Article
Biochemistry & Molecular Biology
Verena Boschert, Jonas Teusch, Urs D. A. Mueller-Richter, Roman C. Brands, Stefan Hartmann
Summary: PKM2 is commonly phosphorylated at Tyr105 in HNSCC, and its levels depend on tyrosine kinase activity. It is also correlated with the expression of CD44 and has an impact on the metabolism of HNSCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yaoting Zhang, Sultan Kadasah, Jiaheng Xie, Dongsheng Gu
Summary: Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a poor prognosis. Recent advancements in immune checkpoint inhibitors have improved the treatment of advanced tumours. However, the emergence of drug resistance has posed challenges in clinical treatment, necessitating further research in immune checkpoint pathways. Our study focused on the NT5E gene, which is associated with the hypoxia-adenosine pathway, and found that overexpression of NT5E in HNSCC is linked to a poor prognosis. The coexpression pattern of HNSCC provides insights for drug resistance and immunotherapy studies.
APPLIED BIONICS AND BIOMECHANICS
(2022)
Article
Otorhinolaryngology
Erin R. Cohen, Carly Misztal, Cortney Dable, Carmen Gomez-Fernandez, Rita G. Bhatia, Patrick Roth, Ruixuan Ma, Samuel Trosman, Carlos Green, Elizabeth Nicolli, Christine T. Dinh, Zoukaa B. Sargi
Summary: Perineural invasion (PNI) in head and neck cutaneous squamous cell carcinoma (HNcSCC) has a negative impact on disease-specific survival. Facial weakness and positive margins are high-risk factors for histopathologic PNI, while multiple nerve involvement and advanced tumor stage are associated with worse survival.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Oncology
Nicole N. Scheff, Alexandria L. Harris, Jinhong Li, Nicole L. Horan, Mark W. Kubik, Seungwon W. Kim, Marci L. Nilsen
Summary: This study examined the prevalence and predictors of perineural invasion (PNI) in head and neck cancer (HNC) patients, stratified by tumor site. The results showed that PNI was associated with pretreatment pain and tumor stage, highlighting the importance of considering tumor location in investigating targeted therapies for tumor regression.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Kun Wu, Yuan-Yuan Mao, Nan-Nan Han, Hanjiang Wu, Sheng Zhang
Summary: The study revealed that PLAU1 facilitated HNSCC cell proliferation, invasion, and metastasis through interaction with MMP1. In vitro experiments showed that inhibition of PLAU1 weakened the invasive and migratory abilities of HNSCC cells, while overexpression of PLAU1 significantly enhanced these capabilities.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo
Summary: Recently, it has been reported that the partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). The study focused on the role of a novel cancer-specific POSTN isoform, Iso5, in HNSCC and found that Iso5 promoted invasion together with another isoform, Iso3. The researchers suggest that Iso5 can be a useful marker for detecting cancer cells undergoing p-EMT and a potential target for diagnosis and therapy in HNSCC.
Article
Cell Biology
Xing Xu, Jun Chen, Yan Li, Xiaojie Yang, Qing Wang, Yanjun Wen, Ming Yan, Jianjun Zhang, Qin Xu, Yan Wei, Wantao Chen, Xu Wang
Summary: Through genomics, metabolomics, and RNA omics studies, it was discovered that inhibition of squalene epoxidase synergistically increased the sensitivity of HNSCC cells to EZH2 inhibitors, providing a basis for the development of new therapeutic strategies for HNSCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Toshimitsu Ohashi, Kosuke Terazawa, Hirofumi Shibata, Norimitsu Inoue, Takenori Ogawa
Summary: This study compared and assessed the metabolic profiles of head and neck squamous cell carcinoma (HNSCC) and normal tissues, finding that HNSCC exhibits enhanced metabolic activity, providing more energy and structural components, which promote rapid tumor growth and progression.
Review
Oncology
Flora Yan, Brittny N. Tillman, Rajiv I. Nijhawan, Divya Srivastava, David J. Sher, Vladimir Avkshtol, Jade Homsi, Justin A. Bishop, Erin M. Wynings, Rebecca Lee, Larry L. Myers, Andrew T. Day
Summary: The current state of high-risk head and neck cutaneous squamous cell carcinoma (HNcSCC) is poorly characterized due to the rapidly evolving nature of the field. Clinical and pathologic risk factors for adverse outcomes are nuanced, leading to challenges in treatment and staging systems. Population-based registries tracking updated, nuanced risk factors and outcomes are needed to guide the development of improved staging systems, along with more randomized controlled trials to evaluate treatment methods.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Rika Noji, Yoshihito Kano, Hideaki Hirai, Iichiroh Onishi, Naoto Nishii, Ryoichi Yoshimura, Satoshi Miyake, Sadakatsu Ikeda, Hiroyuki Harada
Summary: Identifying predictive biomarkers of response and resistance to ICIs is necessary across various malignant tumors, as demonstrated by varying responses to nivolumab in different metastatic lesions within the same patient. Molecular analysis may aid in predicting the efficacy of ICI treatment and selecting appropriate therapeutic agents.
Article
Oncology
Zhenyuan Han, Biao Yang, Yu Wang, Xiuxia Zeng, Zhen Tian
Summary: This study investigated the role of m(5)C RNA modification in head and neck squamous cell carcinoma (HNSCC) and found that dynamic m(5)C modification contributes to HNSCC progression, while the expression patterns of NSUN5, DNMT1, and DNMT3A help to predict the prognosis of HNSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Alexander Gelbard, Catherine Anderson, Lynne D. Berry, Milan R. Amin, Michael S. Benninger, Joel H. Blumin, Jonathan M. Bock, Paul C. Bryson, Paul F. Castellanos, Sheau-Chiann Chen, Matthew S. Clary, Seth M. Cohen, Brianna K. Crawley, Seth H. Dailey, James J. Daniero, Alessandro de Alarcon, Donald T. Donovan, Eric S. Edell, Dale C. Ekbom, Sara Fernandes-Taylor, Daniel S. Fink, Ramon A. Franco, C. Gaelyn Garrett, Elizabeth A. Guardiani, Alexander T. Hillel, Henry T. Hoffman, Norman D. Hogikyan, Rebecca J. Howell, Li-Ching Huang, Lena K. Hussain, Michael M. Johns, Jan L. Kasperbauer, Sid M. Khosla, Cheryl Kinnard, Robbi A. Kupfer, Alexander J. Langerman, Robert J. Lentz, Robert R. Lorenz, David G. Lott, Anne S. Lowery, Samir S. Makani, Fabien Maldonado, Kyle Mannion, Laura Matrka, Andrew J. McWhorter, Albert L. Merati, Matthew C. Mori, James L. Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N. Postma, Lindsay S. Reder, Sarah L. Rohde, Brent E. Richardson, Otis B. Rickman, Clark A. Rosen, Michael J. Rutter, Guri S. Sandhu, Joshua S. Schindler, G. Todd Schneider, Rupali N. Shah, Andrew G. Sikora, Robert J. Sinard, Marshall E. Smith, Libby J. Smith, Ahmed M. S. Soliman, Sigridur Sveinsdottir, Douglas J. Van Daele, David Veivers, Sunil P. Verma, Paul M. Weinberger, Philip A. Weissbrod, Christopher T. Wootten, Yu Shyr, David O. Francis
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2020)
Review
Otorhinolaryngology
Jerome R. Lechien, Jonathan M. Bock, Thomas L. Carroll, Lee M. Akst
CLINICAL OTOLARYNGOLOGY
(2020)
Article
Medicine, Research & Experimental
Tina L. Samuels, Michael T. Zimmermann, Atefeh Zeighami, Wendy Demos, Jessica E. Southwood, Joel H. Blumin, Jonathan M. Bock, Nikki Johnston
Summary: In this in vitro study, brief exposure to pepsin was found to activate cancer-associated signaling pathways in laryngeal cells, revealing new mechanisms by which chronic reflux may contribute to carcinogenesis. The developed cell line provides a novel tool to investigate pepsin-dysregulated pathways identified by RNA sequencing and disparities in tumor susceptibility of laryngeal subsites.
Article
Medicine, Research & Experimental
Caroline A. McCormick, Tina L. Samuels, Michele A. Battle, Talia Frolkis, Joel H. Blumin, Jonathan M. Bock, Clive Wells, Ke Yan, Kenneth W. Altman, Nikki Johnston
Summary: The study found expression of gastric proton pump subunits in the larynx of patients with laryngopharyngeal reflux (LPR) and laryngeal squamous cell carcinoma (LSCC). Cells expressing the full proton pump exhibited mitochondrial damage and changes in gene expression associated with inflammation and cancer, indicating that functional proton pump expression in upper airway mucosa may lead to local cellular and molecular changes with pathological implications.
Article
Audiology & Speech-Language Pathology
Matthew R. Naunheim, Jonathan Bock, Philip A. Doucette, Matthew Hoch, Ian Howell, Michael M. Johns, Aaron M. Johnson, Priya Krishna, David Meyer, Claudio F. Milstein, John Nix, Michael J. Pitman, Trineice Robinson-Martin, Adam D. Rubin, Robert T. Sataloff, Herbert Steven Sims, Ingo R. Titze, Thomas L. Carroll
Review
Otorhinolaryngology
Jerome R. Lechien, Lee M. Akst, Sven Saussez, Lise Crevier-Buchman, Stephane Hans, Maria Rosaria Barillari, Christian Calvo-Henriquez, Jonathan M. Bock, Thomas L. Carroll
Summary: This study investigated the role of laryngopharyngeal reflux (LPR) in nonfunctional laryngeal diseases and found that the association between LPR and laryngotracheal stenosis, leukoplakia, vocal fold granuloma, and laryngeal papillomatosis is currently not well demonstrated. There is significant heterogeneity among studies regarding inclusion criteria, diagnostic methods, and clinical outcome evaluation. Further clinical and experimental studies are needed to confirm the potential relationship between LPR and these select nonfunctional laryngeal diseases.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, Research & Experimental
Douglas R. Sidell, Karthik Balakrishnan, Simon R. Best, Karen Zur, Julia Buckingham, Alessandro De Alarcon, Fuad M. Baroody, Jonathan M. Bock, Emily F. Boss, Charles M. Bower, Paolo Campisi, Sharon F. Chen, Jeffrey M. Clarke, Kevin D. Clarke, Alejandro Cocciaglia, Robin T. Cotton, Giselle Cuestas, Kara L. Davis, Victor H. DeFago, Frederik G. Dikkers, Ines Dossans, Walter Florez, Elizabeth Fox, Aaron D. Friedman, Nazaneen Grant, Osama Hamdi, Norman D. Hogikyan, Kaalan Johnson, Liane B. Johnson, Romaine F. Johnson, Peggy Kelly, Adam M. Klein, Claire M. Lawlor, Nicolas Leboulanger, Alejandro G. Levy, Derek Lam, Greg R. Licameli, Steve Long, David G. Lott, Dayse Manrique, James Scott McMurray, Kara D. Meister, Anna H. Messner, Michael Mohr, Pamela Mudd, Anthony J. Mortelliti, Daniel Novakovic, Julian Ongkasuwan, Shazia Peer, Krysztof Piersiala, Jeremy D. Prager, Seth M. Pransky, Diego Preciado, Tiffany Raynor, Rico N. P. M. Rinkel, Hugo Rodriguez, Veronica P. Rodriguez, John Russell, Maria Laura Scatolini, Patrick Scheffler, David F. Smith, Lee P. Smith, Marshall E. Smith, Richard J. H. Smith, Abraham Sorom, Amalia Steinberg, John A. Stith, Dana Thompson, Jerome W. Thompson, Patricio Varela, David R. White, Andre M. Wineland, Christina J. Yang, Carlton J. Zdanski, Craig S. Derkay
Summary: This study aimed to develop consensus on key points supporting the use of systemic bevacizumab for recurrent respiratory papillomatosis (RRP) treatment. Through a Delphi method-based survey series, consensus was reached on various characteristics across different domains. The study provides guidance for clinicians and centers offering systemic bevacizumab for RRP and may serve as a framework for assessing current practices and centers using this therapy.
Article
Medicine, Research & Experimental
Jerome R. Lechien, Jacqueline E. Allen, Maria R. Barillari, Petros D. Karkos, Huan Jia, Fabio P. Ceccon, Rui Imamura, Osama Metwaly, Carlos M. Chiesa-Estomba, Jonathan M. Bock, Thomas L. Carroll, Sven Saussez, Lee M. Akst
Summary: Global practices of otolaryngologists in managing laryngopharyngeal reflux (LPR) vary significantly, from definitions and prevalence to diagnosis and treatment. International guidelines are needed to improve knowledge and management of LPR worldwide.
Article
Otorhinolaryngology
Jaclyn Lee, Li-Ching Huang, Lynn D. Berry, Catherine Anderson, Milan R. Amin, Michael S. Benninger, Joel H. Blumin, Jonathan M. Bock, Paul C. Bryson, Paul F. Castellanos, Sheau-Chiann Chen, Matthew S. Clary, Seth M. Cohen, Brianna K. Crawley, Seth H. Dailey, James J. Daniero, Alessandro De. Alarcon, Donald T. Donovan, Eric S. Edell, Dale C. Ekbom, Daniel S. Fink, Ramon A. Franco, C. Gaelyn Garrett, Elizabeth A. Guardiani, Alexander T. Hillel, Henry T. Hoffman, Norman D. Hogikyan, Rebecca J. Howell, Lena K. Hussain, Michael M. Johns, Jan L. Kasperbauer, Sid M. Khosla, Cheryl Kinnard, Robbi A. Kupfer, Alexander J. Langerman, Robert J. Lentz, Robert R. Lorenz, David G. Lott, Anne S. Lowery, Samir S. Makani, Fabien Maldonado, Kyle Mannion, Laura Matrka, Andrew J. McWhorter, Albert L. Merati, Matthew Mori, James L. Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N. Postma, Lindsay S. Reder, Sarah L. Rohde, Brent E. Richardson, Otis B. Rickman, Clark A. Rosen, Michael J. Rutter, Guri S. Sandhu, Joshua S. Schindler, G. Todd Schneider, Rupali N. Shah, Andrew G. Sikora, Robert J. Sinard, Marshall E. Smith, Libby J. Smith, Ahmed M. S. Soliman, Sigriour Sveinsdottir, Douglas J. Van Daele, David Veivers, Sunil P. Verma, Paul M. Weinberger, Philip A. Weissbrod, Christopher T. Wootten, Yu Shyr, David O. Francis, Alexander Gelbard
Summary: Patient education, income, and social support were not associated with time to diagnosis or time to disease recurrence in iSGS patients. This suggests that other factors may play a role in influencing surgical outcomes.
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Jerome R. Lechien, Thomas L. Carroll, Jacqueline E. Allen, Tareck Ayad, Necati Enver, Young-Gyu Eun, Paulo S. Perazzo, Fabio Pupo Ceccon, Geraldo D. Sant'Anna, Rui Imamura, Sampath Kumar Raghunandhan, Carlos M. Chiesa-Estomba, Christian Calvo-Henriquez, Sven Saussez, Petros D. Karkos, Marc Remacle, Lee M. Akst, Jonathan M. Bock
Summary: The study found significant variations in LPR knowledge and management across different subspecialties of otolaryngology. Otolaryngologists predominantly rely on symptoms and positive response to empirical treatment to diagnose LPR, but there are differences in diagnostic approaches and treatment methods across specialties.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, Research & Experimental
Marisa A. Ryan, Martin B. Brodsky, Joel H. Blumin, Jonathan M. Bock, Thomas L. Carroll, C. Gaelyn Garrett, Jerome R. Lechien, Julina Ongkasuwan, C. Blake Simpson, Lee M. Akst
Summary: This study utilized a modified Delphi process to identify the most influential publications in laryngology since 2000. A total of 21 papers were recognized as most influential, with several focusing on voice-related topics.
Article
Otorhinolaryngology
Shane W. White, Jonathan M. Bock, Joel H. Blumin, David R. Friedland, Jazzmyne A. Adams, Ling Tong, Kristen Osinski, Jake Luo
Summary: This study evaluated the association between patient socioeconomic and demographic factors and tertiary care utilization for dysphonia in a localized metropolitan area of the American Midwest. Results showed that insurance status, education level, and race were positively correlated with utilization of tertiary laryngology services for the evaluation of dysphonia, while median income did not show a significant correlation.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Christopher M. Kurylo, Daniel Eastwood, Joel H. Blumin, Nikki Johnston, Jonathan M. Bock
Summary: The study found a significant correlation between distal esophageal MNBI and phenotypic and biological markers of LPR, indicating that MNBI has the potential to be used as a diagnostic tool and treatment response predictor for LPR.
Article
Otorhinolaryngology
Mit A. Patel, Jonathan M. Bock, Joel H. Blumin, David R. Friedland, Jazzmyne A. Adams, Ling Tong, Kristen Osinski, Jake Luo
Summary: This study investigates the influence of patient demographics and social determinants of health on the treatment pathways for unilateral vocal fold paralysis (UVFP) at a tertiary laryngology clinic. The findings suggest that gender, ethnicity, and insurance status significantly impact the specific treatment pathways for UVFP. Patients with public insurance are more likely to undergo surgical intervention rather than voice therapy.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Maie M. Zagloul, Jonathan M. Bock, Joel H. Blumin, David R. Friedland, Jazzmyne A. Adams, Ling Tong, Kristen I. Osinksi, Masoud Khani, Jake Luo
Summary: This study evaluates the impact of social determinants of health on care pathways for patients with dysphagia. The findings indicate that race and insurance status are associated with altered care and resource utilization, highlighting the importance of further research to understand their influence on patient outcomes.