期刊
ARCHIVES OF ORAL BIOLOGY
卷 59, 期 2, 页码 102-110出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2013.10.009
关键词
Angiogenesis; Dental pulp cells; Hinokitiol; Hypoxia-inducible factor-1 alpha
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0003750]
- National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea [1220080]
- Korea Health Promotion Institute [1220080] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0003750] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Hinokitiol, a natural iron-chelating agent, is known to have diverse biological and pharmacological activities in various cell types. However, the effect of hinokitiol on dental pulp cells has not yet been reported. In this study, hinokitiol increases hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein levels and vascular endothelial growth factor (VEGF) secretion in human dental pulp cells. The extracellular-signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways are involved in hinokitiol-induced HIF-1 alpha protein expression in dental pulp cells. Conditioned media from hinokitiol-treated pulp cells enhances angiogenesis in vitro and in vivo. Overall, these results show that hinokitiol promotes ERK and p38MAPK activation and HIF-1 alpha-induced VEGF production, thus increasing the angiogenic potential of dental pulp cells. (C) 2013 Elsevier Ltd. All rights reserved.
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