Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexis Poitrasson-Riviere, Jonathan B. Moody, Jennifer M. Renaud, Tomoe Hagio, Liliana Arida-Moody, Christopher J. Buckley, Mouaz H. Al-Mallah, Brahmajee K. Nallamothu, Richard L. Weinberg, Edward P. Ficaro, Venkatesh L. Murthy
Summary: This study combines MFR and relative perfusion quantification to create an integrated MFR (iMFR) for distinguishing obstructive epicardial coronary artery disease (CAD) from microvascular dysfunction. The results show that iMFR can serve as a powerful predictor for diagnosing obstructive stenosis, and the absence of transient ischemic dilation (TID) can help rule out obstructive and high-risk CAD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Roel S. Driessen, Pepijn A. van Diemen, Pieter G. Raijmakers, Juhani Knuuti, Teemu Maaniitty, S. Richard Underwood, Eike Nagel, Lourens F. H. J. Robbers, Ahmet Demirkiran, Martin B. von Bartheld, Peter M. van de Ven, Leonard Hofstra, G. Aernout Somsen, Igor I. Tulevski, Ronald Boellaard, Albert C. van Rossum, Ibrahim Danad, Paul Knaapen
Summary: The diagnostic performance of non-invasive imaging techniques, including SPECT, PET, and MRI, were compared in patients with prior coronary artery disease. The study found that accuracy in diagnosing significant CAD did not significantly differ among these modalities. However, overall diagnostic performances were discouraging and the additive value of non-invasive imaging in this high-risk population is questionable.
EUROPEAN HEART JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elia von Felten, Dominik C. Benz, Georgios Benetos, Jessica Baehler, Dimitri Patriki, Georgios P. Rampidis, Andreas A. Giannopoulos, Adam Bakula, Christoph Graeni, Aju P. Pazhenkottil, Catherine Gebhard, Tobias A. Fuchs, Philipp A. Kaufmann, Ronny R. Buechel
Summary: Assessing regional quantitative myocardial flow measures through N-13-ammonia PET myocardial perfusion imaging can predict adverse cardiac outcomes and all-cause death in patients with suspected coronary artery disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmed Aljizeeri, Ahmed Ibrahim Ahmed, Mousa Alali Alfaris, Dalia Ahmed, Jabir Farea, Awadelkarim Elneama, Ihab Suliman, Mohsen Alharthi, Amjad Ahmed, Ahmed Alsaileek, Mouaz H. Al-Mallah
Summary: This study investigated the incremental prognostic value of CAC and MFR in patients with suspected CAD, finding that both variables added predictive value beyond traditional clinical and MPI factors. While combining CAC and MFR may have a synergistic effect, this was not demonstrated in the multivariate model of this study.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Yamamoto, Michinobu Nagao, Kiyoe Ando, Risako Nakao, Akiko Sakai, Eri Watanabe, Mitsuru Momose, Kayoko Sato, Kenji Fukushima, Shuji Sakai, Nobuhisa Hagiwara
Summary: This study aimed to investigate the influence of low attenuation plaque (LAP) on myocardial flow reserve (MFR) in patients with coronary artery disease (CAD). The results showed that LAP reduced MFR and was an independent predictor of MFR <2.0.
ACADEMIC RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Lin, Pepijn A. van Diemen, Manish Motwani, Priscilla McElhinney, Yuka Otaki, Donghee Han, Alan Kwan, Evangelos Tzolos, Eyal Klein, Keiichiro Kuronuma, Kajetan Grodecki, Benjamin Shou, Richard Rios, Nipun Manral, Sebastien Cadet, Ibrahim Danad, Roel S. Driessen, Daniel S. Berman, Bjarne L. Norgaard, Piotr J. Slomka, Paul Knaapen, Damini Dey
Summary: This study aimed to evaluate the performance of a machine learning score integrating CCTA-based quantitative plaque features for predicting vessel-specific ischemia and impaired myocardial blood flow. The results showed that this machine learning score performed better in predicting ischemia and impaired myocardial blood flow compared to standard CCTA stenosis evaluation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Anand Upadhyaya, Anita Bhandiwad, Jordan Lang, Justin S. Sadhu, Chadwick Barrs, Sudhir Jain, David L. Brown, Linda R. Peterson, Farrokh Dehdashti, Robert J. Gropler, Thomas Hellmuth Schindler
Summary: This study aimed to explore and characterize alterations in coronary circulatory function in relation to increasing body weight with medically controlled cardiovascular risk factors and metabolically unhealthy obesity. The study found that hyperemic MBF progressively decreased in overweight and obese groups, but increased again in the group of morbidly obese individuals comparable to normal weight, indicating contrasting effects of abdominal versus subcutaneous adipose tissue on coronary circulatory function.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Fatih Tamer, Ozgur Omur
Summary: A 59-year-old man with a history of prostate cancer underwent a radical prostatectomy in 2009. Due to rising PSA levels, he underwent a Ga-68-PSMA PET/CT scan in January 2020, which revealed suspicious uptake in the left cerebellar hemisphere. There was no evidence of distant metastases, except for recurrent malignancy at the prostatectomy site. Further MRI showed a meningioma in the left cerebellopontine angle. Although PSMA uptake initially increased after hormone therapy, partial regression was observed after radiotherapy in the affected region.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Jean Michel Saad, Fares Alahdab, Faisal Nabi, Mouaz H. Al-Mallah
Summary: This study observed that positron emission tomography (PET)-derived myocardial flow reserve (MFR) can predict the future cardiovascular risk among high-risk coronary artery bypass grafting (CABG) patients, especially heart failure. This method can be independent of cardiovascular risk factors and perfusion data.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
K. Lance Gould, Danai Kitkungvan, Nils P. Johnson, Tung Nguyen, Richard Kirkeeide, Linh Bui, Monica B. Patel, Amanda E. Roby, Mohammad Madjid, Hongjian Zhu, Dejian Lai
Summary: This study aimed to explore the relationship between reduced quantitative perfusion parameters and mortality with and without revascularization. It found that severely reduced CFR and stress perfusion incurred increasing size-dependent risks, with severely reduced CFC associated with the highest major adverse cardiac event rate and mortality risk. Small regions of CFCsevere predicted high risk due to border zones at risk around the severe center, and this risk could be reduced by revascularization.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Pepijn A. van Diemen, Ruben W. de Winter, Stefan P. Schumacher, Henk Everaars, Michiel J. Bom, Ruurt A. Jukema, Yvemarie B. Somsen, Pieter G. Raijmakers, Rolf A. Kooistra, Janny Timmer, Teemu Maaniitty, Lourens F. Robbers, Martin B. von Bartheld, Ahmet Demirkiran, Albert C. van Rossum, Johan H. Reiber, Juhani Knuuti, Richard S. Underwood, Eike Nagel, Paul Knaapen, Roel S. Driessen, Ibrahim Danad
Summary: This study compared the diagnostic performance of different imaging techniques in patients with chronic coronary syndrome and documented coronary artery disease. It found that quantitative flow ratio (QFR) performed better than other imaging techniques in detecting hemodynamically significant coronary artery disease.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dehua Lu, Haoyi Zhou, Nan Li, Yanpu Wang, Ting Zhang, Fei Wang, Ning Liu, Hua Zhu, Jinming Zhang, Zhi Yang, Zhaofei Liu
Summary: This study aimed to investigate the use of galectin-targeted radiotracer Ga-68-galectracer for PET imaging of tumor hypoxia and prediction of radiotherapy resistance. Results showed that Ga-68-galectracer achieved high contrast imaging in mouse models and lung cancer patients, outperforming F-18-misonidazole in hypoxia detection. Tumors with high levels of galectin expression detected by Ga-68-galectracer PET exhibited significantly lower response to subsequent radiotherapy compared to those with low galectin expression levels.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Robert J. H. Miller, Donghee Han, Ananya Singh, Konrad Pieszko, Piotr J. Slomka, Heidi Gransar, Rebekah Park, Yuka Otaki, John D. Friedman, Sean Hayes, Louise Thomson, Alan Rozanski, Daniel S. Berman
Summary: This study evaluated the independent prognostic value of myocardial perfusion and coronary artery calcium (CAC) in PET examination for major adverse cardiovascular events (MACE). The findings showed that ischemic total perfusion deficit (TPD) and CAC were associated with increased MACE risk. Combining the assessment of atherosclerosis extent and functional measures improved the prediction of MACE risk.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Signe Miang Jensen, Eva Irene Bossano Prescott, Jawdat Abdulla
Summary: This study conducted a comprehensive systematic literature review and meta-analyses to clarify the prognosis of patients with non-obstructive coronary artery disease (NOCAD) and coronary microvascular disease (CMD) assessed as low coronary flow reserve (CFR) according to imaging modalities and sex difference. It was found that low CFR is associated with a poorer prognosis in patients with NOCAD regardless of sex.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Psychology, Biological
Erick A. Perez Alday, Giulia Da Poian, Oleksiy Levantsevych, Nancy Murrah, Lucy Shallenberger, Mhmtjamil Alkhalaf, Ammer Haffar, Belal Kaseer, Yi-An Ko, Jack Goldberg, Nicholas Smith, Rachel Lampert, J. Douglas Bremner, Gari D. Clifford, Viola Vaccarino, Amit J. Shah
Summary: Post-traumatic stress disorder (PTSD) may be associated with cardiovascular disease (CVD), though the exact mechanisms are unclear. This study examined the physiological changes in real-time associated with PTSD, finding that traumatic reminders can lead to autonomic dysregulation, suggesting a potential causal mechanism for increased CVD risk.
Article
Cardiac & Cardiovascular Systems
Ramez Morcos, Haider Al Taii, Muni Rubens, Anshul Saxena, Venkataraghavan Ramamoorthy, Mohamed Hamed, Amr F. Barakat, Nitin Kulkarni, Houman Khalili, Santiago Garcia, Michael Megaly, Emir Veledar, Stavros Stavrakis
Summary: This study compared the in hospital outcomes of patients receiving catheter ablation (CA), left atrial appendage closure (LAAC), and combination of both treatments on the same day. The results showed that there were no significant differences in major adverse cardiovascular and cerebrovascular events (MACCE) between CA and combination treatment, as well as between LAAC and combination treatment.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Psychology, Biological
Shafa-at Ali Sheikh, Erick A. Perez Alday, Ali Bahrami Rad, Oleksiy Levantsevych, Mhmtjamil Alkhalaf, Majd Soudan, Rami Abdulbaki, Ammer Haffar, Nicholas L. Smith, Jack Goldberg, J. Douglas Bremner, Viola Vaccarino, Omer T. Inan, Gari D. Clifford, Amit J. Shah
Summary: Post-traumatic stress disorder (PTSD) is an independent risk factor for incident heart failure, and impedance cardiography (ICG) can help understand the underlying mechanisms. This study found an association between PTSD and lower contractility metrics (PEP and HI) measured through ICG, indicating a potential risk for heart failure.
Article
Surgery
Md Ashfaq Ahmed, Zhenwei Zhang, Venkataraghavan Ramamoorthy, Anshul Saxena, Muni Rubens, Sandeep Appunni, Peter McGranaghan, Ahmed Hasnain Jalal, Emir Veledar
Summary: This study compared the 30-day readmission rates of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) using a national dataset. The study found that the readmission rates were significantly higher in the LRYGB group compared to the LSG group. Factors such as age, chronic obstructive pulmonary disease, hypertension, bleeding disorders, blood urea nitrogen, SGOT, alkaline phosphatase, hematocrit, and operation time were found to predict readmission rates.
Article
Peripheral Vascular Disease
Shabatun J. Islam, Jeong Hwan Kim, Xiaona Li, Yi-An Ko, Peter Baltrus, Gary F. Mitchell, Ervin R. Fox, Mahasin S. Mujahid, Viola Vaccarino, Tene T. Lewis, Herman A. Taylor, Mario Sims, Arshed A. Quyyumi
Summary: The quality of neighborhood environments is connected to arterial stiffness in Black adults, who experience significant health disparities in cardiovascular disease. Improving social characteristics in neighborhoods is associated with better vascular health among Black adults.
Article
Public, Environmental & Occupational Health
Izraelle I. McKinnon, Dayna A. Johnson, Raphiel J. Murden, Christy L. Erving, Rachel Parker, Miriam E. Van Dyke, Viola Vaccarino, Bianca Booker, Renee H. Moore, Tene T. Lewis
Summary: This study examines the impact of violent racism-related events on sleep quality and finds that direct violent racism-related events are associated with poor sleep quality, while indirect events witnessed via social media do not have a significant impact on sleep quality.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Clinical Neurology
Ehimen C. Aneni, Chukwuemeka U. Osondu, Jeffrin Joseph, Guljana Saeed, Javier Valero-Elizondo, Emir Veledar, Khurram Nasir
Summary: This study reveals the relationship between habitual sleep duration, cardiovascular health (CVH), and their impact on healthcare costs and resource utilization. It shows that individuals with 6-8.9 hours and >= 9 hours of sleep are more likely to achieve optimal goals for diet, physical activity, body mass index, and blood pressure. Compared to those who sleep less than 6 hours, individuals with 6-8.9 hours and >= 9 hours of sleep have lower cardiovascular health risks. Furthermore, individuals with 6 or more hours of sleep have lower healthcare expenditures and reduced likelihood of emergency room visits and hospitalizations.
Article
Cardiac & Cardiovascular Systems
Duygu Islek, Alvaro Alonso, Wayne Rosamond, Cameron S. Guild, Kenneth R. Butler, Mohammed K. Ali, Amita Manatunga, Ashley I. Naimi, Viola Vaccarino
Summary: Black patients have higher rates of fatal coronary heart disease than their White counterparts. Racial differences in out-of-hospital fatal coronary heart disease might explain the increased risk among Black patients. This study examines the racial disparities in in-and out-of-hospital fatal coronary heart disease among participants with no history of heart disease, and explores the potential role of socio-economic status in this association.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Samaah Sullivan, An Young, Mariana Garcia, Zakaria Almuwaqqat, Kasra Moazzami, Muhammad Hammadah, Bruno B. Lima, Yingtian Hu, Mohamad Nour Jajeh, Ayman Alkhoder, Lisa Elon, Tene T. Lewis, Amit J. Shah, Puja K. Mehta, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: Microvascular dysfunction during acute mental stress is an important determinant of major adverse cardiovascular events (MACE), particularly among younger and middle-aged women survivors of a heart attack. In this study, microvascular response to stress and transient endothelial dysfunction were measured using reactive hyperemia index and flow-mediated dilation, respectively. The results showed that worse microvascular response to stress was associated with higher risk of MACE among women, while endothelial dysfunction was related to MACE in both men and women.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, Ernest V. Garcia, C. David Cooke, Mariana Garcia, Amit J. Shah, Lisa Elon, Yi-An Ko, Samaah Sullivan, Jonathon Nye, Marly Van Assen, Carlo De Cecco, Paolo Raggi, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: Microcirculatory dysfunction during psychological stress may result in diffuse myocardial ischemia. A novel quantification method for diffuse ischemia during mental stress (dMSI) was developed and its relationship with outcomes after a myocardial infarction (MI) was examined. The study found that higher levels of dMSI were associated with an increased risk of adverse events, particularly in women.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Psychiatry
Alexis K. Okoh, An Young, Mariana Garcia, Samaah Sullivan, Zakaria Almuwaqqat, Yingtian Hu, Chang Liu, Kasra Moazzami, Irina Uphoff, Bruno B. Lima, Yi-An Ko, Lisa Elon, Nour Jajeh, Pratik Rout, Shishir Gupta, Amit J. Shah, J. Douglas Bremner, Tene Lewis, Arshed Quyyumi, Viola Vaccarino
Summary: This study aimed to investigate differences in transient endothelial dysfunction (TED) with mental stress in Black and non-Black individuals with coronary heart disease (CHD), and their potential impact on cardiovascular outcomes. The results showed that Black patients had lower prestress endothelial dysfunction and a higher occurrence of TED with mental stress compared to non-Black patients. TED with mental stress explained a substantial portion of the excess risk of adverse cardiovascular events in Black individuals.
PSYCHOSOMATIC MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kasra Moazzami, Mariana Garcia, Samaah Sullivan, Tene T. Lewis, J. Douglas Bremner, Alexander C. Razavi, Lucy Shallenberger, Yan V. Sun, Paolo Raggi, Amit J. Shah, Arshed A. Quyyumi, Viola Vaccarino
Summary: Among patients with a history of myocardial infarction, a higher level of psychosocial distress is associated with mental stress-induced myocardial ischemia but not with ischemia induced by a conventional stress test.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Zakaria Almuwaqqat, Ernest V. Garcia, C. David Cooke, Amit J. Shah, Jonathon Nye, Samaah Sullivan, Carlo Nicola De Cecco, Marly Van Assen, Arshed A. Quyyumi, Viola Vaccarino
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Maggie Wang, Chang Liu, Anish Shah, Yi-An Ko, Yan Sun, Rachel J. Lampert, Mariana Garcia, Kasra Moazzami, Zakaria Almuwaqqat, Laura Ward, Samaah Sullivan, Paolo Raggi, Doug Bremner, Arshed A. Quyyumi, Viola Vaccarino, Alanna A. Morris, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Anish Shah, Viola Vaccarino, Yi-An Ko, Zakaria Almuwaqqat, Mariana Garcia, Kasra Moazzami, Maggie Wang, Oleksiy Levantsevych, an Young, Laura Ward, Jonathon Nye, Paolo Raggi, David S. Sheps, Rachel J. Lampert, Doug Bremner, Ernest V. Garcia, Arshed A. Quyyumi, Amit J. Shah
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)