Article
Neurosciences
Junjun Zhang, Xiaoyan Yang, Zhenlan Jin, Ling Li
Summary: Our study found that the emergent feature of closure facilitates discrimination of objects, but not holes with the same shape, and this effect was observed in the lateral occipital cortex (LOC) but not in the early visual cortex (EVC). Neural representations of objects with emergent features showed distinct patterns compared to others in LOC, indicating that object formation plays a crucial role in perceptual organization.
Editorial Material
Psychology, Biological
Daniel Lakens, Duygu Uygun Tunc, Mehmet Necip Tunc
Summary: This article discusses three approaches for evaluating generalizability: falsificationism, confirmationism, and neo-operationalism. The author argues that the proposed neo-operationalism does not work for hypothetical concepts in psychology, as these concepts cannot be reduced to their operationalizations.
BEHAVIORAL AND BRAIN SCIENCES
(2022)
Article
Computer Science, Hardware & Architecture
Christoph Groeger
Summary: This text discusses the data challenges of AI in industries and emphasizes the necessity of a data ecosystem for industrial enterprises.
COMMUNICATIONS OF THE ACM
(2021)
Article
Environmental Sciences
Roger Frutos, Olivier Pliez, Laurent Gavotte, Christian A. Devaux
Summary: Since the COVID-19 pandemic began in 2020, the origin of the virus has been heavily debated. The two main hypotheses, natural spillover and laboratory-leak origin, have supporters who build arguments against each other. However, the biased nature of the original question itself is the main problem. The origin of viruses is not determined, but rather a process of evolution and selection.
ENVIRONMENTAL RESEARCH
(2022)
Editorial Material
Psychology, Biological
Shilaan Alzahawi, Benoit Monin
Summary: This passage points out that quantification is crucial for psychology and is the foundation of its scientific status. Although some argue for the adoption of qualitative methods, inferential statistics are still necessary. Instead of discarding useful tools, the focus should be on using inferential statistics in a more thoughtful manner.
BEHAVIORAL AND BRAIN SCIENCES
(2022)
Article
Mathematics
Valentin Ferenczi
Summary: This article studies the properties of proper operator ideals. By extending the construction of Aiena and Gonzalez and analyzing the powers of X-S, it is proven that the ideal of inessential operators is not maximal among proper operator ideals, and that there is no largest proper operator ideal. It is also demonstrated that certain properties hold for general C-linear operators if and only if they hold for these operators seen as real.
MATHEMATISCHE ANNALEN
(2023)
Article
Mathematics
Stefan Schroeer
Summary: This article proves the non-existence of families of Enriques surfaces over the ring of integers, expanding on existing non-existence results for families of various geometric objects. The author's main approach involves studying the local system of numerical classes of invertible sheaves, and the results also depend on counting rational points, classification of rational elliptic surfaces, theory of exceptional Enriques surfaces, theory of Mordell-Weil lattices, and combinatorial study on genus-one fibrations.
ANNALS OF MATHEMATICS
(2023)
Article
Astronomy & Astrophysics
M. James Cline
Summary: Contrary to a recent assertion, this paper argues that there is no electroweak horizon problem.
PHYSICS OF THE DARK UNIVERSE
(2022)
Article
Medicine, General & Internal
Ben Van Calster, Ewout W. W. Steyerberg, Laure Wynants, Maarten van Smeden
Summary: Clinical prediction models should be validated before implementation, as the performance of a model may vary across patient populations and measurement procedures. Validation studies should focus on understanding and quantifying heterogeneity and monitoring performance over time, to ensure that prediction models remain up-to-date and safe for clinical decision-making.
Article
Chemistry, Analytical
Emmanuel Douez, Valentina D'Atri, Davy Guillarme, Daniel Antier, Mathieu Guerriaud, Alain Beck, Herve Watier, Laura Foucault-Fruchard
Summary: Monoclonal antibody (mAb)-based therapies have revolutionized oncology patient care, but their high cost prompted the development of biosimilars as more affordable alternatives. This article focuses on Erbitux® (cetuximab), a monoclonal antibody used for colorectal cancer and head and neck cancer. Despite its patent expiration and profitable sales, Erbitux® has not faced any biosimilar challenges in the US or Europe. The article discusses the complex structure of Erbitux® and the risks associated with demonstrating biosimilarity, as well as the potential of developing Erbitux® biobetters.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Antonio Martin-Bastida, Robert R. Crichton
Summary: This review explores the iron deposition in the brains of PD patients, the role of neuroinflammation and glia cells, and the potential therapeutic effects of iron chelators. The combination of anti-inflammatory drugs with iron chelators is proposed as a better approach to enhance chelator efficacy in treating PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Physics, Multidisciplinary
N. David Mermin
Summary: The idea that the collapse of a quantum state is a physical process stems from a misunderstanding of probability and its role in quantum mechanics.
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Mihee Jang, Sun Ha Paek, Beomseok Jeon
Summary: Bilateral subthalamic nucleus deep brain stimulation showed significant control over diphasic dyskinesia in patients with Parkinson's disease, with approximately 74% of patients experiencing remission after surgery. Patients with younger age of onset and longer disease duration at surgery were more likely to have persistent diphasic dyskinesia.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jialong Chen, Mingque Li, Xueqiong Zhou, Ailun Xie, Ziwei Cai, Chunlai Fu, Yongming Peng, He Zhang, Linhua Liu
Summary: The study revealed a novel feedback mechanism of p38-Parkin-ROS regulating rotenone-induced Parkinson's disease. Both p38 activation and Parkin inactivation contribute to the disruption of Parkin-mediated mitophagy, leading to increased reactive oxygen species (ROS) production. Inhibiting p38 and enhancing Parkin activity can reduce ROS levels and restore cell death and mitochondrial function in rotenone-induced PD models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Ebru Umay, Z. A. Yigman, E. A. Ozturk, I. Gundogdu, B. G. Kocer
Summary: The study found that evaluation parameters of sarcopenia were significantly higher in PD patient groups compared to the control group, and muscle measurements evaluated by MRI in patients with dysphagia are lower than both patients with normal swallowing and control group.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
