Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Badr Abdulmohsin Alsayed, Javed Iqbal Wani, Muffarah Hamid Alharthi, Abdullah M. AL-Shahrani
Summary: The study indicated that ACE-DD genotype and D allele were strongly associated with increased COVID-19 patient severity. Additionally, ACE I/D polymorphism were strongly associated with advanced age, diabetes and ischemic heart disease in COVID-19 patients, while ACE-II genotype was a protective factor against the development of severe COVID-19. ACE2-DD genotype was strongly associated with increased COVID-19 mortality. Moreover, ACE2-CC and CT genotypes were strongly associated with COVID-19 severity. Therefore, the study may help identify susceptible population groups for targeted interventions and public health policy decisions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai
Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Jianhui Du, Jianhua Lan, Hai Yang, Qiao Ying, Guohua Huang, Jian Mou, Jia Long, Zhenghua Qiao, Qiyi Hu
Summary: This meta-analysis reveals that the ACE I/D locus polymorphism is associated with the risk of prostate cancer. The D allele, DD+DI genotype, and DD at the ACE I/D locus are found to increase susceptibility to prostate cancer, suggesting their potential as diagnostic and screening molecular markers for prostate cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Peripheral Vascular Disease
Martina Chiriaco, Domenico Trico, Simone Leonetti, John R. Petrie, Beverley Balkau, Kurt Hojlund, Zoltan Pataky, Peter M. Nilsson, Andrea Natali
Summary: The relationship between adiposity and blood pressure is influenced by sex and ACE genotype, with a stronger effect observed in women and individuals carrying the II variant of the ACE gene.
Article
Clinical Neurology
Addisu Melake, Nega Brhanie
Summary: This study investigates the impact of the ACE gene I/D polymorphism on the risk of ischemic stroke in patients with hypertension. The results show that the ACE-DD genotype and the D allele are significantly more common in hypertensive patients, indicating that they are risk factors for the development of ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Virology
Anna Papadopoulou, Paraskevi C. Fragkou, Eirini Maratou, Dimitra Dimopoulou, Antonis Kominakis, Ioanna Kokkinopoulou, Christos Kroupis, Athina Nikolaidou, Georgios Antonakos, Vasiliki Papaevangelou, Apostolos Armaganidis, Argirios Tsantes, Eftychia Polyzogopoulou, Sotirios Tsiodras, Anastasia Antoniadou, Paraskevi Moutsatsou
Summary: Accumulated data suggests a role of the renin-angiotensin system in COVID-19 pathogenesis, with the ACE insertion/deletion polymorphism potentially increasing the risk for severe disease. A retrospective study found that COVID-19 patients with the DD genotype and D allele carriers had a higher risk of developing severe disease, associated with lower ACE activity. This highlights the need for further research on ACE genotype-based therapies in COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Clinical Neurology
Cindy W. Yoon, Jonguk Kim, Young Ju Suh, Byeong C. Kim, Young Chul Youn, Jee Hyang Jeong, Hyun Jeong Han, Seong Hye Choi
Summary: This study examined the relationship between the ACE insertion/deletion polymorphism and changes in cerebral microbleeds (CMBs) over a 2-year period. The results indicated that individuals with the ACE DD genotype experienced a greater progression of CMBs compared to those with the combined II/ID genotypes, particularly in lobar CMBs. Further studies with larger sample sizes are necessary to confirm this association.
FRONTIERS IN NEUROLOGY
(2023)
Review
Genetics & Heredity
Manabesh Nath, Shubham Misra, Pumanshi Talwar, Deepti Vibha, Achal Kumar Srivastava, Kameshwar Prasad, Pradeep Kumar
Summary: The meta-analysis suggests a significant association between ACE I/D polymorphism and the risk of hemorrhagic stroke, especially in Asian population. This genetic factor may serve as a potential biomarker for susceptibility to hemorrhagic stroke.
Article
Biochemistry & Molecular Biology
Sergej Nadalin, Sanja Devic Pavlic, Vjekoslav Peitl, Dalibor Karlovic, Lena Zatkovic, Smiljana Ristic, Alena Buretic-Tomljanovic, Hrvoje Jakovac
Summary: We investigated the impact of a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) on antipsychotic treatment. The results showed that the ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology, with a weak gender-specific effect and no association with metabolic-syndrome-related parameters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Babak Hadian, Azita Zafarmohtashami, Zeinab Chaghervand, Negar Nouryazdan
Summary: The study investigated the correlation between ACE (I/D) polymorphism and essential hypertension by analyzing the distribution of ACE genotypes and found that individuals with the II genotype have an increased risk of developing the condition. Further research with larger sample sizes is recommended to better understand genetic factors in hypertensive patients.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Elham Ghorbani, Mahsa Mohammadi, Seyed Kazem Malakouti, Hamed Mohammadi-Kangarani, Elaheh Abdollahi, Mansour Torab, Parvaneh Rahimi-Moghaddam
Summary: The deregulation of the renin-angiotensin system (RAS) is believed to play a significant role in suicide, with the ACE gene insertion/deletion (I/D) polymorphism potentially influencing the risk. The study in an Iranian population found a significant association between the DD genotype of ACE I/D polymorphism and suicide attempts, with a potential link to the severity of depression symptoms.
BIOCHEMICAL GENETICS
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study is the first to find an independent association between the ACE D allele and increased risk of LLA, mainly minor amputations, in patients with type 1 diabetes.
Article
Endocrinology & Metabolism
Kamel Mohammedi, Yawa Abouleka, Charlyne Carpentier, Louis Potier, Severine Dubois, Ninon Foussard, Vincent Rigalleau, Jean-Francois Gautier, Pierre Gourdy, Guillaume Charpentier, Ronan Roussel, Andre Scheen, Bernard Bauduceau, Samy Hadjadj, Francois Alhenc-Gelas, Michel Marre, Gilberto Velho
Summary: This study identified a potential association between the ACE gene's D allele and plasma ACE concentration with increased risk of lower-limb amputation in patients with type 1 diabetes, particularly minor amputations.
Letter
Critical Care Medicine
Georgios D. Kitsios, Alison Morris, Bryan J. McVerry
INTENSIVE CARE MEDICINE
(2016)
Article
Critical Care Medicine
Georgios D. Kitsios, Michael J. Morowitz, Robert P. Dickson, Gary B. Huffnagle, Bryan J. McVerry, Alison Morris
JOURNAL OF CRITICAL CARE
(2017)
Letter
Respiratory System
Georgios D. Kitsios, Mauricio Rojas, Daniel J. Kass, Adam Fitch, John C. Sembrat, Shulin Qin, Kristen L. Veraldi, Kevin F. Gibson, Kathleen Lindell, Joseph M. Pilewski, Barbara Methe, Kelvin Li, John McDyer, Bryan J. McVerry, Alison Morris
Editorial Material
Critical Care Medicine
Georgios D. Kitsios, Bryan J. McVerry
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Microbiology
Georgios D. Kitsios, Adam Fitch, Dimitris V. Manatakis, Sarah F. Rapport, Kelvin Li, Shulin Qin, Joseph Huwe, Yingze Zhang, Yohei Doi, John Evankovich, William Bain, Janet S. Lee, Barbara Methe, Panayiotis V. Benos, Alison Morris, Bryan J. McVerry
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Microbiology
Georgios D. Kitsios
Article
Nutrition & Dietetics
Faraaz Ali Shah, Georgios D. Kitsios, Yingze Zhang, Alison Morris, Sachin Yende, David T. Huang, Christopher P. O'Donnell, Bryan J. McVerry
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2020)
Article
Microbiology
Katherine Fair, Daniel G. Dunlap, Adam Fitch, Tatiana Bogdanovich, Barbara Methe, Alison Morris, Bryan J. McVerry, Georgios D. Kitsios
Article
Critical Care Medicine
Georgios D. Kitsios, Libing Yang, Dimitris V. Manatakis, Mehdi Nouraie, John Evankovich, William Bain, Daniel G. Dunlap, Faraaz Shah, Ian J. Barbash, Sarah F. Rapport, Yingze Zhang, Rebecca S. DeSensi, Nathaniel M. Weathington, Bill B. Chen, Prabir Ray, Rama K. Mallampalli, Panayiotis V. Benos, Janet S. Lee, Alison Morris, Bryan J. McVerry
CRITICAL CARE MEDICINE
(2019)
Article
Respiratory System
Yandong Lai, Xiuying Li, Tiao Li, Xiaoyun Li, Toru Nyunoya, Kong Chen, Georgios Kitsios, Mehdi Nouraie, Yingze Zhang, Bryan J. McVerry, Janet S. Lee, Rama K. Mallmapalli, Chunbin Zou
Summary: This study found that PRMT4 is elevated in septic patients and experimental sepsis. Enhanced PRMT4 plays a key role in lymphocyte apoptosis, while it has no effect on monocytes. Inhibition of PRMT4 can attenuate lymphocyte death.
Article
Respiratory System
William Bain, Mohammadreza Tabary, Sara R. Moore, Xiaojing An, Georgios D. Kitsios, Bryan J. McVerry, Prabir Ray, Anuradha Ray, Rama K. Mallampalli, Viviana P. Ferreira, Janet S. Lee, S. Mehdi Nouraie
Summary: Preserved factor H levels are associated with decreased complement activation and reduced mortality in acute respiratory distress syndrome (ARDS). Relative deficiency of factor B or factor H is associated with increased mortality and impaired alternative pathway function. Therapeutic targeting of complement factor exhaustion may improve outcomes in a subset of ARDS patients.
Letter
Respiratory System
Georgios D. Kitsios, Seyed Mehdi Nouraie, Shulin Qin, Yingze Zhang, Prabir Ray, Anuradha Ray, Janet S. Lee, Alison Morris, Bryan J. McVerry, William Bain
Letter
Respiratory System
Georgios D. Kitsios, William Bain, Nameer Al-Yousif, Radha Duttagupta, Asim A. Ahmed, Bryan J. McVerry, Alison Morris
RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Libing Yang, Ghady Haidar, Haris Zia, Rachel Nettles, Shulin Qin, Xiaohong Wang, Faraaz Shah, Sarah F. Rapport, Themoula Charalampous, Barbara Methe, Adam Fitch, Alison Morris, Bryan J. McVerry, Justin O'Grady, Georgios D. Kitsios
RESPIRATORY RESEARCH
(2019)
Article
Medicine, General & Internal
Daniel G. Dunlap, Christopher W. Marshall, Adam Fitch, Sarah F. Rapport, Vaughn S. Cooper, Bryan J. McVerry, Alison Morris, Georgios D. Kitsios
AMERICAN JOURNAL OF CASE REPORTS
(2018)