Article
Biochemistry & Molecular Biology
Milica Manojlovic-Stojanoski, Slavica Borkovic-Mitic, Natasa Nestorovic, Natasa Ristic, Svetlana Trifunovic, Magdalena Stevanovic, Nenad Filipovic, Aleksandar Stojsavljevic, Sladan Pavlovic
Summary: Selenium is an essential element for normal cellular functioning, but low status and high concentrations can both increase oxidative stress. This study compared the effects of selenium nanoparticles and inorganic sodium selenite supplementation on pregnant rats. The results showed that selenium nanoparticles increased fetal lethality and changed antioxidant defense parameters in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Thorsten Braun, Loreen Ehrlich, Wolfgang Henrich, Sebastian Koeppel, Ievgeniia Lomako, Philipp Schwabl, Bettina Liebmann
Summary: The study identified the presence of microplastics (> 50 μm) in placenta and meconium samples from caesarean deliveries, with polyethylene, polypropylene, polystyrene, and polyurethane being the main types detected. However, airborne polyurethane microplastics were also found in the operating room, indicating potential contamination sources. Further research into nano-sized plastics in human tissues is recommended.
Review
Neurosciences
Mariana Astiz, Henrik Oster
Summary: The circadian clock system adapts physiology and behavior to daily recurring changes in the environment. Recent findings suggest that the embryo/fetal molecular clock machinery is present and functional in several tissues early during gestation, entrained by maternal rhythmic signals. This highlights the complex interaction and coordination between maternal, placental, and embryo/fetal clocks in regulating the circadian system's development and response to external perturbations during critical times.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Cassandra M. Herring, Fuller W. Bazer, Gregory A. Johnson, Heewon Seo, Shengdi Hu, Mohammed Elmetwally, Wenliang He, Daniel B. Long, Guoyao Wu
Summary: Supplementing L-arginine (Arg) during early gestation in gilts improves the survival and development of conceptuses. This is achieved by increasing the number of viable fetuses, enhancing placental blood vessel development, improving embryonic survival, increasing placental weight and fetus weight, and promoting the growth of amniotic and allantoic fluids. Arg supplementation also stimulates the syntheses of nitric oxide (NO) and polyamines in the placenta, increases the transportation of water and amino acids, and upregulates the expression of angiogenic factors and aquaporins.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shahla Shojaei, Moustafa S. Ali, Madhumita Suresh, Tushar Upreti, Victoria Mogourian, Michael Helewa, Hagar Labouta
Summary: Current medications for pregnant women may pose fetal risks, prompting the use of nanoparticles for targeted drug delivery to minimize these risks. Understanding the transfer of nanoparticles from mother to fetus is crucial, and placenta-on-a-chip offers a physiologically relevant in vitro model for assessment. There is a need for dynamic placenta-on-a-chip models to evaluate the safety of novel nanoparticle-based therapies during pregnancy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Jorge Carvajal, Paola Casanello, Alberto Toso, Marcelo Farias, Karina Carrasco-Negue, Kenny Araujo, Paola Valero, Javiera Fuenzalida, Caterina Solari, Luis Sobrevia
Summary: The SARS-CoV-2 infection causes COVID-19 disease, which leads to acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The effects of maternal SARS-CoV-2 infection on pregnant women, fetuses, and neonates are still controversial, and it is important to determine the presence of viral and non-viral vertical transmission. SARS-CoV-2 infection alters the function of asymptomatic and symptomatic pregnant women, the fetoplacental unit, and the neonate, and various pregnancy-related diseases, including COVID-19, can affect the fetoplacental function and result in long-term health consequences.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Frank Z. Stanczyk, David F. Archer
Summary: Estetrol (E4) is a promising estrogen for therapeutic use, produced only during pregnancy. It is not known which pathway predominates, but both the fetal liver and the placenta are involved in its production.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Nutrition & Dietetics
Stephen W. D'Souza, Andrew J. Copp, Nicholas D. E. Greene, Jocelyn D. Glazier
Summary: Supplementation with myo-inositol may reduce the risk of neural tube defects, especially for NTDs unresponsive to folic acid. Maternal myo-inositol intake plays a crucial role in embryonic development, establishing active cellular uptake mechanisms and effectively lowering NTD risk in human pregnancy. The generation of materno-fetal inositol concentration gradients and a transport pathway for myo-inositol delivery contribute to inositol's ability to confer embryonic developmental benefit.
ADVANCES IN NUTRITION
(2021)
Article
Environmental Sciences
Isabelle Plante, Louise M. Winn, Cathy Vaillancourt, Petya Grigorova, Lise Parent
Summary: Pregnancy involves significant physiological and psychological changes in the mother to meet the needs of the growing fetus, with potential long-term impacts on health for both mother and baby. Dysregulation of placental function may lead to increased risk of chronic diseases for the fetus later in life.
ENVIRONMENTAL RESEARCH
(2022)
Article
Infectious Diseases
Tito Ramirez-Lozada, Maria Concepcion Loranca-Garcia, Claudia Erika Fuentes-Venado, Carmen Rodriguez-Cerdeira, Esther Ocharan-Hernandez, Marvin A. Soriano-Ursua, Eunice D. Farfan-Garcia, Edwin Chavez-Gutierrez, Xochitl Ramirez-Magana, Maura Robledo-Cayetano, Marco A. Loza-Mejia, Ivonne Areli Garcia Santa-Olalla, Oscar Uriel Torres-Paez, Rodolfo Pinto-Almazan, Erick Martinez-Herrera
Summary: Pregnancy predisposes individuals to viral infection and bacterial coinfections can increase mortality rates for COVID-19, with antibiotics potentially entering the fetal circulation and causing harm. Proper antibiotic use is essential to prevent adverse effects on both the mother and fetus during pregnancy.
Article
Virology
Maria Y. Valdespino-Vazquez, Cecilia A. Helguera-Repetto, Moises Leon-Juarez, Oscar Villavicencio-Carrisoza, Arturo Flores-Pliego, Elsa R. Moreno-Verduzco, Diana L. Diaz-Perez, Isabel Villegas-Mota, Elba Carrasco-Ramirez, Irma E. Lopez-Martinez, David M. Giraldo-Gomez, Rosalia Lira, Martha Yocupicio-Monroy, Mario Rodriguez-Bosch, Edgar E. Sevilla-Reyes, Manuel Cortes-Bonilla, Sandra Acevedo-Gallegos, Horacio Merchant-Larios, Jorge Arturo Cardona-Perez, Claudine Irles
Summary: The study found that congenital SARS-CoV-2 infection is possible during the first trimester of pregnancy, leading to damage in placenta and fetal organs, with organs like lungs and kidneys being specific targets for the coronavirus.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Endocrinology & Metabolism
Harleen Kaur, Beverly S. Muhlhausler, Claire T. Roberts, Kathryn L. Gatford
Summary: The growth hormone (GH)-insulin-like growth factor (IGF) axis undergoes significant changes during pregnancy, with increased secretion of GH and IGFs leading to maternal metabolic adaptations, enhanced placental function, and fetal growth. Exogenous GH or IGF treatment in animal models of normal and compromised pregnancy also promotes similar effects, suggesting alternative approaches to enhance maternal GH abundance during pregnancy for better maternal and fetal outcomes.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charles Megier, Gregoire Dumery, Dominique Luton
Summary: Thyroid hormones and iodine are crucial for regulating various physiological functions, such as metabolic rate, protein synthesis, and fetal development. Imbalances in thyroid and iodine metabolism can have negative effects, especially during pregnancy. The placenta, as the interface between the mother and fetus, plays a vital role in regulating thyroid and iodine metabolism. This review provides an update on the current understanding of thyroid and iodine metabolism in both normal and pathological pregnancies, highlighting their importance for maternal and fetal health.
Review
Nutrition & Dietetics
Carl R. Dahlen, Lawrence P. Reynolds, Joel S. Caton
Summary: Selenium is an essential micronutrient in both vertebrates and invertebrates, and its deficiency or excess can lead to reproductive insufficiency and dysfunction in both males and females. It is associated with various complications during pregnancy and affects gamete and embryo development. Selenium has positive effects on fertility, embryonic development, and antioxidant properties. Supplementation of selenium can improve fetal growth and development, as well as influence placental and mammary gland growth. Further research is needed to explore the potential benefits of selenium supplementation in reproductive processes across different species.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Lisa M. Bebell, Joseph Ngonzi, Frederick A. B. Meier, Chrystalle Katte Carreon, Abraham J. Birungi, Vanessa B. Kerry, Raymond Atwine, Drucilla J. Roberts
Summary: This study highlights the importance of placental examination in understanding the causes of perinatal death and improving child health outcomes in resource-limited settings. The authors developed a training program for health workers to collect and examine placentas, resulting in a significant increase in diagnostic capacity. This model can be applied to other research endeavors to enhance diagnostics and management in similar settings.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Ozmert M. A. Ozdemir, Emine Ozdemir, Yasar Enli, Ozer Oztekin, Hacer Ergin
PEDIATRICS INTERNATIONAL
(2018)
Article
Urology & Nephrology
Tulay Becerir, Selcuk Yuksel, Havva Evrengul, Ahmet Ergin, Yasar Enli
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2019)
Article
Pediatrics
Ozmert M. A. Ozdemir, Ozgun Taban, Yasar Enli, Ferda Bir, Barbaros Sahin, Hacer Ergin
PEDIATRICS INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Musa Sanlialp, Yavuz Dodurga, Burcu Uludag, Yusuf Alihanoglu, Yasar Enli, Mucahit Secme, Hayrani Eren Bostanci, Sara Cetin Sanlialp, Ozge Ozden Tok, Asuman Kaftan, Ismail Dogu Kilic
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Obstetrics & Gynecology
Soner Gok, Berfin Can Gok, Yasar Enli
Summary: This study aimed to compare the levels of leptin, spexin, and visfatin in maternal blood and umbilical cord during delivery between severe preeclampsia (PE) and control group. The results showed that maternal leptin and visfatin levels were significantly higher, while maternal spexin levels were significantly lower in the PE group compared to the control group. Similarly, umbilical cord leptin and visfatin levels were also higher, and spexin levels were lower in the PE group. There was a significant positive correlation between maternal body mass index and maternal blood and umbilical cord leptin and visfatin levels in both groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nurgul Bozkurt, Sueleyman Utku Uzun, Ali Ishan Bozkurt, Sebahat Turgut
Summary: This study aimed to investigate the impact of smoking cessation on the risk of cardiovascular disease in workers. The results showed that within 6 months after quitting smoking, the risk score and CVD risk of employees decreased, and the reduction in coronary heart disease risk was greater in quitters.
Meeting Abstract
Respiratory System
Nurgul Bozkurt, Suleyman Utku Uzun, Ali Ihsan Bozkurt, Sebahat Turgut
Article
Clinical Neurology
Gulfizar Sozeri-Varma, Ceren Bingol, Osman Zulkif Topak, Yasar Enli, Osman Ozdel
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2019)
Article
Pharmacology & Pharmacy
Nurgul Bozkurt, Fatih Altintas, Ali Ihsan Bozkurt, Gunfer Turgut, Sebahat Turgut
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Meeting Abstract
Pediatrics
Tulay Becerir, Selcuk Yuksel, Havva Evrengul, Ahmet Ergin, Yasar Enli
PEDIATRIC NEPHROLOGY
(2018)
Article
Rehabilitation
Melek Tunc-Ata, Mukaddes Mergen-Dalyanoglu, Sebahat Turgut, Gunfer Turgut
JOURNAL OF EXERCISE REHABILITATION
(2017)
Meeting Abstract
Physiology
M. Tunc-Ata, F. Altintas, G. Turgut, S. Turgut
Article
Medicine, Research & Experimental
Senay Topsakal, Fulya Akin, Sabahat Turgut, Emrah Yerlikaya, Guzin F. Yaylali
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Article
Rehabilitation
Melek Tunc-Ata, Gunfer Turgut, Mukaddes Mergen-Dalyanoglu, Sebahat Turgut
JOURNAL OF EXERCISE REHABILITATION
(2017)
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)