Review
Biochemistry & Molecular Biology
Preston Carey, Ethan Low, Elizabeth Harper, M. Sharon Stack
Summary: Proteases, particularly those of the matrix metalloproteinase family, play a crucial role in ovarian cancer progression and metastasis by enhancing migratory ability, ECM breakdown, and tumor support system development. Upregulation of certain proteases influences angiogenesis for tumor growth and development of metastatic implants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jung-A Choi, Hyosun Kim, Hyunja Kwon, Elizabeth Hyeji Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: This study examined the clinical value and therapeutic potential of ascitic autotaxin (ATX) in epithelial ovarian cancer (EOC). The results showed that elevated levels of ascitic ATX were associated with advanced stage, high grade, and a short disease-free period in EOC patients. Combining ascitic ATX and serum CA-125 levels improved the diagnostic accuracy for EOC, and functional studies revealed that ascitic ATX played a role in maintaining cancer stem cell-like characteristics and invadopodia formation in EOC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Hui Sun, Yufeng Wang, Shentao Wang, Yikui Xie, Kun Sun, Shuai Li, Weitong Cui, Kai Wang
Summary: This article investigated the correlation between the expression patterns of collagen family genes and gastric cancer progression using bioinformatics analyses. It was found that many collagen family genes were overexpressed in gastric cancer tissues, especially in the early T stages, highlighting the significance of collagens in tumor enlargement of gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Piotr Dziegiel
Summary: The expression of POSTN is significantly increased in NSCLC and may serve as an independent prognostic factor. POSTN knockdown inhibits the migration and invasion of lung cancer cells, potentially through modulating the expression of MMP-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Cailin O'Connell, Sabrina VandenHeuvel, Aparna Kamat, Shreya Raghavan, Biana Godin
Summary: This review provides an overview of the clinical features and diagnostic importance of ovarian cancer, focusing on the role of proteases in its progression and the potential of protease-enabled nanomedicines for diagnosis and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Preety Bajwa, Kasjusz Kordylewicz, Agnes Bilecz, Ricardo R. Lastra, Kristen Wroblewski, Yuval Rinkevich, Ernst Lengyel, Hilary A. Kenny
Summary: Ovarian cancer preferentially metastasizes in association with mesothelial cell-lined surfaces. The presence of mesothelial cells is required for ovarian cancer metastasis, and the interaction between mesothelial cells and ovarian cancer cells leads to alterations in gene expression and cytokine secretion. The secretion of ANGPTL4 by mesothelial cells promotes ovarian cancer metastasis through various mechanisms.
Article
Multidisciplinary Sciences
Elina A. Pietilae, Jordi Gonzalez-Molina, Lidia Moyano-Galceran, Sanaz Jamalzadeh, Kaiyang Zhang, Laura Lehtinen, S. Pauliina Turunen, Tomas A. Martins, Okan Gultekin, Tarja Lamminen, Katja Kaipio, Ulrika Joneborg, Johanna Hynninen, Sakari Hietanen, Seija Grenman, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpen, Joseph W. Carlson, Kaisa Lehti
Summary: The study reveals that platinum chemotherapy enhances resistance by changing cancer cell adhesion signaling and ECM. The heterogeneity of fibrotic ECM in primary tumors and metastatic sites of HGSC before and after chemotherapy provides insights into cancer aggressiveness and potential treatment strategies. The upregulation of COL6 in metastatic HGSCs post-chemotherapy contributes to resistance and relapse, highlighting the importance of targeting the ECM pathway for therapeutic intervention.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Cell Biology
Rong Jiang, Hongyu Zhang, Jinhua Zhou, Juan Wang, Yuejuan Xu, He Zhang, Yanzheng Gu, Fengqing Fu, Yu Shen, Guangbo Zhang, Lanlan Feng, Xueguang Zhang, Youguo Chen, Fangrong Shen
Summary: XIST and FOXP3 were upregulated, while miR-149-3p was downregulated in OC tissues and cells. High XIST expression indicated a poor prognosis for OC. Inhibition of XIST or elevation of miR-149-3p suppressed malignant behaviors of OC cells, such as proliferation, invasion, migration, and colony formation, and promoted apoptosis and cell cycle arrest. This study suggests that knockdown of XIST increases miR-149-3p expression to inhibit OC development.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Leilei Liang, Jian Li, Jing Yu, Jing Liu, Lin Xiu, Jia Zeng, Tiantian Wang, Ning Li, Lingying Wu
Summary: This study established an invasion-related multigene signature to predict the prognostic risk of ovarian cancer. A 6-gene prognostic risk model was constructed and shown to be independent of clinical features. This signature has the potential to evaluate the prognostic risk of ovarian cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Genya Gorshtein, Olivia Grafinger, Marc G. Coppolino
Summary: During metastasis, cancer cells invade extracellular matrix through invadopodia, which formation depends on intracellular signaling, actin cytoskeleton remodeling, and proteolytic matrix modification. SNAREs facilitate the transport of invadopodium-associated proteins and could be a possible target for disrupting metastatic progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
On-Yu Hong, Hye-Yeon Jang, Kwang-Hyun Park, Young-Ju Jeong, Jong-Suk Kim, Hee Chae
Summary: Triptolide can reduce MMP-9 expression by inhibiting signaling pathways and decrease the invasive ability of breast cancer cells, making it a promising drug for breast cancer treatment.
Article
Medicine, Research & Experimental
Tomonori Masuda, Akihisa Fukuda, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Munemasa Nagao, Osamu Araki, Takaaki Yoshikawa, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Yu Muta, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Toshihiko Masui, Etsuro Hatano, Tomoko Matsuzaki, Makoto Noda, Hiroshi Seno
Summary: RECK downregulation promotes the development and metastasis of pancreatic ductal adenocarcinoma (PDAC) by inducing epithelial-mesenchymal transition (EMT) and inflammatory cancer-associated fibroblast-like cells. Reexpression of RECK reduces metastasis and changes the tumor phenotype from mesenchymal to epithelial, suggesting that RECK could be an important therapeutic target for human PDAC.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Ilias P. Nikas, Cheol Lee, Min Ji Song, Bohyun Kim, Han Suk Ryu
Summary: This study identified potential biomarker discrepancies between paired HGSOC primary tissues and metastatic peritoneal fluid cytology samples, suggesting that cytology from effusions could be considered for biomarker testing when tissue from the primary cancer is also available.