Review
Microbiology
Milan Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Milena Radunovic, Gauri Bapayeva, Antonio Simone Lagana
Summary: Preterm labor refers to birth before 37 weeks of gestation, occurring in 5-20% of pregnancies. Influenced by maternal, fetal, and environmental factors, infectious pathogens may account for 25-40% of preterm birth. The association between maternal periodontal disease, pathogenic oral bacteria in the placenta, and preterm delivery is still controversial in spite of extensive research.
Review
Microbiology
Tian-Jiao Li, Yi-hang Hao, Ya-ling Tang, Xin-hua Liang
Summary: Emerging evidence indicates a strong connection between periodontal diseases, including oral cancer. The pathogens responsible for periodontal diseases play a crucial role in the development of oral cancer by directly interacting with the host's epithelium and indirectly creating an inflammatory environment conducive to carcinogenesis. Additionally, the functional properties of the oral microbial community are associated with cancer development. Maintaining oral hygiene is essential for preventing oral diseases, particularly oral cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Guillermo Gallagher-Cobos, Teresa Almerich-Torres, Jose Maria Montiel-Company, Jose Enrique Iranzo-Cortes, Carlos Bellot-Arcis, Jose Carmelo Ortola-Siscar, Jose Manuel Almerich-Silla
Summary: The aim of this study was to investigate the association between the mother's periodontal condition and perinatal complications, such as preterm birth and low birth weight. The results showed no statistically significant relationship between maternal periodontal disease and preterm birth or low birth weight, but tobacco use during pregnancy was associated with low birth weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Leandro De Oliveira, James M. Roberts, Arundhathi Jeyabalan, Kasey Blount, Christopher W. Redman, Lucilla Poston, Paul T. Seed, Lucy C. Chappell, Marcos Augusto Bastos Dias
Summary: The implementation of a risk stratification model based on biomarkers and clinical factors did not lead to reductions in preterm deliveries. Further training and development of additional risk stratification methods are needed before adopting this intervention into clinical practice.
Article
Obstetrics & Gynecology
Yair J. Blumenfeld, Ivana Maric, David K. Stevenson, Ronald S. Gibbs, Gary M. Shaw
Summary: The study aimed to determine the association between persistent bacterial vaginosis (BV) in pregnancy and the risk of spontaneous preterm birth (sPTB). Analysis of retrospective data from IBM MarketScan Commercial Database showed that women with persistent BV had a higher frequency of sPTB compared to those without BV. Treatment for BV in both the first and second trimester, as well as having three or more prescriptions during pregnancy, were associated with higher odds ratios for sPTB. These findings suggest that persistent BV may pose a higher risk for sPTB than a single episode of BV in pregnancy.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Trishna Mohanty, Prakash Prabhakarrao Doke, Sana Rafiq Khuroo
Summary: This meta-analysis aims to confirm the association between bacterial vaginosis and preterm birth. The results of the study indicate a definite association between bacterial vaginosis and preterm birth.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Chemistry, Multidisciplinary
Ta-Chin Lin, I-Ling Hsu, Wan-Hua Tsai, Yi-Chih Chu, Lung-Ching Kuan, Min-Syuan Huang, Wen-Ling Yeh, Ya-Hui Chen, Shan-Ju Hsu, Wen-Wei Chang
Summary: The study found that VGA-1, a potential agent for bacterial vaginosis (BV) intervention, showed improvement effects in BV patients and reduced recurrent rates. Among the two lactobacillus formulas tested, VGA-1 demonstrated superior efficacy in improving symptoms and reducing recurrent rates in BV patients.
APPLIED SCIENCES-BASEL
(2021)
Article
Obstetrics & Gynecology
Gkp Cunha, L. B. Bastos, S. F. Freitas, R. C. Cavalli, S. M. Quintana
Summary: The study concluded that genital mycoplasma infection is not a risk factor for spontaneous preterm birth, even when combined with other abnormal vaginal microbiota. The presence of bacterial vaginosis did not increase the risk of preterm birth in pregnant women with mycoplasma infection.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pachiappan Arjunan, Radhika Swaminathan, Jessie Yuan, Mohamed Elashiry, Amany Tawfik, Mohamed Al-Shabrawey, Pamela M. Martin, Thangaraju Muthusamy, Christopher W. Cutler
Summary: This study established a novel AMD+PD murine model to investigate the potential role of periodontal infection in AMD progression. The results demonstrated that periodontal infection may enhance the AMD phenotype, with significant changes observed in retinal pathology and gene expression profiles in the AMD+PD mice retinae.
Article
Endocrinology & Metabolism
Arash Derakhshan, Tuija Mannisto, Liangmiao Chen, Joris A. J. Osinga, Ghalia Ashoor, Xuemian Lu, Sofie Bliddal, Fang-Biao Tao, Suzanne J. Brown, Bijay Vaidya, Andrew T. Hattersley, Sachiko Itoh, Polina Popova, Ashraf Aminorroaya, Reiko Kishi, Maryam Kianpour, Elena A. Vasukova, Abel Lopez-Bermejo, Emily Oken, Leda Chatzi, Marina Vafeiadi, Wichor M. Bramer, Judit Bassols, Aitana Lertxundi, Ana Fernandez-Somoano, Paula Carrasco, Juha Auvinen, Kun Huang, Ulla Feldt-Rasmussen, Elena N. Grineva, Erik K. Alexander, Elizabeth N. Pearce, Layal Chaker, John P. Walsh, Robin P. Peeters, Monica Guxens, Eila Suvanto, Kypros H. Nicolaides, Tim I. M. Korevaar
Summary: This study explores the association between gestational FT3 and TT3 levels and adverse obstetric outcomes. The findings suggest that FT3 and TT3 levels have different associations with various adverse obstetric outcomes, with high TT3 associated with an increased risk of gestational hypertension and low TT3 associated with a higher risk of very preterm birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Martina Ferrillo, Mario Migliario, Andrea Roccuzzo, Pedro Molinero-Mourelle, Giovanni Falcicchio, Giuseppina Rosaria Umano, Federica Pezzotti, Pier Luigi Foglio Bonda, Dario Calafiore, Alessandro de Sire
Summary: The study found a correlation between periodontal disease, low vitamin D levels, preterm birth, and low birth weight in pregnant women. Poor oral health and vitamin D deficiency in pregnant women were significantly associated with higher rates of preterm birth and low birth weight.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Michael T. Shen, Betti Shahin, Zhengjia Chen, Guy R. Adami
Summary: This study aimed to determine if patients with severe periodontal disease and multimorbidity show higher levels of periodontal pathogens. The results showed that patients with severe periodontal disease did have higher levels of periodontal pathogens, but those with multimorbidity actually showed lower levels of these pathogens.
Article
Pediatrics
Dario Elias, Lucas Gimenez, Fernando Poletta, Hebe Campana, Juan Gili, Julia Ratowiecki, Mariela Pawluk, Monica Rittler, Maria R. Santos, Rocio Uranga, Silvina L. Heisecke, Viviana Cosentino, Cesar Saleme, Enrique Gadow, Hugo Krupitzki, Jorge S. Lope Camelo
Summary: This study reveals that certain maternal and fetal genes associated with infectious/inflammatory and hormonal regulation processes increase the risk of preterm birth when mothers are exposed to urinary tract infections or vaginal infections, with variations in impact depending on clinical subtype.
PEDIATRIC RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Haiying Guo, Biao Li, Hantao Yao, Danfeng Liu, Rourong Chen, Shuhui Zhou, Yaoting Ji, Lin Zeng, Minquan Du
Summary: This study found that the oral microbiome of AD patients was altered, and the periodontal microbiome was sensitive to cognitive changes. V. parvula and P. gingivalis were associated with AD.
Article
Multidisciplinary Sciences
Agnieszka Kregielczak, Barbara Dorocka-Bobkowska, Ryszard Slomski, Grzegorz Oszkinis, Zbigniew Krasinski
Summary: The aim of this study was to investigate the periodontal status of patients with atherosclerosis and abdominal aortic aneurysms. The results showed that the majority of patients had chronic severe generalized periodontitis, and multiple periodontopathogens were detected in the periodontal pockets.