期刊
ARCHIVES OF GERONTOLOGY AND GERIATRICS
卷 54, 期 3, 页码 E387-E391出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2012.01.006
关键词
Inflammation; Hospitalization; Mortality; Community-dwelling older adults
资金
- National Institute on Aging (NIA) [R01-AG015062, P30AG031054, 1K07AG31779]
- American Cancer Society
- AHRQ
- NIH [1UL 1RR025777]
- HRSA
- Donald W. Reynolds Foundation
- UpToDate
- Department of Veterans Affairs Health Services Research & Development Service [E6326W]
- GCRC from the National Center for Research Resources [M01 RR-00032]
Individuals with multimorbidity may be at increased risk of hospitalization and death. Comorbidity indexes do not capture severity of illness or healthcare utilization; however, inflammation biomarkers that are not disease-specific may predict hospitalization and death in older adults. We sought to predict hospitalization and mortality of older adults using inflammation biomarkers. From a prospective, observational study, 370 community-dwelling adults 65 years or older from central Alabama participated in an in-home assessment and provided fasting blood samples for inflammation biomarker testing in 2004. We calculated an inflammation summary score (range 0-4), one point each for low albumin, high C-reactive protein, low cholesterol, and high interleukin-6. Utilizing Cox proportional hazards models, inflammation summary scores were used to predicted time to hospitalization and death during a 4-year follow up period. The mean age was 73.7 (+/- 5.9 yrs), and 53 (14%) participants had summary scores of 3 or 4. The rates of dying were significantly increased for participants with inflammation summary scores of 2, 3, or 4 (hazard ratio (HR) 2.22, 2.78, and 7.55, respectively; p < 0.05). An inflammation summary score of 4 significantly predicted hospitalization (HR 5.92, p < 0.05). Community-dwelling older adults with biomarkers positive for inflammation had increased rates of being hospitalized or dying during the follow up period. Assessment of the individual contribution of particular inflammation biomarkers in the prediction of health outcomes in older populations and the development of validated summary scores to predict morbidity and mortality are needed. Published by Elsevier Ireland Ltd.
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