Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Article
Cardiac & Cardiovascular Systems
Yun-Jiu Cheng, Yu-He Jia, Feng-Juan Yao, Wei-Yi Mei, Yuan-Sheng Zhai, Ming Zhang, Su-Hua Wu
Summary: This study demonstrates that incident silent myocardial infarction (SMI) is independently associated with an increased risk of sudden cardiac death (SCD) in the general population, particularly in white individuals, men, and younger age groups. Additional research is needed to investigate screening for SMI and the role of standard post-myocardial infarction therapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biology
Brett C. Baggett, Kevin R. Murphy, Elif Sengun, Eric Mi, Yueming Cao, Nilufer N. Turan, Yichun Lu, Lorraine Schofield, Tae Yun Kim, Anatoli Y. Kabakov, Peter Bronk, Zhilin Qu, Patrizia Camelliti, Patrycja Dubielecka, Dmitry Terentyev, Federica del Monte, Bum-Rak Choi, John Sedivy, Gideon Koren
Summary: Progressive tissue remodeling after myocardial infarction promotes cardiac arrhythmias. Little is known about pro-arrhythmic changes in aged animals. In this study, aged rabbits exhibited increased peri-procedural mortality and arrhythmogenic electrophysiological remodeling at the infarct border zone (IBZ) compared to young rabbits. Computational modeling showed that senescent myofibroblast-cardiomyocyte coupling prolongs action potential duration (APD) and facilitates conduction block permissive of arrhythmias. The findings suggest that therapeutic interventions targeting senescent cells may mitigate arrhythmias post-MI with age.
Article
Cardiac & Cardiovascular Systems
Lorraine Sazgary, Christian Puelacher, Giovanna Lurati Buse, Noemi Glarner, Andreas Lampart, Daniel Bolliger, Luzius Steiner, Lorenz Guerke, Thomas Wolff, Edin Mujagic, Stefan Schaeren, Didier Lardinois, Jacqueline Espinola, Christoph Kindler, Angelika Hammerer-Lercher, Ivo Strebel, Karin Wildi, Reka Hidvegi, Johanna Gueckel, Christina Hollenstein, Tobias Breidthardt, Katharina Rentsch, Andreas Buser, Danielle M. Gualandro, Christian Mueller
Summary: MACE incidence after non-cardiac surgery is 15.2% at 30 days and 20.6% at 365 days for high-risk patients, with the risk remaining elevated for about 5 months post-surgery.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David M. Raffel, Thomas C. Crawford, Yong-Woon Jung, Robert A. Koeppe, Guie Gu, Jill Rothley, Kirk A. Frey
Summary: The study evaluated the performance of F-18-4F-MHPG and F-18-3F-PHPG in cardiomyopathy patients, demonstrating their robustness in quantifying regional cardiac sympathetic nerve density. Both tracers provided comparable metrics of nerve density and left ventricular denervation, with F-18-4F-MHPG showing advantages of faster liver clearance and more consistent plasma metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Xuewen Wang, Yongsheng Qian, Yajun Yao, Youcheng Wang, Youjing Zhang, Shujuan Zhang, Qingyan Zhao
Summary: This study demonstrates that MNS can increase ventricular fibrillation threshold in a canine model with MI and the effect may be associated with the cholinergic anti-inflammatory pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Malorie Blancard, Zahia Touat-Hamici, Yuriana Aguilar-Sanchez, Liheng Yin, Guy Vaksmann, Nathalie Roux-Buisson, Veronique Fressart, Isabelle Denjoy, Didier Klug, Nathalie Neyroud, Josefina Ramos-Franco, Ana Maria Gomez, Pascale Guicheney
Summary: A novel RYR2 variant, p.Asp3291Val, was identified in three CPVT families with numerous sudden deaths. This variant results in a loss-of-function RyR2, inducing mild dysfunction in basal conditions but potentially leading to fatal events through its unresponsiveness to adrenergic stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Critical Care Medicine
Monique Anderson Starks, Larry R. Jackson, Anne Hellkamp, Sana M. Al-Khatib, Daniel B. Mark, Kevin L. Thomas, Graham Nichol, Kerry L. Lee, Linda Davidson-Ray, Jeanne Poole, Jill Anderson, George Johnson, Gust H. Bardy
Summary: Patients with MI-SCA were found to have similar adjusted risks of all-cause mortality and sudden cardiac death compared to those with MI-no SCA. However, after ICD implantation, MI-SCA patients had higher mortality risks.
Article
Cardiac & Cardiovascular Systems
Minna Koivunen, Juho Tynkkynen, Niku Oksala, Markku Eskola, Jussi Hernesniemi
Summary: This study aimed to provide comprehensive information on the epidemiology of sudden cardiac arrests (SCA) and sudden cardiac deaths (SCD) after acute coronary syndrome. Through a retrospective study of 10,316 patients with acute coronary syndrome, it was found that the incidence of SCA and SCD was relatively high, accounting for nearly one-third of deaths due to cardiovascular causes. Patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction had a higher incidence of SCA.
AMERICAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Natallia Laptseva, Valentina A. Rossi, Isabella Sudano, Rahel Schwotzer, Frank Ruschitzka, Andreas J. Flammer, Firat Duru
Summary: Amyloidosis is a systemic disease characterized by extracellular deposits of insoluble amyloid in various tissues and organs. Cardiac amyloidosis is a frequent feature of the disease, causing a progressive, restrictive type of cardiomyopathy, and is associated with adverse clinical outcomes and increased mortality. This review aims to provide insights into the arrhythmic features of cardiac amyloidosis by discussing the pathogenesis, challenges in risk stratification, and management strategies for these arrhythmias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fredrik Landfors, Simon Vikstrom, Patrik Wennberg, Jan-Hakan Jansson, Jonas Andersson, Elin Chorell
Summary: This study found that two proteins, LTA4H and HGF, which are linked to inflammation and tissue damage, are independently associated with an increased risk of SCD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Young Choi, Kwan Yong Lee, Sang Hyun Kim, Kyung An Kim, Byung-Hee Hwang, Eun Ho Choo, Sungmin Lim, Chan Jun Kim, Jin-Jin Kim, Jaeho Byeon, Gyu Chul Oh, Doo Soo Jeon, Ki Dong Yoo, Ha-Wook Park, Min Chul Kim, Youngkeun Ahn, Myung Ho Jeong, Youngdeok Hwang, Kiyuk Chang
Summary: This study identified six predictors for early cardiac death after discharge from acute myocardial infarction (AMI), including Killip class ≥3, chronic kidney disease stage ≥4, severe anemia, cardiopulmonary support usage, no dual antiplatelet therapy at discharge, and left ventricular ejection fraction (LVEF) ≤35%. These predictors can help discriminate high-risk patients and provide individualized therapeutic approach in the subacute stage of AMI.
FRONTIERS IN MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew D. Krahn, Jacob Tfelt-Hansen, Rafik Tadros, Christian Steinberg, Christopher Semsarian, Hui-Chen Han
Summary: Inherited arrhythmia syndromes, such as long QT syndrome and Brugada syndrome, are common causes of unexplained cardiac arrest. Less obvious conditions like catecholaminergic polymorphic ventricular tachycardia, short QT syndrome, and early repolarization syndrome may also lead to sudden cardiac death. In cases where extensive testing does not reveal an underlying cause, a diagnosis of idiopathic ventricular fibrillation or short-coupled ventricular fibrillation may be given.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Genetics & Heredity
Luise Mildeberger, Julia Bueto, Verena Wilmes, Stefanie Scheiper-Welling, Constanze Niess, Elise Gradhand, Marcel A. Verhoff, Silke Kauferstein
Summary: Cardiovascular diseases are the leading cause of death worldwide. This study analyzed the potential of different microRNAs (miRNAs) as biomarkers for cardiac death. Blood and tissue samples were collected from myocardial infarction (MI), sudden unexpected death (SUD) and control cases, and the diagnostic power of miR-1, miR-133a, and miR-26a in discriminating different cardiac death causes was assessed.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2023)
Article
Multidisciplinary Sciences
Matthew Halvorsen, Laura Gould, Xiaohan Wang, Gariel Grant, Raquel Moya, Rachel Rabin, Michael J. Ackerman, David J. Tester, Peter T. Lin, John G. Pappas, Matthew T. Maurano, David B. Goldstein, Richard W. Tsien, Orrin Devinsky
Summary: A study found enrichment of unique mutations in genes associated with cardiac and seizure disorders in SUDC patients, suggesting a potential genetic contribution to their death.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)
