamic alcohol were the most common fragrance allergens causing both immediate and delayed reactions, while benzyl alcohol, sorbic acid, and coumarin showed a higher frequency of immediate patch test reactions.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Allergy
Charlene Wee, Chee Hian Tan, Xiahong Zhao, Yik Weng Yew, Anthony Goon
Summary: Recent studies have shown similar or higher rates of positive patch-test results in patients with atopic dermatitis (AD) compared to non-AD patients. This study found that approximately half of the patients who underwent patch testing had a positive reaction, with nickel sulfate being the most frequent sensitizing allergen.
CONTACT DERMATITIS
(2022)
Review
Biochemistry & Molecular Biology
Raffaele Brancaccio, Giuseppe Murdaca, Rossella Casella, Teresa Loverre, Laura Bonzano, Eustachio Nettis, Sebastiano Gangemi
Summary: Skin inflammation is a common feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria, and the pathogenetic mechanisms are not fully understood. This study reviews the role of miRNA in regulating inflammatory mechanisms and innate and adaptive immune responses in these skin conditions. miRNAs are found to be involved in the pathogenesis and regulation of atopic dermatitis, chronic spontaneous urticaria, and allergic contact dermatitis, and they could serve as biomarkers and potential therapeutic targets for these chronic skin conditions.
Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Article
Biology
Dominik Nemeth, Erzsebet Temesvari, Peter Hollo, Gyorgyi Ponyai
Summary: This study found that contact hypersensitivity to preservatives is common in adult atopic dermatitis, particularly among young women. Methylisothiazolinone (MI) and Kathon CG (R) were identified as important allergens. These findings highlight the importance of preservatives in topical therapy and the prevention of exacerbations in atopic dermatitis.
Article
Allergy
Aoife Hollywood, John F. Bourke
Summary: This is a case series of allergic contact dermatitis to F5 in pharmaceutical workers, confirmed by patch testing. With the globalized production of imatinib, more similar cases may arise.
CONTACT DERMATITIS
(2022)
Review
Medicine, General & Internal
Marta Tramontana, Katharina Hansel, Leonardo Bianchi, Chiara Sensini, Nicolo Malatesta, Luca Stingeni
Summary: Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a high impact on quality of life. It is triggered by contact with an allergen in previously sensitized individuals. Symptoms include eczematous dermatitis, erythema, edema, vesicles, scaling, and intense itch. Occupational and non-occupational exposure to allergens is common, and patch testing is required for diagnosis. Nickel, fragrance mix, isothiazolinones, and para-phenylenediamine are commonly positive allergens. Treatment involves avoiding contact with the allergen and using corticosteroid therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Chayada Chaiyabutr, Chudapa Sereeaphinan, Suthasanee Prasertsook, Waranya Boonchai
Summary: This study retrospectively reviewed the medical records of 247 patients with clinically suspected footwear dermatitis at Siriraj Hospital in Bangkok. It found that females were predominant and rubber and leather allergens were still the most common causes of allergic contact dermatitis related to footwear. Dermatologists should stay informed of common and emerging allergens in footwear to provide accurate diagnosis and treatment.
CONTACT DERMATITIS
(2023)
Article
Allergy
Domenico Bonamonte, Katharina Hansel, Paolo Romita, Anna Belloni Fortina, Giampiero Girolomoni, Gabriella Fabbrocini, Cataldo Patruno, Maddalena Napolitano, Annalisa Patrizi, Giuseppe Argenziano, Giuseppe Micali, Piergiacomo Calzavara Pinton, Caterina Foti, Luca Stingeni
Summary: This study aimed to evaluate the prevalence of contact sensitivity in children and investigate its association with AD. The results showed a consistent prevalence of contact allergy among children, with higher sensitivity rate among children with AD than without AD.
CONTACT DERMATITIS
(2022)
Article
Dermatology
Yoon Jin Choi, Ji Yeon Byun, You Won Choi, Joo Young Roh, Hae Young Choi
Summary: This study retrospectively investigated the characteristics of contact sensitization in allergic contact dermatitis (ACD) patients with a history of atopic dermatitis (AD). The results showed a decreased prevalence of contact sensitization in AD patients compared to non-AD patients. Furthermore, AD patients had a higher positivity rate for budesonide, while non-AD patients had a higher prevalence of positive results for balsam of Peru. Nickel sulfate, cobalt chloride, and potassium dichromate were the most common sensitized allergens in both groups.
ANNALS OF DERMATOLOGY
(2023)
Article
Allergy
Marlene Isaksson, Ola Bergendorff, Nils Hamnerius, Ann Ponten, Cecilia Svedman, Inese Hauksson, Magnus Bruze
Summary: The two dialkylthiocarbamyl benzothiazole sulphides, DMTBS and DEBTS, have been found to be good markers for the sensitivity to common rubber additives. Further research is needed to determine the safe test concentrations and confirm their efficacy as new markers for rubber allergy.
CONTACT DERMATITIS
(2023)
Article
Public, Environmental & Occupational Health
C. Huang, D. Greig, H. Cheng
Summary: This study investigated the causes of allergic contact dermatitis in healthcare workers in New Zealand, finding that rubber chemicals, fragrances, preservatives, and topical corticosteroids were the most common allergens. Hand dermatitis was the most common presentation.
OCCUPATIONAL MEDICINE-OXFORD
(2021)
Review
Ophthalmology
Michal Turkiewicz, Ami Shah, Yul W. Yang, Aaron Mangold, Joanne Shen
Summary: The purpose of this review is to summarize the published literature on the pathogenesis and treatment of eyelid allergic contact dermatitis and ocular surface involvement. The review involved a literature search of MEDLINE and analysis of 120 articles. The results suggest that allergic eyelid contact dermatitis is a Type IV hypersensitivity reaction that can be improved through avoidance strategies, patch testing, and use of topical steroids.
Article
Multidisciplinary Sciences
Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, Martin A. Carnerup, Joel Mauricio Correa Da Rosa, David Adrian Ewald, Troels T. Marstrand, Mikkel Krogh-Madsen, Georg Dunstl, Kevin Neil Dack, Anna Ollerstam, Hanne Norsgaard
Summary: This study describes a selective non-steroidal glucocorticoid receptor (GR) agonist, LEO 134310, for topical use, which is rapidly deactivated in the blood resulting in low systemic exposure and a higher therapeutic index compared with currently used glucocorticoids. The selectivity of LEO 134310 for GR was confirmed within a panel of nuclear receptors, and topical treatment with LEO 134310 in minipigs did not result in significant epidermal thinning.
SCIENTIFIC REPORTS
(2022)
Article
Allergy
Benjamin Ungar, Jacob W. Glickman, Alexandra K. Golant, Celina Dubin, Olga Marushchak, Alyssa Gontzes, Daniela Mikhaylov, Giselle K. Singer, Danielle Baum, Nancy Wei, Antonio Sanin, Diana Gruenstein, Mark G. Lebwohl, Ana B. Pavel, Emma Guttman-Yassky
Summary: This study aimed to investigate the hypothesis that targeting Th2 with the IL4Ra-antagonist, dupilumab, could rebalance the Th1/Th2 axis in inflammatory disease patients, potentially leading to attenuated COVID-19 symptoms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Dermatology
Yael Renert-Yuval, Joel Correa da Rosa, Sandra Garcet, Ana B. Pavel, Jennifer Bares, Margot Chima, Jason E. Hawkes, Patricia Gilleaudeau, Mary Sullivan-Whalen, Giselle K. Singer, James G. Krueger, Emma Guttman-Yassky
Summary: This study investigated the utility of two different alopecia areata-targeted questionnaires, and found that the Alopecia Areata Symptom Impact Scale (AASIS) correlated strongly with alopecia areata severity and clinical response. Patients with <= 20% scalp hair loss after treatment reported improvement in multiple quality-of-life items, which may guide clinicians and improve the development of future clinical trials.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsoe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Summary: This study used BRB-seq technique to analyze the transcriptome of tape-stripped skin samples from atopic dermatitis patients and healthy controls. An AD signature consisting of genes related to skin barrier and inflammatory response was identified. However, the low and highly variable transcript counts in tape-stripped samples were a limiting factor for epidermal transcriptome profiling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Thomas U. Marron, Matthew D. Galsky, Bachir Taouli, Maria Isabel Fiel, Stephen Ward, Edward Kim, David Yankelevitz, Deborah Doroshow, Emma Guttman, Benjamin Ungar, Saurabh Mehandru, Benjamin J. Golas, Daniel Labow, John Sfakianos, Sujit S. Nair, Dimple Chakravarty, Michael Buckstein, Xiaoyu Song, Effi Kenigsberg, Sacha Gnjatic, Brian D. Brown, Joseph Sparano, Ashutosh Tewari, Myron Schwartz, Nina Bhardwaj, Miriam Merad
Summary: Window-of-opportunity trials offer a platform to understand the mechanisms of short-duration pre-surgical therapies, but there is a need for a paradigm shift in trial design, specimen collection, and analysis.
Letter
Dermatology
Jill I. Olydam, Linde E. M. de Wijs, Willem A. Dik, Mads A. Ropke, Joel Correa Da Rosa, Dirk Jan Hijnen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Allergy
Ana B. Pavel, Ester Del Duca, Julia Cheng, Jianni Wu, Benjamin Ungar, Yeriel D. Estrada, Carolyn Jack, Catherine Maari, Etienne Saint-Cyr Proulx, Francisco Ramirez-Valle, James G. Krueger, Robert Bissonnette, Emma Guttman-Yassky
Summary: The treatment of inflammatory skin diseases needs experimental models of skin inflammation in humans to predict treatment effects. In this study, four common sensitizers were administered to healthy patients, and it was found that diphencyprone induced the strongest immune response and best modeled the barrier defects characteristic of atopic dermatitis and psoriasis.
Letter
Allergy
Benjamin Ungar, Susan Hartzell, Daniel Lozano-Ojalvo, Sabrina Ghalili, Swaroop Bose, Alexandra K. Golant, Kathryn Tan, Yeriel D. Estrada, Giselle K. Singer, Ana B. Pavel, Paolo Cravedi, Emma Guttman-Yassky
Letter
Dermatology
Shayan Owji, Helen He, Joseph Han, Peter Baek, Daniel Yassky, Nicholas Gulati, Benjamin Ungar, Jonathan Ungar
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Joseph Han, Scott Stratman, Jade N. Young, Dina Poplausky, Shayan Owji, Yen Luu, Yeriel Estrada, Joel Correa da Rosa, James G. Krueger, Nicholas Gulati
Summary: Diphencyprone (DPCP) causes a delayed-type hypersensitivity reaction when applied topically, and is used clinically for various conditions. In this study, proteomic analysis of healthy volunteers showed upregulation of immune cell activation, tissue remodeling, antineoplastic markers, and Th1 axis markers following DPCP application. Negative regulators of immune function were also upregulated, which may explain the therapeutic benefits in autoimmune conditions. The study also revealed a transient Th2 response followed by Th1 polarization. Overall, DPCP induces a complex and evolving immunological response.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Tu Hu, Tanja Todberg, David Adrian Ewald, Ilka Hoof, Joel Correa da Rosa, Lone Skov, Thomas Litman
Summary: The skin transcriptome of atopic dermatitis (AD) is stable over time, with the largest variation due to disease, individual, and skin site. AD-specific differentially expressed genes revealed disrupted skin barrier and activated immune response as the main features of AD. Potential novel targets in AD were also identified. This study provides new methods and insights for future skin research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Allergy
Paola Facheris, Joel Correa Da Rosa, Angel D. D. Pagan, Michael Angelov, Ester Del Duca, Grace Rabinowitz, Pedro Jesus Gomez Arias, Camille Rothenberg Lausell, Yeriel D. D. Estrada, Swaroop Bose, Mashkura Chowdhury, Avner Shemer, Ana B. B. Pavel, Emma Guttman-Yassky
Summary: The unique characteristics of adult-onset atopic dermatitis (AOAD) compared to pediatric-onset AD persisting into adulthood (POAD) have not been well-studied, hindering the development of targeted therapeutics. This study analyzed skin and blood samples from AOAD, POAD, and healthy controls and found that both AOAD and POAD showed immune and barrier dysregulations with shared Th2/Th22 hyperactivation. POAD had greater inflammation and compromised epidermal barrier compared to AOAD. AOAD also had more dysregulated proteins in serum, including pro-inflammatory and cardiovascular-risk markers.
Letter
Dermatology
Ross O'Hagan, Stella A. Caldas, Joel Correa M. da Rosa, Emma Guttman-Yassky, Benjamin Ungar
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Joel Correa da Rosa, Jose O. Aleman, Jason Mohabir, Yupu Liang, Jan L. Breslow, Peter R. Holt
Summary: Obesity is a growing epidemic in the United States, and there is limited understanding of the mechanisms behind weight gain and loss. Integrating omics data has become a popular method to increase understanding of complex phenotypes. The study developed a strategy to screen predictors from a small cohort of obese women, and successfully identified baseline fecal bile acids and regulation in RT-polymerase chain reaction as the most predictive data sources for forecasting weight loss rates.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Letter
Allergy
Benjamin Ungar, Leore Lavin, Alexandra K. Golant, Alyssa Gontzes, Eden David, Yeriel D. Estrada, Giselle K. Singer, Ana B. Pavel, Emma Guttman-Yassky
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
