Editorial Material
Medicine, General & Internal
Christobel M. Saunders, Lesley Stafford, Martha Hickey
Summary: Breast cancer has significant physical and psychological effects, and guidelines and care models are available to alleviate these effects.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Oncology
Zhao Cheng, Asif Johar, Magnus Nilsson, Pernilla Lagergren
Summary: A nationwide prospective cohort study in Sweden involving 331 patients who underwent esophagectomy revealed that postoperative complications, particularly medical and pulmonary complications, may be associated with increased cancer-related fatigue after surgery.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Nille B. Wulff, Susanne O. Dalton, Irene Wessel, Beatriz Arenaz Bua, Helena Lofhede, Eva Hammerlid, Trille K. Kjaer, Christian Godballe, Thomas Kjaergaard, Preben Homoe
Summary: The study aimed to assess the health-related quality of life of patients after total laryngectomy and found a substantial proportion of patients experiencing clinically significant late effects, with increasing levels of these effects being associated with a decreased quality of life.
Article
Otorhinolaryngology
Nicole Starr, Douglas R. Oyler, Aric Schadler, Rony K. Aouad
Summary: Nearly one in five patients prescribed opioids during treatment developed chronic use. Providers should discuss the risk of chronic opioid use, set expectations for opioid weaning, and consider adjunct pain regimens to develop effective pain management strategies.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Josune Martin, Susana Garcia, Ane Anton-Ladislao, Josefa Ferreiro, Maximina Martin, Angel Padierna, Jose M. Quintana
Summary: This study aimed to evaluate the effects of an interdisciplinary intervention on the quality of life (QoL) of breast cancer survivors (BCS) and identify variables associated with improvements in QoL. In a non-randomised quasi-experimental design, 60 BCS were assigned to an interdisciplinary experimental group (EG) or a usual care group (CG). The results showed that patients receiving the interdisciplinary intervention had significant improvements in QoL and symptoms of anxiety and depression. The study suggests that a 6-week interdisciplinary intervention can improve the QoL and symptomatology of anxiety and depression in BCS patients.
Article
Medicine, Research & Experimental
Michelle Adessa, Jaehee Kim, William S. Tierney, Michael Benninger
Summary: This study investigated the relationship between TMD and self-perceived voice-related quality of life impairment. Patients from a TMD clinic completed the VHI questionnaire. The results showed that although most patients had minimal impairment, the majority experienced some level of voice-related QOL impairment.
Article
Oncology
Fleur van der Sijde, Laura Schafthuizen, Freek R. van 't Land, Miranda Moskie, Hanneke W. M. van Laarhoven, Monique van Dijk, Casper H. J. van Eijck
Summary: This study investigated quality of life, pain, sleep, and activity levels in locally advanced pancreatic cancer patients after FOLFIRINOX treatment, finding that most patients had good quality of life, mild pain, high quality of sleep, and moderate levels of activity. The fear of clinical deterioration after FOLFIRINOX was not supported by the study results, indicating that it should not be a reason to refrain from treatment.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Anne Katrine G. Levinsen, Susanne O. Dalton, Ingelise Andersen, Anders Mellemgaard, Marianne S. Oksen, Lena Saltbaek, Nina H. G. Hansen, Signe Carlsen, Trille K. Kjaer
Summary: This study aimed to investigate the association between health-related quality of life (HRQOL) at the time of diagnosis and the completion of planned first-line oncological treatment for lung cancer patients. The study found that patient with reduced function and patients reporting symptoms such as fatigue, pain, appetite loss, and financial difficulties were more likely to not complete the planned treatment. Assessing HRQOL may contribute to optimizing the treatment plan for lung cancer patients.
Article
Dentistry, Oral Surgery & Medicine
Veronika Shavlokhova, Steffen Gruninger, Jurgen Hoffmann, Christian Freudlsperger, Michael Engel
Summary: The study aimed to evaluate the quality of life of adolescent patients who underwent surgical correction of non-syndromal craniosynostosis in infancy. The results showed a negative correlation between the time of surgery and family-related quality of life, but none of the patients had quality-of-life limitations in their later life.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Oncology
Jana Mekis, Primoz Strojan, Dusan Mekis, Irena Hocevar Boltezar
Summary: The study aimed to track the changes in voice quality for two years after radiotherapy (RT) for early glottic cancer. The results showed that only a minority of patients had a normal voice two years post-RT, mainly due to post-RT changes in the larynx, such as fibrosis and scarring of the vocal folds.
Review
Dentistry, Oral Surgery & Medicine
Victorine E. H. W. Brouns, Anne-Lieke M. L. de Waal, Ewald M. Bronkhorst, Anne Marie Kuijpers-Jagtman, Edwin M. Ongkosuwito
Summary: The combined orthodontic-orthognathic treatment improves oral health-related quality of life. The study found that there is a decrease in oral health-related quality of life during the pre-surgical orthodontic treatment phase but improvement after orthodontic-orthognathic treatment.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Oncology
Valentin H. Meissner, Cornelia Peter, Donna P. Ankerst, Stefan Schiele, Juergen E. Gschwend, Kathleen Herkommer, Andreas Dinkel
Summary: This longitudinal study investigates the course and predictors of prostate cancer-related anxiety in long-term survivors treated by radical prostatectomy. The study found that prostate cancer-related anxiety remains stable over 5 years, and factors such as initial anxiety levels, biochemical recurrence, and psychological well-being predict future anxiety.
Article
Health Care Sciences & Services
Alin Nicola, Cristian Oancea, Paula Irina Barata, Mavrea Adelina, Tudor Mateescu, Diana Manolescu, Felix Bratosin, Roxana Manuela Fericean, Raja Akshay Pingilati, Cristian Paleru
Summary: This study investigates the correlation between the development of bronchiectasis after lung resection surgery and the health-related quality of life of patients. The study found that patients with bronchiectasis had poorer overall health status, increased respiratory symptoms, lower physical activity levels, lower quality of life scores, and experienced more severe anxiety symptoms. They also perceived higher levels of stress. Further research is needed to understand the contradictory correlations with stress and physical functioning.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
James R. Duffy, Juliana K. Litts, Daniel S. Fink
Summary: This study adds to the evidence supporting the efficacy of Superior Laryngeal Nerve (SLN) blocks for treating neurogenic cough, showing significant short-term improvement in cough severity index scores. Patients with Vocal Fold Motion/Vibratory Abnormalities (VFA) also demonstrated improvement in CSI scores.
Article
Surgery
Madison A. Hooper, Savannah M. Renshaw, Benjamin K. Poulose
Summary: This study explores the thoughts, feelings, and experiences of patients with mesh-related complications after hernia repair. Through semi-structured interviews, five domains related to the patient experience of mesh-related complications were identified, including indicators of complications, patients' knowledge of potential surgical complications, the relationship and satisfaction with surgeons and surgical teams, the psychosocial impact of hernia repair and mesh-related complications, and functional aspects. These themes provide insight into the patient experience of mesh-related complications and can inform the development of patient-reported outcome measures to determine the true incidence of complications and their impact on quality of life.
Article
Oncology
Kentaro Takada, Yoshihiro Aizawa, Daisuke Sano, Ryo Okuda, Keisuke Sekine, Yasuharu Ueno, Shoji Yamanaka, Jun Aoyama, Kaname Sato, Tatsu Kuwahara, Takashi Hatano, Hideaki Takahashi, Yasuhiro Arai, Goshi Nishimura, Hideki Taniguchi, Nobuhiko Oridate
Summary: The study developed new in vitro and in vivo models of adenoid cystic carcinoma (ACC) using organoid culture and patient-derived tumor xenograft (PDX) techniques. Human ACC-derived organoids were successfully generated, providing insights into understanding the biology of ACC and creating personalized therapy design for patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Goshi Nishimura, Daisuke Sano, Yasuhiro Arai, Takashi Hatano, Hideaki Takahashi, Yosuke Kitani, Kentaro Takada, Takashi Wada, Nobuhiko Oridate
Summary: The study found a high incidence of secondary malignancies in early-stage head and neck cancer patients, especially in hypopharyngeal cancer. It is important to pay attention to and be aware of the incidence of secondary cancer during the follow-up period after controlling the early-stage disease.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yukiko Hori, Akira Kubota, Tomoyuki Yokose, Madoka Furukawa, Takeshi Matsushita, Noriyuki Katsumata, Nobuhiko Oridate
Summary: High density of tumor CD163+ macrophages is associated with poor prognosis in regional control and disease-free survival. Patients with both high density of tumor CD163+ macrophages and intermediate- or high-grade budding score have a poor prognosis for regional control.
Review
Microbiology
Takashi Hatano, Daisuke Sano, Hideaki Takahashi, Nobuhiko Oridate
Summary: The incidence of oropharyngeal cancer is increasing due to its association with HPV, which can evade the immune system and integrate into the host genome, contributing to oncogenesis.
Article
Otorhinolaryngology
Maki Inoue, Kouji Yamamoto, Mariko Hirama, Noboru Ogahara, Masahiro Takahashi, Nobuhiko Oridate
Summary: The study found that the size of the mastoid air cell system at age 3 is an important prognostic factor in children with early-onset otitis media with effusion (OME), and combining this with the duration of ventilation tube placement can better predict the prognosis.
ACTA OTO-LARYNGOLOGICA
(2021)
Article
Oncology
Hiroshi Hyakusoku, Kae Sawakuma, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Kaname Sato, Yasuhiro Isono, Shoko Shimada, Kentaro Takada, Tatsu Kuwahara, Yoshihiro Aizawa, Nobuhiko Oridate
Summary: The study demonstrated that FosL1 plays a crucial role in promoting cell migration, invasion, and proliferation in head and neck squamous cell carcinoma (HNSCC). Knockdown of FosL1 inhibited these processes and patients with higher expression of FosL1 had significantly shorter survival time.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Goshi Nishimura, Daisuke Sano, Yasuhiro Arai, Hideaki Takahashi, Takashi Hatano, Yosuke Kitani, Kentaro Takada, Takashi Wada, Yohei Hiiragi, Nobuhiko Oridate
Summary: Among patients with early-stage laryngeal, oropharyngeal, and hypopharyngeal squamous cell carcinoma, primary control by transoral surgery alone may not be achieved in patients with both risk factors, namely tumor thickness > 7 mm on enhanced CT and poor differentiation on pathological examination.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Nobuyuki Horita, Etsuko Miyagi, Taichi Mizushima, Maki Hagihara, Chiaki Hata, Yuki Hattori, Narihiko Hayashi, Kuniyasu Irie, Hideyuki Ishikawa, Yusuke Kawabata, Yosuke Kitani, Noritoshi Kobayashi, Nobuaki Kobayashi, Yusuke Kurita, Yohei Miyake, Kentaro Miyake, Senri Oguri, Ichiro Ota, Ayako Shimizu, Masanobu Takeuchi, Akimitsu Yamada, Kojiro Yamamoto, Norio Yukawa, Munetaka Masuda, Nobuhiko Oridate, Yasushi Ichikawa, Takeshi Kaneko
Summary: This study examined the incidence and risk factors of severe anaphylaxis induced by intravenous chemotherapy in cancer patients. A total of 27 cases of severe anaphylaxis were observed among 5584 patients, with drugs like carboplatin and paclitaxel being the main culprits. The study highlighted the high-risk settings associated with these severe allergic reactions.
Article
Oncology
Goshi Nishimura, Daisuke Sano, Yasuhiro Arai, Hideaki Takahashi, Takashi Hatano, Yosuke Kitani, Kentaro Takada, Takashi Wada, Yohei Hiiragi, Nobuhiko Oridate
Summary: Hypopharyngeal cancer patients treated with transoral surgery had a higher risk of newly diagnosed secondary cancers compared to patients with other cancers, with the risk being 3.60 times higher. The 3-year survival rates were high, but hypopharyngeal cancer patients were more likely to develop new secondary cancers during follow-up.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Daisuke Sano, Akira Shimizu, Ichiro Tateya, Kazunori Fujiwara, Yo Kishimoto, Takashi Maruo, Yasushi Fujimoto, Terushige Mori, Hisayuki Kato, Kiyoaki Tsukahara, Nobuhiko Oridate
Summary: The laryngopharynx is a crucial area for swallowing, speech, and phonation, and a minimally invasive approach for the treatment of laryngopharyngeal cancer is necessary. Transoral surgery, including TOVS and ELPS, have been developed in Japan as minimally invasive methods for early stage pharyngeal and laryngeal cancers. TORS using the da Vinci Surgical System has been widely reported to provide surgeons with increased visualization and magnification, resulting in precise surgical margins and rapid functional recovery, showing positive treatment outcomes in Japan.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Takuro Okada, Chihiro Fushimi, Takashi Matsuki, Isaku Okamoto, Hiroki Sato, Takahito Kondo, Kunihiko Tokashiki, Takuma Kishida, Tatsuya Ito, Gai Yamashita, Yusuke Aihara, Kenji Hanyu, Yukiomi Kushihashi, Tatsuo Masubuchi, Yuichiro Tada, Kouki Miura, Yuki Harada, Kaho Momiyama, Taku Yamashita, G. O. Omura, Hideaki Takahashi, Nobuhiko Oridate, Kiyoaki Tsukahara
Summary: This study investigated the efficacy and safety of nivolumab at doses of 3 mg/kg and 240 mg/body for recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The results showed that both doses had similar overall response rates, disease control rates, overall survival, progression-free survival, and incidence of immune-related adverse events in patients with R/M SCCHN.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Naomi Kiyota, Makoto Tahara, Junki Mizusawa, Takeshi Kodaira, Hirofumi Fujii, Tomoko Yamazaki, Hiroki Mitani, Shigemichi Iwae, Yasushi Fujimoto, Yusuke Onozawa, Nobuhiro Hanai, Takenori Ogawa, Hiroki Hara, Nobuya Monden, Eiji Shimura, Shujiro Minami, Takashi Fujii, Kaoru Tanaka, Akihiro Homma, Seiichi Yoshimoto, Nobuhiko Oridate, Koichi Omori, Tsutomu Ueda, Kenji Okami, Ichiro Ota, Kiyoto Shiga, Masashi Sugasawa, Takahiro Asakage, Yuki Saito, Shigeyuki Murono, Yasumasa Nishimura, Kenichi Nakamura, Ryuichi Hayashi
Summary: The study demonstrates that chemoradiotherapy with weekly cisplatin is noninferior to 3-weekly cisplatin in terms of overall survival for patients with postoperative high-risk locally advanced squamous cell carcinoma of the head and neck. Weekly cisplatin also leads to fewer adverse reactions compared to the 3-weekly regimen.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Otorhinolaryngology
Tetsuji Sanuki, Nobuhiko Oridate, Ichiro Tateya, Takaharu Nito, Kenji Mizoguchi, Kenichiro Tanabe
Summary: The study aims to investigate evaluation parameters useful for voice monitoring during type 2 thyroplasty (TP2) procedure for adductor spasmodic dysphonia (AdSD) and determine the most appropriate method for selecting titanium bridge size. The results show that the parameters of voice evaluation and acoustic analysis have good consistency at different evaluation stages, indicating their effectiveness. In addition, the study finds that selected width of titanium bridge leads to better ratings compared to unselected width.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Yamato Oki, Hiromitsu Hatakeyama, Masanori Komatsu, Yasuhiro Isono, Hidetaka Ikemiyagi, Jun Tsukiji, Ryoko Higa, Nobuhiko Oridate
Summary: This article presents a case of nasopharyngitis caused by Mycobacterium abscessus subspecies massiliense. The patient underwent surgery and multiple rounds of chemotherapy, resulting in no recurrence for 56 weeks.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Meeting Abstract
Oncology
Hideaki Takahashi, Daisuke Sano, Takashi Hatano, Kaname Sato, Tatsu Kuwahara, Yoshihiro Aizawa, Jun Aoyama, Nobuhiko Oridate
