Review
Medicine, General & Internal
Pawel Dybciak, Dorota Raczkiewicz, Ewa Humeniuk, Tomasz Powrozek, Mariusz Gujski, Teresa Malecka-Massalska, Artur Wdowiak, Iwona Bojar
Summary: This meta-analysis utilized research utilizing the Hospital Anxiety and Depression Scale (HADS) to determine the prevalence, mean level, standardized mean difference, and probability of depression in patients with PCOS. The results indicate an increased risk of depressive symptoms in women with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Huamin Zeng, Ying Zhang, Sikai Huang, Jinghua Wu, Wenrui Ren, Lingru Zhou, Leneng Huang, Yuyin Ye
Summary: Metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels in PCOS patients. However, it does not have a significant effect on hirsutism score or gonadotropin hormone levels, and is not associated with an elevation in side-effects. When the treatment course is greater than 6 months, combination therapy can effectively reduce FBG and improve insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Jeffrey Pea, Jahnay Bryan, Cynthia Wan, Alexis L. Oldfield, Kiran Ganga, Faith E. Carter, Lynn M. Johnson, Marla E. Lujan
Summary: This systematic review and diagnostic meta-analysis examined the diagnostic accuracy of ultrasonographic features of ovarian morphology in the diagnosis of PCOS. The results showed that follicle number per ovary (FNPO) was the most accurate diagnostic marker in adult women. Ovarian volume (OV) and follicle number per single cross-section (FNPS) had similar sensitivities to FNPO but lower specificities and accuracies. In adolescents, ovarian volume may be a reliable ultrasonographic marker for PCOS diagnosis, although current evidence is limited.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Food Science & Technology
Yuling Li, Yong Tan, Guicheng Xia, Jiaqi Shuai
Summary: This meta-analysis summarizes the effects of probiotics, prebiotics, and synbiotics on polycystic ovary syndrome (PCOS). The results show that intake of these supplements can decrease insulin resistance, improve lipid profiles, and have limited effects on anthropometric indices.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Endocrinology & Metabolism
Xiaojie Hu, Yuquan Chen, Yiting Shen, Siyuan Zhou, Wenting Fei, Yuxin Yang, Huafa Que
Summary: Research shows that there is an increased risk of developing Hashimoto's thyroiditis (HT) for patients with polycystic ovary syndrome (PCOS), and vice versa. The prevalence of HT in PCOS patients is higher in India and Turkey, while it is higher in South America for PCOS patients compared to Asia and Europe.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Dan Shan, Jinbiao Han, Yitong Cai, Li Zou, Liangzhi Xu, Yongchun Shen
Summary: This study aimed to explore the reproductive health of first-degree relatives (FDRs) of patients with polycystic ovary syndrome (PCOS). The findings indicated that female PCOS FDRs have a higher prevalence of menstrual irregularities, ovarian morphological changes, and elevated levels of certain hormones. Additionally, fathers of PCOS patients exhibited a higher risk of premature baldness, and male FDRs had elevated levels of specific hormones. These results suggest that FDRs of PCOS patients experience reproductive endocrinological dysregulations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar, Zhengwei Wan
Summary: This study conducted a systematic review and meta-analysis, and found that gut dysbiosis in PCOS is characterized by decreased diversity and alterations in specific bacteria. The imbalance in gut microbiota may lead to a pro-inflammatory environment due to a reduction in short-chain fatty acid (SCFA)-producing and bile-acid-metabolizing bacteria. These findings provide important insights for further understanding the pathogenesis and treatment of PCOS.
Review
Obstetrics & Gynecology
Alberto Sola-Leyva, Inmaculada Perez-Prieto, Nerea M. Molina, Eva Vargas, Susana Ruiz-Duran, Irene Leones-Banos, Analuce Canha-Gouveia, Signe Altmae
Summary: Recent evidence suggests a link between microbial composition and polycystic ovary syndrome (PCOS), but the results are inconsistent. This systematic review aimed to gather current knowledge on microbes in different body sites of women with PCOS and analyze their diversity. The findings suggest that women with PCOS have lower microbial diversity in the gut, which may contribute to the development of PCOS. However, future studies should address the limitations of current research by using larger sample sizes, proper controls, and better study design.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Multidisciplinary Sciences
Mohd Falihin Mohd Shukri, Mohd Noor Norhayati, Salziyan Badrin, Azidah Abdul Kadir
Summary: LC supplementation has a certain effectiveness in the treatment of patients with PCOS, improving body mass index and lipid levels.
Review
Obstetrics & Gynecology
Leyi Fu, Ningning Xie, Fan Qu, Jue Zhou, Fangfang Wang
Summary: This study conducted a systematic review and meta-analysis to investigate the association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS) in adolescents. The results showed that adolescents with PCOS were more than three times as likely to have MetS compared to controls. Obese adolescents with PCOS also had a higher risk of MetS compared to those with obesity but without PCOS. Blood pressure and lipid metabolism were found to be affected in adolescents with PCOS, indicating that PCOS could increase the frequency of MetS by influencing these factors independent of obesity.
REPRODUCTIVE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Yujie Shang, Huifang Zhou, Ruohan He, Wentian Lu
Summary: This study found that diet is significantly related to improved fertility outcomes, reproductive endocrine, and clinical hyperandrogenism in women with PCOS. Low-carbohydrate diets were more effective in optimizing reproductive outcomes, while calorie restriction was critical in ameliorating hyperandrogenism. The positive effects were associated with the treatment duration, with longer duration leading to greater improvement.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Wenwen Yue, Xin Huang, Wenjing Zhang, Shumin Li, Xu Liu, Yian Zhao, Jiaxin Shu, Teng Liu, Weihua Li, Shaozhuang Liu
Summary: This study aimed to evaluate the therapeutic effects of metabolic surgery on obese patients with PCOS. The results showed that metabolic surgery significantly improved clinical symptoms and reproductive outcomes in patients with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Jiacheng Zhang, Haolin Zhang, Xiyan Xin, Yutian Zhu, Yang Ye, Dong Li
Summary: Flavonoids have positive effects on ovarian histomorphology and hormonal status in animal models of PCOS, but more high-quality clinical trials and further experimental studies are needed to elucidate the underlying mechanisms.
Review
Psychology, Multidisciplinary
Rong Tang, Junlan Yang, Yanmei Yu, Yuying Fang
Summary: The meta-analysis showed that CBT demonstrated significant advantages in alleviating anxiety, improving quality of life in hirsutism patients, and increasing compliance and pregnancy rate.
FRONTIERS IN PSYCHOLOGY
(2022)
