Article
Biochemistry & Molecular Biology
Huili Zheng, Xiaofei Liang, Hongli Zhou, Tong Zhou, Xinhui Liu, Jialun Duan, Jin-ao Duan, Yue Zhu
Summary: In this study, the protective effect of Lycium barbarum polysaccharides (LBPs) on premature ovarian insufficiency (POI) was investigated in mice. LBPs improved ovarian reserve, regulated sex hormone levels, normalized estrous cycle, and increased offspring numbers in POI mice. Furthermore, LBPs had positive effects on gut microbiota and metabolism. These findings provide valuable support for the application of LBPs in the treatment of female ovarian function degeneration.
Article
Multidisciplinary Sciences
Muhammad Tanweer Khan, Chinmay Dwibedi, Daniel Sundh, Meenakshi Pradhan, Jamie D. Kraft, Robert Caesar, Valentina Tremaroli, Mattias Lorentzon, Fredrik Backhed
Summary: This study successfully co-isolated Faecalibacterium prausnitzii and Desulfovibrio piger and identified their symbiotic relationship in growth and butyrate production. By adapting Faecalibacterium prausnitzii to tolerate oxygen exposure, researchers developed a next-generation probiotic formulation.
Article
Multidisciplinary Sciences
Olle Bjorkqvist, Ignacio Rangel, Lena Serrander, Cecilia Magnusson, Jonas Halfvarson, Torbjorn Noren, Malin Bergman-Jungestrom
Summary: The study found that FMT can increase the relative abundance of Faecalibacterium prausnitzii in patients with recurrent CDI, and this microbial shift persists for several months later. Further research is needed to determine whether Faecalibacterium prausnitzii actively contributes to the resolution of CDI.
Article
Gastroenterology & Hepatology
Magdy El-Salhy, Renate Winkel, Christina Casen, Trygve Hausken, Odd Helge Gilja, Jan Gunnar Hatlebakk
Summary: According to this study, FMT performed according to the protocol resulted in high treatment response rates and long-term effects, with only a few mild self-limited adverse events.
Article
Gastroenterology & Hepatology
Yuhan Zhang, Ming Lu, Bin Lu, Chengcheng Liu, Yiming Ma, Li Liu, Xiaoping Miao, Junjie Qin, Hongda Chen, Min Dai
Summary: In this study, fecal samples from 1,546 subjects in a screening setting were analyzed using 16S rRNA sequencing to identify microbial signatures for advanced adenomas. The study identified 13 microbial signatures with potential diagnostic value, especially the genus Tyzzerella 4, which demonstrated the highest adjusted AUC. These microbial signatures showed complementary capacity to FIT in detecting advanced adenomas, indicating the promising potential of gut microbiota in optimizing current colorectal cancer screening modalities.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Peng Chen, Fuchao Chen
Summary: This article is related to Ikegami et al's papers.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Tatiani Uceli Maioli, Esther Borras-Nogues, Licia Torres, Sara Candida Barbosa, Vinicius Dantas Martins, Philippe Langella, Vasco Ariston Azevedo, Jean-Marc Chatel
Summary: Research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. An obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, contributing to chronic inflammation and insulin resistance. Modulating the gut microbiota may be a potential treatment approach for these conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Zhi-Luo Deng, Dietmar H. Pieper, Andreas Stallmach, Arndt Steube, Marius Vital, Michael Reck, Irene Wagner-Dobler
Summary: This study reveals that FMT leads to a temporary engraftment of donor microbiota, particularly in butyrate biosynthesis, which helps alleviate pouchitis. However, this engraftment is short-lived and needs to be repeated to achieve therapeutic effects.
Article
Multidisciplinary Sciences
Guojun Tong, Hai Qian, Dongli Li, Jing Li, Jing Chen, Xiongfeng Li
Summary: This study aimed to establish and evaluate a rat model of inflammatory bowel disease (IBD) using antibiotics. The results showed that the antibiotic-induced IBD model was successfully established in SD rats and may serve as a useful model for clinical IBD research.
Article
Endocrinology & Metabolism
Meng Yang, Jing-Hua Wang, Joo-Hyun Shin, Dokyung Lee, Sang-Nam Lee, Jae-Gu Seo, Ji-Hee Shin, Young-Do Nam, Hojun Kim, Xiaomin Sun
Summary: This study found that Faecalibacte-rium prausnitzii strains, isolated from healthy human feces, have therapeutic effects on obesity and related metabolic disorders by regulating the gut-brain axis. The strains reduced body weight gain, liver and fat weights, and calorie intake while improving lipid and glucose metabolism. They also inhibited inflammation, restored gut integrity, and ameliorated hepatic function and insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Hsien-Tai Chiu, Mohammed Abdullah Alshawsh
Summary: This study demonstrated the potential role of F. prausnitzii in the prevention and management of colorectal cancer, showing its anti-tumorigenic and antiproliferative effects, as well as its modulation of gut microbiota diversity in rats.
Article
Immunology
Li-ting Jin, Ming-Zhi Xu
Summary: In obese patients, the connection between the gut microbiota and the onset of non-alcoholic fatty liver (NAFLD) is yet unknown. A study comparing the gut microbiota of obese individuals with and without NAFLD found a lower quantity of Faecalibacterium prausnitzii in the NAFLD group. Bacteroides, Clostridium leptum, and Clostridium butyricum were more prevalent in the NAFLD group, while Bacteroides, Clostridium butyricum, and F. prausnitzii were more prevalent in the simple obesity group. Lymphocytes and F. prausnitzii may play a role in determining the development of NAFLD in obese patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Ana Fernandes, Ana Oliveira, Ana Luisa Carvalho, Raquel Soares, Pedro Barata
Summary: This study found a significant reduction in the relative abundance of Faecalibacterium prausnitzii in the gut microbiota of differentiated thyroid cancer patients compared to controls. The study also showed that radioiodine therapy resulted in an increase in the relative and absolute abundances of this bacterium in most patients.
Article
Oncology
Jordan Kharofa, David Haslam, Rachael Wilkinson, Allison Weiss, Sameer Patel, Kyle Wang, Hope Esslinger, Olugbenga Olowokure, Davendra Sohal, Greg Wilson, Syed Ahmad, Senu Apewokin
Summary: In this study, the stool microbiome of long-term survivors of pancreatic cancer and controls was profiled. Several enriched species previously associated with enhanced tumor immune response were observed, including Faecalibacterium prausnitzii and Akkermansia mucinophilia. These findings suggest that the fecal microbiota may play a role in enhancing the immune response in pancreatic cancer.
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Environmental Sciences
Xianchao Qin, Mengmeng Ji, Xiaogang Wu, Chunjie Li, Yueshu Gao, Ji Li, Qiaoyu Wu, Xiaojun Zhang, Zhenjia Zhang
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Microbiology
Binbin Liu, Xiaojun Zhang, Lars R. Bakken, Lars Snipen, Asa Frostegard
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Xiaogang Wu, Ji Li, Mengmeng Ji, Qiaoyu Wu, Xinxin Wu, Yiming Ma, Weikang Sui, Liping Zhao, Xiaojun Zhang
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Na Fei, Aurelia Bruneau, Xiaojun Zhang, Ruirui Wang, Jinxing Wang, Sylvie Rabot, Philippe Gerard, Liping Zhao
Article
Microbiology
Xiaogang Wu, Yun Wang, Ying Zhu, Hao Tian, Xianchao Qin, Changzheng Cui, Liping Zhao, Pascal Simonet, Xiaojun Zhang
Article
Microbiology
Xinxin Wu, Xiaogang Wu, Ji Li, Qiaoyu Wu, Yiming Ma, Weikang Sui, Liping Zhao, Xiaojun Zhang
Article
Biotechnology & Applied Microbiology
X. Zhang, G. Chen, S. Zhong, T. Wang, M. Ji, X. Wu
JOURNAL OF APPLIED MICROBIOLOGY
(2020)
Review
Biotechnology & Applied Microbiology
Saira Bano, Xiaogang Wu, Xiaojun Zhang
Summary: Soil microbiomes are complex networks with crucial functions for ecosystems. Engineering rhizosphere microbiomes in agriculture is gaining attention, but diverse soil factors impact success. Understanding key factors and microbial responses can optimize microbiomes for increased crop productivity and sustainability.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Soil Science
Liuqing Yang, Xiaojun Zhang, Xiaotang Ju, Di Wu
Summary: Oxygen plays a crucial role in regulating the expression of N-cycle-related genes and nitrogenous gas production in soil. Increasing ammonium application accelerates oxygen consumption in the headspace and induces higher N2O accumulation under oxic conditions. Changes in oxygen status significantly impact the structure of soil microbiota.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Article
Microbiology
Baoyu Xiang, Liping Zhao, Menghui Zhang
Summary: Targeted nutrition intervention with high-fiber diet successfully led to weight loss in an obese boy with Prader-Willi syndrome by impacting the metabolite secretions of gut microbiota. Metagenome-scale metabolic network technology proved to be a cost-efficient solution for screening functional microbial strains and metabolic pathways responding to nutrition therapy.
Article
Microbiology
Xinhui Wang, Baoyu Xiang, Menghui Zhang, Xiaojun Zhang
Summary: In this study, 16 genomes assembled from the metagenome of pig manure digestate enriched with N2O were reported. These denitrifying bacterial genomes all contain the nosZ gene, encoding N2O reductase. The genomes vary in size, completeness, GC content, and contamination levels.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Microbiology
Xuejing Li, Fang Yang, Haosong Yan, Yi Shi, Xiaowei Chang, Mengmeng Zhang, Yan Zhang, Menghui Zhang
Summary: This study investigated the microbial characteristics of the scalp in subjects with mild scalp pruritus and identified physiological factors and bacteria potentially related to pruritus. The results showed that the microbial structures of itchy and non-itchy sites were different but with large variations among individuals.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Ecology
Qiaoyu Wu, Mengmeng Ji, Siyu Yu, Ji Li, Xiaogang Wu, Xiaotang Ju, Binbin Liu, Xiaojun Zhang
Summary: This study investigates the microbial mechanisms of differential N2O emissions in agricultural soils. Results show that N2O accumulation in black soil is significantly higher than in fluvo-aquic soil, regardless of nitrogen and carbon conditions. The abundance of denitrifying genes is higher in fluvo-aquic soil, but the gene ratios responsible for N2O production to reduction do not differ significantly between the two soils. However, the bacterial communities in the soils exhibit obvious discrepancies, with N2O-generating bacteria more abundant in black soil and N2O-reducing bacteria more abundant in fluvo-aquic soil. This knowledge can aid in developing strategies for mitigating N2O emissions in agricultural soils by regulating N2O metabolism phenotypes.
Article
Engineering, Environmental
Xiaokun Liu, Lian Zhang, Rui Shen, Qihong Lu, Qinglu Zeng, Xiaojun Zhang, Zhili He, Simona Rossetti, Shanquan Wang
Summary: This study identified FeS as a major catalyzing matter for the abiotic dechlorination of chloroethenes (CEs) in soil. Acetylene was found to be an indicator of FeS-mediated abiotic CE dechlorination. Organohalide-respiring bacteria (OHRB)-mediated dechlorination enhanced the conversion of CEs to acetylene, while FeS inhibited OHRB-mediated dechlorination and its inhibition could be alleviated by the addition of soil humic substances. Sulfate-reducing bacteria and fermenting microorganisms affected FeS-mediated abiotic dechlorination by re-generating FeS and providing short chain fatty acids, respectively. These findings provide insights into the interactions between abiotic and biotic dechlorination processes in soil and can guide the sustainable management of CE-contaminated sites.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Baoyu Xiang, Liping Zhao, Menghui Zhang
Summary: In this study, a new approach called UGMAGrefiner was proposed, which utilizes the connection and coverage information from unitig level assembly graphs to improve the quality of metagenome-assembled genomes (MAGs). UGMAGrefiner outperforms state-of-the-art binning refine tools and can identify genome specific regions of mixed genomes. It provides an efficient way to obtain more complete MAGs and study genome specific functions.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
