Article
Medicine, Research & Experimental
Axel Sahovaler, Hedyeh Ziai, Felipe Cardemil, Shao Hui Huang, Jie Su, David P. Goldstein, Ralph Gilbert, Ali Hosni, Andrew Hope, John Waldron, Anna Spreafico, Eric Monteiro, Ian Witterick, Jonathan Irish, Patrick Gullane, Wei Xu, Brian O'Sullivan, John R. de Almeida
Summary: Achieving negative surgical margins is important for disease control in mucosal melanoma of the head and neck. Radiotherapy may enhance surgical outcomes, and immunotherapy shows therapeutic benefit in recurrent and/or metastatic disease.
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Qing-Qing Xu, Qing-Jie Li, Liu Chen, Xin-Yi Su, Jing-Xia Song, Juan Du, Lei Chen, Li-Xia Lu
Summary: A nomogram was developed to predict the prognosis of patients with mucosal melanoma of the head and neck, with high diagnostic accuracy. Patients were stratified into different risk groups based on their nomogram scores, allowing for individualized treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Motoo Nomura
Summary: This study aims to discuss future directions for multimodal definitive treatment of head and neck mucosal melanoma, a rare clinical subtype of melanoma or head and neck cancer. Surgery is considered as the main treatment for locally advanced cases, with adjuvant radiotherapy playing a role in local disease control.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Qing-Qing Xu, Qing-Jie Li, Cheng-Long Huang, Mu-Yan Cai, Mei-Fang Zhang, Shao-Han Yin, Li-Xia Lu, Lei Chen
Summary: The research found that through the IHC signature, the survival rate of patients with head and neck mucosal melanoma can be predicted, and better prognostic predictions can be made through group classification. Multivariable analysis showed that IHC score, T stage, and primary tumor site were independent variables in predicting survival rate.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Costantino Ricci, Maria V. Altavilla, Barbara Corti, Ernesto Pasquini, Livo Presutti, Anna M. Baietti, Luca Amorosa, Tiziana Balbi, Chiara Baldovini, Francesca Ambrosi, Marco Grillini, Antonia D'Errico, Michelangelo Fiorentino, Maria P. Foschini
Summary: PRAME is a cancer-testis antigen that can be used to differentiate between benign and malignant melanocytic lesions. In this study, PRAME stain was performed on mucosal melanocytic tumors of the head and neck region to evaluate the most reliable diagnostic score. The best-performing cutoff of PRAME-positive cells (<60%/= 60%) showed high accuracy in differentiating between benign and malignant tumors. However, some PRAME-negative malignant tumors were identified, particularly in the palatal area.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Otorhinolaryngology
Marc C. Grant-Freemantle, Billy Lane O'Neill, Anthony James P. Clover
Summary: Surgery is the mainstay treatment for mucosal melanoma, but recent studies suggest that radiotherapy, especially in combination with surgery, may improve survival outcomes for head and neck mucosal melanoma (HNMM) patients. Radiotherapy can reduce the risk of death and local recurrence in HNMM patients. However, radiotherapy alone has worse survival outcomes compared to surgery.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Thyago Morais Vicente da Silva, Thayanara Silva Melo, Romulo Cesar de Alencar, Jose Ricardo Dias Pereira, Jair Carneiro Leao, Igor Henrique Morais Silva, Luiz Alcino Gueiros
Summary: Photobiomodulation therapy (PBMT) has a significant positive impact on promoting surgical alveolar mucosal lining in patients who have undergone head and neck radiation therapy, leading to faster healing and reduced postoperative pain.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Esteban Brenet, Pierre Philouze, Camille Schiffler, Pascal Pommier, Carole Crozes, Nazim Benzerdjeb, Elodie Monchet, Camille Boulagnon-Rombi, Jean Ton Van, Fabien Podeur, Stephanie Servagi-Vernat, Xavier Liem, Jean-Claude Merol, Philippe Ceruse, Anne-Agathe Serre, Sylvie Chabaud, Morbize Julieron, Sophie Deneuve
Summary: This study compared the impact of two radiation modalities on loco-regional control, survival, and tumor emergence in patients with unilateral head and neck carcinoma of unknown primary. The results showed similar outcomes in terms of locoregional control, contralateral lymph node recurrence, and tumor emergence between the UL-RT and COMP-RT groups.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Arash Abiri, Tyler M. Yasaka, Brandon M. Lehrich, Khodayar Goshtasbi, Peter Papagiannopoulos, Bobby A. Tajudeen, Maie A. St. John, Jeremy P. Harris, Edward C. Kuan
Summary: The study found that in patients with head and neck mucosal melanoma, surgery with immunotherapy (SI) had better overall survival than surgery alone, while SI and surgery with adjuvant radiotherapy and immunotherapy (SRI) were more beneficial for overall survival than surgery with adjuvant radiotherapy. Factors such as age, gender, tumor localization, stage, and surgical margins were associated with increased mortality risk in patients.
Article
Dentistry, Oral Surgery & Medicine
Jiong Lyu, Yuwen Miao, Fang Yu, Chengdong Chang, Wei Guo, Huiyong Zhu
Summary: The study found high frequencies of CDK4 and TERT amplification in oral mucosal melanoma (OMM). The amplifications tended to occur together in OMM and were associated with higher protein expression levels. Knockdown of CDK4 led to cell cycle delays, and OMM cells were sensitive to the CDK4 inhibitor abemaciclib, which showed synergistic effects with dacarbazine in inhibiting cell viability.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Medicine, General & Internal
Jad Wehbe, Dominic Jaikaransingh, Abigail Walker
Summary: This paper discusses the use of immunotherapy in mucosal melanoma of the head and neck. Studies have shown that immunotherapy can improve survival rates. However, larger clinical trials are needed to accurately assess the efficacy of immunotherapy due to the rarity of the disease.
Article
Oncology
Kristian Hastoft Jensen, Ivan Vogelius, Claus Ernst Moser, Elo Andersen, Jesper Grau Eriksen, Jorgen Johansen, Mohammad Farhadi, Maria Andersen, Jens Overgaard, Jeppe Friborg
Summary: This study found that the risk of bloodstream infections (BSIs) in patients with head and neck squamous cell carcinoma undergoing radiotherapy or chemoradiation is associated with age, cancer stage, and performance status, with Staphylococcus aureus being a common pathogen. The 30-day post-BSI mortality rate was 26%, and BSIs contributed to 10% of early non-cancer deaths. Empiric antibiotic treatment should prioritize coverage for S. aureus in this population.
BRITISH JOURNAL OF CANCER
(2021)
Editorial Material
Otorhinolaryngology
Brandon M. Lehrich, Arash Abiri, Theodore V. Nguyen, Benjamin F. Bitner, Charles C. L. Tong, Edward C. Kuan
Summary: Head and neck mucosal melanomas have a diverse and low mutational burden. A subset of patients (approximately 13%) have ROS1 mutations, which are actionable driver mutations. ROS1-mutated patients have improved overall survival, potentially due to their higher mutational burden.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Otorhinolaryngology
Antoine Moya-Plana, David Mangin, Pierre Blanchard, Rais Obongo, Odile Casiraghi, Francois Bidault, Stephane Temam, Caroline Robert, Philippe Gorphe
Summary: The study found that the cN status is not a prognostic factor in patients with resectable head and neck mucosal melanoma. Elective lymph node dissection should not be routinely performed in cN0 patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Ludovic de Gabory, Alice Waubant, Benjamin Verillaud, Justin Michel, Olivier Malard, Cecile Rumeau, Roger Jankowski, Antoine Moya-Plana, Sebastien Vergez, Valentin Favier, Geoffrey Mortuaire, Christian Righini, Vincent Patron, Juliette Thariat, Charles Dupin, Julien Coelho, Antoine Benard
Summary: This study compared the local oncological outcomes of endoscopic and external surgical treatment for sinonasal intestinal-type adenocarcinomas and identified factors associated with recurrence. The results showed that the endoscopic approach had better surgical margins, lower recurrence rate, and fewer surgical complications. The invasion of surgical margins and the presence of signet-ring cells were identified as independent factors of recurrence.
Article
Oncology
Cora N. Sternberg, Daniel P. Petrylak, Joaquim Bellmunt, Hiroyuki Nishiyama, Andrea Necchi, Howard Gurney, Jae-Lyun Lee, Michiel S. van der Heijden, Eli Rosenbaum, Nicolas Penel, See-Tong Pang, Jian-Ri Li, Xavier Garcia del Muro, Florence Joly, Zsuzsanna Papai, Weichao Bao, Peter Ellinghaus, Chengxing Lu, Mitchell Sierecki, Sabine Coppieters, Keiko Nakajima, Tatiane Cristine Ishida, David Quinn
Summary: The purpose of this study was to assess the efficacy and safety of rogaratinib compared to chemotherapy in patients with FGFR-positive advanced/metastatic UC. The results showed comparable overall survival and response rates between rogaratinib and chemotherapy, with manageable side effects. Exploratory analysis suggested that FGFR3 gene alterations may be better predictors of rogaratinib response in FGFR-altered UC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Florian Chatelet, Francois Regis Ferrand, Sarah Atallah, Juliette Thariat, Francois Mouawad, Nicolas Fakhry, Olivier Malard, Caroline Even, Erwan de Mones, Emmanuelle Uro-Coste, Nazim Benzerdjeb, Stephane Hans, Sylvie Testelin, Olivier Mauvais, Diane Evrard, Vianney Bastit, Sebastien Salas, Florent Espitalier, Marion Classe, Laurence Digue, Melanie Dore, Stephanie Wong, Charles Dupin, France Nguyen, Jeremie Bettoni, Ariane Lapierre, Emilien Colin, Pierre Philouze, Sebastien Vergez, Bertrand Baujat, Philippe Herman, Benjamin Verillaud
Summary: This study analyzed data from the national REFCOR multi-center cohort to investigate the prognostic factors in acinic cell carcinomas (AciCCs) and assess the impact of postoperative radiotherapy and prophylactic neck dissection. The results suggest the importance of long-term follow-up in AciCC patients and indicate that surgery alone may be an option for selected patients without high-grade transformation. Prophylactic neck dissection may be beneficial for patients with advanced stage or high-grade tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Letter
Urology & Nephrology
Binghao Zhao, Ruidong Zhang, Jiamin Wu
Article
Medicine, General & Internal
Dorian Culie, Renaud Schiappa, Tanguy Pace-Loscos, Bruno Guelfucci, Sebastien Vergez, Renaud Garrel, Nicolas Fakhry, Olivier Dassonville, Gilles Poissonnet, Benjamin Lallemant, Anne Sudaka, Esma Saada-Bouzid, Karen Benezery, Stephane Temam, Phillipe Gorphe, Emmanuel Chamorey, Alexandre Bozec
Summary: Nutritional support is crucial for tolerating and completing OPSCC treatment, but the impact of HPV status on nutritional support is debated. This study aimed to evaluate the use of RFT and its prognostic factors in OPSCC patients undergoing radiotherapy. A multicentric retrospective study included all OPSCC patients treated from 2009 to 2014. Multivariate analysis showed that tongue base involvement and concurrent chemotherapy were significantly associated with the use of RFT. HPV status was not a prognostic factor for enteral nutrition during radiotherapy for OPSCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mariam H. Mella, Emilien Chabrillac, Agnes Dupret-Bories, Mathilde Mirallie, Sebastien Vergez
Summary: Minimally invasive surgery, specifically transoral robotic surgery (TORS), has become popular in the field of surgical oncology for the treatment of head and neck cancer. TORS utilizes wristed instruments and a magnified three-dimensional view for enhanced surgical comfort and safety in hard-to-access areas. However, the expansion of TORS must be based on high-level evidence to ensure comparable oncological outcomes to traditional approaches. This narrative review evaluates the current role of TORS in head and neck cancer treatment and identifies remaining knowledge gaps.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ioana Brudasca, Pierre Philouze, Sylvain Moriniere, Benjamin Lallemant, Sebastien Vergez, Olivier Malard, Pierre-Eric Roux, Noemie Rossello, Caroline Payen, Philippe Ceruse
Summary: This study compared two minimally invasive approaches, transoral laser microsurgery (TLM) and transoral robot-assisted surgery (TORS), for the treatment of squamous cell carcinoma (SCC) in the base of the tongue (BOT). The study found no significant difference in oncological outcomes between the two techniques, with TORS removing larger tumors but having shorter operative times. Both TLM and TORS were found to be effective treatment options for BOT SCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Oncology
N. Penel, L. Lebellec, J. -y. Blay
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Florence Duffaud, Jean-Yves Blay, Axel Le Cesne, Christine Chevreau, Pascaline Boudou-Rouquette, Elsa Kalbacher, Nicolas Penel, Christophe Perrin, Valerie Laurence, Emmanuelle Bompas, Esma Saada-Bouzid, Corinne Delcambre, Francois Bertucci, Mathilde Cancel, Camille Schiffler, Laure Monard, Corinne Bouvier, Vincent Vidal, Nathalie Gaspar, Sylvie Chabaud
Summary: Although the primary endpoint was not met statistically in this randomised cohort, there is evidence to suggest that regorafenib might modestly delay tumour progression in relapsed ES after failure of prior chemotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Anne Laprie, Georges Noel, Leonor Chaltiel, Gilles Truc, Marie-Pierre Sunyach, Marie Charissoux, Nicolas Magne, Pierre Auberdiac, Julian Biau, Soleakhena Ken, Fatima Tensaouti, Jonathan Khalifa, Ingrid Sidibe, Franck-Emmanuel Roux, Laure Vieillevigne, Isabelle Catalaa, Sergio Boetto, Emmanuelle Uro-Coste, Stephane Supiot, Valerie Bernier, Thomas Filleron, Muriel Mounier, Muriel Poublanc, Pascale Olivier, Jean-Pierre Delord, Elizabeth Cohen-Jonathan-Moyal
Summary: MRSI-guided dose escalation in newly diagnosed GBM patients did not improve overall survival (OS).
Article
Oncology
Nicolas Penel, Coralie Cantarel, Claire Chemin-Airiau, Francoise Ducimetiere, Francois Gouin, Francois Le Loarer, Maud Toulmonde, Sophie Piperno-Neumann, Carine Bellera, Charles Honore, Jean-Yves Blay, Simone Mathoulin-Pelissier
Summary: This study reveals that the incidence of limb and trunk soft tissue sarcomas did not decrease during the COVID-19 pandemic, and there was an increase in the number of surgeries performed in labeled centers. Quality indicators, such as the rate of R0 resection, also improved during the pandemic. This highlights the resilience of the nationwide network organization in managing rare tumors during the pandemic.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Oncology
Pauline Parent, Gautier Marcq, Sola Adeleke, Anthony Turpin, Stergios Boussios, Elie Rassy, Nicolas Penel
Summary: Immune checkpoint inhibitors (ICIs) are commonly used for treating advanced urothelial cancer, but a significant number of patients do not respond to them, and the lack of validated predictive biomarkers hinders the success of ICI strategy. Identifying biomarkers of response to ICI is crucial for guiding treatment decisions. The most evaluated biomarkers include programmed death ligand 1 expression, microsatellite instability/defective mismatch repair phenotype, and tumor mutational burden.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Marine Lottin, Alexandre Escande, Luc Bauchet, Marie Albert-Thananayagam, Mael Barthoulot, Matthieu Peyre, Mathieu Boone, Sonia Zouaoui, Jacques Guyotat, Guillaume Penchet, Johan Pallud, Henry Dufour, Evelyne Emery, Michel Lefranc, Sebastien Freppel, Houman Namaki, Edouard Gueye, Jean-Jacques Lemaire, Bertrand Muckensturm, Robin Srour, Stephane Derrey, Apolline Monfilliette, Jean-Marc Constans, Claude-Alain Maurage, Bruno Chauffert, Nicolas Penel
Summary: This retrospective study analyzed the clinical outcomes of 88 patients with intracranial solitary fibrous tumours (iSFTs). Gross tumour resection was found to be beneficial for prognosis and reduced local recurrence without impacting overall survival. High-grade tumours were associated with poorer progression-free survival and local recurrence-free survival. More than 40% of patients experienced local recurrence and were mostly treated with surgery and radiotherapy. The first relapse was a turning point in iSFT evolution, with shorter recurrence intervals over time. Managing repeated recurrence and disseminated disease remains challenging and local techniques should be considered.
Article
Oncology
Pierre Pouvreau, Julien Coelho, Cecile Rumeau, Olivier Malard, Renaud Garrel, Justin Michel, Christian Righini, Sebastien Vergez, Robin Baudouin, Vianney Bastit, Jean-Paul Marie, Aude Villepelet, Antoine Moya-Plana, Pierre Philouze, Nicolas Saroul, Laurence Digue, Amaury Daste, Sophie Renard, Sylvain Moriniere, Florent Carsuzaa, Benjamin Verillaud, Gilles Poissonnet, Philippe Schultz, Esteban Brenet, Francois Mouawad, Juliette Thariat, Noemie Vulquin, Claire Castain, Ludovic de Gabory, Charles Dupin
Summary: This study aimed to explore the treatment and prognostic factors of sinonasal undifferentiated carcinoma (SNUC). The results showed that surgery did not benefit overall survival in SNUC patients treated with irradiation, while the addition of chemotherapy tended to improve disease-free survival.