Article
Obstetrics & Gynecology
Liisa Verho, Minna Tikkanen, Outi Ayras, Karoliina Aarnio, Kirsi Rantanen, Aino Korhonen, Anna Richardt, Hannele Laivuori, Mika Gissler, Petra Ijas
Summary: This study aims to compare the outcomes of subsequent pregnancies between women with a previous pregnancy-associated stroke (PAS) and matched controls. The results show that women with a previous PAS are more likely to experience hypertensive disorders of pregnancy and any diabetes during pregnancy in their subsequent pregnancies, and the risk of PAS recurrence is considerable.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Behavioral Sciences
Yunyun Xiong, Shang Wang, Zixiao Li, Marc Fisher, Liyuan Wang, Yong Jiang, Xinying Huang, Xing-Quan Zhao, Xia Meng, Yongjun Wang
Summary: A pooled analysis of three consecutive national cohorts in China over 13 years found that the predictive ability of the Stroke Prognosis Instrument-II (SPI-II) and Essen Stroke Risk Score (ESRS) for 1-year subsequent stroke risk was limited and gradually decreased. These scores may not be useful for current clinical practice.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Joao Pedro Marto, Alexander Salerno, Errikos Maslias, Dimitris Lambrou, Ashraf Eskandari, Davide Strambo, Patrik Michel
Summary: The study assessed the management of in-stroke-unit ischemic stroke (ISUS) and found that patients with ISUS had more known stroke onset time, fewer missed treatment opportunities, higher endovascular treatment rates, and better long-term outcomes compared to other strokes occurring in the stroke unit.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Eliza Miller, Anni E. Kauko, Sarah Tom, Hannele Laivuori, Teemu A. Niiranen, Natalie Bello
Summary: The study found that adverse pregnancy outcomes are associated with an earlier onset of maternal cerebrovascular disease, especially in cases where women had more than one affected pregnancy.
Article
Cardiac & Cardiovascular Systems
Marie Eriksson, Anton Grundberg, Erik Inge, Mia von Euler
Summary: This study aimed to estimate and compare the risk of stroke recurrence in men and women, taking into account the competing risk of death. The findings showed that the risk of stroke recurrence has decreased in both men and women, but women's higher age and other risk factors contribute to their higher risk compared with men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Environmental Sciences
Tao Liu, Yong Jiang, Jianxiong Hu, Zixiao Li, Yuming Guo, Xing Li, Jianpeng Xiao, Lixia Yuan, Guanhao He, Weilin Zeng, Haidong Kan, Zuhua Rong, Gongbo Chen, Jun Yang, Yongjun Wang, Wenjun Ma
Summary: Short-term exposure to PM1 may increase the risk of incidence and recurrence of stroke in China, and the effects varied across different types of stroke and regions. Geographically targeted strategies and measures are needed to control air pollution for reducing the burden of stroke from PM1.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Public, Environmental & Occupational Health
Li Zhang, Xianqi Li, Charles D. A. Wolfe, Matthew D. L. O'Connell, Yanzhong Wang
Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between diabetes and stroke recurrence, demonstrating that diabetes is an independent risk factor for stroke recurrence among patients with ischemic stroke.
Article
Endocrinology & Metabolism
Fang Wang, Jinjing Wang, Yunfei Han, Xuan Shi, Xiaohui Xu, Chao Hou, Jie Gao, Shuanggen Zhu, Xinfeng Liu
Summary: This study found an association between triglyceride-glucose index and stroke recurrence in elderly patients with ischemic stroke in China. The triglyceride-glucose index could serve as a predictive marker for stroke recurrence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Brian H. Buck, Naveed Akhtar, Anas Alrohimi, Khurshid Khan, Ashfaq Shuaib
Summary: Stroke mimics account for a significant proportion of hospital admissions, and accurate diagnosis with multi-modal CT or MRI is essential to avoid unnecessary treatment and costs. Prompt resolution of symptoms can be achieved in neurological and medical mimics, while treatment of functional disorders may be challenging and incomplete.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Min Wu, Xiaohao Zhang, Jingjing Chen, Mingming Zha, Kang Yuan, Kangmo Huang, Yi Xie, Jianzhong Xue, Xinfeng Liu
Summary: This study evaluated the association between low-grade inflammation (LGI) and stroke recurrence in patients with ischemic stroke. The results showed that an elevated LGI score was independently associated with a higher risk of stroke recurrence, regardless of other vascular risk factors.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Neurosciences
Siqi Li, Anxin Wang, Xue Tian, Yingting Zuo, Xia Meng, Yumei Zhang
Summary: This study demonstrated that elevated GGT levels were positively associated with an increased risk of stroke adverse outcomes, namely, recurrence, ischemic stroke, and combined vascular events.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Xing Zhang, Si Cheng, Zixiao Li, Hongqiu Gu, Yingyu Jiang, Hao Li, Xia Meng, Yongjun Wang
Summary: This study found no independent association between shortened telomere length (TL) and risk of recurrent stroke in Chinese patients with ischemic stroke or transient ischemic attack (TIA) after adjusting for covariates. However, TL was significantly associated with stroke recurrence in older patients (>65 years), but further replication is needed.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Elizabeth Lounsbury, Naomi Niznick, Ranjeeta Mallick, Brian Dewar, Alexandra Davis, Dean A. Fergusson, Dar Dowlatshahi, Michel Shamy
Summary: This systematic review and meta-analysis on the recurrence rate of cervical artery dissection found low overall rates of recurrent CAD and even lower rates of recurrence associated with ischemia. Further research and analysis are needed to improve patient-level risk stratification.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Shih-Kai Hung, Moon-Sing Lee, Hon-Yi Lin, Liang-Cheng Chen, Chi-Jou Chuang, Chia-Hui Chew, Ben-Hui Yu, Hsuan-Ju Yang, Feng-Chun Hsu, Wen-Yen Chiou
Summary: This study investigated the relationship between different subtypes of hypertensive disorders of pregnancy (HDP), stroke risk, and follow-up time. The results showed that women with HDP had a higher risk of stroke compared to those without HDP, and this risk was associated with the time after childbirth. Among the different HDP subtypes, chronic hypertension with superimposed preeclampsia had the highest stroke risk, while chronic preexisting hypertension had the lowest risk. Furthermore, HDP combined with preeclampsia further increased the risk of stroke.
Article
Cardiac & Cardiovascular Systems
Narayanaswamy Venketasubramanian, Mei Leng Chan
Summary: This study examined the impact of various vascular risk factors on stroke recurrence among stroke survivors referred to a driving assessment and rehabilitation program. The retrospective analysis of medical records showed that age was the main factor influencing stroke recurrence.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Chiara Dallagiovanna, Michela Cappellari, Francesco D'Ambrosi, Marco Reschini, Karina Kordas, Letizia Li Piani, Francesca Filippi, Edgardo Somigliana
Summary: A retrospective cohort study on 594 singleton pregnancies found that the endometrial preparation protocol, either natural cycle or programming cycle with hormonal replacement therapy, did not have a significant impact on the risk of hypertensive disorders in pregnancy.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Edgardo Somigliana, Andrea Busnelli, Erkan Kalafat, Paola Vigano, Baris Ata
Summary: Most proposed definitions of recurrent implantation failure (RIF) are not statistically based. Recently, statistical approaches have been proposed, but their effectiveness relies on endorsement from the scientific community.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Editorial Material
Medicine, General & Internal
Michele Orsi, Edgardo Somigliana
Article
Nutrition & Dietetics
Rosa Casas, Sara Castro-Barquero, Francesca Crovetto, Marta Larroya, Ana Maria Ruiz-Leon, Laura Segales, Ayako Nakaki, Lina Youssef, Leticia Benitez, Francesc Casanovas-Garriga, Eduard Vieta, Fatima Crispi, Eduard Gratacos, Ramon Estruch
Summary: This study aimed to evaluate the association of Dietary Inflammatory Index (DII) score during pregnancy with maternal body mass index (BMI), Mediterranean diet (MD) adherence, and perinatal outcomes. The results showed that a proinflammatory diet was significantly associated with maternal overweight and fetal undergrowth.
Article
Obstetrics & Gynecology
Laura Buggio, Edgardo Somigliana, Greta Sergenti, Federica Ottolini, Dhouha Dridi, Paolo Vercellini
Summary: Our study failed to find an association between AGD and the presence of endometriosis. Therefore, AGD does not seem to be a reliable indicator of the presence of endometriosis in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Article
Medicine, General & Internal
Michele Orsi, Edgardo Somigliana, Fulvia Milena Cribiu, Gianluca Lopez, Laura Buggio, Manuela Wally Ossola, Enrico Ferrazzi
Summary: This study examined the prevalence and clinical impact of adenomyosis among women undergoing pregnancy-related hysterectomy. The findings suggest that adenomyosis is associated with obstetric complications and may impact perinatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Paola Vigano, Marco Reschini, Marta Ciaffaglione, Veronica Cuce, Maira Casalechi, Laura Benaglia, Paolo Vercellini, Edgardo Somigliana
Summary: This study aimed to compare the factors underlying infertility in women with endometriosis. The results showed that there were no significant differences in fertilization rate, embryo quality, and clinical pregnancy rate between women with and without endometriosis. Therefore, conventional IVF can still be used in endometriosis patients unless there is a male factor involved.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Paolo Vercellini, Paola Vigano, Veronica Bandini, Laura Buggio, Nicola Berlanda, Edgardo Somigliana
Summary: This review synthesized systematic reviews and meta-analyses published in the last 5 years to explore the association between endometriosis and adenomyosis with reproductive and obstetric outcomes. The findings suggest that women with endometriosis and adenomyosis have reduced pregnancy and live birth rates, increased miscarriage rates, and higher risks of various adverse obstetric outcomes. Women with deep infiltrating endometriosis and severe adenomyosis should be considered at high obstetric risk and referred to tertiary care centers for safe management during pregnancy and delivery. It is uncertain whether the same applies to pregnant women with minimal endometriosis and adenomyosis forms. Emerging evidence suggests that some adverse outcomes observed in women with endometriosis are associated with coexisting adenomyosis.
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
Edgardo Somigliana, Fabio Parazzini, Alice Goisis, Giovanna Esposito, Letizia Li Piani, Francesca Filippi, Paola Vigano
Summary: The article calls for more research on infertile couples to understand their intended number of children and the rate of return after the first IVF treatment. This could potentially impact clinical practice by improving chances of conceiving a second child and identifying barriers to non-return or a gap between intended and realized number of children. However, the current evidence is insufficient to recommend any interventions.
HUMAN REPRODUCTION
(2023)
Article
Nutrition & Dietetics
Irene Casas, Ayako Nakaki, Rosalia Pascal, Sara Castro-Barquero, Lina Youssef, Mariona Genero, Leticia Benitez, Marta Larroya, Maria Laura Boutet, Giulia Casu, Alex Gomez-Gomez, Oscar J. Pozo, Ivette Morilla, Anabel Martinez-aran, Eduard Vieta, Maria Dolores Gomez-Roig, Rosa Casas, Ramon Estruch, Eduard Gratacos, Fatima Crispi, Francesca Crovetto
Summary: A study investigated the effects of a Mediterranean diet intervention on stress, well-being, and sleep quality in pregnant women. The results showed that pregnant women who followed a Mediterranean diet had reduced stress and anxiety, and improved sleep quality.
Article
Medicine, General & Internal
Julia Ponce, Teresa Cobo, Clara Murillo, Anna Gonce, Nadia Dominguez, Francesca Crovetto, Laura Guirado, Montse Palacio, Mar Bennasar
Summary: Preterm prelabour rupture of membranes (PPROMs) before viability carries significant perinatal mortality and morbidity. Clinical management and prenatal counselling are a challenge, especially in twin pregnancies, due to scarce evidence on how previable PPROM affects this population. This study aimed to describe pregnancy outcomes of twin pregnancies complicated with previable PPROM and evaluate potential prognostic factors that may predict perinatal mortality. The overall survival rate of twin pregnancies complicated with previable PPROM is poor but similar to singletons. No prognostic factors, apart from achieving periviability, were identified as individual predictors of perinatal mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Obstetrics & Gynecology
Pietro Santulli, Paola Vigano, Edgardo Somigliana
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Alessandra Chine, Marco Reschini, Gianfranco Fornelli, Ludovica Basili, Andrea Busnelli, Paola Vigano, Ludovico Muzii, Edgardo Somigliana
Summary: Low ovarian reserve, indicated by anti-Mullerian hormone (AMH) or antral follicle count (AFC), does not increase the risk of miscarriage in young women conceiving with ART.
HUMAN REPRODUCTION OPEN
(2023)
Review
Obstetrics & Gynecology
Paolo Vercellini, Veronica Bandini, Laura Buggio, Giussy Barbara, Nicola Berlanda, Dhouha Dridi, Maria Pina Frattaruolo, Edgardo Somigliana
Summary: This study aimed to investigate a cost-saving measure for the treatment of endometriosis by using a non-standard dosing regimen of a 3.75 mg depot formulation of triptorelin. The extended-interval dosing regimen, with injections every 6 weeks instead of every 4 weeks, reduced the cost by one-third without compromising pain relief.
HUMAN REPRODUCTION OPEN
(2023)
Article
Obstetrics & Gynecology
Valentina Bonanni, Marco Reschini, Irene La Vecchia, Marta Castiglioni, Ludovico Muzii, Paolo Vercellini, Edgardo Somigliana
Summary: This study suggests that small and asymptomatic fibroids that do not encroach the endometrial cavity do not significantly affect female fertility. This information is clinically relevant when counseling infertile women with small fibroids and an otherwise unremarkable diagnostic work-up. Surgery may still be considered but only in selected cases.
HUMAN REPRODUCTION OPEN
(2022)