期刊
ARCHIVES OF MICROBIOLOGY
卷 192, 期 12, 页码 1019-1022出版社
SPRINGER
DOI: 10.1007/s00203-010-0633-1
关键词
AiiA enzyme; Biofilm; Quorum sensing; V. cholerae
类别
资金
- Council of Scientific and Industrial Research, Govt. of India
Vibrio cholerae is the causative agent of water-borne diarrheal disease, cholera. The formation of biofilm favors survival and persistence of V. cholerae in the aquatic environment and also inside the host. AHL lactonase (AiiA), a metallo-beta-lactamase produced by Bacillus spp., blocks quorum sensing in Gram-negative bacteria by hydrolyzing N-acyl-homoserine lactones (AHLs). In the present investigation, AiiA-mediated inhibition of V. cholerae biofilm was studied. Two novel alleles of aiiA-encoding genes from Bacillus spp. were expressed in E. coli, and the results demonstrated that AiiA enzyme is a potent inhibitor of V. cholerae biofilm.
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