Review
Biochemistry & Molecular Biology
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis, Sebastiano Gangemi
Summary: Microbiome dysbiosis and cytokine alternations play crucial roles in the development of atopic dermatitis (AD) and psoriasis (PsO), two highly prevalent and burdensome pruritic skin conditions worldwide. Interleukin (IL)-33 and IL-31 are major drivers in the pathogenesis and maintenance of AD and PsO, and their potential as therapeutic targets is under extensive investigation. The relationship between dysbiosis and immunological changes has been studied extensively, with ongoing debate on the primary causative factor behind AD and PsO. This literature review aims to support the hypothesis that dysbiosis is the origin of IL-33/IL-31 dysregulation in AD and PsO, and discusses current therapeutic options targeting IL-31, IL-33, and/or the microbiome.
Review
Biochemistry & Molecular Biology
Monika Marko, Rafal Pawliczak
Summary: Atopic dermatitis (AD) and psoriasis are inflammatory skin diseases with increasing prevalence worldwide, causing decreased quality of life and socioeconomic burden. Resveratrol and its derivatives, based on natural compounds, show potential therapeutic effects through anti-inflammatory and antioxidant pathways.
Article
Multidisciplinary Sciences
Justine Segaud, Wenjin Yao, Pierre Marschall, Francois Daubeuf, Christine Lehalle, Beatriz German, Pierre Meyer, Pierre Hener, Cecile Hugel, Eric Flatter, Marine Guivarch, Laetitia Clauss, Stefan F. Martin, Mustapha Oulad-Abdelghani, Mei Li
Summary: Allergic sensitisation in the skin can lead to allergic dermatitis and further to airway asthma. This study examines the difference between superficial or deep skin sensitisation, characterises the immune cells generated, and shows differential TSLP and IL-1 beta involvement.
NATURE COMMUNICATIONS
(2022)
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Article
Dermatology
Chloe Grolleau, Andreea Calugareanu, Sarah Demouche, Audrey Nosbaum, Delphine Staumont-Salle, Helene Aubert, Charles Cassius, Marie Jachiet, Anne Saussine, Martine Bagot, Herve Bachelez, Maxime Battistella, Claire Hotz, Aurelie Du Thanh, Marie-Noelle Crepy, David Bergerat, Marine Merandet, Rachel Onifarasoaniaina, Antonio Alberdi, Alexandre How-Kit, Jean-David Bouaziz, Helene Le-Buanec
Summary: Dupilumab, a therapeutic antibody targeting IL-4 and IL-13 receptor subunit alpha, has been used for treating atopic dermatitis (AD). Recent reports have shown cases of psoriasis-like reactions induced by dupilumab treatment for AD. The pathogenesis of dupilumab-induced psoriatic eruption (DI-Pso) involves a shift in skin immune responses from T helper 2 to IL-36 and T helper 17 polarization, as well as intensified skin barrier alterations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yubin Xu, Saizhen Chen, Lingling Zhang, Guirong Chen, Jinguang Chen
Summary: The study indicates that Huanglian Jiedu decoction can treat atopic dermatitis by regulating the antigen presentation function of dendritic cells, weakening T-lymphocyte activation, and subsequently exerting anti-inflammatory and anti-pruritus effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Review
Immunology
Dengmei Xia, Yiyi Wang, Yue Xiao, Wei Li
Summary: Single-cell RNA sequencing (scRNA-seq) is a new technology that characterizes molecular heterogeneity at the single-cell level. It provides a deeper understanding of cell diversity in inflammatory skin diseases and sheds new light on cell-cell communication in disease responses. It holds promise as a tool in precision medicine for defining cell subsets with potential treatment targets and characterizing cell-specific responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jie Yang, Minglu Xiao, Kui Ma, Hongyu Li, Mingzi Ran, Shuxu Yang, Yuguang Yang, Xiaobing Fu, Siming Yang
Summary: This review systematically discusses the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Jocelyn M. Biagini, John W. Kroner, Asel Baatyrbek Kyzy, Alexandra Gonzales, Hua He, Mariana Stevens, Brittany Grashel, Daniel Spagna, Samuel Paul, Rahul Patel, Angelo Bucci, Michael G. Sherenian, Liza Bronner Murrison, Lisa J. Martin, Gurjit K. Khurana Hershey
Summary: This study investigates the atopic march in Black and White children and identifies distinct allergic trajectories in these populations. It reveals that Black children have a higher risk of asthma despite a more intact skin barrier and less sensitization, food allergy, and allergic rhinitis. Conversely, White children have a lower risk of asthma despite a more dysfunctional skin barrier and higher rates of sensitization, food allergy, and allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara
Summary: IL-33 and IL-37 co-regulate the balance between inflammation and anti-inflammation, and are involved in the pathogenesis of inflammatory skin diseases such as AD and psoriasis. AHR-mediated regulation of their expression may offer new therapeutic strategies for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Biochemistry & Molecular Biology
Liis Ilves, Aigar Ottas, Bret Kaldvee, Kristi Abram, Ursel Soomets, Mihkel Zilmer, Viljar Jaks, Kulli Kingo
Summary: This study analyzed the metabolomic profiles of patients with atopic dermatitis (AD) and psoriasis (PS), and found clear differences between the two diseases. AD was associated with a deficient barrier function, while PS was associated with elevated cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Barbara Yang, Hazel Wilkie, Mrinmoy Das, Maheshwor Timilshina, Wayne Bainter, Brian Woods, Michelle Daya, Meher P. Boorgula, Rasika A. Mathias, Peggy Lai, Carter R. Petty, Edie Weller, Hani Harb, Talal A. Chatila, Donald Y. M. Leung, Lisa A. Beck, Eric L. Simpson, Tissa R. Hata, Kathleen C. Barnes, Wanda Phipatanakul, Juan-Manuel Leyva-Castillo, Raif S. Geha
Summary: The IL-4Ra R576 polymorphism is associated with the severity of AD and exacerbates allergic skin inflammation in mice. Both hematopoietic cells and stromal cells contribute to the mutants' exaggerated allergic skin inflammation, as demonstrated by bone marrow radiation chimeras.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
