Review
Biochemistry & Molecular Biology
Rui Lima, Andreia Monteiro, Antonio J. Salgado, Susana Monteiro, Nuno A. Silva
Summary: Spinal cord injury (SCI) is a debilitating condition that lacks effective treatment options. Recent research has uncovered the complex mechanisms involved in SCI, leading to the development of new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hasan Al-Nashash, Angelo H. All
Summary: This article discusses the therapeutic effects and possible mechanisms of hypothermia in patients with traumatic spinal cord injury (SCI). Early hypothermia has neuroprotective effects mainly during the first- and second-month post-SCI, but its beneficial effects gradually diminish over time. The article also mentions the potential complications and side effects of hypothermia.
Article
Cell Biology
Yilin Pang, Xinjie Liu, Xu Wang, Xuelian Shi, Lei Ma, Yan Zhang, Tiangang Zhou, Chenxi Zhao, Xu Zhang, Baoyou Fan, Jian Hao, Wenxiang Li, Xiaoqing Zhao, Rong Zhang, Songlin Zhou, Xiaohong Kong, Shiqing Feng, Xue Yao
Summary: Edaravone, an FDA-approved drug, has a neuroprotective effect on spinal cord injury and other central nervous system diseases. It exerts this effect by inhibiting ferroptosis and reducing neuroinflammation. The mechanism may be applicable to other neurological diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Salman Hemani, Olabisi Lane, Sunil Agarwal, Shan Ping Yu, Anna Woodbury
Summary: Erythropoietin (EPO) as a neuroprotective treatment option shows potential, but may lead to thrombosis and adverse events when administered in normonemic adults. A systematic review of 388 citations found that 13 studies noted adverse effects from EPO in the treatment of normonemic adults.
NEUROCHEMICAL RESEARCH
(2021)
Article
Behavioral Sciences
Artur Shvetcov, Marc J. Ruitenberg, Fabien Delerue, Wendy A. Gold, David A. Brown, Caitlin A. Finney
Summary: Spinal cord injury (SCI) refers to the damage of the spinal cord caused by either trauma or disease. SCI is characterized by various injury phases that affect the transmission of sensory and motor signals, resulting in temporary or long-term functional deficits. Estrogens and estrogenic compounds have been shown to effectively alleviate the effects of SCI, making them potential treatment options.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Manoj K. Gottipati, Samuel A. T. Ellman, Devan L. Puhl, Zhen Guan, Phillip G. Popovich, Edmund F. Palermo, Ryan J. Gilbert
Summary: The study found that utilizing poly(pro-E2) films can improve neuroprotection in spinal cord injury models, although increasing the released E2 dose did not have a significant impact. Future work will focus on developing poly(pro-E2) biomaterials that can more precisely release therapeutic doses of E2.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Masao Koda, Hideki Hanaoka, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoshihito Ozawa, Tadami Fujiwara, Takeo Furuya, Yasushi Ijima, Junya Saito, Mitsuhiro Kitamura, Takuya Miyamoto, Seiji Ohtori, Yukei Matsumoto, Tetsuya Abe, Hiroshi Takahashi, Kei Watanabe, Toru Hirano, Masayuki Ohashi, Hirokazu Shoji, Tatsuki Mizouchi, Norio Kawahara, Masahito Kawaguchi, Yugo Orita, Takeshi Sasamoto, Masahito Yoshioka, Masafumi Fujii, Katsutaka Yonezawa, Daisuke Soma, Hiroshi Taneichi, Daisaku Takeuchi, Satoshi Inami, Hiroshi Moridaira, Haruki Ueda, Futoshi Asano, Yosuke Shibao, Ikuo Aita, Yosuke Takeuchi, Masaya Mimura, Jun Shimbo, Yukio Someya, Sumio Ikenoue, Hiroaki Sameda, Kan Takase, Yoshikazu Ikeda, Fumitake Nakajima, Mitsuhiro Hashimoto, Fumio Hasue, Takayuki Fujiyoshi, Koshiro Kamiya, Masahiko Watanabe, Hiroyuki Katoh, Yukihiro Matsuyama, Tomohiko Hasegawa, Go Yoshida, Hideyuki Arima, Yu Yamato, Shin Oe, Daisuke Togawa, Sho Kobayashi, Koji Akeda, Eiji Kawamoto, Hiroshi Imai, Toshihiko Sakakibara, Akihiro Sudo, Yasuo Ito, Takeshi Kikuchi, Tomoyuki Takigawa, Takuya Morita, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Shinji Kotaka, Hideo Baba, Tsuyoshi Okudaira, Hiroaki Konishi, Takayuki Yamaguchi, Keigo Ito, Yoshito Katayama, Taro Matsumoto, Tomohiro Matsumoto, Haruo Kanno, Toshimi Aizawa, Ko Hashimoto, Toshimitsu Eto, Takehiro Sugaya, Michiharu Matsuda, Kazunari Fushimi, Satoshi Nozawa, Chizuo Iwai, Toshihiko Taguchi, Tsukasa Kanchiku, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Takashi Sakai, Yasuaki Imajo, Masashi Yamazaki
Summary: The clinical trial of G-CSF treatment for acute spinal cord injury patients did not show significant primary efficacy, but subanalysis suggested potential benefits for specific populations.
Article
Biochemistry & Molecular Biology
Azizul Haque, Arabinda Das, Supriti Samantaray, Denise Matzelle, Mollie Capone, Gerald Wallace, Aarti N. Husarik, Saied Taheri, Russel J. Reiter, Abhay Varma, Swapan K. Ray, Naren L. Banik
Summary: This study demonstrated that PRM treatment for 7 days can reduce post-SCI lesion volume, attenuate neuronal cell death, inflammation, and axonal damage, and modify the balance of apoptotic proteins. PRM also enhances angiogenesis and microvascular growth, with neuroprotection potentially mediated through estrogen receptors. The inhibition of glial activation, decreased inflammation and cell death, and increased angiogenesis by PRM lead to improved functional outcome in the rat model as evaluated by the BBB locomotor scale.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jonas Blixt, Yutong Song, Michael Wanecek, Eli Gunnarson
Summary: Erythropoietin (EPO) has neuroprotective effects in models of central nervous system injury such as traumatic brain injury (TBI) and ischemic stroke. Previous studies have shown that EPO can preserve astrocyte function and decrease brain edema in TBI. In this study, the effects of EPO on astrocytes in an in vitro model of ischemia were explored, and it was found that EPO increased glutamate uptake, restored intracellular acidification, and increased lactate release, suggesting its potential contribution to neuroprotection in ischemic stroke and brain ischemia secondary to TBI.
Article
Materials Science, Multidisciplinary
Yixuan Liu, Feng Lin, Tianhui Zhang, Cheng Wu, Wanguo Liu, Hao Wang, Chunsheng Xiao, Xuesi Chen
Summary: Neuroprotective therapy for traumatic spinal cord injury (SCI) still faces challenges, and the toxic reactive aldehydes produced immediately after SCI promote oxidative stress and inflammation, worsening the secondary injury. To address this, a drug-free polypeptide (PPAH) was designed and synthesized to scavenge toxic aldehydes and mitigate secondary SCI. In vitro and in vivo experiments demonstrated PPAH's ability to scavenge reactive aldehydes, protect against damage in neurocytes, and improve functional recovery in a rat SCI model. PPAH shows promise as an effective therapy for SCI.
SCIENCE CHINA-MATERIALS
(2023)
Article
Engineering, Biomedical
Jile Xie, Jiaying Li, Jinjin Ma, Meimei Li, Xingran Wang, Xinya Fu, Yanxia Ma, Huilin Yang, Bin Li, Saijilafu
Summary: Due to the limited regenerative ability of the central nervous system, effective treatments for spinal cord injury have been lacking. The study found that a MgO/PLCL scaffold loaded with PUR and RA can reduce glial scar formation and promote neuronal differentiation of endogenous NSCs, leading to partial recovery of locomotor function in SCI mice.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jian Zhao, Ailang Pang, Saige Yin, Meifeng Yang, Xuemei Zhang, Rong Zhang, Jingfei Liu, Yuanqi Gu, Shanshan Li, Yan Hu, Yue Zhang, Yingchun Ba, Buliang Meng, Xinwang Yang
Summary: OM-LV20 promotes structural and functional recovery of spinal cord injury by increasing neuronal survival, enhancing BDNF and TrkB expression, and regulating oxidative stress balance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Jinyu An, Xue Jiang, Zhe Wang, Yingqiao Li, Zhiru Zou, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu
Summary: This study demonstrates the potential of nano-targeted drug delivery systems in improving the microenvironment after spinal injury. The prepared MH-DS@M-Lips nanoliposomes effectively bind calcium ions to reduce calcium-associated neuronal apoptosis and gradually release minocycline hydrochloride for better anti-inflammatory effects. The targeting capability of MH-DS@M-Lips was confirmed through various imaging techniques. In vitro and in vivo experiments showed that MH-DS@M-Lips treatment resulted in high behavioral scores in SCI mice, indicating its potential for SCI treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings
Summary: This study demonstrated that intraperitoneal injection of midostaurin in injured rats led to alterations in local inflammasome and gene expression, resulting in enhanced recovery and improved coordination between forelimbs and hindlimbs after injury. Histological analysis also indicated improved tissue preservation and functionality in treated animals during the chronic phase of injury. Overall, systemic administration of midostaurin proved to be an effective strategy for mitigating cervical secondary SCI damage.
Article
Plant Sciences
Tomoharu Kuboyama, Seiya Kominato, Misaki Nagumo, Chihiro Tohda
Summary: The study focused on evaluating herbal medicine constituents that induce M2 predominance for the treatment of SCI. Polygalae Radix (PR) was found to induce M2 predominance in microglia, improve motor function in SCI model mice, and showed potential for protecting against axonal degeneration in the injured spinal cord.
Article
Orthopedics
Alexandros Mavrodontidis, Marios Lykissas, Panayiotis Koulouvaris, Dimitrios Pafilas, Vasilios Kontogeorgakos, Charalampos Zalavras
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
(2015)
Article
Critical Care Medicine
Konstantinos G. Makridis, Theofilos Karachalios, Vasilios A. Kontogeorgakos, Leonidas S. Badras, Konstantinos N. Malizos
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2015)
Article
Orthopedics
Andreas F. Mavrogenis, Georgios N. Panagopoulos, Panayiotis D. Megaloikonomos, Vasilios G. Igoumenou, Ioannis Galanopoulos, Christos T. Vottis, Panayiotis Karabinas, Panayiotis Koulouvaris, Vasilios A. Kontogeorgakos, John Vlamis, Panayiotis J. Papaapagelopoulos
Article
Orthopedics
Athanasios Drakos, Vasilios Raoulis, Konstantinos Karatzios, Nikolaos Doxariotis, Vasilios Kontogeorgakos, Konstantinos Malizos, Sokratis E. Varitimidis
JOURNAL OF ORTHOPAEDIC TRAUMA
(2016)
Article
Orthopedics
Vasileios A. Kontogeorgakos, Andreas F. Mavrogenis, Georgios N. Panagopoulos, Apostolos Lagaras, Antonios Koutalos, Konstantinos N. Malizos
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2016)
Editorial Material
Oncology
Panayiotis D. Megaloikonomos, Andreas F. Mavrogenis, Georgios N. Panagopoulos, Vasileios A. Kontogeorgakos
Article
Orthopedics
Panayiotis J. Papagelopoulos, Olga D. Savvidou, Panagiotis Koutsouradis, George D. Chloros, Ioanna K. Bolia, Vasileios I. Sakellariou, Vasileios A. Kontogeorgakos, Ioannis I. Mavrodontis, Andreas F. Mavrogenis, Panos Diamantopoulos
Article
Orthopedics
Vasileios Kontogeorgakos, Antonios Koutalos, Michael Hantes, Gregory Manoudis, Leonidas Badras, Konstantinos Malizos
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2015)
Article
Medicine, Research & Experimental
Nicholaos I. Papachristou, Harry C. Blair, Eleni S. Kalyvioti, Spyros A. Syggelos, Eleni A. Karavia, Vassilios Kontogeorgakos, Dragana Nikitovic, George N. Tzanakakis, Kyriakos E. Kypreos, Dionysios J. Papachristou
LABORATORY INVESTIGATION
(2018)
Review
Orthopedics
Vasileios A. Kontogeorgakos, William C. Eward, Brian E. Brigman
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2019)
Review
Anesthesiology
Theodosios Saranteas, Iosifina Koliantzaki, Olga Savvidou, Marina Tsoumpa, Georgia Eustathiou, Vasileios Kontogeorgakos, Rizos Souvatzoglou
MINERVA ANESTESIOLOGICA
(2019)
Review
Oncology
Ioanna Gazouli, Anastasios Kyriazoglou, Ioannis Kotsantis, Maria Anastasiou, Anastasios Pantazopoulos, Maria Prevezanou, Ioannis Chatzidakis, Georgios Kavourakis, Panagiota Economopoulou, Vasileios Kontogeorgakos, Panayiotis Papagelopoulos, Amanda Psyrri
Summary: Osteosarcoma is the most common primary bone cancer predominantly affecting young individuals. Despite the improved chances of cure with surgery and cytotoxic chemotherapy, recurrent and refractory disease remains a significant therapeutic challenge. A systematic review of available clinical evidence on the treatment of recurrent and/or refractory osteosarcoma in the past two decades found that most treatments failed to elicit objective responses, with no identified driver mutations as effective treatment targets or predictive biomarkers for treatment effectiveness. Continued clinical and preclinical research is needed to uncover the biological mechanisms of recurrent and refractory osteosarcoma and expand therapeutic options for pre-treated patients.
Article
Biochemistry & Molecular Biology
Afroditi Kastrenopoulou, Kyriakos E. Kypreos, Nicholaos Papachristou, Stavros Georgopoulos, Ioulia Mastora, Ioanna Papadimitriou-Olivgeri, Argyro Spentzopoulou, Dragana Nikitovic, Vassilios Kontogeorgakos, Harry C. Blair, Dionysios J. Papachristou
Summary: In this study, the researchers investigated the impact of APOA1 on bone marrow adipocytes using ApoA1 knockout mice. The results showed that APOA1 deficiency led to an increase in the number of adipocytes in the bone marrow, which resembled white adipocytes. Furthermore, the expression of brown/beige adipocyte-specific markers was reduced, and there was a decrease in the compartments of hematopoietic stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Vasileios A. Kechagias, Theodoros Bbbb Grivas, Panagiotis J. Papagelopoulos, Vasileios A. Kontogeorgakos, Konstantinos Vlasis
Summary: This study compared the morphology of the spine and the pelvis of patients with hip or knee OA to a control group, revealing significant differences in various truncal parameters. Patients with OA had greater forward inclination of the spine, scoliosis, vertebral rotation, trunk torsion, and pelvic obliquity, which could have significant negative effects on their quality of life.
CLINICS IN ORTHOPEDIC SURGERY
(2021)
Article
Surgery
Vasileios A. Kontogeorgakos, Dionysios J. Papachristou, Sokratis Varitimidis
JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME
(2016)