Article
Clinical Neurology
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson
Summary: This study demonstrates that vD supplementation is the major determinant of vD levels in people with MS, with genetic factors playing a smaller role.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Sara E. Gombash, Priscilla W. Lee, Elizabeth Sawdai, Amy E. Lovett-Racke
Summary: Vitamin D insufficiency during childhood is associated with the development of multiple sclerosis (MS), possibly due to abnormal immune responses and vulnerability of the central nervous system.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Dirk Lemke, Rainer Johannes Klement, Felix Schweiger, Beatrix Schweiger, Jorg Spitz
Summary: Vitamin D-3 plays an important role in treating autoimmune diseases, and high-dose vitamin D-3 therapy can improve treatment outcomes. Acquired vitamin D resistance may be a plausible pathomechanism for the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Oscar D. Pons-Belda, M. Agustina Alonso-Alvarez, Juan David Gonzalez-Rodriguez, Laura Mantecon-Fernandez, Fernando Santos-Rodriguez
Summary: FGF23 was identified as circulating phosphatonin in human pathology and plays a pathogenic role in various diseases. However, its metabolism in children is largely unknown. This review focuses on the metabolism of FGF23 in pediatric age and its relationship with vitamin D metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Biochemistry & Molecular Biology
Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki
Summary: Vitamin D and VDR play critical roles in maintaining calcium homeostasis, bone formation, and immune response against cancer. Mutations in the VDR gene are associated with manifestations of type II rickets and abnormal bone formation. The unliganded VDR is crucial for maintaining the hair cycle and normal skin.
Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Jose Enrique de la Rubia Orti, Maria Faus Garcia, Eraci Drehmer, Esther Navarro-Illana, Julia Casani-Cubel, Belen Proano, Claudia Emmanuela Sanchis-Sanchis, Juan Domenech Escriva
Summary: The study found that MS patients in the Valencian region have low intake of vitamin D, which is significantly negatively correlated with vegetable protein intake, lower than animal protein, and significantly negatively correlated with high blood levels of IL-6, possibly due to high intake of unsaturated fats.
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Article
Clinical Neurology
Sarah M. Orton, Amarpreet Sangha, Mehul Gupta, Kristina Martens, Luanne M. Metz, A. P. J. de Koning, Gerald Pfeffer
Summary: Abnormal expression of vitamin D may be associated with the onset and severity of multiple sclerosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cell Biology
Carsten Carlberg, Marcin P. Mycko
Summary: Environmental factors, such as low vitamin D levels, contribute to the susceptibility of multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. Vitamin D3, through its metabolite 1,25(OH)2D3, modulates the epigenome and transcriptome of immune cells, reducing inflammatory reactions and promoting immunological tolerance in T cells, thus preventing MS.
Article
Biochemistry & Molecular Biology
Marie Bicikova, Ludmila Macova, Martin Hill
Summary: Vitamin D plays an important role in immunomodulation, brain development, and functioning. Its potential immunoprotective role in COVID-19 has been discussed. This study found that individuals who took vitamin D had a significantly lower risk of COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kate R. Barratt, Rebecca K. Sawyer, Gerald J. Atkins, Rene St-Arnaud, Paul H. Anderson
Summary: The study showed that elevating serum 25(OH)D levels independently improves bone mineralisation in XLH mice, especially without causing hypercalcemia. This suggests the need for further research on increasing 25(OH)D levels in XLH patients to establish its role in improving bone mineralisation.
Article
Immunology
Fatima A. H. Al-Jaberi, Cornelia Geisler Crone, Thomas Lindenstrom, Nicolai Skovbjerg Arildsen, Emilia Saederup Lindelov, Louise Aagaard, Eva Gravesen, Rasmus Mortensen, Aase Bengaard Andersen, Klaus Olgaard, Jessica Xin Hjaltelin, Soren Brunak, Charlotte Menne Bonefeld, Martin Kongsbak-Wismann, Carsten Geisler
Summary: Tuberculosis is a serious health issue affecting a significant portion of the global population, with a quarter being infected with Mycobacterium tuberculosis. Vitamin D plays a crucial role in the immune response against M. tuberculosis, but research is hindered by a lack of suitable experimental models. Studying families with hereditary vitamin D-resistant rickets (HVDRR) provides unique insights into the immunoregulatory effects of vitamin D. A case study of an HVDRR patient with impaired cathelicidin production highlights the importance of vitamin D in combating M. tuberculosis pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Michaela Tanja Haindl, Muammer Ucal, Willibald Wonisch, Michaela Lang, Marta Nowakowska, Milena Z. Z. Adzemovic, Michael Khalil, Christian Enzinger, Sonja Hochmeister
Summary: Vitamin D is an antioxidant supplement that has been widely discussed in relation to multiple sclerosis (MS). This study investigates the effects of vitamin D on cortical pathology, oxidative stress, and neurofilament light chain levels in a rat model of demyelination. The findings suggest a positive impact of vitamin D on cellular features of cortical pathology.
Article
Clinical Neurology
Marton Konig, Aslaug Rudjord Lorentzen, Hilde Marie Torgauten, The Trung Tran, Stine Schikora-Rustad, Eline Benno Vaage, Ase Mygland, Stig Wergeland, Jan Aarseth, Ingeborg Aase S. Aaberge, Oivind Torkildsen, Trygve Holmoy, Tone Berge, Kjell-Morten Myhr, Hanne Flinstad Harbo, Jan Terje Andersen, Ludvig Andre Munthe, Arne Soraas, Elisabeth Gulowsen Celius, John Torgils Vaage, Fridtjof Lund-Johansen, Gro Owren Nygaard
Summary: This study aimed to characterize humoral immunity after mRNA-COVID-19 vaccination in people with multiple sclerosis (pwMS). The study found that patients treated with fingolimod or rituximab had reduced humoral immunity. It is important to carefully time the vaccinations for patients treated with rituximab.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Karine Eid, Oivind Torkildsen, Jan Aarseth, Mari Aalstad, Alok Bhan, Elisabeth G. Celius, Marianna Cortese, Anne Kjersti Daltveit, Trygve Holmoy, Kjell-Morten Myhr, Trond Riise, Stephan Schuler, Cecilie F. Torkildsen, Stig Wergeland, Nils Erik Gilhus, Marte-Helene Bjork
Summary: This study found that childhood sexual and emotional abuse were associated with an increased risk of developing multiple sclerosis (MS). The risk was higher for those exposed to multiple categories of abuse.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Letter
Clinical Neurology
Gro Owren Nygaard, Hilde Torgauten, Lars Skattebol, Einar August Hogestol, Piotr Sowa, Kjell-Morten Myhr, Oivind Torkildsen, Elisabeth Gulowsen Celius
Summary: Rebound disease activity can occur after switching from fingolimod to cladribine or rituximab in the treatment of multiple sclerosis (MS). This study found that the risk of rebound was lower when switching to rituximab compared to cladribine, indicating a better initial clinical outcome with rituximab.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Anne Lise K. Hestvik, Jette Lautrup Frederiksen, Helle Hvilsted Nielsen, Oivind Torkildsen, Camilla Eek, Yumin Huang-Link, Sara Haghighi, Jon A. Tsai, Matthias Kant
Summary: This study found that teriflunomide treatment for multiple sclerosis resulted in stable quality of life, decreased relapse activity, and high treatment satisfaction.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Karine Eid, Oivind Torkildsen, Jan Aarseth, Elisabeth G. Celius, Marianna Cortese, Trygve Holmoy, Akash Kapali, Kjell-Morten Myhr, Cecilie F. Torkildsen, Stig Wergeland, Nils Erik Gilhus, Marte-Helene Bjork
Summary: Women with multiple sclerosis (MS) are more likely to experience systematic emotional abuse, rape, and revictimization as adults compared to women without MS.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Brit Ellen Rod, Oivind Torkildsen, Kjell-Morten Myhr, Lars Bo, Stig Wergeland
Summary: Our study found minimal transfer of rituximab into breast milk in nursing mothers, and the levels of rituximab in infant serum were difficult to detect. The B cell counts in infants were unaffected.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Ingrid Anne Lie, Kristin Wesnes, Silje S. Kvistad, Iman Brouwer, Stig Wergeland, Trygve Holmoy, Rune Midgard, Alla Bru, Astrid Edland, Randi Eikeland, Sonia Gosal, Hanne F. Harbo, Grethe Kleveland, Yvonne S. Sorenes, Nina Oksendal, Frederik Barkhof, Hugo Vrenken, Kjell-Morten Myhr, Lars Bo, Oivind Torkildsen
Summary: This study assessed the long-term effects of smoking on patients with RRMS. The results showed that smoking was associated with brain atrophy and disability progression, suggesting that patients should quit smoking shortly after diagnosis to prevent long-term disability progression.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Letter
Clinical Neurology
Ingrid Anne Lie, Brit Ellen Rod, Silje Stokke Kvistad, Trygve Holmoy, Kjell-Morten Myhr, Oivind Torkildsen, Stig Wergeland
Summary: This study investigated the effect of IFN beta-1a treatment on serum EBV antibody levels in patients with relapsing-remitting MS and found no significant associations between treatment and EBV antibody levels.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Nina Grytten, Kjell-Morten Myhr, Elisabeth G. Celius, Espen Benjaminsen, Rune Midgard, Anita Vatne, Jan H. Aarseth, Janne Mannseth, Oivind Torkildsen
Summary: This study aims to determine the differences in all-cause mortality and mortality following a cancer diagnosis between multiple sclerosis (MS) patients and matched population controls. The study found that the all-cause mortality among MS patients was five times higher than that of the controls, and the mortality following a cancer diagnosis was two times higher. In addition, MS patients had higher mortality rates following urinary system, colorectal, hematological, ovarian, and breast cancer diagnoses. High education was inversely associated with mortality among MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Jakob Rishovd Karlowicz, Mattias Klakegg, Jan Harald Aarseth, Lars Bo, Kjell-Morten Myhr, Hilde Marie Torgauten, Oivind Torkildsen, Stig Wergeland
Summary: This retrospective cohort study found that patients with multiple sclerosis (MS) treated with rituximab had a higher risk of hematological adverse events, including hypogammaglobulinemia, severe lymphopenia, neutropenia, and infections leading to hospitalization. The risk was higher in patients with longer treatment duration, lympho- or neutropenia, and primary progressive MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
T. H. Rasmussen, M. Konig, A. R. Lorentzen, S. Schikora-Rustad, T. Berge, T. Holmoy, O. Torkildsen, S. Wergeland, M. H. Overas, E. A. Hogestol, H. M. Torgauten, H. F. Harbo, E. G. Celius, L. A. Munthe, J. T. Vaage, F. L. Johansen, G. O. Nygaard
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
T. Kalincik, S. Sharman, I. Roos, M. Freedman, H. Atkins, J. Burman, J. Massey, I. Sutton, B. Withers, R. Macdonell, A. Grigg, O. Torkildsen, L. Bo, A. Lehmann, D. Horakova, E. Havrdova, E. Krasulova, M. Trneny, T. Kozak, A. van der Walt, H. Butzkueven, P. McCombe, B. Van Wijmeersch, K. Buzzard, O. Skibina, J. Lechner-Scott, B. Willekens, M. Barnett, E. Cartechini, S. Ozakbas, R. Alroughani, G. Izquierdo, S. Eichau, C. Boz, J. Kuhle, F. Patti, M. Terzi, A. Prat, M. Girard, P. Duquette, P. Grammond, M. Onofrj, A. Lugaresi, S. Khoury, A. Soysal, M. Slee, J. Prevost, R. Turkoglu, B. Sharrack, J. Snowden
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
T. Kalincik, S. Sharmin, I. Roos, M. S. Freedman, H. Atkins, J. Burman, J. Massey, I. Sutton, B. Withers, R. Macdonell, A. Grigg, O. Torkildsen, L. Bo, A. K. Lehmann, D. Horakova, E. K. Havrdova, E. Krasulova, M. Trneny, T. Kozak, A. van der Walt, H. Butzkueven, B. Van Wijmeersch, P. McCombe, K. Buzzard, O. Skibina, J. Lechner-Scott, B. Willekens, M. Barnett, E. Cartechini, G. Izquierdo, S. Eichau, F. Patti, S. Hodgkinson, J. Prevost, M. Onofrj, A. Lugaresi, R. Alroughani, E. Butler, A. Prat, M. Girard, P. Duquette, P. Grammond, F. Grand'Maison, G. Laureys, L. Van Hijfte, D. Maimone, B. Sharrack, J. Snowden
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
T. Kalincik, S. Sharmin, I. Roos, J. Massey, I. Sutton, B. Withers, M. Freedman, H. Atkins, D. Horakova, E. Kubala Havrdova, E. Krasulova, M. Trneny, T. Kozak, J. Burman, R. Macdonell, A. Grigg, O. Torkildsen, L. Bo, A. K. Lehmann, B. Sharrack, J. Snowden
MULTIPLE SCLEROSIS JOURNAL
(2022)