Article
Ophthalmology
Min Xu, Huirong Xu, Xiao Li, Fang Chen
Summary: The study analyzed and compared the macular morphology and microcirculation characteristics in DME patients with and without SRD. The results suggest that disruptions in EZ and ELM, increased number of HF, and thickening and hyperperfusion of the choroid may be involved in the pathogenesis of SRD in DME.
Article
Multidisciplinary Sciences
Hae Min Kang, Jeong Hoon Choi, Hyoung Jun Koh, Sung Chul Lee
Summary: The study found that both peripapillary and subfoveal choroidal thickness significantly decreased over 12 months in patients with unilateral central retinal vein occlusion (CRVO), while no significant changes were observed in the contralateral eyes. The absolute reduction amount and reduction ratio of PCT and SFCT were significantly greater in the CRVO-affected eyes compared to the contralateral eyes.
Article
Endocrinology & Metabolism
Kuebra Ozata Gundogdu, Emine Dogan, Erkan celik, Guersoy Alagoz
Summary: This study evaluated the outcomes of IVR treatment in patients with DME, including those with and without SRD. The results showed that both groups experienced improvements in visual acuity and macular thickness after three consecutive IVR injections. However, patients with SRD had lower visual gains compared to those without SRD.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Ophthalmology
Bekir Kucuk, Ender Sirakaya, Cagatay Karaca
Summary: Aflibercept was more effective than ranibizumab in treating macular edema with serous retinal detachment following branch retinal vein occlusion during the first 3 months, but the effects were similar between the two groups in the subsequent 9 months.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Lulu Chen, Mingzhen Yuan, Lu Sun, Youxin Chen
Summary: The study found that patients with SRD had thicker choroid before treatment, and SRD may contribute to better anatomical recovery in RVO patients after receiving a single anti-VEGF treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Oncology
Inci Elif Erbahceci Timur, Bilge Tarim, Esra Dag Seker, Nagihan Ugurlu
Summary: This study aimed to investigate the role of blood-derived inflammatory markers in macular edema (ME) secondary to retinal vein occlusion (RVO) with and without serous retinal detachment (SRD). The results showed that patients with SRD had higher levels of neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation index (SII) compared to those without SRD and healthy controls. SII was found to be a reliable tool for predicting SRD in ME secondary to RVO.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Ankush Kawali, Srinivasan Sanjay, Ashwin Mohan, Padmamalini Mahendradas, Rohit Shetty
Summary: This study evaluated the efficacy of topical interferon alfa-2b in treating uveitic macular edema. The results showed that using topical IFN four times a day could improve central macular thickness, but the efficacy was limited. Long-term therapy may improve its effectiveness.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Oren Tomkins-Netzer, Susan L. Lightman, Alyce E. Burke, Elizabeth A. Sugar, Lyndell L. Lim, Glenn J. Jaffe, Michael M. Altaweel, John H. Kempen, Janet T. Holbrook, Douglas A. Jabs
Summary: The study found that nearly all uveitic macular edema can resolve with sufficient time and treatment, but relapse is common. Eyes with resolved macular edema had better visual acuity results, suggesting that controlling inflammation and resolving edema may be important treatment targets.
Article
Multidisciplinary Sciences
Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi
Summary: The study quantitatively evaluated retinal pigment epithelium changes in patients with age-related macular degeneration using prototype multi-contrast optical coherence tomography. The results showed that multi-contrast OCT is useful for objective evaluation of changes in the retinal pigment epithelium.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Robert M. Kinast, Sharon D. Solomon, Leo D. P. Cubillan, Anna Hovakimyan, Nisha Acharya, Emmett T. Cunningham
Summary: This study aimed to describe the prevalence and causes of clinically detectable uveitic serous retinal detachment (SRD), with Vogt-Koyanagi-Harada (VKH) disease being the most commonly identified cause. Apart from VKH disease, other non-infectious and infectious inflammatory disorders were also associated with this distinctive clinical finding.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Nisha R. Acharya, Albert T. Vitale, Elizabeth A. Sugar, Janet T. Holbrook, Alyce E. Burke, Jennifer E. Thorne, Michael M. Altaweel, John H. Kempen, Douglas A. Jabs
Summary: This study evaluated the effectiveness of three different intravitreal treatments for persistent or recurrent uveitic macular edema. The results showed that dexamethasone was more effective than methotrexate or ranibizumab in treating uveitic macular edema. However, there was a risk of increased intraocular pressure with dexamethasone treatment.
Review
Medicine, General & Internal
Slawomir Jan Teper
Summary: Uveitic macular edema is a common complication in uveitis patients, leading to serious visual impairment in a significant proportion of cases. Despite the availability of various treatment options, many patients fail to achieve satisfactory improvement in visual acuity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Ender Sirakaya, Deniz Kilic, Hatice Aslan Sirakaya
Summary: This comparative study evaluated the effects of ranibizumab, aflibercept, and bevacizumab treatments in treatment-naive diabetic macular edema (DME) patients with serous retinal detachment (SRD). The results showed that aflibercept treatment resulted in significantly greater reduction in central retinal thickness (CRT) and SRD height compared to the other two treatments at 3 months. However, there were no significant differences between the three treatments at 6 months.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Jayoung Ahn, Daniel Duck-Jin Hwang
Summary: This study evaluated longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes affected with branch and central retinal vein occlusion (BRVO and CRVO, respectively) and fellow eyes. It found that the global pRNFL thickness of fellow eyes in the BRVO and CRVO groups decreased significantly at 24 months compared to baseline, while the fellow eyes of patients with CRVO had significantly lower pRNFL thickness at 12 and 24 months compared to those of the BRVO and normal control groups. These results suggest that fellow eyes of patients with BRVO and CRVO are susceptible to pRNFL damage.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xiaojing Xiong, Xu Chen, Huafeng Ma, Zheng Zheng, Yazhu Yang, Zhu Chen, Zixi Zhou, Jiaxin Pu, Qingwei Chen, Minming Zheng
Summary: Our study identified 60 differential metabolites between RVO-ME patients and controls, as well as 40 differential metabolites between mild and severe RVO-ME patients. Pathway analysis revealed significant alterations in valine, leucine, and isoleucine biosynthesis; ascorbate and aldarate metabolism; and pantothenate and coenzyme A biosynthesis in RVO-ME compared to controls. Adenosine, threonic acid, pyruvic acid, and pyro-L-glutaminyl-l-glutamine were identified as potential biomarkers for distinguishing RVO-ME from controls, while urocanic acid, diethanolamine, 8-butanoylneosolaniol, niacinamide, paraldehyde, phytosphingosine, 4-aminobutyraldehyde, dihydrolipoate, and 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide showed potential for distinguishing between mild and severe RVO-ME.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
