Article
Psychiatry
Caroline E. E. Temcheff, Alexa Martin-Storey, Annie Lemieux, Eric Latimer, Michele Dery
Summary: Children with conduct problems are more likely to use medical services in adulthood, and there is limited knowledge on how medical service use develops during childhood and adolescence. Understanding the developmental trajectories of medical service use for specific types of problems and their association with childhood conduct problems can help clinicians intervene at critical periods to prevent future problems and increased service use.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Merete G. Oie, Kjetil Sundet, Elisabeth Haug, Pal Zeiner, Ole Klungsoyr, Bjorn R. Rund
Summary: The study compared EOS, ADHD, and a healthy control group on cognitive tests over 25 years, finding cognitive stagnation in EOS group from T1 to T2 but significant improvement from T2 to T3, while the ADHD group consistently improved over the study period, supporting a maturational delay hypothesis for ADHD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Pediatrics
Samantha J. Brooks, Olga E. Titova, Emma L. Ashworth, Simon B. A. Bylund, Inna Feldman, Helgi B. Schioth
Summary: Physical conditions in children and adolescents are often underreported and may contribute to mental health disorders. This study aimed to examine the incidence of psychosomatic complaints in adolescents with conduct problems. The results showed that adolescents with higher psychosomatic complaint scores also had higher conduct problem scores, especially older boys.
Article
Family Studies
Hepsi Swarna, Philip S. J. Leonard, Weiqiu Yu
Summary: The study aimed to examine the relationship between childhood conduct problems and adolescent outcomes prospectively. It found that childhood conduct problems were associated with non-violent offenses and substance use in adolescence, but not with physically violent offenses or deviant lifestyle. Moreover, children with conduct problems before the age of 10 were more likely to meet the diagnostic criteria for conduct disorder in adolescence.
CANADIAN JOURNAL OF FAMILY AND YOUTH
(2022)
Article
Clinical Neurology
Jonathan D. Santoro, Peter K. Moon, Michelle Han, Emily S. McKenna, Elizabeth Tong, Sarah J. MacEachern, Nils D. Forkert, Kristen W. Yeom
Summary: Individuals with medically refractory migraine headache show significant changes in apparent diffusion coefficient in multiple brain structures, suggesting structural connectivity issues may predispose some patients to more medically refractory pain disorders such as migraine headache. Volumetric differences were not observed between the two groups.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychology, Developmental
Yali Jiang, Yidian Gao, Daifeng Dong, Xiaoqiang Sun, Weijun Situ, Shuqiao Yao
Summary: This study investigated morphological differences in the brains of Chinese adolescents diagnosed with conduct disorder (CD) using surface-based morphometry methods. The results showed that adolescents with low callous unemotional (CU) traits, compared to healthy controls, had increased cortical surface area in the left inferior temporal cortex and right precuneus, but decreased surface area in the left superior temporal cortex. There were no significant differences in cortical surface area between adolescents with high CU traits and healthy controls. Additionally, adolescents with low CU traits had greater cortical thickness in the left rostral middle frontal cortex compared to those with high CU traits.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Philip T. Veliz, Marian E. Berryhill
Summary: This study found that mild traumatic brain injury (mTBI) may increase the incidence of affective and behavioral symptoms, particularly among adolescents. Therefore, extended screening for mTBI history and monitoring of related symptoms are necessary for adolescents.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2023)
Article
Psychology, Clinical
Kristin Smyth, Alison Salloum, Jaclyn Herring
Summary: This study aimed to gain an understanding of the lived experience of interpersonal relationships and early-onset bipolar disorder during adolescence through retrospective reports of emerging adults. Participants described adolescence as a period of constant challenges in managing symptoms, maintaining social functioning, and dealing with changes in family and peer relationships, which provide interpersonal support. Future qualitative studies should further explore the impact of normative social development and family functioning on the course of illness and treatment outcomes.
JOURNAL OF MENTAL HEALTH
(2021)
Article
Psychiatry
Derin Cobia, Chaz Rich, Matthew J. Smith, Pedro Engel Gonzalez, Will Cronenwett, John G. Csernansky, Lei Wang
Summary: Early-onset schizophrenia (EOS) and adult-onset schizophrenia (AOS) both exhibit thalamic shape abnormalities, but EOS has more severe abnormalities. These thalamic abnormalities are related to the clinical and cognitive aspects of the illness.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Lucy Karwatowska, Leonard Frach, Tabea Schoeler, Jorim J. Tielbeek, Joseph Murray, Eco de Geus, Essi Viding, Jean-Baptiste Pingault
Summary: Observational studies have found an association between low resting heart rate (RHR) and higher levels of antisocial behavior (ASB), but it is unclear if this represents a causal relationship. To investigate further, the study conducted various genetic analyses but found no evidence of a causal association between RHR and ASB. The findings suggest that individual differences in autonomic nervous system functioning indexed by RHR are unlikely to directly contribute to the development of ASB.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Katherine O'Connell, Kathryn Berluti, Shawn A. Rhoads, Abigail A. Marsh
Summary: Individuals with high levels of antisociality tend to engage in fewer social distancing measures, posing potential health risks to themselves and their community during the COVID-19 pandemic.
Article
Medicine, General & Internal
Joao Paulo Lima Santos, Michele Bertocci, Genna Bebko, Tina Goldstein, Tae Kim, Satish Iyengar, Lisa Bonar, MaryKay Gill, John Merranko, Anastasia Yendiki, Boris Birmaher, Mary L. Phillips, Amelia Versace
Summary: Diffusion Magnetic Resonance Imaging (dMRI) studies have found abnormalities in emotion regulation circuits in patients with early-onset bipolar disorder (BD), and this study aims to examine the contribution of previous illness and its neural correlates. The results show that a higher number of depressive episodes during childhood/adolescence and higher percentage of time with syndromic depression were associated with lower fractional anisotropy (FA) in certain brain regions. Lower FA in these regions was also correlated with higher depressive and anxiety symptoms. Interestingly, higher FA in certain brain regions was protective against the recurrence of depressive episodes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Developmental
Ivy N. Defoe, Atika Khurana, Laura M. Betancourt, Hallam Hurt, Daniel Romer
Summary: The present study aimed to examine the predictive nature of the behavioral disinhibition model (BDM) from early to late adolescence. The study found that changes in impulsivity during early adolescence can predict the emergence of antisocial personality disorder (APD) and alcohol use disorder (AUD) in late adolescence, mediated by changes in alcohol use and conduct problems during mid-adolescence.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Clinical Neurology
Kamalini G. Ranasinghe, Kiwamu Kudo, Leighton Hinkley, Alexander Beagle, Hannah Lerner, Danielle Mizuiri, Anne Findlay, Bruce L. Miller, Joel H. Kramer, Maria Luisa Gorno-Tempini, Gil D. Rabinovici, Katherine P. Rankin, Paul A. Garcia, Heidi E. Kirsch, Keith Vossel, Srikantan S. Nagarajan
Summary: Patients with Alzheimer's disease with subclinical epileptiform activity show altered neuronal synchrony, which can be accurately quantified using resting-state magnetoencephalography. These quantitative neurophysiological measures can serve as biomarkers to improve diagnosis and select appropriate patients for therapy.
Article
Immunology
Tamaki Kato, Yoshiteru Tamura, Hiroshi Matsumoto, Osamu Kobayashi, Hideaki Ishiguro, Masaya Ogawa, Koyo Tsujikawa, Yasuhiro Hasegawa, Mitsuhiro Sakamoto, Masaaki Konagaya, Hideki Houzen, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Akio Yokoseki, Osamu Onodera, Shigeaki Nonoyama
Summary: This study reports that patients with EAOH exhibit immunological abnormalities, including lymphopenia, decreased levels of T cells, B cells, and antibodies. Additionally, mild radiosensitivity was observed in lymphocytes from EAOH patients.
CLINICAL IMMUNOLOGY
(2021)
Review
Clinical Neurology
Barbara Borroni, Caroline Graff, Orla Hardiman, Albert C. Ludolph, Fermin Moreno, Markus Otto, Marco Piccininni, Anne M. Remes, James B. Rowe, Harro Seelaar, Elka Stefanova, Latchezar Traykov, Giancarlo Logroscino
Summary: FRONTIERS is a European research study aimed at improving the understanding of FTLD-related disorders and their epidemiology, with the goal of promoting appropriate public health service policies and treatment strategies.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Negin Holland, Maura Malpetti, Timothy Rittman, Elijah E. Mak, Luca Passamonti, Sanne S. Kaalund, Frank H. Hezemans, P. Simon Jones, George Savulich, Young T. Hong, Tim D. Fryer, Franklin Aigbirhio, John T. O'Brien, James B. Rowe
Summary: The relationship between in vivo synaptic density and molecular pathology in primary tauopathies, especially in progressive supranuclear palsy and corticobasal degeneration, is investigated in this study. It is found that there is a biphasic correlation between synaptic density and molecular pathology, with regions rich in synapses more vulnerable to pathological aggregates accumulation, followed by synaptic loss as a response to the molecular pathology. These findings contribute to a better understanding of the pathophysiology of primary tauopathies and may inform the design of future clinical trials.
Article
Clinical Neurology
Georgia Peakman, Lucy L. Russell, Rhian S. Convery, Jennifer M. Nicholas, John C. Van Swieten, Lize C. Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonca, Chris R. Butler, Alex Gerhard, Simon Ducharme, Isabelle Le Ber, Fabrizio Tagliavini, Isabel Santana, Florence Pasquier, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer
Summary: The study compared the CDR+NACC FTLD and FRS in genetic forms of FTD, finding that both measures were correlated with disease severity in mutation carriers. However, discrepancies in disease staging were observed between the two scales and with clinician-judged symptomatic status. The study suggests that a new scale incorporating key symptoms in the FTD spectrum may be needed in future assessments.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Ece Kocagoncu, David Nesbitt, Tina Emery, Laura E. Hughes, Richard N. Henson, James B. Rowe
Summary: The study focuses on cognitive frailty and compared the structural and neurophysiological properties of cognitively frail adults with Alzheimer’s disease and mild cognitive impairment. The results suggest that cognitive frailty may represent a spectrum of normal aging rather than the onset of Alzheimer’s disease.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maura Malpetti, Sanne S. Kaalund, Kamen A. Tsvetanov, Timothy Rittman, Mayen Briggs, Kieren S. J. Allinson, Luca Passamonti, Negin Holland, P. Simon Jones, Tim D. Fryer, Young T. Hong, Antonina Kouli, W. Richard Bevan-Jones, Elijah Mak, George Savulich, Maria Grazia Spillantini, Franklin Aigbirhio, Caroline H. Williams-Gray, John T. O'Brien, James B. Rowe
Summary: The study found that F-18-flortaucipir PET does not correspond to neuropathologic staging in PSP. The analytic approach seeking to mirror in vivo neuropathology staging with PET-to-autopsy correlational analyses might enable in vivo staging with next-generation tau PET tracers; however, further evidence and comparisons with postmortem data are needed.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dace Apsvalka, Catarina S. Ferreira, Taylor W. Schmitz, James B. Rowe, Michael C. Anderson
Summary: This study demonstrates that inhibitory control activates the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, and these regions play a crucial role in action and thought stopping.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Arabella Bouzigues, Lucy L. Russell, Georgia Peakman, Martina Bocchetta, Caroline Greaves, Rhian S. Convery, Emily Todd, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Sandro Sorbi, Chris R. Butler, Caroline Graff, Alexander Gerhard, Tobias Langheinrich, Robert Laforce, Raquel Sanchez-Valle, Alexandre de Mendonca, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Adrian Danek, Markus Otto, Florence Pasquier, Isabel Santana, Jonathan D. Rohrer
Summary: This study finds that MAPT mutation carriers develop early naming impairments likely associated with semantic knowledge deficits, while C9orf72 and GRN mutation carriers can have more widespread brain atrophy.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Thomas E. Cope, Laura E. Hughes, Holly N. Phillips, Natalie E. Adams, Amirhossein Jafarian, David Nesbitt, Moataz Assem, Alexandra Woolgar, John Duncan, James B. Rowe
Summary: The study demonstrates the causal role of the multiple demand (MD) network in automatic auditory change detection, showing that atrophy of any MD node impairs auditory neurophysiological response. Different neurodegenerative syndromes display altered connectivity within the MD network, with evidence of partially effective compensation mechanisms. Damage to any node of the MD network is found to impair top-down control of sensation, providing a common mechanism for impaired change detection across dementia syndromes.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Alessandro Tomassini, Frank H. Hezemans, Rong Ye, Kamen A. Tsvetanov, Noham Wolpe, James B. Rowe
Summary: This study confirms the association between locus coeruleus integrity and response inhibition ability using MRI imaging. It also demonstrates that the connectivity between presupplementary motor area (preSMA) and right inferior frontal gyrus (rIFG) plays a mediating role in this association. These findings suggest that the locus coeruleus noradrenergic system regulates inhibitory control in healthy individuals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Andrea Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Negin Holland, Tim D. Fryer, John T. O'Brien, James B. Rowe, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis
Summary: This study decomposes neural information into synergistic and redundant components, showing the role of core brain regions in supporting higher cognition and demonstrating that humans leverage synergistic information more than macaques. The study also reveals the distinct roles of redundant and synergistic interactions in neural information processing.
NATURE NEUROSCIENCE
(2022)
Review
Clinical Neurology
Michael C. B. David, Martina Del Giovane, Kathy Y. Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A. Malhotra
Summary: This study assessed the efficacy of drugs with noradrenergic action in improving cognitive and neuropsychiatric symptoms in Alzheimer's disease. The findings showed a small positive effect on global cognition and a large positive effect on apathy. This suggests that repurposing established noradrenergic drugs may offer effective treatment for certain symptoms in Alzheimer's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Astronomy & Astrophysics
Luca Cacciapuoti, Laura Inno, Giovanni Covone, Veselin B. Kostov, Thomas Barclay, Elisa Quintana, Knicole D. Colon, Keivan G. Stassun, Benjamin Hord, Steven Giacalone, Stephen R. Kane, Kelsey Hoffman, Jason Rowe, Gavin Wang, Kevin Collins, Karen A. Collins, Thiam-Guan Tan, Francesco Gallo, Christian Magliano, Riccardo M. Ienco, Markus Rabus, David R. Ciardi, Elise Furlan, Steve B. Howell, Crystal L. Gnilka, Nicholas J. Scott, Kathryn Lester, Carl Ziegler, Cesar Briceno, Nicholas Law, Andrew W. Mann, Christopher J. Burke, Samuel N. Quinn, Angelo Ciaramella, Pasquale De Luca, Stefano Fiscale, Alessandra Rotundi, Livia Marcellino, Ardelio Galletti, Ida Bifulco, Fabrizio Oliva, Alton Spencer, Lisa Kaltenegger, Scott McDermott, Zahra Essack, Jon M. Jenkins, Bill Wohler, Joshua N. Winn, S. Seager, Roland Vanderspek, George Zhou, Avi Shporer, Diana Dragomir, William Fong
Summary: We report the discovery of a three-planet system around the bright, Sun-like star HD 22946. Two planets have been validated, and a third potential planet has been identified. The system is dynamically stable and may have room for additional planets. Further study of the star and its planets could provide valuable insights into their masses and atmospheres.
ASTRONOMY & ASTROPHYSICS
(2022)
Article
Astronomy & Astrophysics
Antoine Darveau-Bernier, Loic Albert, Geert Jan Talens, David Lafreniere, Michael Radica, Rene Doyon, Neil J. Cook, Jason F. Rowe, Romain Allart, Etienne Artigau, Bjorn Benneke, Nicolas Cowan, Lisa Dang, Nestor Espinoza, Doug Johnstone, Lisa Kaltenegger, Olivia Lim, Tyler Pauly, Stefan Pelletier, Caroline Piaulet, Arpita Roy, Pierre-Alexis Roy, Jared Splinter, Jake Taylor, Jake D. Turner
Summary: The SOSS mode of the NIRISS instrument is specifically designed for characterizing the atmospheres of exoplanets, but due to mechanical constraints, there is a potential contamination signal in the extracted spectrum.
PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF THE PACIFIC
(2022)
Article
Cell Biology
Ashwin V. Venkataraman, Ayla Mansur, Gaia Rizzo, Courtney Bishop, Yvonne Lewis, Ece Kocagoncu, Anne Lingford-Hughes, Mickael Huiban, Jan Passchier, James B. Rowe, Hideo Tsukada, David J. Brooks, Laurent Martarello, Robert A. Comley, Laigao Chen, Adam J. Schwarz, Richard Hargreaves, Roger N. Gunn, Eugenii A. Rabiner, Paul M. Matthews
Summary: This study provides in vivo evidence for the widespread presence of cellular stress and bioenergetic abnormalities in early-stage Alzheimer's disease, which could be helpful for early diagnosis and treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Joseph Giorgio, Ankeet Tanna, Maura Malpetti, Simon R. White, Jingshen Wang, Suzanne Baker, Susan Landau, Tomotaka Tanaka, Christopher Chen, James B. Rowe, John O'Brien, Jurgen Fripp, Michael Breakspear, William Jagust, Zoe Kourtzi
Summary: This study used a two-stage approach to harmonize cognitive data from different cohorts and derive a cross-cohort score for cognitive impairment due to AD. The results showed that the cognitive composites were robust across cohorts and achieved comparable sensitivity to AD-related cognitive decline. This approach offers a simple and effective way for researchers to harmonize and pool cognitive data for the study of cognitive decline in AD.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)