Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
K. Ugur, F. Erman, S. Turkoglu, Y. Aydin, A. Aksoy, A. Lale, Z. K. Karagoz, I Ugur, R. F. Akkoc, M. Yalniz
Summary: This study investigated the association between asprosin, visfatin, subfatin, and biochemical values, demographic data, and body composition measurements in MetS patients with and without obesity. The results showed that there were correlations between asprosin and BMI, urea, and fasting insulin levels in the MetS group, as well as correlations between visfatin and BMI, waist circumference in the MetS + Obese and MetS groups. There were also significant relationships between visfatin values and asprosin and subfatin in all groups.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Nutrition & Dietetics
Hiroki Nishikawa, Akira Asai, Shinya Fukunishi, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Health Care Sciences & Services
George E. Zakynthinos, Vasiliki Tsolaki, Evangelos Oikonomou, Manolis Vavouranakis, Gerasimos Siasos, Epaminondas Zakynthinos
Summary: Metabolic syndrome and atrial fibrillation are closely related, as metabolic syndrome affects the left atrium in multiple ways, leading to the progression of atrial fibrillation. A holistic treatment approach can improve patient outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Yan Hao, Ya-juan Zhu, Song Zou, Pei Zhou, Ya-wen Hu, Qi-xiang Zhao, Lin-na Gu, Hao-zhou Zhang, Zhen Wang, Jiong Li
Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Article
Medicine, General & Internal
Jelena Nesic, Biljana Ljujic, Vesna Rosic, Aleksandar Djukic, Milenko Rosic, Ivica Petrovic, Nenad Zornic, Ivan P. Jovanovic, Sara Petrovic, Svetlana Djukic
Summary: Adiponectin and interleukin-33 are associated in patients with metabolic syndrome, with adiponectin potentially serving as an early marker and interleukin-33 being a potential predictor of inflammatory status in the early stage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Marcin Gierach, Anna Rasmus, Edyta Orlowska
Summary: MetS patients performed worse in verbal fluency tests, possibly influenced by metabolic factors, especially in phonetic verbal fluency which is associated with the frontal cortex. Lower switching indicates possible executive dysfunctions, highlighting the need to focus on patients with MetS in therapy and improve their metabolic components to enhance cognitive function.
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lin-Nei Hsu, Ju-Chuan Hu, Po-Yen Chen, Wei-Chia Lee, Yao-Chi Chuang
Summary: This article discusses the interaction and common pathophysiological mechanisms between metabolic syndrome and overactive bladder. Understanding this association may help identify new diagnostic biomarkers and therapeutic targets.
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Article
Medicine, General & Internal
Elizabeth Perez-Cruz, Daniela Castro-Martinez, Otto Pavel Gonzalez-Guzman
Summary: The study found a significant association between sarcopenic obesity and insulin resistance in young adults, but no significant association with metabolic syndrome.
Article
Endocrinology & Metabolism
Monika Sarnat-Kucharczyk, Maria Swierkot, Gabriela Handzlik, Grazyna Kulawik, Krystyna Jagoda, Iga Grochola-Malecka, Joanna Fryzewska, Ewa Mrukwa-Kominek, Jerzy Chudek
Summary: rATG therapy offers long-lasting improvement in moderate-to-severe steroid-resistant Graves' orbitopathy with improvement in functional vision. The therapy is well-tolerated.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Allergy
Zbigniew Doniec, Magdalena Olszanecka-Glinianowicz, Piotr Hantulik, Agnieszka Almgren-Rachtan, Jerzy Chudek
Summary: This multicenter study demonstrated that Salflumix Easyhaler is highly effective and well-tolerated in patients with asthma. It showed good compliance with the device and high patient satisfaction in everyday clinical practice.
Review
Nutrition & Dietetics
Ewelina Burnatowska, Agnieszka Wikarek, Paulina Oboza, Natalia Ogarek, Mateusz Glinianowicz, Piotr Kocelak, Magdalena Olszanecka-Glinianowicz
Summary: Obesity is a known risk factor for the development of polycystic ovary syndrome (PCOS), particularly phenotype A. PCOS is a major cause of fertility disorders in women of reproductive age. Treatment of hormonal disorders associated with PCOS has been pursued for years to restore ovulation and regular menstrual cycles. Obesity treatment has been proven effective for many women, but may be challenging due to underlying emotional eating, eating disorders, and impaired reward system. Recognizing and treating these disorders, including the appropriate use of pharmacotherapy and psychotherapy, is crucial for effective obesity treatment in women with PCOS.
Review
Biochemistry & Molecular Biology
Slawomir Lizakowski, Alicja Debska-Slizien, Ilona Kurnatowska, Maciej J. Zaucha, Marcin Matuszewski, Beata Naumnik, Marcin Adamczak, Jerzy Chudek, Magdalena Durlik, Carla Ferrandiz-Pulido, Bartosz Foroncewicz, Ryszard Gellert, Magdalena Krajewska, Michal Nowicki, Andrzej Wiecek, Jolanta Malyszko
Summary: Onco-nephrology is a new medical field that connects the aspects of kidney injury in cancer patients and cancers in patients with kidney disease. It involves drug-induced nephrotoxicity, electrolyte disorders, paraneoplastic syndromes, and increased cancer rates in dialysis and transplant patients. Proper evaluation of kidney function helps optimize chemotherapy and reduce complications.
ACTA BIOCHIMICA POLONICA
(2023)
Review
Nutrition & Dietetics
Magdalena Olszanecka-Glinianowicz, Artur Mazur, Jerzy Chudek, Beata Kos-Kudla, Leszek Markuszewski, Dominika Dudek, Piotr Major, Piotr Malczak, Wieslaw Tarnowski, Pawel Jaworski, Elzbieta Tomiak
Summary: Obesity in adults and its complications are significant public health problems. A comprehensive search was conducted to collect relevant literature on obesity from various databases. The joint consensus statement of multiple Polish medical associations outlines the definition, causes, and diagnosis of obesity, as well as the treatment options, including bariatric surgery and the role of primary care. Interdisciplinary cooperation and considering patients' needs are emphasized for long-term effectiveness in obesity management.
Article
Medicine, General & Internal
Aleksandra Biernacka-Bartnik, Piotr Kocelak, Aleksander Jerzy Owczarek, Piotr Stanislaw Choreza, Leszek Markuszewski, Pawel Madej, Monika Puzianowska-Kuznicka, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
Summary: This study aimed to estimate the cut-off value for HOMA-IR discriminating insulin resistance based on SHBG level in women with PCOS. Data from 854 Caucasian women with PCOS were analyzed, and a cut-off value of 2.1 was found for HOMA-IR to determine insulin resistance based on SHBG level.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Adriana Stryczynska-Mirocha, Stanislaw Lacki-Zynzeling, Maciej Borowka, Zofia I. Niemir, Sylwia Kozak, Aleksander J. Owczarek, Jerzy Chudek
Summary: This study found that even mild reduction in eGFR is a risk factor for the development of neutropenia and a potential risk factor for febrile neutropenia (FN).
SUPPORTIVE CARE IN CANCER
(2023)
Review
Medicine, Research & Experimental
Piotr Kocelak, Monika Puzianowska-Kuznicka, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Summary: Atherosclerosis is a complex process involving endothelial dysfunction, vascular inflammation, vascular smooth muscle cell proliferation, angiogenesis, and calcification. Upregulation of the Wnt signaling pathway is one pathomechanism of atherosclerosis. This study provides a summary of the role of Wnt signaling and sclerostin in atherosclerosis, vascular calcification, aneurysms, and mortality.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Kimsa-Furdzik, Anna Bednarek, Grzegorz Hibner, Paulina Czajka-Francuz, Sylwia Cison-Jurek, Dobromila Karawasiecka, Bozena Szymczak, Jerzy Wojnar, Jerzy Chudek, Tomasz Francuz
Summary: This study investigated the predictive role of vitamin D (VD) in the survival of breast cancer (BC) patients. The results showed that BC patients had a higher frequency of VD deficiency compared to the control group, and this deficiency increased during chemotherapy treatment. The concentrations of VD active forms and catabolites decreased after chemotherapy. Furthermore, BC patients without VD deficiency at baseline had significantly longer survival. These findings highlight the importance of VD supplementation in BC patients with low VD levels.
Article
Biochemistry & Molecular Biology
Sylwia Cison-Jurek, Paulina Czajka-Francuz, Tomasz Francuz, Aleksander J. Owczarek, Bozena Szymczak, Jerzy Wojnar, Jerzy Chudek
Summary: This study assessed the predictive value of prolactin (PRL) and a panel of cytokines, chemokines, and growth factors for the risk of rapid progression in colorectal cancer (CRC) patients starting palliative chemotherapy (CTH).
Article
Pharmacology & Pharmacy
P. Oboza, N. Ogarek, M. Olszanecka-Glinianowic, P. Kocelak
Summary: As of March 21, 2022, a total of 6.1 million deaths from COVID-19 have been reported, with the majority occurring in the United States, Brazil, and India. The estimated global mortality rate during the pandemic was 120.3 deaths per 100,000 population between January 2020 and December 2021. This analysis indicates that multiple organ failure, resulting from various pathological mechanisms including genetic predisposition to severe inflammatory response, is the primary cause of death from COVID-19. Increased inflammatory response affects both the lungs locally and systemic thrombotic microangiopathy, with thrombotic changes in microcirculation being the dominant factor.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Joanna Rypel, Paulina Kubacka, Joanna Mykala-Ciesla, Jacek Pajak, Weronika Bulska-Bedkowska, Jerzy Chudek
Summary: Breast cancer is a heterogeneous disease with different subtypes. Triple-negative breast cancer is a subtype with poor prognosis, while adenoid cystic carcinoma of the breast is a rare subtype with usually favorable prognosis. There are no established recommendations for the treatment of advanced adenoid cystic carcinoma.
MEDICINA-LITHUANIA
(2023)
