Article
Nutrition & Dietetics
Veronica Arreaza-Gil, Ivan Escobar-Martinez, Manuel Suarez, Francisca Isabel Bravo, Begona Muguerza, Anna Arola-Arnal, Cristina Torres-Fuentes
Summary: Gut microbiota and biological rhythms are key factors that affect physiological and metabolic processes. This study found that seasonal changes in photoperiod significantly altered gut microbiota composition and influenced diet-induced obesity development.
Article
Food Science & Technology
Hatice Ozcaliskan Ilkay, Derya Karabulut, Gonca Kamaci Ozocak, Ecmel Mehmetbeyoglu, Emin Kaymak, Betul Kisioglu, Betul Cicek, Asli Akyol
Summary: The study aimed to investigate the protective effects of quinoa in glucose homeostasis in a model of cafeteria diet-induced obesity. Results showed that quinoa lowered body weight, blood glucose, and insulin levels, increased liver IRS-1 and AMPK gene expressions, and enhanced pancreatic beta-cell insulin immunoreactivity. Quinoa may be useful in preventing obesity and associated metabolic disorders.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Andreu Gual-Grau, Maria Guirro, Noemi Boque, Lluis Arola
Summary: Genetic factors and sex can influence the gut microbiota composition and obesity status of rats fed a CAF diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biology
Syed Mohammed Basheeruddin Asdaq, Shrey Tambe, Yahya Mohzari, Ahmed Alrashed, Hamdan Najib Alajami, Awad Othman Aljohani, Abdullah Ali Al Mushtawi, Majed Sultan Alenazy, Rakan Fahad Alamer, Abdulmajead Khalid Alanazi, Syed Imam Rabbani
Summary: This study evaluated the anti-obesity potential of almonds under different dietary conditions. Results showed that almond can prevent weight gain, improve lipid parameters, and stabilize CNS parameters. The high dose almond preparation was most effective in reducing body weight.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Jakub Poloczek, Wojciech Kazura, Elzbieta Chelmecka, Katarzyna Michalczyk, Jerzy Jochem, Janusz Gumprecht, Dominika Stygar
Summary: Over-nutrition leads to glycemic control failure and obesity, which can be mitigated by bariatric surgery and specific dietary protocol. The study measured the levels of antioxidant markers and lipid peroxidation markers in rats fed with different diets and subjected to surgery. The results showed that the diet change strongly influenced antioxidant marker activity, while bariatric surgery had a greater effect on superoxidase dismutase activity. All dietary protocols increased ceruloplasmin activity, and cafeteria diet decreased total antioxidant capacity levels. Bariatric surgery and no change in diet reduced lipid peroxidation and lipofuscin levels, respectively.
Article
Multidisciplinary Sciences
Arzu Kabasakal Cetin, Tugba Alkan Tug, Atila Gulec, Asli Akyol
Summary: The study showed that maternal taurine supplementation has modest protective effects against cafeteria diet-induced maternal obesity. However, in the setting of normal pregnancy, taurine supplementation may lead to increased neonatal mortality. Further research is needed to explore the optimal dosage of taurine supplementation and its long-term effects on offspring.
Article
Biochemistry & Molecular Biology
Aynaz Tajaddini, Michael D. Kendig, Kelly V. Prates, R. Frederick Westbrook, Margaret J. Morris
Summary: Maternal obesity increases the risk of health complications in offspring, and the effects can be exacerbated by offspring exposure to unhealthy diets. This study found that offspring from obese mothers who were fed an unhealthy "cafeteria" diet had smaller size, more abdominal fat, and altered gene expression in the liver. Additionally, maternal obesity enhanced the negative effects of postweaning unhealthy diet on male offspring, while having minimal impact on female offspring. These findings highlight the importance of understanding the sex-specific detrimental effects of maternal obesity on offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Arzu Kabasakal Cetin, Yucel Buyukdere, Atila Gulec, Asli Akyol
Summary: Maternal taurine supplementation can reduce adiposity and alter hepatic gene expression patterns, mitigating the detrimental effects of maternal obesogenic diet on offspring. The offspring supplemented with taurine showed lower fat deposition and body fat compared to those without supplementation. Genes related to steroid hormone biosynthesis, cholesterol metabolism, and fatty acid degradation were down-regulated in the taurine-supplemented offspring.
NUTRITION RESEARCH
(2023)
Article
Nutrition & Dietetics
Jonas Laget, Irene Cortijo, Juliana H. H. Boukhaled, Karen Muyor, Flore Duranton, Bernard Jover, Fabrice Raynaud, Anne-Dominique Lajoix, Angel Argiles, Nathalie Gayrard
Summary: Obesity exacerbates renal inflammation and fibrosis in chronic kidney disease (CKD). Certain substances such as interleukin 11, dipeptidyl peptidase 4, and serpin 1 may directly affect the process of fibrosis.
Article
Nutrition & Dietetics
Alex Subias-Gusils, Adam Alvarez-Monell, Noemi Boque, Antoni Caimari, Josep M. Del Bas, Roger Marine-Casado, Montserrat Solanas, Rosa M. Escorihuela
Summary: This study showed that a dietary intervention based on a calorie-restricted cafeteria diet and a polyphenolic compound can improve body weight, food intake, and metabolic parameters in obese rats, and reduce sucrose intake and preference. Supplementation with Oleuropein also helps to reduce hedonic responses to high sucrose concentrations.
Article
Nutrition & Dietetics
Samia Squizani, Jeferson Jantsch, Fernanda da Silva Rodrigues, Matheus Filipe Braga, Sarah Eller, Tiago Franco de Oliveira, Alexandre Kleber Silveira, Jose Claudio Fonseca Moreira, Marcia Giovenardi, Marilene Porawski, Renata Padilha Guedes
Summary: This study aimed to evaluate the effects of zinc supplementation on the intestinal microbiota, fatty acid profile, and neurofunctional parameters in obese rats. The findings showed that zinc supplementation did not protect obese animals from intestinal dysbiosis, but an increase in acetate levels was observed, suggesting a partial beneficial effect of zinc.
Article
Immunology
Amanda Goulart, Naira Ferreira Anchieta, Pedro Alexandre Sampaio, Vania Brazao, Jefferson Luiz Da Silva, Gisele Bulhoes Portapilla, Andressa Duarte, Daiane Yukie Tezuca, Maiara Voltarelli Providello, Angelita Maria Stabile, Jose Clovis do Prado Jr
Summary: The study found that a cafeteria diet can impair the cell-mediated immune response against T. cruzi in rats, leading to a significant reduction in CD3(+) CD4(+) helper splenic T cells, CD11b, and macrophages in obese-infected rats compared to non-obese-infected rats. Additionally, macrophages from obese animals showed reduced RT1b levels compared to control animals, and INF-gamma levels were lower in obese-infected rats compared to their counterparts.
Article
Neurosciences
Clarisse Giovana Maciel Reis, Arthur Rocha-Gomes, Amanda Escobar Teixeira, Dalila Gomes de Oliveira, Camilla Mainy Oliveira Santiago, Alexandre Alves da Silva, Tania Regina Riul, Eduardo de Jesus Oliveira
Summary: The aim of this study was to evaluate the effects of hypercaloric diets on behavior, inflammation, and redox status. The results showed that long-term hypercaloric diets lead to obesity and systemic inflammation, resulting in increased levels of amygdala TNFa and anxiety-like behaviors.
Article
Medicine, Research & Experimental
Daniela Esteves Ferreira dos Reis Costa, Natalia Ferreira de Araujo, Natalia Ribeiro Cabacinha Nobrega, Naiara de Assis Rabelo Ribeiro, Amanda Carla Clemente de Oliveira, Luciano dos Santos Aggum Capettini, Adaliene Versiani Matos Ferreira, Daniella Bonaventura
Summary: The study revealed that the CAF diet induced obesity and metabolic disorders, but the contractile profile of perivascular adipose tissue may play a protective role in restoring impaired vascular contraction in the early stages.
Article
Multidisciplinary Sciences
Poliana E. Correia, Clarissa B. Gomes, Vinicius A. Bandeira, Thais Marten, Gabriella R. Natividade, Paula Merello, Erica Tozawa, Carlos T. S. Cerski, Alexandre Budu, Ronaldo Araujo, Bruno D. Arbo, Maria Flavia M. Ribeiro, Carlos C. Barros, Fernando Gerchman
Summary: This study assessed the effects of a cafeteria diet on body weight and glucose homeostasis in B1 receptor knockout mice (B1RKO). The results showed that B1RKO mice had a higher body weight gain compared to wild-type mice when fed a cafeteria diet. The cafeteria diet also increased fat accumulation and hepatic AKT phosphorylation in both genotypes. However, B1RKO mice exhibited lower glycemic response and insulin sensitivity during glucose tolerance and insulin tolerance tests. This resistance was overcome by increased insulin secretion in response to high glucose levels, resulting in higher glucose uptake despite lower insulin sensitivity. Islets from B1RKO mice delivered 4 times more insulin compared to wild-type mice. Overall, the cafeteria diet increased beta-cell function in B1RKO mice, compensating for diet-induced insulin resistance and leading to a healthier glycemic response despite higher weight gain.
Article
Endocrinology & Metabolism
Sabrina Pereira Silva, Otavio Garcia Martins, Liciane Fernandes Medeiros, Priscila Centeno Crespo, Carlus Augustu Tavares do Couto, Joice Soares de Freitas, Andressa de Souza, Amanda Morastico, Luis Augusto Xavier Cruz, Paulo Roberto Stefani Sanches, Wolnei Caumo, Giovana Duzzo Gamaro, Iraci Lucena da Silva Torres, Izabel Cristina Custodio de Souza
Summary: This study evaluated the effect of transcranial direct current stimulation (tDCS) on a chronic inflammatory pain model in rats. The results showed that tDCS treatment was able to reverse mechanical allodynia, decrease thermal hyperalgesia, and reduce local inflammation.
NEUROIMMUNOMODULATION
(2022)
Article
Behavioral Sciences
Etiane Micheli Meyer Callai, Lisandra Eda Fusinato Zin, Luciana Santa Catarina, Deise Ponzoni, Carlos Alberto Saraiva Goncalves, Adriana Fernanda Kuckartz Vizuete, Milton Cristian Cougo, Jamile Boff, Edela Puricelli, Elissa Kerli Fernandes, Iraci Lucena da Silva Torres, Alexandre Silva Quevedo
Summary: This study aimed to evaluate the effects of a single session of transcranial direct current stimulation (tDCS) on pain sensitivity, inflammatory parameters, and astrocyte activity in rats. The results showed that a single tDCS session had analgesic, anti-inflammatory, and neuroprotective effects. This non-invasive and inexpensive therapy could potentially be an alternative for reducing pain, inflammation, and neurodegeneration.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
Alvaro de Oliveira Franco, Camila Fernanda da Silveira Alves, Paul Vicuna, Janete Bandeira, Maria Adelia de Aratanha, Iraci L. S. Torres, Felipe Fregni, Wolnei Caumo
Summary: There are differences in intra- and interhemispheric functional connectivity between the motor and prefrontal cortices in fibromyalgia patients with different responses to the conditioned pain modulation (CPM) test. These differences may also be influenced by the presence of psychiatric disorders.
Article
Psychology, Biological
Betina Franceschini Tocchetto, Leticia Ramalho, Maxciel Zortea, Samara Machado Bruck, Rafaela Brugnera Tomedi, Rael Lopes Alves, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
Summary: This study compared the peripheral body temperature rhythm between individuals with fibromyalgia and healthy controls, and found that the peripheral body temperature rhythm was not able to effectively distinguish fibromyalgia patients from the control group. Additionally, the peripheral body temperature of fibromyalgia patients was correlated with the severity of depression symptoms and pain intensity.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mariana Uczay, Pricila Pfluger, Jaqueline Nascimento Picada, Joao Denis Medeiros de Oliveira, Iraci Lucena da SilvaTorres, Helouise Richardt Medeiros, Maria Helena Vendruscolo, Gilsane von Poser, Patricia Pereira
Summary: This study investigated the mechanism of action of Asperuloside (ASP) and geniposide (GP) in pilocarpine-induced seizures. The results showed that GP and ASP could reduce the latency to the first seizure, as well as the expression of GluN2B receptor and COX-2.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Fabricio Finamor, Vanessa Leal Scarabelot, Liciane Fernandes Medeiros, Dirson Joao Stein, Morgana Duarte da Silva, Etiane Callai, Wolnei Caumo, Andressa de Souza, Iraci L. S. Torres
Summary: This study evaluated the involvement of GABAergic, glutamatergic, opioidergic systems, and BDNF levels in trigeminal neuropathic pain (TNP) in rats. The results suggest that GABA, phenobarbital, and morphine can reverse the hyperalgesia induced by TNP. Glutamatergic antagonists can increase pain threshold, and BDNF levels are elevated in TNP and normal tissues. These findings contribute to our understanding of the neural mechanisms underlying TNP.
NEUROSCIENCE LETTERS
(2023)
Article
Clinical Neurology
Bruno Schein, Gerardo Beltran, Barbara Regina Franca, Paulo R. S. Sanches, Danton P. Silva, Iraci Lucena Torres, Felipe Fegni, Wolnei Caumo
Summary: This study compared the effects of HAS, a-tDCS on the l-DLPFC, and rest-testing on pain measures and MEP. The results showed that HAS increased pain tolerance compared to a-tDCS, while a-tDCS increased MEP amplitude compared to HAS. These findings contribute to the investigation of HAS and a-tDCS as approaches to counteract maladaptive neuroplasticity in fibromyalgia.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Victor Bento Oliveira, Fabio Wildson Gurgel Costa, Alex Nogueira Haas, Renan Magalhaes Montenegro Junior, Rodrigo Otavio Rego
Summary: This study aimed to summarize the evidence on the effect of subgingival instrumentation (with or without open flap) on the reduction of glycosylated haemoglobin (HbA1c). The meta-analysis of 12 randomized controlled trials showed that subgingival instrumentation can significantly reduce HbA1c levels and have important clinical value for diabetes control in patients with type 2 diabetes mellitus.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Josimar Macedo de Castro, Joice Soares de Freitas, Dirson Joao Stein, Isabel Cristina de Macedo, Wolnei Caumo, Iraci L. S. Torres
Summary: This study investigated the effects of tDCS on biometric, behavioral, and neurochemical parameters in chronically stressed rats fed a hyper-palatable cafeteria diet (CAFD). The results showed that CAFD increased body weight, caloric consumption, adiposity, and liver weight, and also altered central parameters. The chronic restraint stress model (CRS) resulted in increased adrenals in rats with standard diet (SD), and anxiety-like and anhedonic behaviors in rats with CAFD. tDCS provided neurochemical shifts in CAFD-fed stressed rats, while in stressed rats SD-fed induced a decrease in adrenals weight, relative visceral adiposity, and serum NPY levels. These findings highlight the potential of tDCS technique for stress-related eating disorders.
NEUROCHEMICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Larisse Longo, Josimar Macedo de Castro, Melina Belen Keingeski, Pabulo Henrique Rampelotto, Dirson Joao Stein, Gabriel Tayguara Silveira Guerreiro, Valessa Emanoele Gabriel de Souza, Carlos Thadeu Schmidt Cerski, Carolina Uribe-Cruz, Iraci L. S. Torres, Mario Reis Alvares-da-Silva
Summary: This study found that nicotinamide riboside (NR) and dietary restriction (DR) have potential therapeutic effects on metabolic dysfunction-associated fatty liver disease. In an obesity model, NR reduced liver lipids, inflammation, and fibrosis, and improved gut microbiota. DR delayed the onset of liver abnormalities and improved gut microbiota.
Article
Public, Environmental & Occupational Health
Michele Gabriela Schmidt, Iraci L. S. Torres, Douglas Nunes Stahnke, Vera Maria Vieira Paniz
Summary: The paper examines the consumption of low-dose naltrexone (LDN) in the 26 Brazilian capitals and the Federal District from 2014 to 2020. The study finds higher LDN consumption in the Mid-West, South, and Southeast regions, and lower consumption in the North and Northeast. 55.6% of the capitals show an increasing trend in LDN consumption, while the remaining 44.4% remain stable, with no decreasing coefficients. Despite limited evidence, the data highlights the increasing prescription, dispensing, and consumption of LDN in Brazil, particularly in the central-south regions.
CIENCIA & SAUDE COLETIVA
(2023)
Article
Anesthesiology
Lisiane Santos da Silva, Roberta Stroher Toledo, Dirson Joao Stein, Josimar Macedo de Castro, Wolnei Caumo, Iraci L. S. Torres
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lisandra Eda Fusinato Zin, Adriana Fernanda K. Vizuete, Etiane Micheli Meyer Callai, Luciana Santa Catarina, Fernanda Froes, Ana Paula Moreira, Charlanne de Oliveira Marques, Miriara B. Leal, Deise Ponzoni, Edela Puricelli, Iraci Lucena da Silva Torres, Carlos-Alberto Goncalves, Alexandre Silva Quevedo
Summary: Evidence suggests that transcranial direct current stimulation (tDCS) can be used as a therapeutic intervention for epilepsy, depression, and pain disorders. The cellular and molecular mechanisms underlying the therapeutic benefits of tDCS are still unknown. This study focused on the role of astrocytes in mediating the neuroprotective effects of tDCS and found that a single session of tDCS increased pain threshold and induced inflammatory and astroglial changes in the hippocampus. These findings contribute to a better understanding of tDCS as a therapeutic strategy for nervous disorders and highlight the importance of astrocytes as therapeutic targets.
NEUROCHEMICAL RESEARCH
(2023)
Article
Oncology
Helouise Richardt Medeiros, Jose Antonio Fagundes Assumpcao, Dirson Joao Stein, Eduardo Cremonese Filippi-Chiela, Felipe Fregni, Wolnei Caumo, Paulo Roberto Stefani Sanches, Iraci L. S. Torres
Summary: The viability of SH-SY5Y neuroblastoma cells was reduced after 24 h and 6 days of exposure to SMS (p<0.05), while there were no differences for the other time points (p>0.05). However, this effect was not associated with cell death or cell cycle arrest (p>0.05). In contrast, the viability of HMV-II melanoma cells, used as a control, was not affected. Additionally, stimulated SH-SY5Y cells showed a decrease in mitochondrial mass at both exposure times and a reduction in autophagy and cell proliferation after 6 days (p<0.05).
ANTICANCER RESEARCH
(2023)
Article
Clinical Neurology
Wolnei Caumo, Matheus Soldatelli, alvaro de Oliveira Franco, Felipe Picon, Juliana avila Duarte, Ricardo Scherer, Janete Bandeira, Maxciel Zortea, Iraci Lucena Da Silva Torres, Felipe Fregni, Wolnei Caumo
Summary: This study investigated the differences in resting-state functional connectivity (rs-FC) of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) in fibromyalgia patients. The results showed that non-responders had decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG). The rs-FC of S1-PAG in the left-brain hemisphere was correlated with central sensitization symptoms, sleep quality, and pain scores.
KOREAN JOURNAL OF PAIN
(2023)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)
