Article
Biochemistry & Molecular Biology
Yuexiang Li, Yunfeng Ma, Jianan Yu, Cancan Li, Da Yu, Ruoxi Dai, Quanli Li, Chris Ying Cao
Summary: Researchers developed a dual functional polypeptide LL37-C15 with antibacterial and anti-inflammatory properties, which can effectively treat periodontitis. The polypeptide selectively destroys bacterial cell membrane and protects animal cell membrane. This study provides a promising new approach for periodontitis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Rima Erviana, Yutthakan Saengkun, Prapenpuksiri Rungsa, Nisachon Jangpromma, Patcharaporn Tippayawat, Sompong Klaynongsruang, Jureerut Daduang, Sakda Daduang
Summary: The rising prevalence of antimicrobial resistance is a severe health issue. The invention of new antimicrobial agents, such as antimicrobial peptides like Heteroscorpine-1, shows promise in combating bacterial strains. Mutants of CeHS-1 have potential to be developed as novel antimicrobial peptides with increased efficacy and reduced toxicity.
Article
Microbiology
Clemens Moeller, Lena Heinbockel, Patrick Garidel, Thomas Gutsmann, Karl Mauss, Gunther Weindl, Satoshi Fukuoka, Dominik Loser, Timm Danker, Klaus Brandenburg
Summary: This study analyzed the toxic behavior of Aspidasept and Aspidasept II and their part structures in various cellular models, as well as conducting electrophysiological experiments targeting the hERG channel and experiments on mouse neurobehavior and local lymph nodes. The data provided conclusive information about the potential toxic effects of these peptides, specifying a therapeutic window for their clinical application.
Article
Entomology
Lizhen Guo, Min Tang, Shiqi Luo, Xin Zhou
Summary: In this study, a class of antimicrobial peptides (AMPs) called Cecropin was identified from insect transcriptomes using bioinformatics. The identified Cecropin genes were found in several insects and their antimicrobial activity against bacteria was validated. This study provides a reliable analytical method for the discovery of AMPs, which have promising applications in diverse fields.
Article
Entomology
Kangkang Chen, Shiqi Lu, Jiahui Song, Xiaoyi Dou, Xiangyi Wei, Xinyan Wang, Xu Liu, Congjing Feng
Summary: This study investigates the role of MMP14 in immune responses and antimicrobial activity in Ostrinia furnacalis larvae. The knockdown of MMP14 in the larvae reduces phenoloxidase (PO) activity and Cecropin expression, while enhancing the expressions of Lysozyme, Attacin, Gloverin, and Moricin. The knockdown of MMP14 also decreases larvae survival to bacterial infections.
Article
Pharmacology & Pharmacy
Hyeju Lee, Byeongkwon Kim, Minju Kim, Seoyeong Yoo, Jinkyeong Lee, Eunha Hwang, Yangmee Kim
Summary: The antimicrobial peptide T. ni cecropin demonstrated significant antibacterial and antibiofilm activities against colistin-resistant Escherichia coli. It targeted the outer membrane of E. coli and interacted strongly with lipopolysaccharide. Additionally, T. ni cecropin showed anti-inflammatory and anti-septic effects, suggesting its potential as a therapeutic agent.
Article
Biochemistry & Molecular Biology
Chih-Lung Wu, Ya-Han Chih, Hsin-Ying Hsieh, Kuang-Li Peng, Yi-Zong Lee, Bak-Sau Yip, Shih-Che Sue, Jya-Wei Cheng
Summary: Cecropins, a type of antimicrobial peptides found in the innate immune system of Cecropia moths, exhibit broad-spectrum antimicrobial and anticancer activities. This study developed a strategy to produce recombinant KR12AGPWR6 with enhanced antimicrobial properties through a self-cleavage system. The results showed that the recombinant KR12AGPWR6 exhibited similar antimicrobial activities compared to the chemically synthesized peptide. This method provides a potential strategy for large-scale production of AMPs.
Article
Immunology
Min Kyoung Shin, Byungjo Lee, Seung Tae Kim, Jung Sun Yoo, Jung-Suk Sung
Summary: This study presents a new approach to develop therapeutic agents with antimicrobial and anti-inflammatory properties by designing functional peptides based on biological resources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisco Ramos-Martin, Claudia Herrera-Leon, Nicola D'Amelio
Summary: Cecropin A and Cecropin XJ are antimicrobial peptides with activity against esophageal cancer cells. They exhibit different structural adaptations when interacting with DPC micelles, with CecA forming a three-helix bundle for enhanced adaptability. Specific interactions with different lipid bilayers may account for their selective targeting of cancer, bacterial, and mitochondrial membranes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Xiaolong Lin, Tao Fu, Yuqing Lei, Jiajia Xu, Sa Wang, Fuming He, Zhijian Xie, Ling Zhang
Summary: This study developed a new antibacterial hydrogel with excellent antimicrobial activity, histocompatibility, and wound healing potential. The hydrogel released antibacterial peptides to inhibit bacterial biofilm formation and regulate inflammatory responses, as well as promote angiogenesis, thereby aiding in the rapid healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Maolin Tian, Junfang Liu, Jinwei Chai, Jiena Wu, Xueqing Xu
Summary: Brevinin-2MP is a novel antimicrobial peptide with anti-inflammatory properties that can destroy bacterial cell membranes and inhibit the expression of inflammatory mediators induced by LPS. It has been shown to alleviate acute inflammatory responses and could be a promising candidate for the treatment of bacterial inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Runzhe Wu, Xunxi Dong, Qiang Wang, Zirui Zhang, Jianhua Wang, Xiao Wang
Summary: The study synthesized D1018M and D1018 peptides with improved activity and found that they exhibited enhanced resistance against proteases; D1018M showed slightly increased antimicrobial activity, and these peptides had low cytotoxicity, strong inhibitory effects on E. coli, and excellent inhibition capacity against LPS-induced proinflammation response.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jinqiao Li, Yan Liang, Minhong Su, Jiena Wu, Jinwei Chai, Weichen Xiong, Guoxiang Mo, Xin Chen, Xueqing Xu
Summary: In this study, a novel Temporin peptide, named Temporin-FL, was found in the skin of Fejervarya limnocharis frog. Temporin-FL showed selective antibacterial activity against Gram-positive bacteria through a membrane destruction mechanism. It also demonstrated protective effects against Staphylococcus aureus-induced sepsis and exhibited anti-inflammatory effects by neutralizing the action of LPS/LTA and inhibiting MAPK pathway activation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Andrew A. Walker, Samuel D. Robinson, Jean-Paul Paluzzi, David J. Merritt, Samantha A. Nixon, Christina Schroeder, Jiayi Jin, Mohaddeseh Hedayati Goudarzi, Andrew C. Kotze, Zoltan Dekan, Andy Sombke, Paul F. Alewood, Bryan G. Fry, Marc E. Epstein, Irina Vetter, Glenn F. King
Summary: The study reveals that the limacodid caterpillar, Doratifera vulnerans, produces a complex venom containing 151 proteinaceous toxins, most of which are peptides <10 kDa. Three families of venom peptides seem to be responsible for inducing pain in mammals. The findings suggest that lepidopteran venoms are a potential source of novel bioactive peptides.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Infectious Diseases
Hyosuk Son, Seong-Cheol Park, Young-Min Kim, Jong-Kook Lee, Soyoung Park, Taeuk Guk, A-Mi Yoon, Hye Song Lim, Mi-Kyeong Jang, Jung Ro Lee
Summary: This study investigated the anti-inflammatory potential of 10 designed XI(W)K (X: lysine, arginine, or glutamic acid) alpha-helical peptides in macrophages and a mouse model against endotoxin. WIKE-14 peptide, with a helix-to-helix structure and glutamic acid substitution at the 12th amino acid, suppressed pro-inflammatory cytokines in macrophages by inhibiting the binding between LPS and macrophages. WIKE-14 peptide also exhibited potent anti-inflammatory activity in a mouse model of inflammation in the ears and lungs induced by LPS.