Article
Oncology
Yan Liu, Jun Wei, Chao Wang, Zihui Meng, Duqiang Luo, Xiaoling Zhao, Ruizhi Hou
Summary: The study found that microRNA-543 is downregulated in PC, while LINC00847 and STK31 are upregulated. MicroRNA-543 functions as a tumor suppressor through the LINC00847/microRNA-543/STK31 axis in PC.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jianing Yang, Joel E. E. Barkley, Bikash Bhattarai, Kameron Firouzi, Bradley J. J. Monk, Dean V. V. Coonrod, Frederic Zenhausern
Summary: The study aimed to develop a method to detect EC-specific microRNA biomarkers from liquid biopsy samples for early diagnosis of endometrial cancer. A total of 82 endometrial fluid samples were collected and processed in two phases. Fourteen microRNA biomarkers with significant expression variation were selected for validation in the second phase. The research demonstrated the feasibility of collecting and detecting miRNA from endometrial fluid, but further validation with a larger set of clinical samples is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alexandros G. Sykaras, Konstantinos Christofidis, Ekaterini Politi, Stamatios Theocharis
Summary: Endometrial cancer (EC) is a major cause of cancer-related death among women, with increasing incidence and unchanged survival rates. Understanding the pathogenesis of EC is critical for developing new diagnostic and therapeutic approaches. Exosomes have emerged as valuable sources of biomarkers in EC, serving as shuttles for biomolecule transfer between cells. These biomolecules play crucial roles in cancer pathogenesis, progression, and regulation of tumor cells, making them attractive therapeutic targets. This review focuses on the functions of exosomes in EC, particularly their potential as diagnostic and prognostic biomarkers or therapeutic vectors.
Article
Genetics & Heredity
Junhui Liang, Wenjing Sun, Hui Song, Chong Wang, Qianqian Li, Chunyan Li, Deying Wei, Yingzi Zhao, Changzhong Li, Hui Zhang
Summary: The study confirmed the involvement of NOL6 in endometrial cancer and showed that NOL6 can boost the growth and spread of cancer cells by controlling TWIST1 expression. This research provides new insights into the molecular mechanisms underlying endometrial cancer.
Article
Neurosciences
Jin-Gang He, Hai-Yun Zhou, Shi-Ge Xue, Jia-Jing Lu, Jun-Feng Xu, Bin Zhou, Zhuang-Li Hu, Peng-Fei Wu, Li-Hong Long, Lan Ni, You Jin, Fang Wang, Jian-Guo Chen
Summary: The study found that the expression of TWIST1 in the brain is positively correlated with depressive behaviors, chronic stress can elevate TWIST1 expression in the medial prefrontal cortex of mice which can be reversed by fluoxetine treatment. Overexpression of TWIST1 increases susceptibility to stress, while knockdown of TWIST1 prevents defective dendrite morphogenesis in mice and alleviates depressive-like behaviors. The prodepressant property of TWIST1 is mediated by the repression of miR-214-PPAR-delta signaling and mitochondrial function, which can be mimicked by genetic and pharmacological inhibition of PPAR-delta.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Oncology
Fahime Jahanbakhshi, Parisa Maleki Dana, Bita Badehnoosh, Bahman Yousefi, Mohammad Ali Mansournia, Moghadeseh Jahanshahi, Zatollah Asemi, Jamal Halajzadeh
Summary: Curcumin extracted from turmeric is a safe agent with various properties for treating diseases. The incidence of endometrial cancer is increasing, requiring the discovery of new approaches for better care.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Sichao Liu, Min Wang, Xianglin Lv, Jing Zhou, Le Gao
Summary: In this study, researchers investigated the role of circCCL22, a type of circular RNA, in the progression of endometrial cancer (EC). They found that circCCL22 is highly upregulated in EC tissues and cells, and its knockdown inhibits EC cell proliferation, migration, and invasion. Mechanistically, circCCL22 acts as a sponge for miR-543 to regulate the expression of its targeted gene CDC25A in EC cells. These findings suggest that circCCL22 could be a potential therapeutic target for EC.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Yanni Zhang, Pan Ge, Dangxia Zhou, Rong Xing, Lizhi Bai
Summary: This study reveals that circRNA-FOXO3 promotes DDP sensitivity in NSCLC cells by regulating the miR-543/Foxo3 axis-mediated glycolysis balance. Inhibition of miR-543 can increase sensitivity of NSCLC cells to DDP, and overexpression of miR-543 partially reverses the decrease in chemoresistance induced by circRNA-FOXO3.
Article
Oncology
Xiaowen Zhang, Nan Wu, Jin Wang
Summary: The newly discovered circular RNA hsa-circ_0058106 is upregulated in laryngeal cancer and is associated with lymph node metastasis and advanced clinical stages. Silencing hsa-circ_0058106 inhibits migration and invasion of laryngeal cancer cells, and suppresses epithelial-mesenchymal transition (EMT). Mechanistically, hsa-circ_0058106 sponges miR-153 to regulate Snail1 expression and blocks the nuclear translocation of Twist1.
Article
Oncology
Yibing Li, Jianing Huo, Junjian He, Xiaoxin Ma
Summary: This study found that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis. The MONC/miR-636/GLCE axis may provide novel treatment avenues for human EC. The tumor suppressive effect of MONC in nude mice was also verified in this study, with miR-636 rescuing the effect of overexpressing MONC.
CANCER CELL INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Emma J. Crosbie, Sarah J. Kitson, Jessica N. McAlpine, Asima Mukhopadhyay, Melanie E. Powell, Naveena Singh
Summary: Endometrial cancer is the most common gynaecological cancer in high income countries, with a global rise in incidence. Obesity is the major underlying cause, posing challenges for diagnosis and treatment. Early presentation with postmenopausal bleeding ensures cure, but advanced cases have poor prognosis. Minimally invasive surgical staging and targeted chemotherapeutic strategies are important advances.
Review
Oncology
Antonija Hanzek, Christian Siatka, Anne-Cecile E. Duc
Summary: This manuscript provides an overview on the origin, analysis, and clinical significance of urine microRNAs in gynecological cancers, focusing on ovarian and endometrial cancer. MicroRNAs, as non-invasive biomarkers, show great potential due to their feasibility and stability in body fluids. Specific miRNA expression signatures have been identified in ovarian and endometrial cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Peripheral Vascular Disease
Tomoyasu Otsuki, Noboru Fukuda, Lan Chen, Takahiro Ueno, Masari Otsuki, Masanori Abe
Summary: This study demonstrates that upregulation of TWIST1 in GMCs from SHRs leads to increased expression of the C3 gene, potentially contributing to the synthetic phenotype of mesenchymal tissue in hypertension.
HYPERTENSION RESEARCH
(2022)
Article
Health Care Sciences & Services
Leyi Ni, Chengyun Tang, Yuning Wang, Jiaming Wan, Morgan G. Charles, Zilong Zhang, Chen Li, Ruijie Zeng, Yiyao Jin, Penghao Song, Ming Wei, Bocen Li, Jin Zhang, Zhenghao Wu
Summary: This study investigated the differential expression of microRNA (miRNA) in patients with endometrial cancer and found that 12 significantly differentially expressed miRNAs may be associated with the prognosis of patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yunfeng Song, Lei Ye, Yuan Tan, Huan Tong, Zeheng Lv, Xiaoping Wan, Yiran Li
Summary: This study found that the level of exosomal SERPINA5 was increased in the plasma of EC patients, while the expression of SERPINA5 in EC patients was decreased and low expression of SERPINA5 indicated worse survival outcomes. Moreover, overexpression of SERPINA5 or high exosomal SERPINA5 levels suppressed the metastatic potential of EC cells by suppressing the activation of the integrin beta 1/FAK signaling pathway. Exosomal SERPINA5 also inhibited tumor growth and metastasis.
