期刊
ARCHIVES OF MEDICAL SCIENCE
卷 7, 期 2, 页码 189-194出版社
TERMEDIA PUBLISHING HOUSE LTD
DOI: 10.5114/aoms.2011.22067
关键词
antibodies to citrullinated protein/peptide; anti-cyclic citrullinated peptide; anti-mutated citrullinated vimentin; anti-Sa; rheumatoid arthritis; American College of Rheumatology
Antibodies to citrullinated proteins/peptides (ACPAs) are the second serological marker to have recently been included in the 2010 ACR/EULAR Rheumatoid Arthritis (RA) Classification Criteria, which are focused on early diagnosis and therapy. This review discusses their history and some clinical aspects of ACPAs, focusing on the diagnostic utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies as a marker of RA as compared to the widely used rheumatoid factor (RF). Simultaneously, this review aims to raise physician awareness and interest in anti-citrullinated vimentin antibody (anti-Sa/anti-MCV), another member of the ACPA family, which appears to have a better predictive value as a marker of RA than anti-CCP or RE and correlates closely with disease activity and therapeutic response among patients with RA.
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