期刊
ARCHIVES OF MICROBIOLOGY
卷 192, 期 3, 页码 151-155出版社
SPRINGER
DOI: 10.1007/s00203-010-0549-9
关键词
Protein function; Homology-based transfer; Ontologies; Sequence and structure Motifs
类别
资金
- Faculty of Engineering and Science
- Department of Biological Sciences
- Department of Computing at Cork Institute of Technology
As the protein databases continue to expand at an exponential rate, fed by daily uploads from multiple large scale genomic and metagenomic projects, the problem of assigning a function to each new protein has become the focus of significant research interest in recent times. Herein, we review the most recent advances in the field of automated function prediction (AFP). We begin by defining what is meant by biological function and the means of describing such functions using standardised machine readable ontologies. We then focus on the various function-prediction programs available, both sequence and structure based, and outline their associated strengths and weaknesses. Finally, we conclude with a brief overview of the future challenges and outstanding questions in the field, which still remain unanswered.
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